{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T02:24:34Z","timestamp":1787279074656,"version":"build-2736575974"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T00:00:00Z","timestamp":1781308800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"vor","delay-in-days":69,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"crossref","award":["grant no. 2023J011797"],"award-info":[{"award-number":["grant no. 2023J011797"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Natural Science Foundation of Fujian Provincial Health Commission","award":["grant no. 2024CXB014"],"award-info":[{"award-number":["grant no. 2024CXB014"]}]},{"name":"Quanzhou High-Level Talent Innovation and Entrepreneurship Project","award":["grant no. 2024QZC013YR"],"award-info":[{"award-number":["grant no. 2024QZC013YR"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cardiovasc Disord"],"DOI":"10.1186\/s12872-026-06129-5","type":"journal-article","created":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T03:05:16Z","timestamp":1781319916000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Differential expression of metabolic genes distinguishes physiological from pathological cardiac hypertrophy"],"prefix":"10.1186","volume":"26","author":[{"given":"Xiaojian","family":"Cai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sihuang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangwei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quanfu","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Diao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liling","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,13]]},"reference":[{"issue":"7","key":"6129_CR1","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1038\/s41569-018-0007-y","volume":"15","author":"M Nakamura","year":"2018","unstructured":"Nakamura M, Sadoshima J. Mechanisms of physiological and pathological cardiac hypertrophy. Nat Rev Cardiol. 2018;15(7):387\u2013407. https:\/\/doi.org\/10.1038\/s41569-018-0007-y.","journal-title":"Nat Rev Cardiol"},{"issue":"1","key":"6129_CR2","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1093\/eurheartj\/ehaf524","volume":"47","author":"A Peikert","year":"2026","unstructured":"Peikert A, Fontana M, Solomon SD, Thum T. Left ventricular hypertrophy and myocardial fibrosis in heart failure with preserved ejection fraction: mechanisms and treatment. Eur Heart J. 2026;47(1):37\u201353. https:\/\/doi.org\/10.1093\/eurheartj\/ehaf524 . PubMed PMID: 40892534IF: 35.6 Q1 B1; PubMed Central PMCID: PMC12765563IF: 35.6 Q1 B1.","journal-title":"Eur Heart J"},{"issue":"13","key":"6129_CR3","doi-asserted-by":"publisher","first-page":"1780","DOI":"10.3390\/cells12131780","volume":"12","author":"F Bazgir","year":"2023","unstructured":"Bazgir F, Nau J, Nakhaei-Rad S, Amin E, Wolf MJ, Saucerman JJ, et al. The microenvironment of the pathogenesis of cardiac hypertrophy. Cells. 2023;12(13):1780. https:\/\/doi.org\/10.3390\/cells12131780 . PubMed PMID: 37443814IF: 5.2 Q2 B2; PubMed Central PMCID: PMC10341218IF: 5.2 Q2 B2.","journal-title":"Cells"},{"issue":"12","key":"6129_CR4","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1038\/s41569-023-00887-x","volume":"20","author":"J Ritterhoff","year":"2023","unstructured":"Ritterhoff J, Tian R. Metabolic mechanisms in physiological and pathological cardiac hypertrophy: new paradigms and challenges. Nat Rev Cardiol. 2023;20(12):812\u201329. https:\/\/doi.org\/10.1038\/s41569-023-00887-x.","journal-title":"Nat Rev Cardiol"},{"issue":"7","key":"6129_CR5","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1093\/nar\/gkv007","volume":"43","author":"ME Ritchie","year":"2015","unstructured":"Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W, et al. limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 2015;43(7):e47\u201347. https:\/\/doi.org\/10.1093\/nar\/gkv007.","journal-title":"Nucleic Acids Res"},{"issue":"5","key":"6129_CR6","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1089\/omi.2011.0118","volume":"16","author":"G Yu","year":"2012","unstructured":"Yu G, Wang LG, Han Y, He QY. clusterProfiler: an R package for comparing biological themes among gene clusters. OMICS J Integr Biol. 2012;16(5):284\u20137. https:\/\/doi.org\/10.1089\/omi.2011.0118.","journal-title":"OMICS J Integr Biol"},{"issue":"11","key":"6129_CR7","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1101\/gr.1239303","volume":"13","author":"P Shannon","year":"2003","unstructured":"Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, et al. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 2003;13(11):2498\u2013504. https:\/\/doi.org\/10.1101\/gr.1239303 . PubMed PMID: 14597658IF: 5.5 Q1 B1; PubMed Central PMCID: PMC403769IF: 5.5 Q1 B1.","journal-title":"Genome Res"},{"issue":"D1","key":"6129_CR8","doi-asserted-by":"publisher","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","volume":"51","author":"D Szklarczyk","year":"2023","unstructured":"Szklarczyk D, Kirsch R, Koutrouli M, Nastou K, Mehryary F, Hachilif R, et al. The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest. Nucleic Acids Res. 2023;51(D1):D638\u201346. https:\/\/doi.org\/10.1093\/nar\/gkac1000 . PubMed PMID: 36370105IF: 13.1 Q1 B2; PubMed Central PMCID: PMC9825434IF: 13.1 Q1 B2.","journal-title":"Nucleic Acids Res"},{"key":"6129_CR9","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.biopha.2017.06.002","volume":"93","author":"X Li","year":"2017","unstructured":"Li X, Zhang ZL, Wang HF. Fusaric acid (FA) protects heart failure induced by isoproterenol (ISP) in mice through fibrosis prevention via TGF-\u03b21\/SMADs and PI3K\/AKT signaling pathways. Biomed Pharmacother. 2017;93:130\u201345. https:\/\/doi.org\/10.1016\/j.biopha.2017.06.002.","journal-title":"Biomed Pharmacother"},{"issue":"2","key":"6129_CR10","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1161\/circulationaha.117.030811","volume":"138","author":"L Zhou","year":"2018","unstructured":"Zhou L, Miao K, Yin B, Li H, Fan J, Zhu Y, et al. Cardioprotective Role of Myeloid-Derived Suppressor Cells in Heart Failure. Circulation. 2018;138(2):181\u201397. https:\/\/doi.org\/10.1161\/circulationaha.117.030811.","journal-title":"Circulation"},{"issue":"1","key":"6129_CR11","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.apsb.2022.08.016","volume":"13","author":"R Chen","year":"2023","unstructured":"Chen R, Zhang S, Liu F, Xia L, Wang C, Sandoghchian Shotorbani S, et al. Renewal of embryonic and neonatal-derived cardiac-resident macrophages in response to environmental cues abrogated their potential to promote cardiomyocyte proliferation via jagged-1\u2013Notch1. Acta Pharm Sin B. 2023;13(1):128\u201341. https:\/\/doi.org\/10.1016\/j.apsb.2022.08.016.","journal-title":"Acta Pharm Sin B"},{"issue":"48","key":"6129_CR12","doi-asserted-by":"publisher","first-page":"41062","DOI":"10.1021\/acsnano.5c13265","volume":"19","author":"G Chen","year":"2025","unstructured":"Chen G, Sun Q, Xiong S, Cao T, Du B, Wang Q, et al. Spatial Lipid Metabolic Remodeling from Placenta to Multiple Suborgans during the Gestational Micro- or Nanoplastics Exposure. ACS Nano. 2025;19(48):41062\u201375. https:\/\/doi.org\/10.1021\/acsnano.5c13265 . PubMed PMID: 41263540IF: 16.0 Q1 B1.","journal-title":"ACS Nano"},{"issue":"12","key":"6129_CR13","doi-asserted-by":"publisher","first-page":"5623","DOI":"10.7150\/thno.44836","volume":"10","author":"Y Li","year":"2020","unstructured":"Li Y, Xiong Z, Yan W, Gao E, Cheng H, Wu G, et al. Branched chain amino acids exacerbate myocardial ischemia\/reperfusion vulnerability via enhancing GCN2\/ATF6\/PPAR-\u03b1 pathway-dependent fatty acid oxidation. Theranostics. 2020;10(12):5623\u201340. https:\/\/doi.org\/10.7150\/thno.44836 . PubMed PMID: 32373236IF: 13.3 Q1 B1; PubMed Central PMCID: PMC7196282IF: 13.3 Q1 B1.","journal-title":"Theranostics"},{"issue":"10","key":"6129_CR14","doi-asserted-by":"publisher","first-page":"1924","DOI":"10.2337\/db19-0423","volume":"68","author":"M Ljubkovic","year":"2019","unstructured":"Ljubkovic M, Gressette M, Bulat C, Cavar M, Bakovic D, Fabijanic D, et al. Disturbed fatty acid oxidation, endoplasmic reticulum stress, and apoptosis in left ventricle of patients with type 2 diabetes. Diabetes. 2019;68(10):1924\u201333. https:\/\/doi.org\/10.2337\/db19-0423.","journal-title":"Diabetes"},{"issue":"1","key":"6129_CR15","doi-asserted-by":"publisher","first-page":"4671","DOI":"10.1038\/s41467-019-12482-1","volume":"10","author":"JW Miklas","year":"2019","unstructured":"Miklas JW, Clark E, Levy S, Detraux D, Leonard A, Beussman K, et al. TFPa\/HADHA is required for fatty acid beta-oxidation and cardiolipin re-modeling in human cardiomyocytes. Nat Commun. 2019;10(1):4671. https:\/\/doi.org\/10.1038\/s41467-019-12482-1.","journal-title":"Nat Commun"},{"issue":"5","key":"6129_CR16","doi-asserted-by":"publisher","first-page":"100792","DOI":"10.1016\/j.jlr.2025.100792","volume":"66","author":"C Eke","year":"2025","unstructured":"Eke C, Babcock S, Gaston G, Elizondo G, Chung H, Asal A, et al. Cardiomyopathy in a c.1528G\u2009>\u2009C hadha mouse is associated with cardiac tissue lipotoxicity and altered cardiolipin species. J Lipid Res. 2025;66(5):100792. https:\/\/doi.org\/10.1016\/j.jlr.2025.100792.","journal-title":"J Lipid Res"},{"key":"6129_CR17","doi-asserted-by":"publisher","first-page":"6","DOI":"10.34133\/research.0006","volume":"2022","author":"H Miao","year":"2022","unstructured":"Miao H, Li B, Wang Z, Mu J, Tian Y, Jiang B, et al. Lipidome atlas of the developing heart uncovers dynamic membrane lipid attributes underlying cardiac structural and metabolic maturation. Research. 2022;2022:6. https:\/\/doi.org\/10.34133\/research.0006.","journal-title":"Research"},{"issue":"39","key":"6129_CR18","doi-asserted-by":"publisher","first-page":"17259","DOI":"10.1021\/acs.est.4c04373","volume":"58","author":"K Su","year":"2024","unstructured":"Su K, Liu J, Chen J, Wu H, Tang W, Sun S, et al. Bisphenol C Induces Cardiac Developmental Defects by Disrupting m6 A Homeostasis. Environ Sci Technol. 2024;58(39):17259\u201369. https:\/\/doi.org\/10.1021\/acs.est.4c04373.","journal-title":"Environ Sci Technol"},{"issue":"5","key":"6129_CR19","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1007\/s10557-020-07014-9","volume":"35","author":"J Guti\u00e9rrez-Cuevas","year":"2021","unstructured":"Guti\u00e9rrez-Cuevas J, Sandoval-Rodr\u00edguez A, Monroy-Ram\u00edrez HC, Vazquez-Del Mercado M, Santos-Garc\u00eda A, Armend\u00e1riz-Borunda J. Prolonged-release pirfenidone prevents obesity-induced cardiac steatosis and fibrosis in a mouse NASH model. Cardiovasc Drugs Ther. 2021;35(5):927\u201338. https:\/\/doi.org\/10.1007\/s10557-020-07014-9.","journal-title":"Cardiovasc Drugs Ther"},{"key":"6129_CR20","doi-asserted-by":"publisher","first-page":"157492","DOI":"10.1016\/j.phymed.2025.157492","volume":"148","author":"Ylei Ma","year":"2025","unstructured":"Ma Ylei, Huo X, wei, Wong C, Zhou F, jie, Li S, ze, Zhang H, et al. Salvianolic acid A targets glutamic-oxaloacetic transaminase 2 to ameliorate doxorubicin-induced myocardial oxidative injury by activating malate-aspartate NADH shuttle. Phytomedicine. 2025;148:157492. https:\/\/doi.org\/10.1016\/j.phymed.2025.157492.","journal-title":"Phytomedicine"},{"issue":"1","key":"6129_CR21","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1186\/s12872-023-03648-3","volume":"23","author":"X Liu","year":"2023","unstructured":"Liu X, Li X, Zhou H. Changes in glutamic oxaloacetic transaminase 2 during rat physiological and pathological cardiomyocyte hypertrophy. BMC Cardiovasc Disord. 2023;23(1):595\u2013603. https:\/\/doi.org\/10.1186\/s12872-023-03648-3.","journal-title":"BMC Cardiovasc Disord"},{"issue":"1","key":"6129_CR22","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1038\/labinvest.2010.156","volume":"91","author":"Y Liang","year":"2011","unstructured":"Liang Y, Liu D, Ochs T, Tang C, Chen S, Zhang S, et al. Endogenous sulfur dioxide protects against isoproterenol-induced myocardial injury and increases myocardial antioxidant capacity in rats. Lab Invest. 2011;91(1):12\u201323. https:\/\/doi.org\/10.1038\/labinvest.2010.156.","journal-title":"Lab Invest"},{"issue":"1","key":"6129_CR23","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1186\/s12967-023-04498-5","volume":"21","author":"C Rocca","year":"2023","unstructured":"Rocca C, Soda T, De Francesco EM, Fiorillo M, Moccia F, Viglietto G, et al. Mitochondrial dysfunction at the crossroad of cardiovascular diseases and cancer. J Transl Med. 2023;21(1):635. https:\/\/doi.org\/10.1186\/s12967-023-04498-5 . PubMed PMID: 37726810IF: 7.5 Q1 B2; PubMed Central PMCID: PMC10507834IF: 7.5 Q1 B2.","journal-title":"J Transl Med"}],"container-title":["BMC Cardiovascular Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12872-026-06129-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-026-06129-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-026-06129-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T02:00:15Z","timestamp":1787277615000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12872-026-06129-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,13]]},"references-count":23,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["6129"],"URL":"https:\/\/doi.org\/10.1186\/s12872-026-06129-5","relation":{},"ISSN":["1471-2261"],"issn-type":[{"value":"1471-2261","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,13]]},"assertion":[{"value":"30 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study involving human specimens was approved by the Ethics Committee of the First Hospital of Quanzhou (approval number: 2023-K078), and written informed consent was obtained from all participants in accordance with the Declaration of Helsinki. Animal experiments were approved by the Animal Ethics Committee of Huaqiao University (approval number: LHJJ2025043) and conducted in accordance with institutional guidelines for the care and use of laboratory animals.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"732"}}