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The long-term epidemiological burden of this cardiorenal comorbidity remains understudied despite the advances in mechanical circulatory support and critical care. We aimed to analyze nationwide mortality trends and disparities involving co-occurring CS and ARF in the United States.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Death records from the CDC WONDER database were analyzed retrospectively (1999\u20132023), including adults aged\u2009\u2265\u200945 years listing CS and ARF as underlying or contributing causes. Age-Adjusted Mortality Rates (AAMRs) per 1,000,000 population were standardized to the 2000 U.S. population. Temporal trend assessment and annual percent changes (APCs) were computed through the Joinpoint regression program.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 48,926 deaths were identified with AAMR, increasing significantly from 7.0 in 1999 to 43.5 in 2023. Rates showed a steady incline from 2005 to 2019 (APC: 7.78), followed by a sharp acceleration from 2019 to 2023 (APC: 24.16). Males exhibited mortality rates nearly double those of females (20.5 vs. 10.5). Non-Hispanic (NH) African Americans had the highest AAMR (20.7) among racial groups. Geographically, the West (17.1) and non-metropolitan regions (12.9) experienced the highest mortality burdens.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The past two decades marked the surge in CS and ARF-related mortality rates following a sharp acceleration since 2019. Persistent disparities among males, NH African Americans, and rural populations highlight the urgent need for targeted resource allocation and improved access to advanced cardiorenal therapies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical trial number<\/jats:title>\n                    <jats:p>Not applicable.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12872-026-05698-9","type":"journal-article","created":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T07:47:00Z","timestamp":1772610420000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cardiogenic shock and acute renal failure associated mortality trends in the United States: a retrospective analysis of death records from 1999 to 2023"],"prefix":"10.1186","volume":"26","author":[{"given":"Muhammad Shaheer Bin","family":"Faheem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Tawassul","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syeda Lyba","family":"Onaiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anushah","family":"Faheem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan e","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naveed","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumaya","family":"Samadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,4]]},"reference":[{"issue":"1","key":"5698_CR1","doi-asserted-by":"publisher","first-page":"9","DOI":"10.3390\/jcdd13010009","volume":"13","author":"S Jana","year":"2026","unstructured":"Jana S, Wijesinghe M, DiCaro MV, Lei K, Houshmand N, Ahsan C. 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