{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T08:10:43Z","timestamp":1778746243091,"version":"3.51.4"},"reference-count":5,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cardiovasc Disord"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The prevalence of secondary mitral regurgitation (SMR) is increasing due to the aging population. SMR management is a complex disease because at least 2 pathologies are involved. SMR and severely reduced EF are independent risk factors for adverse outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case summary<\/jats:title>\n                    <jats:p>We present the case of a 57-year-old man who presented with dyspnea NYHA III. On echocardiography, a combination of SMR and DCM with EF of 20% were diagnosed. Indirect mitral annuloplasty after CRT-CSP was performed based on the patient\u2019s clinical profile and high surgical repair risk. The 3-month follow-up was uneventful.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Mitral valve repair techniques in ventricular SMR with severely reduced EF are controversial due to ongoing debates about long-term repair durability in the setting of left ventricular remodeling. Percutaneous strategies are an alternative for high-risk surgical patients and their indication expanded for more complex anatomy and patient\u00b4s comorbidity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Indirect mitral annuloplasty with the Carillion device in patients with CRT-CSP due to low EF and severe mitral regurgitation is feasible for the treatment of these combined pathologies and allows more physiological pacing and future M-TEER.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Graphical abstract<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1186\/s12872-026-05682-3","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T13:34:52Z","timestamp":1778679292000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Indirect mitral annuloplasty using Carillon device after conduction system pacing resynchronization in patient with severe mitral regurgitation: a case report"],"prefix":"10.1186","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3315-4167","authenticated-orcid":false,"given":"Abdelrahman","family":"Elhakim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4533-160X","authenticated-orcid":false,"given":"Mohamed","family":"Elhakim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osama","family":"Bisht","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter W.","family":"Radke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Saad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,5,13]]},"reference":[{"key":"5682_CR1","doi-asserted-by":"publisher","unstructured":".Praz F, Borger MA, Lanz J, Marin-Cuartas M, Abreu A, Adamo M, Ajmone Marsan N, Barili F, Bonaros N, Cosyns B, De Paulis R, Gamra H, Jahangiri M, Jeppsson A, Klautz RJM, Mores B, P\u00e9rez-David E, P\u00f6ss J, Prendergast BD, Rocca B, Rossello X, Suzuki M, Thiele H, Tribouilloy CM, Wojakowski W. ESC\/EACTS Scientific Document Group. 2025 ESC\/EACTS Guidelines for the management of valvular heart disease. Eur Heart J 2025 Aug 29: ehaf194. https:\/\/doi.org\/10.1093\/eurheartj\/ehaf194. Epub ahead of print. PMID: 40878295.","DOI":"10.1093\/eurheartj\/ehaf194"},{"key":"5682_CR2","doi-asserted-by":"publisher","unstructured":".Barnes C, Sharma H, Gamble J, Dawkins S. Management of secondary mitral regurgitation: From drugs to devices. Heart. https:\/\/doi.org\/10.1136\/heartjnl-2022-322001. Published online ahead of print 22\/08\/23.","DOI":"10.1136\/heartjnl-2022-322001"},{"issue":"19","key":"5682_CR3","doi-asserted-by":"publisher","first-page":"1787","DOI":"10.1056\/NEJMoa2408739","volume":"391","author":"S .Baldus","year":"2024","unstructured":".Baldus S, Doenst T, Pfister R, Gummert J, Kessler M, Boekstegers P, Investigators MATTERHORN. Transcatheter Repair versus Mitral-Valve Surgery for Secondary Mitral Regurgitation. N Engl J Med. 2024;391(19):1787\u201398. https:\/\/doi.org\/10.1056\/NEJMoa2408739. Epub 2024 Aug 31. PMID: 39216093.","journal-title":"N Engl J Med"},{"issue":"2","key":"5682_CR4","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1002\/ehf2.13273","volume":"8","author":"MS Khan","year":"2021","unstructured":"Khan MS, Siddiqi TJ, Butler J, Friede T, Levy WC, Witte KK, et al. Functional outcomes with Carillon device over 1 year in patients with functional mitral regurgitation of Grades 2\u2009+\u2009to 4+: results from the REDUCE-FMR trial. ESC Heart Fail. 2021;8(2):872\u20138. Epub 2021 Feb 22. PMID: 33619896; PMCID: PMC8006711.","journal-title":"ESC Heart Fail"},{"issue":"4","key":"5682_CR5","doi-asserted-by":"publisher","first-page":"euaf050","DOI":"10.1093\/europace\/euaf050","volume":"27","author":"M Glikson","year":"2025","unstructured":"Glikson M, Burri H, Abdin A, Cano O, Curila K, De Pooter J, et al. European Society of Cardiology (ESC) clinical consensus statement on indications for conduction system pacing, with special contribution of the European Heart Rhythm Association of the ESC and endorsed by the Asia Pacific Heart Rhythm Society, the Canadian Heart Rhythm Society, the Heart Rhythm Society, and the Latin American Heart Rhythm Society. EP Europace. 2025;27(4):euaf050. https:\/\/doi.org\/10.1093\/europace\/euaf050.","journal-title":"EP Europace"}],"container-title":["BMC Cardiovascular Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12872-026-05682-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-026-05682-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-026-05682-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T07:28:40Z","timestamp":1778743720000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12872-026-05682-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,13]]},"references-count":5,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["5682"],"URL":"https:\/\/doi.org\/10.1186\/s12872-026-05682-3","relation":{},"ISSN":["1471-2261"],"issn-type":[{"value":"1471-2261","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,13]]},"assertion":[{"value":"28 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Written informed consent was obtained from the patient in line with COPE for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.\u201d","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"418"}}