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To date, more than 50 genes have been identified as being associated with DCM. Mutations in the\n                      <jats:italic>Bcl-2-associated athanogene 3 (BAG3)<\/jats:italic>\n                      gene (NM_004281.4) play a significant role in DCM pathogenesis. However, further investigation is required for comprehensive screening of\n                      <jats:italic>BAG3<\/jats:italic>\n                      gene mutations. The identification of\n                      <jats:italic>BAG3<\/jats:italic>\n                      mutations is crucial for diagnosing DCM and elucidating its molecular mechanisms.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>To detect DCM-related gene mutations in the proband, next-generation sequencing was performed on DNA samples, with results subsequently confirmed through Sanger sequencing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A novel duplication frameshift mutation, c.633dup (p.His212ThrfsTer43), was identified within exon 3 of the\n                      <jats:italic>BAG3<\/jats:italic>\n                      gene in a patient diagnosed with DCM.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The detection of a novel duplication frameshift mutation, c.633dup, in the\n                      <jats:italic>BAG3<\/jats:italic>\n                      gene contributes to the expanding knowledge of\n                      <jats:italic>BAG3<\/jats:italic>\n                      mutations.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12872-026-05747-3","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T23:04:53Z","timestamp":1773875093000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A novel duplication frameshift mutation in the BAG3 gene in a patient with dilated cardiomyopathy"],"prefix":"10.1186","volume":"26","author":[{"given":"Wei","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaihang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiguang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,18]]},"reference":[{"key":"5747_CR1","doi-asserted-by":"publisher","first-page":"3503","DOI":"10.1093\/eurheartj\/ehad194","volume":"44","author":"E Arbelo","year":"2023","unstructured":"Arbelo E, et al. 2023 ESC Guidelines for the management of cardiomyopathies. 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