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We assessed arterial stiffness in patients with psoriasis on long-term treatment with infliximab.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Forty-eight patients with psoriasis (age 46\u2009\u00b1\u200914 years, 31% women) receiving treatment with infliximab were matched to 103 controls based on age, sex and body mass index (BMI). Arterial stiffness was assessed by carotid-femoral pulse wave velocity (cfPWV). Psoriasis severity was assessed by the psoriasis area and severity index (PASI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The patients had been treated with infliximab for 4.9\u2009\u00b1\u20093.9 years and 85% were also treated with methotrexate. Current PASI-score was 0.79\u2009\u00b1\u20090.75, indicating well treated psoriasis. The prevalence of metabolic syndrome (42%), hypertension (50%) and diabetes (4%) were similar between patients and controls, while a higher proportion of patients were smokers (40% vs. 16%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003). Average cfPWV was 7.9\u2009\u00b1\u20091.6\u00a0m\/s in the psoriasis group and 7.3\u2009\u00b1\u20091.5\u00a0m\/s in the control group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.049), both reflecting normal values. In multivariable linear regression analysis in the total study population, having psoriasis remained associated with higher cfPWV (\u03b2 0.40,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.010) after adjusting for age, sex, systolic blood pressure (SBP), heart rate, BMI and smoking. In patients with psoriasis, higher SBP (\u03b2 0.33,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009) and BMI (\u03b2 0.27,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.021) were associated with higher cfPWV after adjustment for PASI score, age and sex.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients with psoriasis on long-term treatment with systemic therapies, arterial stiffness was slightly higher than in matched controls, despite excellent response to treatment and low PASI score.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12872-026-06198-6","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T23:38:02Z","timestamp":1782862682000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Arterial stiffness in patients with moderate to severe psoriasis on long term treatment with infliximab"],"prefix":"10.1186","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-7889-3747","authenticated-orcid":false,"given":"Jonar Strand","family":"Hagenes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6330-0364","authenticated-orcid":false,"given":"Anja","family":"Linde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5755-4959","authenticated-orcid":false,"given":"K\u00e5re Steinar","family":"Tveit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9015-741X","authenticated-orcid":false,"given":"Ester","family":"Kringeland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3558-9914","authenticated-orcid":false,"given":"Helga","family":"Midtb\u00f8","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,1]]},"reference":[{"key":"6198_CR1","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.jaad.2020.04.139","volume":"84","author":"S Mehrmal","year":"2021","unstructured":"Mehrmal S, Uppal P, Nedley N, Giesey RL, Delost GR. 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Written informed consent was obtained from all participants in the study.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"KST has served as a consultant or lecturer for, or received travel support from AbbVie, Novartis, Almirall, Orion, Jansen, Leo, Medac, Mundipharma, Pfizer, Sanofi, Serona, Shire, Takeda, Boehringer Ingelheim, Bristol Myers Squibb, UCB, Arctic Bioscience, Galderma and Celgene. HM has received speaker honorarium from Boehringer Ingelheim, Pfizer, AstraZeneca and Bayer not related to the current work. All other authors report no conflict of interest.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"810"}}