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The relationship between\n                      <jats:italic>APOE<\/jats:italic>\n                      polymorphisms and PMI was analyzed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      15(1.5%) individuals carried \u025b2\/\u025b2, 147(14.6%) had \u025b2\/\u025b3, 16(1.6%) presented with \u025b2\/\u025b4, 670(66.5%) were \u025b3\/\u025b3 carriers, 149(14.8%) had \u025b3\/\u025b4, and 10 (1.0%) carried \u025b4\/\u025b4. The proportion of \u025b2\/\u025b3 genotype was significantly lower in the PMI group than in controls (7.7% vs. 18.8%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), whereas the prevalence of \u025b3\/\u025b4 genotype was substantially higher in the PMI group (20.6% vs. 11.3%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Logistic regression analysis identified some associated factors: smoking (odds ratio [OR]: 3.057, 95% confidence interval [CI]: 2.098\u20134.455,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), hypertension (OR: 4.474, 95% CI: 3.273\u20136.117,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and dyslipidemia (OR: 1.805, 95% CI: 1.333\u20132.443,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Additionally, genetic factors were associated with PMI: the\n                      <jats:italic>APOE<\/jats:italic>\n                      \u025b3\/\u025b4 genotype (vs. \u025b3\/\u025b3, OR: 1.548, 95% CI: 1.038\u20132.309,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.032) and the presence of \u025b4 allele (vs. \u025b3, OR: 1.521, 95% CI: 1.033\u20132.241,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.034) were confirmed as independent associated factors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b53\/\u03b54 genotype was significantly associated with PMI, suggesting that this genotype could serve as a potential genetic marker for PMI risk assessment.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12872-026-05513-5","type":"journal-article","created":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T09:05:10Z","timestamp":1768467910000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Apolipoprotein E \u025b3\/\u025b4 genotype is associated with premature myocardial infarction: a hospital based retrospective study"],"prefix":"10.1186","volume":"26","author":[{"given":"Hao","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoliang","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kehui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanliang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,15]]},"reference":[{"issue":"1","key":"5513_CR1","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1186\/s12872-023-03231-w","volume":"23","author":"N Salari","year":"2023","unstructured":"Salari N, Morddarvanjoghi F, Abdolmaleki A, Rasoulpoor S, Khaleghi AA, Hezarkhani LA, et al. 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