{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T05:22:35Z","timestamp":1788153755130,"version":"build-2803163510"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"vor","delay-in-days":66,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Association of Prehospital Research Promotion"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cardiovasc Disord"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In prehospital settings, myocardial infarction (MI) diagnosis relies on symptoms and electrocardiogram (ECG) analysis. The cardiac electrical biomarker (CEB) has been developed to quantify abnormal multipolar electrical activity through a 12-lead ECG, reflecting ischemia-related cellular disruption. This study primarily aimed to assess recruitment capacity and operational feasibility for a future large-scale prospective prehospital study involving CEB measurements. Secondary objectives were to describe successful CEB acquisition and to identify practical barriers to data collection in the prehospital environment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This pilot study was a secondary analysis of prospectively collected observational data from the \u201cAmbulance R\u00e9gion de Bienne\u201d service (covering 120,000 inhabitants) between March and September 2023. Adult patients managed for suspected acute coronary syndrome who underwent a prehospital 12-lead ECG with attempted CEB acquisition and were subsequently admitted to the Biel Hospital Centre were eligible. Analyses were descriptive and focused on feasibility-related endpoints.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 70 patients were identified, of whom 60 met eligibility criteria. Regarding recruitment feasibility, a mean enrolment rate of 7.7 patients per month was observed, corresponding to roughly one patient per 70 prehospital missions. Regarding operational experience with CEB acquisition, technical and practical barriers were identified, including telemetry connectivity issues, workflow constraints, and documentation limitations. Successful CEB acquisition was variable; however, the true failure rate could not be reliably determined due to incomplete systematic documentation of all attempted acquisitions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Recruitment of eligible patients for a future large-scale study appears potentially feasible, with an observed rate of 7.7 patients per month within this single EMS. However, while operational barriers were identified, reliable CEB acquisition could not be assessed due to incomplete capture of failed acquisition attempts. These findings primarily inform study design and implementation strategy for future investigations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12872-026-06145-5","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T22:44:11Z","timestamp":1782427451000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Recruitment capacity and operational barriers to prehospital cardiac electrical biomarker acquisition: an ambulance-based pilot study"],"prefix":"10.1186","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-7868-1399","authenticated-orcid":false,"given":"Aur\u00e8le","family":"Nicolet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6989-6421","authenticated-orcid":false,"given":"Laurent","family":"Suppan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1663-5249","authenticated-orcid":false,"given":"Loric","family":"Stuby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,26]]},"reference":[{"key":"6145_CR1","unstructured":"Office f\u00e9d\u00e9ral de la statistique. 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The committee determined that it was not responsible for evaluating the project. All patient data were anonymized, and appropriate authorizations were obtained for database access. Informed consent was not obtained from the subjects involved in the study as it was observational, fully anonymized and health data collection was very limited.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"758"}}