{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T04:47:53Z","timestamp":1790657273975,"version":"4.1.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":58,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"The Project of Hospital capability enhancement project of Xiyuan Hospital, CACMS","award":["NO. XYZX0204-02"],"award-info":[{"award-number":["NO. XYZX0204-02"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cardiovasc Disord"],"DOI":"10.1186\/s12872-026-05959-7","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T13:55:15Z","timestamp":1779112515000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association between platelet\/high-density lipoprotein cholesterol ratio and incidence of coronary heart disease: insights from the UK Biobank"],"prefix":"10.1186","volume":"26","author":[{"given":"Chen","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changgeng","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dazhuo","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,18]]},"reference":[{"key":"5959_CR1","doi-asserted-by":"publisher","first-page":"2361","DOI":"10.1016\/j.jacc.2022.11.005","volume":"80","author":"M Vaduganathan","year":"2022","unstructured":"Vaduganathan M, Mensah GA, Turco JV, Fuster V, Roth GA. The Global Burden of Cardiovascular Diseases and Risk: A Compass for Future Health. J Am Coll Cardiol. 2022;80:2361\u201371.","journal-title":"J Am Coll Cardiol"},{"key":"5959_CR2","doi-asserted-by":"publisher","first-page":"256","DOI":"10.21037\/atm.2016.06.33","volume":"4","author":"F Sanchis-Gomar","year":"2016","unstructured":"Sanchis-Gomar F, Perez-Quilis C, Leischik R, Lucia A. Epidemiology of coronary heart disease and acute coronary syndrome. Annals translational Med. 2016;4:256.","journal-title":"Annals translational Med"},{"key":"5959_CR3","doi-asserted-by":"publisher","first-page":"2135","DOI":"10.1016\/j.jacc.2024.11.009","volume":"85","author":"SV Rao","year":"2025","unstructured":"Rao SV, O\u2019Donoghue ML, Ruel M, Rab T, Tamis-Holland JE, Alexander JH, et al. 2025 ACC\/AHA\/ACEP\/NAEMSP\/SCAI Guideline for the Management of Patients With Acute Coronary Syndromes: A Report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines. J Am Coll Cardiol. 2025;85:2135\u2013237.","journal-title":"J Am Coll Cardiol"},{"key":"5959_CR4","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1093\/eurjpc\/zwaa037","volume":"28","author":"F Savira","year":"2021","unstructured":"Savira F, Wang BH, Kompa AR, Ademi Z, Owen AJ, Liew D, et al. The impact of coronary heart disease prevention on work productivity: a 10-year analysis. Eur J Prev Cardiol. 2021;28:418\u201325.","journal-title":"Eur J Prev Cardiol"},{"key":"5959_CR5","doi-asserted-by":"publisher","first-page":"e3403","DOI":"10.1002\/dmrr.3403","volume":"37","author":"I Jialal","year":"2021","unstructured":"Jialal I, Jialal G, Adams-Huet B. The platelet to high density lipoprotein -cholesterol ratio is a valid biomarker of nascent metabolic syndrome. Diabetes Metab Res Rev. 2021;37:e3403.","journal-title":"Diabetes Metab Res Rev"},{"key":"5959_CR6","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1186\/s12944-024-02342-3","volume":"23","author":"J Chen","year":"2024","unstructured":"Chen J, Wang B, Liu C, Li C, Meng T, Wang J, et al. Association between platelet to high-density lipoprotein cholesterol ratio (PHR) and hypertension: evidence from NHANES 2005\u20132018. Lipids Health Dis. 2024;23:346.","journal-title":"Lipids Health Dis"},{"key":"5959_CR7","doi-asserted-by":"publisher","first-page":"15641","DOI":"10.1038\/s41598-024-66747-x","volume":"14","author":"L Yan","year":"2024","unstructured":"Yan L, Hu X, Wu S, Zhao S. Association of platelet to high-density lipoprotein cholesterol ratio with hyperuricemia. Sci Rep. 2024;14:15641.","journal-title":"Sci Rep"},{"key":"5959_CR8","doi-asserted-by":"publisher","first-page":"30082","DOI":"10.1038\/s41598-024-81637-y","volume":"14","author":"P Chen","year":"2024","unstructured":"Chen P, Zhu M, Guo M, Shi D, Chen Z, Du J. Platelet to high density lipoprotein cholesterol ratio is associated with diabetes and prediabetes in NHANES 2005 to 2018. Sci Rep. 2024;14:30082.","journal-title":"Sci Rep"},{"key":"5959_CR9","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1186\/s12944-023-01861-9","volume":"22","author":"CF Lu","year":"2023","unstructured":"Lu CF, Cang XM, Liu WS, Wang LH, Huang HY, Sang SM, et al. Association between the platelet\/high-density lipoprotein cholesterol ratio and nonalcoholic fatty liver disease: results from NHANES 2017\u20132020. Lipids Health Dis. 2023;22:130.","journal-title":"Lipids Health Dis"},{"key":"5959_CR10","doi-asserted-by":"publisher","first-page":"23283","DOI":"10.1038\/s41598-024-75453-7","volume":"14","author":"B Wang","year":"2024","unstructured":"Wang B, Wang J, Liu C, Hu X. The potential of platelet to high-density lipoprotein cholesterol ratio (PHR) as a novel biomarker for heart failure. Sci Rep. 2024;14:23283.","journal-title":"Sci Rep"},{"key":"5959_CR11","doi-asserted-by":"publisher","first-page":"e184","DOI":"10.1161\/ATVBAHA.124.318260","volume":"45","author":"M Pilard","year":"2025","unstructured":"Pilard M, Babran S, Martel C. Regulation of Platelet Function by HDL. Arterioscler Thromb Vasc Biol. 2025;45:e184\u2013200.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"5959_CR12","doi-asserted-by":"publisher","first-page":"26403","DOI":"10.31083\/RCM26403","volume":"26","author":"Y Huang","year":"2025","unstructured":"Huang Y, Hou X, Lv F, Gong Z. Association of the Platelets to High Density Lipoprotein Cholesterol Ratio and Risk of Heart Disease Events in Middle-Aged and Elderly Chinese Population: A Retrospective Cohort Study Utilizing the CHARLS Database. Rev Cardiovasc Med. 2025;26:26403.","journal-title":"Rev Cardiovasc Med"},{"key":"5959_CR13","doi-asserted-by":"publisher","first-page":"1402336","DOI":"10.3389\/fendo.2024.1402336","volume":"15","author":"H Zhang","year":"2024","unstructured":"Zhang H, Xu Y, Xu Y. The value of the platelet\/high-density lipoprotein cholesterol ratio in predicting depression and its cardiovascular disease mortality: a population-based observational study. Front Endocrinol (Lausanne). 2024;15:1402336.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"5959_CR14","doi-asserted-by":"publisher","first-page":"2731","DOI":"10.2147\/JIR.S458950","volume":"17","author":"W Wu","year":"2024","unstructured":"Wu W, Jia C, Xu X, He Y, Xie Y, Zhou Y, et al. Impact of Platelet-to-HDL-Cholesterol Ratio on Long-Term Mortality in Coronary Artery Disease Patients with or Without Type 2 Diabetes: Insights from a Chinese Multicenter Cohort. J Inflamm Res. 2024;17:2731\u201344.","journal-title":"J Inflamm Res"},{"key":"5959_CR15","doi-asserted-by":"publisher","first-page":"e1001779","DOI":"10.1371\/journal.pmed.1001779","volume":"12","author":"C Sudlow","year":"2015","unstructured":"Sudlow C, Gallacher J, Allen N, Beral V, Burton P, Danesh J, et al. UK biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age. PLoS Med. 2015;12:e1001779.","journal-title":"PLoS Med"},{"key":"5959_CR16","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1186\/s12944-024-02115-y","volume":"23","author":"H Zhang","year":"2024","unstructured":"Zhang H, Xu Y, Xu Y. The association of the platelet\/high-density lipoprotein cholesterol ratio with self-reported stroke and cardiovascular mortality: a population-based observational study. Lipids Health Dis. 2024;23:121.","journal-title":"Lipids Health Dis"},{"key":"5959_CR17","doi-asserted-by":"crossref","unstructured":"Chaudhary PK, Kim S, Kim S. An Insight into Recent Advances on Platelet Function in Health and Disease. Int J Mol Sci. 2022;23.","DOI":"10.3390\/ijms23116022"},{"key":"5959_CR18","doi-asserted-by":"crossref","unstructured":"Bonacina F, Pirillo A, Catapano AL, Norata GD. HDL in Immune-Inflammatory Responses: Implications beyond Cardiovascular Diseases. Cells. 2021;10.","DOI":"10.3390\/cells10051061"},{"key":"5959_CR19","doi-asserted-by":"publisher","first-page":"120151","DOI":"10.1016\/j.jad.2025.120151","volume":"392","author":"D Du","year":"2026","unstructured":"Du D, Zhu H, Hu X, Shen Y, Luo F. The relationship between the platelet\/high-density lipoprotein cholesterol ratio and depressive symptoms in Chinese adults: cross-sectional and longitudinal evidence. J Affect Disord. 2026;392:120151.","journal-title":"J Affect Disord"},{"key":"5959_CR20","doi-asserted-by":"publisher","first-page":"1367919","DOI":"10.3389\/fcvm.2024.1367919","volume":"11","author":"H Zhou","year":"2024","unstructured":"Zhou H, Li X, Wang W, Zha Y, Gao G, Li S, et al. Immune-inflammatory biomarkers for the occurrence of MACE in patients with myocardial infarction with non-obstructive coronary arteries. Front Cardiovasc Med. 2024;11:1367919.","journal-title":"Front Cardiovasc Med"},{"key":"5959_CR21","doi-asserted-by":"publisher","first-page":"544921","DOI":"10.2147\/JIR.S544921","volume":"19","author":"Z Yang","year":"2026","unstructured":"Yang Z, Li Z, Gao Y, et al. The Combined Effect of Platelet-to-HDL-Cholesterol Ratio and Glycemic Metabolism Status on the Prognosis of Patients Undergoing Percutaneous Coronary Intervention: A Large-Scale Retrospective Cohort Study. J Inflamm Res. 2026;19:544921.","journal-title":"J Inflamm Res"},{"key":"5959_CR22","doi-asserted-by":"crossref","unstructured":"Ter Horst R, van den Munckhof ICL, Schraa K, Aguirre-Gamboa R, Jaeger M, Smeekens SP et al. Sex-Specific Regulation of Inflammation and Metabolic Syndrome in Obesity. Arteriosclerosis, thrombosis, and vascular biology. 2020;40:1787\u2009\u2013\u2009800.","DOI":"10.1161\/ATVBAHA.120.314508"},{"key":"5959_CR23","doi-asserted-by":"publisher","first-page":"1479245","DOI":"10.3389\/fneur.2024.1479245","volume":"15","author":"X Hou","year":"2024","unstructured":"Hou X, Zhu M, Zhu Z, Li Y, Chen X, Zhang X. Association between platelet-to-high-density lipoprotein cholesterol ratio and future stroke risk: a national cohort study based on CHARLS. Front Neurol. 2024;15:1479245.","journal-title":"Front Neurol"},{"issue":"1","key":"5959_CR24","doi-asserted-by":"publisher","first-page":"12829","DOI":"10.1038\/s41598-026-43526-4","volume":"16","author":"Y He","year":"2026","unstructured":"He Y, Zhao Q, Cai Q. Association of platelet to HDL-C ratio with short-term mortality in critically ill intracerebral hemorrhage patients: a MIMIC-IV analysis. Sci Rep. 2026;16(1):12829. Published 2026 Mar 10.","journal-title":"Sci Rep"},{"key":"5959_CR25","doi-asserted-by":"publisher","first-page":"1580359","DOI":"10.3389\/fcvm.2025.1580359","volume":"12","author":"H Luo","year":"2025","unstructured":"Luo H, Li G, Chen Y, Shen Y, Shen W. Association of platelet-to-high-density lipoprotein cholesterol ratio and its cumulative exposure with cardiovascular disease risk: a prospective cohort study in Chinese population. Front Cardiovasc Med. 2025;12:1580359.","journal-title":"Front Cardiovasc Med"}],"container-title":["BMC Cardiovascular Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12872-026-05959-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-026-05959-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-026-05959-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T22:17:16Z","timestamp":1784067436000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12872-026-05959-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,18]]},"references-count":25,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["5959"],"URL":"https:\/\/doi.org\/10.1186\/s12872-026-05959-7","relation":{},"ISSN":["1471-2261"],"issn-type":[{"value":"1471-2261","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,18]]},"assertion":[{"value":"18 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was conducted using data from the UK Biobank, which was approved by the North West Multicenter Research Ethics Committee (reference number: 11\/NW\/0382). All participants provided written informed consent. All methods were performed in accordance with the relevant guidelines and regulations, including the Declaration of Helsinki. This research was conducted using the UK Biobank Resource under application number 105474.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"595"}}