{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T03:49:17Z","timestamp":1788407357577,"version":"build-2803163510"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":67,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cardiovasc Disord"],"DOI":"10.1186\/s12872-026-06098-9","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T05:46:00Z","timestamp":1781156760000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Severe hypercapnia and hemodynamic instability following a sudden elevation in end-tidal CO\u2082 during thoraco-laparoscopic esophagectomy: a case report and literature review"],"prefix":"10.1186","volume":"26","author":[{"given":"Yan","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunling","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,11]]},"reference":[{"key":"6098_CR1","doi-asserted-by":"crossref","unstructured":"Ito S, Takahashi A, Ueno H, Takiguchi S, Kajiwara Y, Kakeji Y et al. Annual report on National Clinical Database 2021 for gastroenterological surgery in Japan. Ann Gastroenterol Surg. 2024;9(1):32\u201359.","DOI":"10.1002\/ags3.12868"},{"issue":"2","key":"6098_CR2","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/0003-4975(94)92215-2","volume":"58","author":"RS Wolfer","year":"1994","unstructured":"Wolfer RS, Krasna MJ, Hasnain JU, McLaughlin JS. Hemodynamic effects of carbon dioxide insufflation during thoracoscopy. Ann Thorac Surg. 1994;58(2):404\u20138.","journal-title":"Ann Thorac Surg"},{"issue":"1","key":"6098_CR3","doi-asserted-by":"publisher","first-page":"88","DOI":"10.4097\/kjae.2016.69.1.88","volume":"69","author":"H-J Park","year":"2016","unstructured":"Park H-J, Kim D-K, Yang M-K, Seo J-E, Kwon J-H. Carbon dioxide pneumothorax occurring during laparoscopy-assisted gastrectomy due to a congenital diaphragmatic defect: a case report. Korean J Anesthesiol. 2016;69(1):88\u201392.","journal-title":"Korean J Anesthesiol"},{"issue":"1","key":"6098_CR4","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1186\/s12893-020-00868-8","volume":"20","author":"MS Chae","year":"2020","unstructured":"Chae MS, Kwak J, Roh K, Kim M, Park S, Choi HJ, et al. Pneumoperitoneum-induced pneumothorax during laparoscopic living donor hepatectomy: a case report. BMC Surg. 2020;20(1):206.","journal-title":"BMC Surg"},{"issue":"10","key":"6098_CR5","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.4187\/respcare.06094","volume":"64","author":"S Fujimoto","year":"2019","unstructured":"Fujimoto S, Suzuki M, Sakamoto K, Ibusuki R, Tamura K, Shiozawa A, et al. Comparison of End-Tidal, Arterial, Venous, and Transcutaneous PCO2. Resp Care. 2019;64(10):1208\u201314.","journal-title":"Resp Care"},{"issue":"12","key":"6098_CR6","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1097\/PEC.0000000000001682","volume":"34","author":"ST Selby","year":"2018","unstructured":"Selby ST, Abramo T, Hobart-Porter N. An Update on End-Tidal CO2 Monitoring. Pediatr Emerg Care. 2018;34(12):888\u201392.","journal-title":"Pediatr Emerg Care"},{"issue":"8","key":"6098_CR7","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1034\/j.1399-6576.1999.430811.x","volume":"43","author":"H Morisaki","year":"2002","unstructured":"Morisaki H, Serita R, Innami Y, Kotake Y, Takeda J. Permissive hypercapnia during thoracic anaesthesia. Acta Anaesthesiol Scand. 2002;43(8):845\u20139.","journal-title":"Acta Anaesthesiol Scand"},{"issue":"1","key":"6098_CR8","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1097\/00000542-199401000-00020","volume":"80","author":"R Lister David","year":"1994","unstructured":"Lister David R, Rudston-Brown B, Warriner CB, McEwen J, Chan M, Walley Keith R. Carbon Dioxide Absorption Is Not Linearly Related to Intraperitoneal Carbon Dioxide Insufflation Pressure in Pigs. Anesthesiology. 1994;80(1):129\u201336.","journal-title":"Anesthesiology"},{"issue":"1","key":"6098_CR9","first-page":"18","volume":"24","author":"A Musgjerd","year":"2009","unstructured":"Musgjerd A, Beebe D, Prielipp RC. IntraoperativeHypercapnea During Thoracoscopy\u2014ACase Report. APSF Newsl. 2009;24(1):18.","journal-title":"APSF Newsl"},{"issue":"7","key":"6098_CR10","first-page":"e5075","volume":"11","author":"A De Cassai","year":"2019","unstructured":"De Cassai A, Boetto R, Gabellini G, Cillo U. Massive Carbon Dioxide Embolism During Laparoscopic Liver Resection: A Case Report. Cureus. 2019;11(7):e5075.","journal-title":"Cureus"},{"issue":"1","key":"6098_CR11","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/s40981-020-00345-4","volume":"6","author":"K Takechi","year":"2020","unstructured":"Takechi K, Ito M, Peng Y, Daizen W, Shimizu I. Laparoscopic image of carbon dioxide embolism during laparoscopic hepatectomy: a case report. JA Clin Rep. 2020;6(1):39.","journal-title":"JA Clin Rep"},{"issue":"4","key":"6098_CR12","doi-asserted-by":"publisher","first-page":"030006052110047","DOI":"10.1177\/03000605211004765","volume":"49","author":"M Bao","year":"2021","unstructured":"Bao M, Cai W, Zhu S, Kang X. Carbon dioxide embolism with severe hypotension as an initial symptom during laparoscopy: a case report. J Int Med Res. 2021;49(4):03000605211004765.","journal-title":"J Int Med Res"},{"issue":"9","key":"6098_CR13","doi-asserted-by":"publisher","first-page":"2908","DOI":"10.12998\/wjcc.v10.i9.2908","volume":"10","author":"S Jeon","year":"2022","unstructured":"Jeon S, Hong J-M, Lee HJ, Kim Y, Kang H, Hwang B-y, et al. Paradoxical carbon dioxide embolism during laparoscopic hepatectomy without intracardiac shunt: A case report. World J Clin Cases. 2022;10(9):2908\u201315.","journal-title":"World J Clin Cases"},{"issue":"1","key":"6098_CR14","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/s40981-024-00695-3","volume":"10","author":"N Haraguchi","year":"2024","unstructured":"Haraguchi N, Naito Y, Shibasaki M, Sawa T. Tracheal injury diagnosed by a sudden increase in end-tidal carbon dioxide levels during mediastinoscopic subtotal esophagectomy: a case report. JA Clin Rep. 2024;10(1):11.","journal-title":"JA Clin Rep"},{"key":"6098_CR15","doi-asserted-by":"crossref","unstructured":"Shiga M, Shiga M, Isoda B, Nitta S, Kojo K, Nagumo Y et al. A case of cerebral infarction caused by carbon dioxide embolism during robotic-assisted laparoscopic partial nephrectomy. Urol Case Rep. 2025;60:103016.","DOI":"10.1016\/j.eucr.2025.103016"},{"issue":"1","key":"6098_CR16","first-page":"e01909","volume":"19","author":"AY Pai","year":"2025","unstructured":"Pai AY, Rosecrance KG, Ding AL, Dhoon TQ, Jutric Z, Rajan GR. Managing Recurrent Carbon Dioxide Embolism During Laparoscopic Hepatectomy With Transesophageal Echocardiography Guidance: A Case Report. Pract. 2025;19(1):e01909.","journal-title":"Pract"},{"issue":"2","key":"6098_CR17","doi-asserted-by":"publisher","first-page":"58","DOI":"10.5812\/atr.6444","volume":"1","author":"E Razi","year":"2012","unstructured":"Razi E, Moosavi GA, Omidi K, Saebi A, Razi A. Correlation of End-Tidal Carbon Dioxide with Arterial Carbon Dioxide in Mechanically Ventilated Patients. Arch Trauma Res. 2012;1(2):58\u201362.","journal-title":"Arch Trauma Res"},{"issue":"6","key":"6098_CR18","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.bjae.2023.03.002","volume":"23","author":"J Pippalapalli","year":"2023","unstructured":"Pippalapalli J, Lumb AB. The respiratory system and acid\u2013base disorders. BJA Educ. 2023;23(6):221\u20138.","journal-title":"BJA Educ"},{"issue":"4","key":"6098_CR19","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/s44254-025-00155-w","volume":"3","author":"F Fei","year":"2025","unstructured":"Fei F, Li X, Xu Y, Yin F, Zheng T, Yu H. Effect of synchronized intermittent mandatory versus manual assistance ventilation during anesthetic emergence on postoperative atelectasis in patients undergoing laparoscopic abdominal surgery: a randomized controlled trial. Anesthesiol Perioper Sci. 2025;3(4):61.","journal-title":"Anesthesiol Perioper Sci"},{"key":"6098_CR20","unstructured":"Ungerleider RM, Nelson K, Meliones J, Quartermain M, Jacobs J. Critical Heart Disease in Infants and Children (Third Edition). Elsevier Enhanced Digital Version: Amsterdam. 2019. ISBN: 978-1-4557-0760-7"},{"issue":"4","key":"6098_CR21","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1097\/00000542-197410000-00006","volume":"41","author":"J Cullen David","year":"1974","unstructured":"Cullen David J, Eger Edmond I. Cardiovascular Effects of Carbon Dioxide in Man. Anesthesiology. 1974;41(4):345\u20138.","journal-title":"Anesthesiology"},{"issue":"2","key":"6098_CR22","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1152\/jappl.1990.69.2.710","volume":"69","author":"JD Brofman","year":"1990","unstructured":"Brofman JD, Leff AR, Munoz NM, Kirchhoff C, White SR. Sympathetic secretory response to hypercapnic acidosis in swine. J Appl Physiol. 1990;69(2):710\u20137.","journal-title":"J Appl Physiol"},{"issue":"1","key":"6098_CR23","doi-asserted-by":"publisher","first-page":"2635616","DOI":"10.1155\/2022\/2635616","volume":"2022","author":"A Almanza-Hurtado","year":"2022","unstructured":"Almanza-Hurtado A, Polanco Guerra C, Mart\u00ednez-\u00c1vila MC, Borr\u00e9-Naranjo D, Rodr\u00edguez-Yanez T, Due\u00f1as-Castell C, et al. Hypercapnia from Physiology to Practice. Int J Clin Pract. 2022;2022(1):2635616.","journal-title":"Int J Clin Pract"},{"issue":"6","key":"6098_CR24","doi-asserted-by":"publisher","first-page":"R303","DOI":"10.1186\/cc13173","volume":"17","author":"M Stengl","year":"2013","unstructured":"Stengl M, Ledvinova L, Chvojka J, Benes J, Jarkovska D, Holas J, et al. Effects of clinically relevant acute hypercapnic and metabolic acidosis on the cardiovascular system: an experimental porcine study. Crit Care. 2013;17(6):R303.","journal-title":"Crit Care"},{"issue":"3","key":"6098_CR25","doi-asserted-by":"publisher","first-page":"386","DOI":"10.3171\/jns.1995.82.3.0386","volume":"82","author":"M Yoshihara","year":"1995","unstructured":"Yoshihara M, Bandoh K, Marmarou A. Cerebrovascular carbon dioxide reactivity assessed by intracranial pressure dynamics in severely head injured patients. J Neurosurg. 1995;82(3):386\u201393.","journal-title":"J Neurosurg"},{"issue":"5","key":"6098_CR26","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1161\/01.STR.5.5.630","volume":"5","author":"RL Grubb","year":"1974","unstructured":"Grubb RL, Raichle ME, Eichling JO, Ter-Pogossian MM. The Effects of Changes in PaCO2 Cerebral Blood Volume, Blood Flow, and Vascular Mean Transit Time. Stroke. 1974;5(5):630\u20139.","journal-title":"Stroke"},{"issue":"3","key":"6098_CR27","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1002\/j.2040-4603.2019.tb00083.x","volume":"9","author":"RL Hoiland","year":"2019","unstructured":"Hoiland RL, Fisher JA, Ainslie PN. Regulation of the Cerebral Circulation by Arterial Carbon Dioxide. Compr Physiol. 2019;9(3):1101\u201354.","journal-title":"Compr Physiol"},{"issue":"2","key":"6098_CR28","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1007\/s00134-016-4611-1","volume":"43","author":"N Nin","year":"2017","unstructured":"Nin N, Muriel A, Pe\u00f1uelas O, Brochard L, Lorente JA, Ferguson ND, et al. Severe hypercapnia and outcome of mechanically ventilated patients with moderate or severe acute respiratory distress syndrome. Intens Care Med. 2017;43(2):200\u20138.","journal-title":"Intens Care Med"}],"container-title":["BMC Cardiovascular Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12872-026-06098-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-026-06098-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-026-06098-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T02:46:06Z","timestamp":1786934766000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12872-026-06098-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,11]]},"references-count":28,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["6098"],"URL":"https:\/\/doi.org\/10.1186\/s12872-026-06098-9","relation":{},"ISSN":["1471-2261"],"issn-type":[{"value":"1471-2261","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,11]]},"assertion":[{"value":"29 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The report has received ethical approval from the Clinical Research Ethics Committee of West China Hospital.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Verbal informed consent was obtained from the patient for publication.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"709"}}