{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T18:18:51Z","timestamp":1785521931586,"version":"3.56.0"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":61,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Medical and Health Technology Project of Hangzhou","award":["A20241444"],"award-info":[{"award-number":["A20241444"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cardiovasc Disord"],"DOI":"10.1186\/s12872-026-05958-8","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T23:03:39Z","timestamp":1780009419000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Semaglutide in non-diabetic obese Chinese patients with acute coronary syndrome: a multicenter retrospective study"],"prefix":"10.1186","volume":"26","author":[{"given":"Chao-lun","family":"Jin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-ying","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-shu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling-long","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,29]]},"reference":[{"key":"5958_CR1","unstructured":"World Health Organization. Obesity and overweight. Fact sheet. December 2022. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/obesity-and-overweight."},{"issue":"10113","key":"5958_CR2","doi-asserted-by":"publisher","first-page":"2627","DOI":"10.1016\/S0140-6736(17)32129-3","volume":"390","author":"NCD Risk Factor Collaboration (NCD-RisC)","year":"2017","unstructured":"NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128\u00b79 million children, adolescents, and adults. Lancet. 2017;390(10113):2627\u201342.","journal-title":"Lancet"},{"key":"5958_CR3","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1161\/01.CIR.67.5.968","volume":"67","author":"HB Hubert","year":"1983","unstructured":"Hubert HB, Feinleib M, McNamara PM, et al. Obesity as an independent risk factor for cardiovascular disease: a 26-year follow-up of participants in the Framingham heart study. Circulation. 1983;67:968\u201377.","journal-title":"Circulation"},{"key":"5958_CR4","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1016\/S0140-6736(13)61836-X","volume":"383","author":"Y Lu","year":"2014","unstructured":"Global Burden of Metabolic Risk Factors for Chronic Diseases Collaboration (BMI Mediated Effects), Lu Y, Hajifathalian K, et al. metabolic mediators of the effects of body-mass index, overweight, and obesity on coronary heart disease and stroke: a pooled analysis of 97 prospective cohorts with 1\u22c58 million participants. Lancet. 2014;383:970\u201383.","journal-title":"Lancet"},{"key":"5958_CR5","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1093\/eurheartj\/ehq041","volume":"31","author":"S Verma","year":"2010","unstructured":"Verma S, Mehta SR, Granger CB, et al. Obesity and outcomes in acute coronary syndrome: insights from a large multinational registry. Eur Heart J. 2010;31:1237\u201345.","journal-title":"Eur Heart J"},{"issue":"19","key":"5958_CR6","doi-asserted-by":"publisher","first-page":"1834","DOI":"10.1056\/NEJMoa1607141","volume":"375","author":"SP Marso","year":"2016","unstructured":"Marso SP, Bain SC, Consoli A, et al. Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes. N Engl J Med. 2016;375(19):1834\u201344.","journal-title":"N Engl J Med"},{"issue":"24","key":"5958_CR7","doi-asserted-by":"publisher","first-page":"2221","DOI":"10.1056\/NEJMoa2307563","volume":"389","author":"AM Lincoff","year":"2023","unstructured":"Lincoff AM, Brown-Frandsen K, Colhoun HM, et al. Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes. N Engl J Med. 2023;389(24):2221\u201332.","journal-title":"N Engl J Med"},{"issue":"8","key":"5958_CR8","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1111\/dom.14725","volume":"24","author":"JPH Wilding","year":"2022","unstructured":"Wilding JPH, Batterham RL, Davies M, et al. Weight regain and cardiometabolic effects after withdrawal of semaglutide: The STEP 1 trial extension. Diabetes Obes Metab. 2022;24(8):1553\u201364.","journal-title":"Diabetes Obes Metab"},{"issue":"14","key":"5958_CR9","doi-asserted-by":"publisher","first-page":"1414","DOI":"10.1001\/jama.2021.3224","volume":"325","author":"D Rubino","year":"2021","unstructured":"Rubino D, Abrahamsson N, Davies M, et al. Effect of Continued Weekly Subcutaneous Semaglutide vs Placebo on Weight Loss Maintenance in Adults With Overweight or Obesity: The STEP 4 Randomized Clinical Trial. JAMA. 2021;325(14):1414\u201325.","journal-title":"JAMA"},{"issue":"2","key":"5958_CR10","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1001\/jama.2021.23619","volume":"327","author":"DM Rubino","year":"2022","unstructured":"Rubino DM, Greenway FL, Khalid U, et al. Effect of Weekly Subcutaneous Semaglutide vs Daily Liraglutide on Body Weight in Adults With Overweight or Obesity Without Diabetes: The STEP 8 Randomized Clinical Trial. JAMA. 2022;327(2):138\u201350.","journal-title":"JAMA"},{"issue":"12","key":"5958_CR11","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1056\/NEJMoa2306963","volume":"389","author":"MN Kosiborod","year":"2023","unstructured":"Kosiborod MN, Abildstr\u00f8m SZ, Borlaug BA, et al. Semaglutide in Patients with Heart Failure with Preserved Ejection Fraction and Obesity. N Engl J Med. 2023;389(12):1069\u201384.","journal-title":"N Engl J Med"},{"issue":"18","key":"5958_CR12","doi-asserted-by":"publisher","first-page":"2231","DOI":"10.1016\/j.jacc.2018.08.1038","volume":"72","author":"K Thygesen","year":"2018","unstructured":"Thygesen K, Alpert JS, Jaffe AS, et al. Fourth Universal Definition of Myocardial Infarction (2018). J Am Coll Cardiol. 2018;72(18):2231\u201364.","journal-title":"J Am Coll Cardiol"},{"issue":"8","key":"5958_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.18637\/jss.v042.i08","volume":"42","author":"D Ho","year":"2011","unstructured":"Ho D, Imai K, King G, et al. MatchIt: Nonparametric Preprocessing for Parametric Causal Inference. J Stat Softw. 2011;42(8):1\u201328.","journal-title":"J Stat Softw"},{"issue":"3","key":"5958_CR14","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1080\/00273171.2011.568786","volume":"46","author":"PC Austin","year":"2011","unstructured":"Austin PC. An Introduction to Propensity Score Methods for Reducing the Effects of Confounding in Observational Studies. Multivar Behav Res. 2011;46(3):399\u2013424.","journal-title":"Multivar Behav Res"},{"key":"5958_CR15","doi-asserted-by":"crossref","unstructured":"Sharma KK, Mathur M, Lodha S et al. Study of differences in presentation, risk factors and management in diabetic and nondiabetic patients with acute coronary syndrome. Indian J Endocrinol Metab. 2016;20(3):354\u20138.","DOI":"10.4103\/2230-8210.179990"},{"issue":"12","key":"5958_CR16","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1093\/eurjpc\/zwad133","volume":"30","author":"CYL Yaow","year":"2023","unstructured":"Yaow CYL, Chong B, Chin YH, et al. Higher risk of adverse cardiovascular outcomes in females with type 2 diabetes Mellitus: an Umbrella review of systematic reviews. Eur J Prev Cardiol. 2023;30(12):1227\u201335.","journal-title":"Eur J Prev Cardiol"},{"issue":"1","key":"5958_CR17","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1186\/s12933-025-02607-w","volume":"24","author":"D Hullon","year":"2025","unstructured":"Hullon D, Subeh GK, Volkova Y, et al. The role of glucagon-like peptide-1 receptor (GLP-1R) agonists in enhancing endothelial function: a potential avenue for improving heart failure with preserved ejection fraction (HFpEF). Cardiovasc Diabetol. 2025;24(1):70.","journal-title":"Cardiovasc Diabetol"},{"key":"5958_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bbrc.2023.01.049","volume":"647","author":"Q Zhu","year":"2023","unstructured":"Zhu Q, Luo Y, Wen Y, et al. Semaglutide inhibits ischemia\/ reperfusion-induced cardiomyocyte apoptosis through activating PKG\/PKC\u03b5\/ERK1\/2 pathway. Biochem Biophys Res Commun. 2023;647:1\u20138.","journal-title":"Biochem Biophys Res Commun"},{"issue":"7","key":"5958_CR19","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1111\/bph.17327","volume":"182","author":"K Lin","year":"2025","unstructured":"Lin K, Wang A, Zhai C, et al. Semaglutide protects against diabetes-associated cardiac inflammation via Sirt3-dependent RKIP pathway. Br J Pharmacol. 2025;182(7):1561\u201381.","journal-title":"Br J Pharmacol"},{"issue":"8 Pt 1","key":"5958_CR20","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1016\/j.jchf.2023.05.010","volume":"11","author":"MN Kosiborod","year":"2023","unstructured":"Kosiborod MN, Abildstr\u00f8m SZ, Borlaug BA, et al. Design and Baseline Characteristics of STEP-HFpEF Program Evaluating Semaglutide in Patients With Obesity HFpEF Phenotype. JACC Heart Fail. 2023;11(8 Pt 1):1000\u201310.","journal-title":"JACC Heart Fail"},{"issue":"22","key":"5958_CR21","doi-asserted-by":"publisher","first-page":"2087","DOI":"10.1016\/j.jacc.2023.09.811","volume":"82","author":"J Butler","year":"2023","unstructured":"Butler J, Abildstr\u00f8m SZ, Borlaug BA, et al. Semaglutide in Patients With Obesity and Heart Failure Across Mildly Reduced or Preserved Ejection Fraction. J Am Coll Cardiol. 2023;82(22):2087\u201396.","journal-title":"J Am Coll Cardiol"}],"container-title":["BMC Cardiovascular Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12872-026-05958-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-026-05958-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-026-05958-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T17:09:31Z","timestamp":1785517771000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12872-026-05958-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,29]]},"references-count":21,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["5958"],"URL":"https:\/\/doi.org\/10.1186\/s12872-026-05958-8","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-9161583\/v1","asserted-by":"object"}]},"ISSN":["1471-2261"],"issn-type":[{"value":"1471-2261","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,29]]},"assertion":[{"value":"18 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study protocol was approved by the Ethics Committee of Hangzhou Tenth People\u2019s Hospital (Approval No.: K 2021-12) as the central ethics committee for this multicenter study. Ethical approval or institutional data sharing authorization was also obtained from the other two participating centers (Hangzhou Ninth People\u2019s Hospital and Hangzhou Geriatric Hospital) in accordance with local institutional review board requirements. The study was performed in accordance with the principles of the Declaration of Helsinki. Written informed consent to participate in this retrospective study was obtained from all enrolled participants at the time of hospital admission and percutaneous coronary intervention (PCI).","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Informed consent given by the patients enrolled in the current study was obtained at the time of surgery.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"644"}}