{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T23:00:37Z","timestamp":1790290837955,"version":"4.1.0"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T00:00:00Z","timestamp":1783123200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":83,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cardiovasc Disord"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Critical aortic valve stenosis in neonates and infants is a life-threatening congenital heart disease characterized by severe left ventricular outflow tract obstruction and compromised systemic perfusion. Balloon aortic valvuloplasty (BAV) has become an established initial treatment option; however, data on early outcomes in this vulnerable population remain relatively limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective single-center study included 30 neonates and infants (\u2264\u200912 months) with critical aortic valve stenosis who underwent balloon aortic valvuloplasty between 2016 and 2024. Clinical, echocardiographic, and hemodynamic parameters were analyzed before and after the procedure. Early procedural success, complications, and short-term outcomes were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Balloon aortic valvuloplasty resulted in a significant immediate reduction in transaortic pressure gradients (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), indicating effective relief of left ventricular outflow tract obstruction. Left ventricular systolic function improved or remained stable in the majority of patients. New-onset or increased aortic regurgitation occurred in some cases, predominantly mild to moderate in severity, while severe regurgitation was uncommon. Early mortality was low, and most patients demonstrated favorable early clinical stabilization. Some patients required reintervention or surgical referral because of residual stenosis or progressive aortic regurgitation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Balloon aortic valvuloplasty is a safe and effective first-line treatment for critical aortic valve stenosis in neonates and infants, providing rapid hemodynamic improvement with acceptable early outcomes. The procedure represents an important therapeutic strategy in the initial management of this high-risk pediatric population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12872-026-06170-4","type":"journal-article","created":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T04:35:25Z","timestamp":1783139725000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Balloon aortic valvuloplasty for critical aortic stenosis in neonates and infants: early outcomes from a single-center cohort"],"prefix":"10.1186","volume":"26","author":[{"given":"Elnur","family":"Imanov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esmira M.","family":"Nasibova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7505-3738","authenticated-orcid":false,"given":"Esmira M.","family":"Nasibova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,4]]},"reference":[{"issue":"4","key":"6170_CR1","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1161\/01.CIR.0000112284.01947.8B","volume":"109","author":"DW Brown","year":"2004","unstructured":"Brown DW, Gauvreau K, Moran AM, et al. Critical aortic stenosis in neonates: outcomes following balloon aortic valvuloplasty. Circulation. 2004;109(4):543\u20139. https:\/\/doi.org\/10.1161\/01.CIR.0000112284.01947.8B.","journal-title":"Circulation"},{"issue":"1","key":"6170_CR2","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/S0735-1097(00)01062-5","volume":"37","author":"BW McCrindle","year":"2001","unstructured":"McCrindle BW, Blackstone EH, Williams WG, et al. Aortic valve repair and balloon valvotomy in neonates and infants: determinants of outcome. J Am Coll Cardiol. 2001;37(1):194\u2013200. https:\/\/doi.org\/10.1016\/S0735-1097(00)01062-5.","journal-title":"J Am Coll Cardiol"},{"issue":"5","key":"6170_CR3","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1016\/j.athoracsur.2009.07.035","volume":"88","author":"ML Brown","year":"2009","unstructured":"Brown ML, Dearani JA, Burkhart HM, et al. The outcomes of neonatal aortic stenosis treated with balloon valvuloplasty or surgical valvotomy. Ann Thorac Surg. 2009;88(5):1537\u201344. https:\/\/doi.org\/10.1016\/j.athoracsur.2009.07.035.","journal-title":"Ann Thorac Surg"},{"issue":"7","key":"6170_CR4","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.1007\/s00246-014-0913-7","volume":"35","author":"SA Maskatia","year":"2014","unstructured":"Maskatia SA, Petit CJ, Travers CD, et al. Balloon aortic valvuloplasty in neonates and infants: contemporary outcomes and predictors of reintervention. Pediatr Cardiol. 2014;35(7):1232\u20138. https:\/\/doi.org\/10.1007\/s00246-014-0913-7.","journal-title":"Pediatr Cardiol"},{"issue":"5","key":"6170_CR5","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1007\/s11936-001-0029-3","volume":"3","author":"DB McElhinney","year":"2001","unstructured":"McElhinney DB, Lock JE, Keane JF. Management of critical aortic stenosis in the neonate. Curr Treat Options Cardiovasc Med. 2001;3(5):413\u201323. https:\/\/doi.org\/10.1007\/s11936-001-0029-3.","journal-title":"Curr Treat Options Cardiovasc Med"},{"issue":"15","key":"6170_CR6","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1136\/hrt.2009.188870","volume":"96","author":"FT Riede","year":"2010","unstructured":"Riede FT, Kostelka M, D\u00e4hnert I. Balloon valvuloplasty for congenital aortic stenosis in infants and children: immediate and mid-term results. Heart. 2010;96(15):1208\u201313. https:\/\/doi.org\/10.1136\/hrt.2009.188870.","journal-title":"Heart"},{"issue":"5","key":"6170_CR7","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1017\/S1047951115001643","volume":"26","author":"C Alva","year":"2016","unstructured":"Alva C, D\u00edaz-Gonz\u00e1lez M, Jim\u00e9nez-Arteaga S, et al. Balloon aortic valvuloplasty in neonates and infants with critical aortic stenosis: early and mid-term outcomes. Cardiol Young. 2016;26(5):873\u20139. https:\/\/doi.org\/10.1017\/S1047951115001643.","journal-title":"Cardiol Young"},{"issue":"5","key":"6170_CR8","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1007\/s00246-012-0611-3","volume":"34","author":"CJ McMahon","year":"2013","unstructured":"McMahon CJ, Kenny D, Walsh KP. Interventional catheterization in neonates with critical left-sided obstructive lesions. Pediatr Cardiol. 2013;34(5):1023\u201332. https:\/\/doi.org\/10.1007\/s00246-012-0611-3.","journal-title":"Pediatr Cardiol"},{"issue":"2","key":"6170_CR9","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1111\/j.1747-0803.2011.00585.x","volume":"7","author":"GD Hill","year":"2012","unstructured":"Hill GD, Ginde S, Rios R, et al. Outcomes of balloon aortic valvuloplasty in critical neonatal aortic stenosis. Congenit Heart Dis. 2012;7(2):111\u20138. https:\/\/doi.org\/10.1111\/j.1747-0803.2011.00585.x.","journal-title":"Congenit Heart Dis"},{"issue":"3","key":"6170_CR10","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.ijcard.2005.08.048","volume":"110","author":"A Beitzke","year":"2006","unstructured":"Beitzke A, Gamillscheg A, Tulzer G, et al. Balloon valvuloplasty as primary treatment for congenital aortic stenosis in infancy. Int J Cardiol. 2006;110(3):332\u20137. https:\/\/doi.org\/10.1016\/j.ijcard.2005.08.048.","journal-title":"Int J Cardiol"}],"container-title":["BMC Cardiovascular Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12872-026-06170-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-026-06170-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-026-06170-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T22:45:45Z","timestamp":1790289945000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12872-026-06170-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,4]]},"references-count":10,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["6170"],"URL":"https:\/\/doi.org\/10.1186\/s12872-026-06170-4","relation":{},"ISSN":["1471-2261"],"issn-type":[{"value":"1471-2261","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,4]]},"assertion":[{"value":"4 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study protocol was approved by the Ethics Committee of Azerbaijan Medical University, Baku, Azerbaijan (Protocol No. AMU\/EC-2025-047\/O; approved on September 26, 2025). Due to the retrospective design of the study and the use of anonymized clinical data, the requirement for informed consent was waived by the ethics committee. All procedures performed in this study were conducted in accordance with the ethical standards of the institutional research committee and with the 1964 Declaration of Helsinki and its later amendments.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"837"}}