{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T16:40:46Z","timestamp":1780072846438,"version":"3.54.0"},"reference-count":101,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T00:00:00Z","timestamp":1765238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"vor","delay-in-days":35,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["148634"],"award-info":[{"award-number":["148634"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["186076"],"award-info":[{"award-number":["186076"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["143278"],"award-info":[{"award-number":["143278"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000222","name":"Heart and Stroke Foundation of Canada","doi-asserted-by":"publisher","award":["New Investigator Award"],"award-info":[{"award-number":["New Investigator Award"]}],"id":[{"id":"10.13039\/501100000222","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000222","name":"Heart and Stroke Foundation of Canada","doi-asserted-by":"publisher","award":["Grant-in-Aid"],"award-info":[{"award-number":["Grant-in-Aid"]}],"id":[{"id":"10.13039\/501100000222","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cardiovasc Disord"],"DOI":"10.1186\/s12872-025-05413-0","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T07:26:40Z","timestamp":1765265200000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Integrated bioinformatic and in vivo analysis confirms the cardioprotective role of OPA1"],"prefix":"10.1186","volume":"26","author":[{"given":"Claire","family":"Fong-McMaster","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena M.","family":"Pulente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke S.","family":"Kennedy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler K.T.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Myers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel N.","family":"Kanaan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charbel Y.","family":"Karam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Cope","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle M.","family":"Levesque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ella","family":"McIlroy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilka","family":"Lorenzen-Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig J.","family":"Goergen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan D.","family":"Fullerton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miroslava","family":"Cuperlovic-Culf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin E.","family":"Mulvihill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary-Ellen","family":"Harper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,9]]},"reference":[{"issue":"10","key":"5413_CR1","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1038\/s41569-024-01046-6","volume":"21","author":"MS Khan","year":"2024","unstructured":"Khan MS, Shahid I, Bennis A, Rakisheva A, Metra M, Butler J. Global epidemiology of heart failure. Nat Rev Cardiol. 2024;21(10):717\u201334.","journal-title":"Nat Rev Cardiol"},{"issue":"6","key":"5413_CR2","doi-asserted-by":"publisher","first-page":"e027852","DOI":"10.1161\/JAHA.122.027852","volume":"12","author":"T Yan","year":"2023","unstructured":"Yan T, Zhu S, Yin X, Xie C, Xue J, Zhu M, et al. Burden, Trends, and inequalities of heart failure globally, 1990 to 2019: A secondary analysis based on the global burden of disease 2019 study. J Am Heart Assoc. 2023;12(6):e027852.","journal-title":"J Am Heart Assoc"},{"issue":"4","key":"5413_CR3","first-page":"531","volume":"37","author":"M McDonald","year":"2021","unstructured":"McDonald M, Virani S, Chan M, Ducharme A, Ezekowitz JA, Giannetti N, et al. CCS\/CHFS Heart Failure Guidelines Update: Defining a New Pharmacologic Standard of Care for Heart Failure With Reduced Ejection Fraction. Can J Cardiol. 2021;37(4):531\u201346.","journal-title":"Can J Cardiol"},{"issue":"1","key":"5413_CR4","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.jacbts.2019.07.009","volume":"5","author":"HN Sabbah","year":"2020","unstructured":"Sabbah HN. Targeting the mitochondria in heart failure. JACC Basic Transl Sci. 2020;5(1):88\u2013106.","journal-title":"JACC Basic Transl Sci"},{"issue":"4","key":"5413_CR5","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1038\/nrcardio.2016.203","volume":"14","author":"DA Brown","year":"2017","unstructured":"Brown DA, Perry JB, Allen ME, Sabbah HN, Stauffer BL, Shaikh SR, et al. Mitochondrial function as a therapeutic target in heart failure. Nat Rev Cardiol. 2017;14(4):238\u201350.","journal-title":"Nat Rev Cardiol"},{"issue":"2","key":"5413_CR6","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1161\/CIRCRESAHA.124.323800","volume":"135","author":"A Hinton","year":"2024","unstructured":"Hinton A, Claypool SM, Neikirk K, Senoo N, Wanjalla CN, Kirabo A, et al. Mitochondrial structure and function in human heart failure. Circ Res. 2024;135(2):372\u201396.","journal-title":"Circ Res"},{"issue":"12","key":"5413_CR7","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1161\/CIRCRESAHA.111.258723","volume":"109","author":"Y Chen","year":"2011","unstructured":"Chen Y, Liu Y, Dorn GW. Mitochondrial fusion is essential for organelle function and cardiac homeostasis. Circ Res. 2011;109(12):1327\u201331.","journal-title":"Circ Res"},{"issue":"2","key":"5413_CR8","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.tem.2015.12.001","volume":"27","author":"T Wai","year":"2016","unstructured":"Wai T, Langer T. Mitochondrial dynamics and metabolic regulation. Trends Endocrinol Metab. 2016;27(2):105\u201317.","journal-title":"Trends Endocrinol Metab"},{"issue":"4","key":"5413_CR9","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1016\/j.cmet.2014.03.011","volume":"19","author":"P Mishra","year":"2014","unstructured":"Mishra P, Carelli V, Manfredi G, Chan DC. Proteolytic cleavage of Opa1 stimulates mitochondrial inner membrane fusion and couples fusion to oxidative phosphorylation. Cell Metab. 2014;19(4):630\u201341.","journal-title":"Cell Metab"},{"issue":"1","key":"5413_CR10","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.cell.2006.06.025","volume":"126","author":"C Frezza","year":"2006","unstructured":"Frezza C, Cipolat S, Martins De Brito O, Micaroni M, Beznoussenko GV, Rudka T, et al. OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion. Cell. 2006;126(1):177\u201389.","journal-title":"Cell"},{"issue":"4","key":"5413_CR11","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.bbabio.2018.01.005","volume":"1859","author":"V Del Dotto","year":"2018","unstructured":"Del Dotto V, Fogazza M, Carelli V, Rugolo M, Zanna C. Eight human OPA1 isoforms, long and short: what are they for? Biochimica et Biophysica Acta (BBA). 2018;1859(4):263\u20139.","journal-title":"Biochimica et Biophysica Acta (BBA)"},{"issue":"12","key":"5413_CR12","doi-asserted-by":"publisher","first-page":"2557","DOI":"10.1016\/j.celrep.2017.05.073","volume":"20","author":"V Del Dotto","year":"2017","unstructured":"Del Dotto V, Mishra P, Vidoni S, Fogazza M, Maresca A, Caporali L, et al. OPA1 Isoforms in the Hierarchical Organization of Mitochondrial Functions. Cell Rep. 2017;20(12):2557\u201371.","journal-title":"Cell Rep"},{"issue":"17","key":"5413_CR13","doi-asserted-by":"publisher","first-page":"7115","DOI":"10.1074\/jbc.M116.762567","volume":"292","author":"H Lee","year":"2017","unstructured":"Lee H, Smith SB, Yoon Y. The short variant of the mitochondrial dynamin OPA1 maintains mitochondrial energetics and cristae structure. J Biol Chem. 2017;292(17):7115\u201330.","journal-title":"J Biol Chem"},{"issue":"10","key":"5413_CR14","doi-asserted-by":"publisher","first-page":"7743","DOI":"10.1074\/jbc.C200677200","volume":"278","author":"A Olichon","year":"2003","unstructured":"Olichon A, Baricault L, Gas N, Guillou E, Valette A, Belenguer P, et al. Loss of OPA1 perturbs the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis. J Biol Chem. 2003;278(10):7743\u20136.","journal-title":"J Biol Chem"},{"issue":"6","key":"5413_CR15","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1016\/j.cmet.2015.05.007","volume":"21","author":"T Varanita","year":"2015","unstructured":"Varanita T, Soriano ME, Romanello V, Zaglia T, Quintana-Cabrera R, Semenzato M, et al. The OPA1-dependent mitochondrial cristae remodeling pathway controls atrophic, apoptotic, and ischemic tissue damage. Cell Metab. 2015;21(6):834\u201344.","journal-title":"Cell Metab"},{"issue":"19","key":"5413_CR16","doi-asserted-by":"publisher","first-page":"6543","DOI":"10.1074\/jbc.RA119.010983","volume":"295","author":"H Lee","year":"2020","unstructured":"Lee H, Smith SB, Sheu SS, Yoon Y. The short variant of optic atrophy 1 (OPA1) improves cell survival under oxidative stress. J Biol Chem. 2020;295(19):6543\u201360.","journal-title":"J Biol Chem"},{"issue":"1","key":"5413_CR17","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1093\/cvr\/cvp181","volume":"84","author":"L Chen","year":"2009","unstructured":"Chen L, Gong Q, Stice JP, Knowlton AA. Mitochondrial OPA1, apoptosis, and heart failure. Cardiovasc Res. 2009;84(1):91\u20139.","journal-title":"Cardiovasc Res"},{"issue":"4","key":"5413_CR18","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1007\/s10557-018-6805-y","volume":"32","author":"HN Sabbah","year":"2018","unstructured":"Sabbah HN, Gupta RC, Singh-Gupta V, Zhang K, Lanfear DE. Abnormalities of mitochondrial dynamics in the failing heart: normalization following long-term therapy with Elamipretide. Cardiovasc Drugs Ther. 2018;32(4):319\u201328.","journal-title":"Cardiovasc Drugs Ther"},{"issue":"3","key":"5413_CR19","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1093\/cvr\/cvs117","volume":"94","author":"J Piquereau","year":"2012","unstructured":"Piquereau J, Caffin F, Novotova M, Prola A, Garnier A, Mateo P, et al. Down-regulation of OPA1 alters mouse mitochondrial morphology, PTP function, and cardiac adaptation to pressure overload. Cardiovasc Res. 2012;94(3):408\u201317.","journal-title":"Cardiovasc Res."},{"issue":"5","key":"5413_CR20","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.112.003012","volume":"1","author":"L Chen","year":"2012","unstructured":"Chen L, Liu T, Tran A, Lu X, Tomilov AA, Davies V, et al. OPA1 mutation and late-onset cardiomyopathy: mitochondrial dysfunction and mtDNA instability. J Am Heart Assoc. 2012;1(5):e003012.","journal-title":"J Am Heart Assoc"},{"issue":"6265","key":"5413_CR21","doi-asserted-by":"publisher","first-page":"aad0116","DOI":"10.1126\/science.aad0116","volume":"350","author":"T Wai","year":"2015","unstructured":"Wai T, Garc\u00eda-Prieto J, Baker MJ, Merkwirth C, Benit P, Rustin P, et al. Imbalanced OPA1 processing and mitochondrial fragmentation cause heart failure in mice. Science. 2015;350(6265):aad0116.","journal-title":"Science"},{"issue":"434","key":"5413_CR22","doi-asserted-by":"publisher","first-page":"eaan4935","DOI":"10.1126\/scitranslmed.aan4935","volume":"10","author":"R Acin-Perez","year":"2018","unstructured":"Acin-Perez R, Lechuga-Vieco AV, Del Mar Mu\u00f1oz M, Nieto-Arellano R, Torroja C, S\u00e1nchez-Cabo F, et al. Ablation of the stress protease OMA1 protects against heart failure in mice. Sci Transl Med. 2018;10(434):eaan4935.","journal-title":"Sci Transl Med"},{"issue":"31","key":"5413_CR23","doi-asserted-by":"publisher","first-page":"eadp0443","DOI":"10.1126\/sciadv.adp0443","volume":"10","author":"S Ahola","year":"2024","unstructured":"Ahola S, Pazurek LA, Mayer F, Lampe P, Hermans S, Becker L, et al. Opa1 processing is dispensable in mouse development but is protective in mitochondrial cardiomyopathy. Sci Adv. 2024;10(31):eadp0443.","journal-title":"Sci Adv"},{"issue":"7","key":"5413_CR24","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1093\/cvr\/cvy052","volume":"114","author":"Y Guo","year":"2018","unstructured":"Guo Y, Wang Z, Qin X, Xu J, Hou Z, Yang H, et al. Enhancing fatty acid utilization ameliorates mitochondrial fragmentation and cardiac dysfunction via rebalancing optic atrophy 1 processing in the failing heart. Cardiovasc Res. 2018;114(7):979\u201391.","journal-title":"Cardiovasc Res."},{"key":"5413_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102755","volume":"63","author":"M Semenzato","year":"2023","unstructured":"Semenzato M, Kohr MJ, Quirin C, Menab\u00f2 R, Alanova P, Alan L, et al. Oxidization of optic atrophy 1 cysteines occurs during heart ischemia-reperfusion and amplifies cell death by oxidative stress. Redox Biol. 2023;63:102755.","journal-title":"Redox Biol"},{"issue":"3","key":"5413_CR26","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1109\/MCSE.2007.55","volume":"9","author":"JD Hunter","year":"2007","unstructured":"Hunter JD. Matplotlib: a 2D graphics environment. Comput Sci Eng. 2007;9(3):90\u20135.","journal-title":"Comput Sci Eng"},{"issue":"60","key":"5413_CR27","doi-asserted-by":"publisher","first-page":"3021","DOI":"10.21105\/joss.03021","volume":"6","author":"M Waskom","year":"2021","unstructured":"Waskom M. Seaborn: statistical data visualization. J Open Source Softw. 2021;6(60):3021.","journal-title":"J Open Source Softw"},{"issue":"3","key":"5413_CR28","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1038\/s41592-019-0686-2","volume":"17","author":"P Virtanen","year":"2020","unstructured":"Virtanen P, Gommers R, Oliphant TE, Haberland M, Reddy T, Cournapeau D, et al. SciPy 1.0: fundamental algorithms for scientific computing in python. Nat Methods. 2020;17(3):261\u201372.","journal-title":"Nat Methods"},{"issue":"3","key":"5413_CR29","doi-asserted-by":"publisher","first-page":"R25","DOI":"10.1186\/gb-2010-11-3-r25","volume":"11","author":"MD Robinson","year":"2010","unstructured":"Robinson MD, Oshlack A. A scaling normalization method for differential expression analysis of RNA-seq data. Genome Biol. 2010;11(3):R25.","journal-title":"Genome Biol"},{"issue":"3\u20134","key":"5413_CR30","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1007\/BF01251916","volume":"61","author":"JA Hardy","year":"1985","unstructured":"Hardy JA, Wester P, Winblad B, Gezelius C, Bring G, Eriksson A. The patients dying after long terminal phase have acidotic brains; implications for biochemical measurements on autopsy tissue. J Neural Transm. 1985;61(3\u20134):253\u201364.","journal-title":"J Neural Transm"},{"key":"5413_CR31","unstructured":"Biospecimen Research Database .Bethesda (MD). National Cancer Institute, Biorepositories and Biospecimen Research Branch. Available from http:\/\/biospecimens.cancer.gov\/brd [cited 2024 Aug 15]."},{"key":"5413_CR32","doi-asserted-by":"crossref","unstructured":"Seabold S, Perktold J. statsmodels: Econometric and statistical modeling with python. Proceedings of the 9th Python in Science Conference. 2010. In.","DOI":"10.25080\/Majora-92bf1922-011"},{"issue":"2","key":"5413_CR33","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/S0169-7439(01)00155-1","volume":"58","author":"S Wold","year":"2001","unstructured":"Wold S, Sj\u00f6str\u00f6m M, Eriksson L. PLS-regression: a basic tool of chemometrics. Chemom Intell Lab Syst. 2001;58(2):109\u201330.","journal-title":"Chemom Intell Lab Syst"},{"key":"5413_CR34","doi-asserted-by":"crossref","unstructured":"Kira K, Rendell LA. A Practical Approach to Feature Selection. In: Machine Learning Proceedings 1992. Elsevier; 1992 . pp. 249\u201356. Available from: https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/B9781558602472500371 [cited 2024 Aug 15].","DOI":"10.1016\/B978-1-55860-247-2.50037-1"},{"key":"5413_CR35","doi-asserted-by":"publisher","unstructured":"Moore JH, White BC. Tuning ReliefF for Genome-Wide Genetic Analysis. In: Marchiori E, Moore JH, Rajapakse JC, editors. Evolutionary Computation,Machine Learning and Data Mining in Bioinformatics. Berlin, Heidelberg: Springer Berlin Heidelberg; 2007. pp. 166\u201375. (Lecture Notes in Computer Science; vol. 4447). Available from: http:\/\/link.springer.com\/https:\/\/doi.org\/10.1007\/978-3-540-71783-6_16 [cited 2024 Aug 15].","DOI":"10.1007\/978-3-540-71783-6_16"},{"issue":"85","key":"5413_CR36","first-page":"2825","volume":"12","author":"F Pedregosa","year":"2011","unstructured":"Pedregosa F, Varoquaux G, Gramfort A, Michel V, Thirion B, Grisel O, et al. Scikit-learn: machine learning in python. J Mach Learn Res. 2011;12(85):2825\u201330.","journal-title":"J Mach Learn Res"},{"key":"5413_CR37","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.jbi.2018.07.015","volume":"85","author":"RJ Urbanowicz","year":"2018","unstructured":"Urbanowicz RJ, Olson RS, Schmitt P, Meeker M, Moore JH. Benchmarking relief-based feature selection methods for bioinformatics data mining. J Biomed Inform. 2018;85:168\u201388.","journal-title":"J Biomed Inform"},{"key":"5413_CR38","doi-asserted-by":"publisher","unstructured":"Kononenko I. Estimating attributes: Analysis and extensions of RELIEF. In: Bergadano F, Raedt L,Machine Learning: ECML-94., Berlin H. 1994. pp. 171\u201382. (Carbonell JG, Siekmann J, Goos G, Hartmanis J, editors. Lecture Notes in Computer Science; vol. 784). Available from: http:\/\/link.springer.com\/https:\/\/doi.org\/10.1007\/3-540-57868-4_57 [cited 2024 Aug 15].","DOI":"10.1007\/3-540-57868-4_57"},{"issue":"11\u201312","key":"5413_CR39","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1002\/cem.1360","volume":"24","author":"CM Andersen","year":"2010","unstructured":"Andersen CM, Bro R. Variable selection in regression\u2014a tutorial. J Chemom. 2010;24(11\u201312):728\u201337.","journal-title":"J Chemom"},{"key":"5413_CR40","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.jbi.2018.07.014","volume":"85","author":"RJ Urbanowicz","year":"2018","unstructured":"Urbanowicz RJ, Meeker M, La Cava W, Olson RS, Moore JH. Relief-based feature selection: introduction and review. J Biomed Inform. 2018;85:189\u2013203.","journal-title":"J Biomed Inform"},{"key":"5413_CR41","doi-asserted-by":"crossref","unstructured":"Ge SX, Jung D, Yao R. ShinyGO: a graphical gene-set enrichment tool for animals and plants. Valencia A, editor. Bioinformatics. 2020;36(8):2628\u20139.","DOI":"10.1093\/bioinformatics\/btz931"},{"issue":"D1","key":"5413_CR42","doi-asserted-by":"publisher","first-page":"D330","DOI":"10.1093\/nar\/gky1055","volume":"47","author":"The Gene Ontology Consortium","year":"2019","unstructured":"The Gene Ontology Consortium. The gene ontology resource: 20 years and still going strong. Nucleic Acids Res. 2019;47(D1):D330\u20138.","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"5413_CR43","doi-asserted-by":"publisher","first-page":"D605","DOI":"10.1093\/nar\/gkaa1074","volume":"49","author":"D Szklarczyk","year":"2021","unstructured":"Szklarczyk D, Gable AL, Nastou KC, Lyon D, Kirsch R, Pyysalo S, et al. The STRING database in 2021: customizable protein\u2013protein networks, and functional characterization of user-uploaded gene\/measurement sets. Nucleic Acids Res. 2021;49(D1):D605\u201312.","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"5413_CR44","doi-asserted-by":"publisher","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","volume":"51","author":"D Szklarczyk","year":"2023","unstructured":"Szklarczyk D, Kirsch R, Koutrouli M, Nastou K, Mehryary F, Hachilif R, et al. The STRING database in 2023: protein\u2013protein association networks and functional enrichment analyses for any sequenced genome of interest. Nucleic Acids Res. 2023;51(D1):D638\u201346.","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"5413_CR45","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.cell.2013.08.032","volume":"155","author":"S Cogliati","year":"2013","unstructured":"Cogliati S, Frezza C, Soriano ME, Varanita T, Quintana-Cabrera R, Corrado M, et al. Mitochondrial Cristae shape determines respiratory chain supercomplexes assembly and respiratory efficiency. Cell. 2013;155(1):160\u201371.","journal-title":"Cell."},{"issue":"1","key":"5413_CR46","doi-asserted-by":"publisher","first-page":"H197","DOI":"10.1152\/ajpheart.00133.2021","volume":"321","author":"FW Damen","year":"2021","unstructured":"Damen FW, Salvas JP, Pereyra AS, Ellis JM, Goergen CJ. Improving characterization of hypertrophy-induced murine cardiac dysfunction using four-dimensional ultrasound-derived strain mapping. Am J Physiol-Heart Circ Physiol. 2021;321(1):H197-207.","journal-title":"Am J Physiol-Heart Circ Physiol."},{"issue":"3","key":"5413_CR47","doi-asserted-by":"publisher","first-page":"H359","DOI":"10.1152\/ajpheart.00476.2021","volume":"322","author":"MM Dann","year":"2022","unstructured":"Dann MM, Clark SQ, Trzaskalski NA, Earl CC, Schepers LE, Pulente SM, et al. Quantification of murine myocardial infarct size using 2-D and 4-D high-frequency ultrasound. Am J Physiol Heart Circ Physiol. 2022;322(3):H359\u201372.","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"2","key":"5413_CR48","doi-asserted-by":"publisher","first-page":"H293","DOI":"10.1152\/ajpheart.00733.2022","volume":"325","author":"FW Damen","year":"2023","unstructured":"Damen FW, Gramling DP, Ahlf Wheatcraft D, Wilpan RY, Costa MW, Goergen CJ. Application of 4-D ultrasound-derived regional strain and proteomics analysis in Nkx2-5 -deficient male mice. Am J Physiol-Heart Circ Physiol. 2023;325(2):H293-310.","journal-title":"Am J Physiol-Heart Circ Physiol"},{"issue":"2","key":"5413_CR49","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1007\/s00335-023-09995-y","volume":"34","author":"MA Oestereicher","year":"2023","unstructured":"Oestereicher MA, Wotton JM, Ayabe S, Bou About G, Cheng TK, Choi JH, et al. Comprehensive ECG reference intervals in C57BL\/6N substrains provide a generalizable guide for cardiac electrophysiology studies in mice. Mamm Genome Off J Int Mamm Genome Soc. 2023;34(2):180\u201399.","journal-title":"Mamm Genome Off J Int Mamm Genome Soc"},{"issue":"1","key":"5413_CR50","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1038\/s41592-020-01018-x","volume":"18","author":"C Stringer","year":"2021","unstructured":"Stringer C, Wang T, Michaelos M, Pachitariu M. Cellpose: a generalist algorithm for cellular segmentation. Nat Methods. 2021;18(1):100\u20136.","journal-title":"Nat Methods"},{"issue":"6","key":"5413_CR51","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1038\/nprot.2012.058","volume":"7","author":"M Spinazzi","year":"2012","unstructured":"Spinazzi M, Casarin A, Pertegato V, Salviati L, Angelini C. Assessment of mitochondrial respiratory chain enzymatic activities on tissues and cultured cells. Nat Protoc. 2012;7(6):1235\u201346.","journal-title":"Nat Protoc"},{"issue":"4","key":"5413_CR52","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.mito.2009.03.003","volume":"9","author":"W Guo","year":"2009","unstructured":"Guo W, Jiang L, Bhasin S, Khan SM, Swerdlow RH. DNA extraction procedures meaningfully influence qPCR-based MtDNA copy number determination. Mitochondrion. 2009;9(4):261\u20135.","journal-title":"Mitochondrion."},{"issue":"4","key":"5413_CR53","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2009\u2013 \u2206\u2206CT method. Methods. 2001;25(4):402\u20138.","journal-title":"Methods"},{"issue":"1","key":"5413_CR54","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1214\/aoms\/1177730491","volume":"18","author":"HB Mann","year":"1947","unstructured":"Mann HB, Whitney DR. On a test of whether one of two random variables is stochastically larger than the other. Ann Math Stat. 1947;18(1):50\u201360.","journal-title":"Ann Math Stat"},{"issue":"1","key":"5413_CR55","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2307\/2331554","volume":"6","author":"Student","year":"1908","unstructured":"Student. The probable error of a mean. Biometrika. 1908;6(1):1\u201325.","journal-title":"Biometrika"},{"issue":"302","key":"5413_CR56","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1080\/14786440009463897","volume":"50","author":"KX Pearson","year":"1900","unstructured":"Pearson KX. On the criterion that a given system of deviations from the probable in the case of a correlated system of variables is such that it can be reasonably supposed to have arisen from random sampling. Lond Edinb Dublin Philos Mag J Sci. 1900;50(302):157\u201375.","journal-title":"Lond Edinb Dublin Philos Mag J Sci"},{"issue":"6","key":"5413_CR57","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1038\/ng.2653","volume":"45","author":"J Lonsdale","year":"2013","unstructured":"Lonsdale J, Thomas J, Salvatore M, Phillips R, Lo E, Shad S, et al. The Genotype-Tissue Expression (GTEx) project. Nat Genet. 2013;45(6):580\u20135.","journal-title":"Nat Genet."},{"issue":"7675","key":"5413_CR58","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1038\/nature24277","volume":"550","author":"GTEx Consortium","year":"2017","unstructured":"GTEx Consortium. Genetic effects on gene expression across human tissues. Nature. 2017;550(7675):204\u201313.","journal-title":"Nature"},{"issue":"2","key":"5413_CR59","doi-asserted-by":"publisher","first-page":"H317","DOI":"10.1152\/ajpheart.00632.2023","volume":"326","author":"MA Ali","year":"2024","unstructured":"Ali MA, Gioscia-Ryan R, Yang D, Sutton NR, Tyrrell DJ. Cardiovascular aging: spotlight on mitochondria. Am J Physiol Heart Circ Physiol. 2024;326(2):H317-33.","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"10","key":"5413_CR60","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.1161\/CIRCRESAHA.116.307505","volume":"118","author":"EJ Lesnefsky","year":"2016","unstructured":"Lesnefsky EJ, Chen Q, Hoppel CL. Mitochondrial metabolism in aging heart. Circ Res. 2016;118(10):1593\u2013611.","journal-title":"Circ Res"},{"issue":"6","key":"5413_CR61","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.1016\/j.cmet.2017.04.021","volume":"25","author":"C Tezze","year":"2017","unstructured":"Tezze C, Romanello V, Desbats MA, Fadini GP, Albiero M, Favaro G, et al. Age-Associated loss of OPA1 in muscle impacts muscle Mass, metabolic Homeostasis, systemic Inflammation, and epithelial senescence. Cell Metab. 2017;25(6):1374-e13896.","journal-title":"Cell Metab."},{"issue":"5","key":"5413_CR62","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1089\/bio.2015.0032","volume":"13","author":"LJ Carithers","year":"2015","unstructured":"Carithers LJ, Ardlie K, Barcus M, Branton PA, Britton A, Buia SA, et al. A novel approach to high-quality postmortem tissue procurement: the GTEx project. Biopreserv Biobank. 2015;13(5):311\u20139.","journal-title":"Biopreserv Biobank"},{"issue":"3","key":"5413_CR63","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1152\/physiolgenomics.00041.2003","volume":"16","author":"O Tarnavski","year":"2004","unstructured":"Tarnavski O, McMullen JR, Schinke M, Nie Q, Kong S, Izumo S. Mouse cardiac surgery: comprehensive techniques for the generation of mouse models of human diseases and their application for genomic studies. Physiol Genomics. 2004;16(3):349\u201360.","journal-title":"Physiol Genomics"},{"issue":"10","key":"5413_CR64","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1161\/CIRCRESAHA.121.318241","volume":"128","author":"GD Lopaschuk","year":"2021","unstructured":"Lopaschuk GD, Karwi QG, Tian R, Wende AR, Abel ED. Cardiac energy metabolism in heart failure. Circ Res. 2021;128(10):1487\u2013513.","journal-title":"Circ Res"},{"key":"5413_CR65","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.freeradbiomed.2018.01.012","volume":"117","author":"RF Ribeiro Junior","year":"2018","unstructured":"Ribeiro Junior RF, Dabkowski ER, Shekar KC, O\u00b4Connell KA, Hecker PA, Murphy MP. MitoQ improves mitochondrial dysfunction in heart failure induced by pressure overload. Free Radic Biol Med. 2018;117:18\u201329.","journal-title":"Free Radic Biol Med"},{"issue":"1","key":"5413_CR66","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1093\/cvr\/cvr274","volume":"93","author":"DF Dai","year":"2012","unstructured":"Dai DF, Hsieh EJ, Liu Y, Chen T, Beyer RP, Chin MT, et al. Mitochondrial proteome remodelling in pressure overload-induced heart failure: the role of mitochondrial oxidative stress. Cardiovasc Res. 2012;93(1):79\u201388.","journal-title":"Cardiovasc Res"},{"issue":"13","key":"5413_CR67","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1161\/CIRCULATIONAHA.115.020502","volume":"133","author":"A Shirakabe","year":"2016","unstructured":"Shirakabe A, Zhai P, Ikeda Y, Saito T, Maejima Y, Hsu CP, et al. Drp1-dependent mitochondrial autophagy plays a protective role against pressure overload\u2013induced mitochondrial dysfunction and heart failure. Circulation. 2016;133(13):1249\u201363.","journal-title":"Circulation"},{"key":"5413_CR68","doi-asserted-by":"crossref","unstructured":"Marvasti TB, Alibhai FJ, Yang GJ, Li S, Wu J, Yau T et al. Heart Failure Impairs Bone Marrow Hematopoietic Stem Cell Function and Responses to Injury. J Am Heart Assoc. 2023 ;12(11):e027727.","DOI":"10.1161\/JAHA.122.027727"},{"issue":"4","key":"5413_CR69","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1007\/s00418-008-0541-5","volume":"131","author":"Y Xia","year":"2009","unstructured":"Xia Y, Lee K, Li N, Corbett D, Mendoza L, Frangogiannis NG. Characterization of the inflammatory and fibrotic response in a mouse model of cardiac pressure overload. Histochem Cell Biol. 2009;131(4):471\u201381.","journal-title":"Histochem Cell Biol"},{"issue":"25","key":"5413_CR70","doi-asserted-by":"publisher","first-page":"2089","DOI":"10.1161\/CIRCULATIONAHA.119.041694","volume":"140","author":"E Martini","year":"2019","unstructured":"Martini E, Kunderfranco P, Peano C, Carullo P, Cremonesi M, Schorn T, et al. Single-cell sequencing of mouse heart immune infiltrate in pressure overload\u2013driven heart failure reveals extent of immune activation. Circulation. 2019;140(25):2089\u2013107.","journal-title":"Circulation"},{"key":"5413_CR71","doi-asserted-by":"crossref","unstructured":"Kleiner JL, K\u00f6pke O, Faron A, Zhang Y, Cornelssen J, Coburn M et al. Characterization of Transverse Aortic Constriction in Mice Based on the Specific Recruitment of Leukocytes to the Hypertrophic Myocardium and the Aorta Ascendens. Kennedy S, editor. Mediators Inflamm. 2021;2021:1376859.","DOI":"10.1155\/2021\/1376859"},{"issue":"1","key":"5413_CR72","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/1471-2350-13-65","volume":"13","author":"GJ Almind","year":"2012","unstructured":"Almind GJ, Ek J, Rosenberg T, Eiberg H, Larsen M, LuCamp L, et al. Dominant optic atrophy in Denmark \u2013 report of 15 novel mutations in OPA1, using a strategy with a detection rate of 90%. BMC Med Genet. 2012;13(1):65.","journal-title":"BMC Med Genet"},{"issue":"7","key":"5413_CR73","doi-asserted-by":"publisher","first-page":"E692","DOI":"10.1002\/humu.21025","volume":"30","author":"M Ferr\u00e9","year":"2009","unstructured":"Ferr\u00e9 M, Bonneau D, Milea D, Chevrollier A, Verny C, Dollfus H, et al. Molecular screening of 980 cases of suspected hereditary optic neuropathy with a report on 77 novel OPA1 mutations. Hum Mutat. 2009;30(7):E692-705.","journal-title":"Hum Mutat."},{"issue":"1","key":"5413_CR74","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1007\/s00415-008-0571-x","volume":"255","author":"M Liguori","year":"2008","unstructured":"Liguori M, Russa A, Manna I, Andreoli V, Caracciolo M, Spadafora P, et al. A phenotypic variation of dominant optic atrophy and deafness (ADOAD) due to a novel OPA1 mutation. J Neurol. 2008;255(1):127\u20139.","journal-title":"J Neurol"},{"issue":"3","key":"5413_CR75","doi-asserted-by":"publisher","first-page":"e225","DOI":"10.1111\/aos.12038","volume":"91","author":"P Liskova","year":"2013","unstructured":"Liskova P, Ulmanova O, Tesina P, Melsova H, Diblik P, Hansikova H, et al. Novel OPA1 missense mutation in a family with optic atrophy and severe widespread neurological disorder. Acta Ophthalmol (Copenh). 2013;91(3):e225-231.","journal-title":"Acta Ophthalmol (Copenh)"},{"issue":"2","key":"5413_CR76","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1093\/brain\/awm272","volume":"131","author":"G Hudson","year":"2008","unstructured":"Hudson G, Amati-Bonneau P, Blakely EL, Stewart JD, He L, Schaefer AM, et al. Mutation of OPA1 causes dominant optic atrophy with external ophthalmoplegia, ataxia, deafness and multiple mitochondrial DNA deletions: a novel disorder of MtDNA maintenance. Brain. 2008;131(2):329\u201337.","journal-title":"Brain"},{"key":"5413_CR77","doi-asserted-by":"crossref","unstructured":"Le Page S, Niro M, Fauconnier J, Cellier L, Tamareille S, Gharib A et al. Increase in Cardiac Ischemia-Reperfusion Injuries in Opa1+\/- Mouse Model. Bertrand L, editor. PLOS ONE. 2016;11(10):e0164066.","DOI":"10.1371\/journal.pone.0164066"},{"key":"5413_CR78","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.103010","volume":"69","author":"W Cai","year":"2024","unstructured":"Cai W, Chong K, Huang Y, Huang C, Yin L. Empagliflozin improves mitochondrial dysfunction in diabetic cardiomyopathy by modulating ketone body metabolism and oxidative stress. Redox Biol. 2024;69:103010.","journal-title":"Redox Biol"},{"key":"5413_CR79","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2023.175531","volume":"942","author":"Y Lyu","year":"2023","unstructured":"Lyu Y, Huo J, Jiang W, Yang W, Wang S, Zhang S, et al. Empagliflozin ameliorates cardiac dysfunction in heart failure mice via regulating mitochondrial dynamics. Eur J Pharmacol. 2023;942:175531.","journal-title":"Eur J Pharmacol"},{"issue":"5","key":"5413_CR80","doi-asserted-by":"publisher","first-page":"4474","DOI":"10.18632\/aging.102899","volume":"12","author":"T Xin","year":"2020","unstructured":"Xin T, Lu C. Irisin activates Opa1-induced mitophagy to protect cardiomyocytes against apoptosis following myocardial infarction. Aging. 2020;12(5):4474\u201388.","journal-title":"Aging"},{"key":"5413_CR81","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2021.102098","volume":"46","author":"C Liu","year":"2021","unstructured":"Liu C, Han Y, Gu X, Li M, Du Y, Feng N, et al. Paeonol promotes Opa1-mediated mitochondrial fusion via activating the CK2\u03b1-Stat3 pathway in diabetic cardiomyopathy. Redox Biol. 2021;46:102098.","journal-title":"Redox Biol"},{"issue":"22","key":"5413_CR82","doi-asserted-by":"publisher","first-page":"2676","DOI":"10.15252\/embj.201488349","volume":"33","author":"DA Patten","year":"2014","unstructured":"Patten DA, Wong J, Khacho M, Soubannier V, Mailloux RJ, Pilon-Larose K, et al. OPA1\u2010dependent Cristae modulation is essential for cellular adaptation to metabolic demand. EMBO J. 2014;33(22):2676\u201391.","journal-title":"EMBO J"},{"issue":"45","key":"5413_CR83","doi-asserted-by":"publisher","first-page":"15927","DOI":"10.1073\/pnas.0407043101","volume":"101","author":"S Cipolat","year":"2004","unstructured":"Cipolat S, Martins de Brito O, Dal Zilio B, Scorrano L. OPA1 requires Mitofusin 1 to promote mitochondrial fusion. Proc Natl Acad Sci U S A. 2004;101(45):15927\u201332.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"5413_CR84","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1038\/cdd.2012.128","volume":"20","author":"YE Kushnareva","year":"2013","unstructured":"Kushnareva YE, Gerencser AA, Bossy B, Ju WK, White AD, Waggoner J, et al. Loss of OPA1 disturbs cellular calcium homeostasis and sensitizes for excitotoxicity. Cell Death Differ. 2013;20(2):353\u201365.","journal-title":"Cell Death Differ"},{"issue":"11","key":"5413_CR85","doi-asserted-by":"publisher","first-page":"a004242","DOI":"10.1101\/cshperspect.a004242","volume":"3","author":"CJ Fearnley","year":"2011","unstructured":"Fearnley CJ, Roderick HL, Bootman MD. Calcium signaling in cardiac myocytes. Cold Spring Harb Perspect Biol. 2011;3(11):a004242\u2013004242.","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"1","key":"5413_CR86","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1172\/JCI62834","volume":"123","author":"AR Marks","year":"2013","unstructured":"Marks AR. Calcium cycling proteins and heart failure: mechanisms and therapeutics. J Clin Invest. 2013;123(1):46\u201352.","journal-title":"J Clin Invest"},{"issue":"21","key":"5413_CR87","doi-asserted-by":"publisher","first-page":"2038","DOI":"10.1161\/CIRCULATIONAHA.115.020226","volume":"133","author":"H Sun","year":"2016","unstructured":"Sun H, Olson KC, Gao C, Prosdocimo DA, Zhou M, Wang Z, et al. Catabolic defect of branched-chain amino acids promotes heart failure. Circulation. 2016;133(21):2038\u201349.","journal-title":"Circulation"},{"issue":"1","key":"5413_CR88","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1186\/s12933-019-0892-3","volume":"18","author":"GM Uddin","year":"2019","unstructured":"Uddin GM, Zhang L, Shah S, Fukushima A, Wagg CS, Gopal K, et al. Impaired branched chain amino acid oxidation contributes to cardiac insulin resistance in heart failure. Cardiovasc Diabetol. 2019;18(1):86.","journal-title":"Cardiovasc Diabetol"},{"issue":"2","key":"5413_CR89","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1113\/jphysiol.2003.045104","volume":"551","author":"A Garnier","year":"2003","unstructured":"Garnier A, Fortin D, Delom\u00e9nie C, Momken I, Veksler V, Ventura-Clapier R. Depressed mitochondrial transcription factors and oxidative capacity in rat failing cardiac and skeletal muscles. J Physiol. 2003;551(2):491\u2013501.","journal-title":"J Physiol"},{"issue":"10","key":"5413_CR90","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.1093\/cvr\/cvx100","volume":"113","author":"D Abdurrachim","year":"2017","unstructured":"Abdurrachim D, Nabben M, Hoerr V, Kuhlmann MT, Bovenkamp P, Ciapaite J, et al. Diabetic db\/db mice do not develop heart failure upon pressure overload: a longitudinal in vivo PET, MRI, and MRS study on cardiac metabolic, structural, and functional adaptations. Cardiovasc Res. 2017;113(10):1148\u201360.","journal-title":"Cardiovasc Res"},{"issue":"4","key":"5413_CR91","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2021.101140","volume":"297","author":"CA Schmidt","year":"2021","unstructured":"Schmidt CA, Fisher-Wellman KH, Neufer PD. From OCR and ECAR to energy: perspectives on the design and interpretation of bioenergetics studies. J Biol Chem. 2021;297(4):101140.","journal-title":"J Biol Chem"},{"issue":"4","key":"5413_CR92","doi-asserted-by":"publisher","first-page":"H529","DOI":"10.1152\/ajpheart.00699.2012","volume":"304","author":"M Schwarzer","year":"2013","unstructured":"Schwarzer M, Schrepper A, Amorim PA, Osterholt M, Doenst T. Pressure overload differentially affects respiratory capacity in interfibrillar and subsarcolemmal mitochondria. Am J Physiol-Heart Circ Physiol. 2013;304(4):H529\u201337.","journal-title":"Am J Physiol-Heart Circ Physiol"},{"issue":"3","key":"5413_CR93","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1038\/s41418-022-01076-y","volume":"30","author":"R S\u00e1nchez-Rodr\u00edguez","year":"2023","unstructured":"S\u00e1nchez-Rodr\u00edguez R, Tezze C, Agnellini AHR, Angioni R, Venegas FC, Cioccarelli C, et al. OPA1 drives macrophage metabolism and functional commitment via p65 signaling. Cell Death Differ. 2023;30(3):742\u201352.","journal-title":"Cell Death Differ"},{"issue":"1","key":"5413_CR94","doi-asserted-by":"publisher","first-page":"2958","DOI":"10.1038\/s41467-018-05387-y","volume":"9","author":"P Amini","year":"2018","unstructured":"Amini P, Stojkov D, Felser A, Jackson CB, Courage C, Schaller A, et al. Neutrophil extracellular trap formation requires OPA1-dependent glycolytic ATP production. Nat Commun. 2018;9(1):2958.","journal-title":"Nat Commun"},{"issue":"7","key":"5413_CR95","doi-asserted-by":"publisher","first-page":"2194","DOI":"10.1038\/s41418-021-00747-6","volume":"28","author":"M Corrado","year":"2021","unstructured":"Corrado M, Samard\u017ei\u0107 D, Giacomello M, Rana N, Pearce EL, Scorrano L. Deletion of the mitochondria-shaping protein Opa1 during early thymocyte maturation impacts mature memory T cell metabolism. Cell Death Differ. 2021;28(7):2194\u2013206.","journal-title":"Cell Death Differ"},{"issue":"8","key":"5413_CR96","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2023.105211","volume":"25","author":"U Jin","year":"2023","unstructured":"Jin U, Park SJ, Lee BG, Kim JB, Kim SJ, Joe EH, et al. Critical roles of parkin and PINK1 in coxsackievirus B3-induced viral myocarditis. Microbes Infect. 2023;25(8):105211.","journal-title":"Microbes Infect"},{"issue":"2","key":"5413_CR97","doi-asserted-by":"publisher","first-page":"351","DOI":"10.3390\/v15020351","volume":"15","author":"Y Mohamud","year":"2023","unstructured":"Mohamud Y, Li B, Bahreyni A, Luo H. Mitochondria dysfunction at the heart of viral myocarditis: mechanistic insights and therapeutic implications. Viruses. 2023;15(2):351.","journal-title":"Viruses"},{"issue":"18","key":"5413_CR98","doi-asserted-by":"publisher","first-page":"8277","DOI":"10.1073\/pnas.88.18.8277","volume":"15","author":"HA Rockman","year":"1991","unstructured":"Rockman HA, Ross RS, Harris AN, Knowlton KU, Steinhelper ME, Field LJ, et al. Segregation of atrial-specific and inducible expression of an atrial natriuretic factor transgene in an in vivo murine model of cardiac hypertrophy. Proc Natl Acad Sci U S A. 1991;15(18):8277\u201381.","journal-title":"Proc Natl Acad Sci U S A."},{"key":"5413_CR99","doi-asserted-by":"publisher","first-page":"1026884","DOI":"10.3389\/fphys.2022.1026884","volume":"13","author":"M Huang","year":"2022","unstructured":"Huang M, Yu L, Wang X, Wang M, Li W, Tang J, et al. Evaluation of the transverse aortic constriction model in ICR and C57BL\/6J mice. Front Physiol. 2022;13:1026884.","journal-title":"Front Physiol"},{"issue":"1","key":"5413_CR100","doi-asserted-by":"publisher","first-page":"5844","DOI":"10.1038\/s41598-019-42209-7","volume":"9","author":"DA Richards","year":"2019","unstructured":"Richards DA, Aronovitz MJ, Calamaras TD, Tam K, Martin GL, Liu P, et al. Distinct phenotypes induced by three degrees of transverse aortic constriction in mice. Sci Rep. 2019;9(1):5844.","journal-title":"Sci Rep"},{"key":"5413_CR101","doi-asserted-by":"publisher","first-page":"3167","DOI":"10.1038\/s41598-018-21548-x","volume":"8","author":"D Merino","year":"2018","unstructured":"Merino D, Gil A, G\u00f3mez J, Ruiz L, Llano M, Garc\u00eda R, et al. Experimental modelling of cardiac pressure overload hypertrophy: modified technique for precise, reproducible, safe and easy aortic arch banding-debanding in mice. Sci Rep. 2018;8:3167.","journal-title":"Sci Rep"}],"container-title":["BMC Cardiovascular Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-025-05413-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12872-025-05413-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-025-05413-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T03:03:29Z","timestamp":1768359809000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12872-025-05413-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,9]]},"references-count":101,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["5413"],"URL":"https:\/\/doi.org\/10.1186\/s12872-025-05413-0","relation":{},"ISSN":["1471-2261"],"issn-type":[{"value":"1471-2261","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,9]]},"assertion":[{"value":"18 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All experiments involving mice were conducted in accordance with the principles of the Canadian Council of Animal Care and were approved by the Animal Care Committee of the University of Ottawa (UOHI-AUP-2909 and AUP-4381).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Craig Goergen is a paid consultant of FUJIFILM VisualSonics Inc.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"31"}}