{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T13:14:06Z","timestamp":1783343646943,"version":"3.54.6"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":17,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cardiovasc Disord"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to evaluate whether peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1\u03b1) could serve as a marker of myocardial ischemia by examining its association with cross-clamp time, which reflects the duration of ischemia, in patients undergoing coronary artery bypass grafting (CABG).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study included 44 adult patients who underwent open-heart surgery at the Cardiovascular Surgery Clinic between June 2024 and December 2024. Serum samples separated from the blood collected after cross-clamping and at the pump outlet were analyzed in our hospital\u2019s central laboratory for the PGC-1\u03b1 study. PGC-1\u03b1 levels were analyzed in terms of clinical parameters, lactate and high-sensitivity cardiac troponin T (hs-cTnT) levels of the patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Preoperative PGC-1\u03b1 levels did not differ significantly from postoperative levels (2.06\u2009\u00b1\u20095.75 vs. 1.43\u2009\u00b1\u20093.35,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.608), whereas hs-cTnT levels increased significantly after surgery (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Preoperative PGC-1\u03b1 showed a moderate positive correlation with DM (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.366,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.015) but no significant association with other clinical variables, including ICU duration (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.078,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.616), glucose, or HbA1c (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). In the multivariable analysis, DM (odds ratio [OR]\u2009=\u20093.060,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) and ICU duration (OR\u2009=\u20091.466,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) were independently associated with PGC-1\u03b1, whereas preoperative glucose and HbA1c were not. ROC analysis demonstrated that hs-cTnT showed a significant discriminative ability for cross-clamp time in non-DM patients (AUC\u2009=\u20090.844, 95% CI: 0.684\u20131.000,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002), whereas this relationship was not observed in DM patients. In contrast, PGC-1\u03b1 did not demonstrate a significant discriminative performance in either group (AUC\u2009=\u20090.300\u20130.535,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PGC-1\u03b1 was not associated with cross-clamp time or conventional markers of acute myocardial injury in patients undergoing coronary artery bypass grafting, indicating that it does not reflect ischemic duration. In contrast, hs-cTnT levels were significantly associated with the cross-clamp time in non-diabetic patients, whereas this relationship was not observed in diabetic individuals. The association of PGC-1\u03b1 with diabetes mellitus and ICU duration suggests that it may reflect metabolic status rather than acute myocardial injury.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12872-026-06151-7","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T08:36:03Z","timestamp":1781858163000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of the mitochondrial regulator PGC-1\u03b1 with diabetes mellitus and myocardial ischemia\u2013reperfusion injury in coronary artery bypass grafting"],"prefix":"10.1186","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2982-9918","authenticated-orcid":false,"given":"Ayla","family":"Yildiz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6346-9664","authenticated-orcid":false,"given":"S\u00fcleyman","family":"Yazici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9412-4570","authenticated-orcid":false,"given":"Z\u00fclfiye","family":"Yildiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,19]]},"reference":[{"issue":"4","key":"6151_CR1","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.carpath.2005.03.006","volume":"14","author":"LM Buja","year":"2005","unstructured":"Buja LM. 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Written informed consent was obtained from all participants prior to their inclusion in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"568"}}