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Although nitric oxide (NO) underpins endothelial function and has been implicated in several cardiovascular conditions, its association with subclinical hypertension-mediated organ damage remains unclear. This study aimed to investigate the relationship between nitrite\/nitrate (NOx)\u2014an indirect index of NO pathways and subclinical myocardial and renal dysfunction in patients with HT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study prospectively screened 433 adult hypertensive patients, of whom 400 were included in a cross-sectional analysis after exclusion of conditions potentially confounding cardiac or renal assessment, including end-stage renal disease requiring dialysis. All participants underwent transthoracic echocardiography to assess ventricle functions using left ventricular global longitudinal strain (LV-GLS) and provided a spot urine sample for the measurement of the urine albumin\/creatinine ratio (UACR). In addition to NOx levels, inducible and endothelial nitric oxide synthase levels were evaluated from participants\u2019 blood samples.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      NOx levels were significantly associated with reduced LV-GLS and higher UACR values. In multivariate analysis, lower NOx levels were independently associated with impaired LV-GLS (OR: 0.817; 95% CI: 0.783\u20130.853;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and albuminuria (OR: 0.905; 95% CI: 0.877\u20130.934;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>NOx may represent an independent biochemical parameter associated with subclinical myocardial and renal dysfunction in patients with HT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12872-026-05575-5","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T02:34:02Z","timestamp":1770345242000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The role of nitric oxide in hypertensive target organ damage in patients without renal impairment: insights from left ventricular global longitudinal strain and albuminuria"],"prefix":"10.1186","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9152-1199","authenticated-orcid":false,"given":"Ayca","family":"Arslan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2599-8589","authenticated-orcid":false,"given":"Metin","family":"Ogun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1871-5157","authenticated-orcid":false,"given":"Dogan","family":"Ilis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2694-8978","authenticated-orcid":false,"given":"Inanc","family":"Artac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0855-7625","authenticated-orcid":false,"given":"Mahsum","family":"Aykal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7385-120X","authenticated-orcid":false,"given":"Muammer","family":"Karakayali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5656-058X","authenticated-orcid":false,"given":"Ozturk","family":"Demir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0457-3124","authenticated-orcid":false,"given":"Emrah","family":"Kaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0898-6340","authenticated-orcid":false,"given":"Nazlican","family":"Buyukyurt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8156-315X","authenticated-orcid":false,"given":"Yavuz","family":"Karabag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0070-9197","authenticated-orcid":false,"given":"Ibrahim","family":"Rencuzogullari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,6]]},"reference":[{"issue":"6","key":"5575_CR1","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1161\/HYP.0000000000000066","volume":"71","author":"PK Whelton Jr","year":"2018","unstructured":"Whelton PK, Carey RM, Aronow WS, Casey DE Jr, Collins KJ, Dennison Himmelfarb C, et al. 2017 ACC\/AHA\/AAPA\/ABC\/ACPM\/AGS\/APhA\/ASH\/ASPC\/NMA\/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: executive summary: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines. 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