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However, CE-SSFP utilizes gadolinium contrast, which is contraindicated in patients with severe renal insufficiency. Native T1-mapping is a non-contrast CMR method which has been shown feasible in assessing MaR, enabling patients with gadolinium contrast contraindications to be examined. However, native T1-mapping data have been presented in the sub-acute phase suggesting to also depict infarct size (IS), as assessed by late gadolinium enhancement (LGE). Therefore, it is unclear whether native T1-mapping depicts MaR or IS during the first week after reperfusion. We hypothesized that native T1-mapping agrees with MaR as assessed by CE-SSFP and overestimates IS as assessed by LGE in an experimental pig model and in patients during the first week after STEMI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A retrospective analysis was performed using CMR images from an infarct\/reperfusion experimental pig model. CMR imaging was performed at 2\u00a0h, 24\u00a0h and 7 days after reperfusion in a serially imaged group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20097) and at 4 days in a single-timepoint imaged group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20094). Also, STEMI patients with a single vessel LAD occlusion (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200911) were CMR imaged between 3 to 7 days after reperfusion. Native T1-mapping MOLLI, CE-SSFP and LGE were acquired for each scan in both animals and patients. In animals, images with an additional T1-mapping sequence, SASHA, were acquired. Enhanced areas on T1-maps, CE-SSFP and LGE images were quantified and compared.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>In pigs<\/jats:italic>\n                      , native T1-mapping MOLLI agreed with CE-SSFP in the single-timepoint- and serially imaged groups (bias: 0.3\u2009\u00b1\u20096.6% (mean\u2009\u00b1\u20092SD), and 0.9\u2009\u00b1\u200918%), respectively. Native T1-mapping SASHA also agreed with CE-SSFP in the serially imaged group (bias: -0.1\u2009\u00b1\u200918%). However, MOLLI overestimated IS by LGE in pigs in the serially- and single-timepoint imaged groups (bias: 21\u2009\u00b1\u200926%, and 18\u2009\u00b1\u200917%), respectively. Similar results were seen in patients (MOLLI vs. CE-SSFP: 0.8\u2009\u00b1\u20097.5%, and MOLLI vs. LGE: 31\u2009\u00b1\u200922%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings suggest that native T1-mapping agrees with CE-SSFP during the first week after myocardial infarction when evaluating MaR. Also, native T1-mapping overestimates the LGE hyperintense area, indicating that native T1-mapping does not primarily depict infarct size.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12872-026-05507-3","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T23:04:58Z","timestamp":1769123098000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Native T1-mapping using cardiovascular magnetic resonance detects myocardium at risk during the first week following myocardial infarction in a swine model and in patients - comparison to contrast-enhanced cine steady-state free precession"],"prefix":"10.1186","volume":"26","author":[{"given":"Theodor","family":"Lav","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Nordlund","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christos","family":"Xanthis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Berg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Bidhult","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony H.","family":"Aletras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Jablonowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,1,22]]},"reference":[{"issue":"2","key":"5507_CR1","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.jacc.2019.05.024","volume":"74","author":"B Ibanez","year":"2019","unstructured":"Ibanez B, Aletras AH, Arai AE, Arheden H, Bax J, Berry C, et al. 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The study was performed in compliance with the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"CX and AA are Founders and Shareholders at Corsmed AB, Lund, Sweden. JB was employed by the med-tech company Syntach AB, Lund, Sweden, when experiments were performed. TL, DN, SB, and RJ have nothing to declare.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"86"}}