{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T23:00:18Z","timestamp":1790290818045,"version":"4.1.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T00:00:00Z","timestamp":1783123200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":83,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100011496","name":"Science and Technology Bureau, Changsha","doi-asserted-by":"publisher","award":["KQ2202367"],"award-info":[{"award-number":["KQ2202367"]}],"id":[{"id":"10.13039\/501100011496","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002767","name":"Department of Science and Technology of Hunan Province","doi-asserted-by":"publisher","award":["2022JJ70156"],"award-info":[{"award-number":["2022JJ70156"]}],"id":[{"id":"10.13039\/501100002767","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cardiovasc Disord"],"DOI":"10.1186\/s12872-026-06214-9","type":"journal-article","created":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T03:42:23Z","timestamp":1783136543000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Elevated plasma TMAO levels associated with all-cause mortality in CAD patients in South China"],"prefix":"10.1186","volume":"26","author":[{"given":"Hao","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-yuan","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi-ya","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-xing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-zhi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bi-lian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,4]]},"reference":[{"key":"6214_CR1","unstructured":"Wang Z, Ma L, Liu M, Fan J, Hu S. Summary of the 2022 Report on Cardiovascular Health and Diseases in China. Chin Med J (Engl) n.d."},{"key":"6214_CR2","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1007\/s11883-021-00910-x","volume":"23","author":"MS Thomas","year":"2021","unstructured":"Thomas MS, Fernandez ML. Trimethylamine N-Oxide (TMAO), Diet and Cardiovascular Disease. Curr Atheroscler Rep. 2021;23:12. https:\/\/doi.org\/10.1007\/s11883-021-00910-x.","journal-title":"Curr Atheroscler Rep"},{"key":"6214_CR3","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1016\/j.jacc.2019.11.060","volume":"75","author":"Y Heianza","year":"2020","unstructured":"Heianza Y, Ma W, DiDonato JA, Sun Q, Rimm EB, Hu FB, Rexrode KM, Manson JE, Qi L. Long-Term Changes in Gut Microbial Metabolite Trimethylamine N-Oxide and Coronary Heart Disease Risk. J Am Coll Cardiol. 2020;75:763\u201372. https:\/\/doi.org\/10.1016\/j.jacc.2019.11.060.","journal-title":"J Am Coll Cardiol"},{"key":"6214_CR4","doi-asserted-by":"publisher","first-page":"110856","DOI":"10.1016\/j.nut.2020.110856","volume":"78","author":"MA Farhangi","year":"2020","unstructured":"Farhangi MA. Gut microbiota-dependent trimethylamine N-oxide and all-cause mortality: Findings from an updated systematic review and meta-analysis. Nutrition. 2020;78:110856. https:\/\/doi.org\/10.1016\/j.nut.2020.110856.","journal-title":"Nutrition"},{"key":"6214_CR5","doi-asserted-by":"publisher","unstructured":"Romano KA, Vivas EI, Amador-Noguez D, Rey FE. Intestinal Microbiota Composition Modulates Choline Bioavailability from Diet and Accumulation of the Proatherogenic Metabolite Trimethylamine- N -Oxide. mBio. 2015;6:e02481-14. https:\/\/doi.org\/10.1128\/mBio.02481-14","DOI":"10.1128\/mBio.02481-14"},{"key":"6214_CR6","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1161\/ATVBAHA.119.312592","volume":"39","author":"DM Shih","year":"2019","unstructured":"Shih DM, Zhu W, Schugar RC, Meng Y, Jia X, Miikeda A, Wang Z, Zieger M, Lee R, Graham M, Allayee H, Cantor RM, Mueller C, Brown JM, Hazen SL, Lusis AJ. Genetic Deficiency of Flavin-Containing Monooxygenase 3 (Fmo3) Protects Against Thrombosis but Has Only a Minor Effect on Plasma Lipid Levels\u2014Brief Report. Arterioscler Thromb Vasc Biol. 2019;39:1045\u201354. https:\/\/doi.org\/10.1161\/ATVBAHA.119.312592.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"6214_CR7","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/nature09922","volume":"472","author":"Z Wang","year":"2011","unstructured":"Wang Z, Klipfell E, Bennett BJ, Koeth R, Levison BS, DuGar B, Feldstein AE, Britt EB, Fu X, Chung Y-M, Wu Y, Schauer P, Smith JD, Allayee H, Tang WHW, DiDonato JA, Lusis AJ, Hazen SL. Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature. 2011;472:57\u201363. https:\/\/doi.org\/10.1038\/nature09922.","journal-title":"Nature"},{"key":"6214_CR8","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1186\/s12944-018-0939-6","volume":"17","author":"L Ding","year":"2018","unstructured":"Ding L, Chang M, Guo Y, Zhang L, Xue C, Yanagita T, Zhang T, Wang Y. Trimethylamine-N-oxide (TMAO)-induced atherosclerosis is associated with bile acid metabolism. Lipids Health Dis. 2018;17:286. https:\/\/doi.org\/10.1186\/s12944-018-0939-6.","journal-title":"Lipids Health Dis"},{"key":"6214_CR9","doi-asserted-by":"publisher","first-page":"2129","DOI":"10.1016\/j.apsb.2021.12.011","volume":"12","author":"B Guan","year":"2022","unstructured":"Guan B, Tong J, Hao H, Yang Z, Chen K, Xu H, Wang A. Bile acid coordinates microbiota homeostasis and systemic immunometabolism in cardiometabolic diseases. Acta Pharm Sin B. 2022;12:2129\u201349. https:\/\/doi.org\/10.1016\/j.apsb.2021.12.011.","journal-title":"Acta Pharm Sin B"},{"key":"6214_CR10","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1161\/HYPERTENSIONAHA.120.14759","volume":"76","author":"VE Brunt","year":"2020","unstructured":"Brunt VE, Gioscia-Ryan RA, Casso AG, VanDongen NS, Ziemba BP, Sapinsley ZJ, Richey JJ, Zigler MC, Neilson AP, Davy KP, Seals DR. Trimethylamine-N-Oxide Promotes Age-Related Vascular Oxidative Stress and Endothelial Dysfunction in Mice and Healthy Humans. Hypertension. 2020;76:101\u201312. https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.120.14759.","journal-title":"Hypertension"},{"key":"6214_CR11","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1186\/s12967-024-05120-y","volume":"22","author":"Q Jin","year":"2024","unstructured":"Jin Q, Zhang C, Chen R, Jiang L, Li H, Wu P, Li L. Quinic acid regulated TMA\/TMAO-related lipid metabolism and vascular endothelial function through gut microbiota to inhibit atherosclerotic. J Transl Med. 2024;22:352. https:\/\/doi.org\/10.1186\/s12967-024-05120-y.","journal-title":"J Transl Med"},{"key":"6214_CR12","doi-asserted-by":"publisher","first-page":"1671","DOI":"10.1161\/CIRCULATIONAHA.116.025338","volume":"135","author":"W Zhu","year":"2017","unstructured":"Zhu W, Wang Z, Tang WHW, Hazen SL. Gut Microbe-Generated Trimethylamine N -Oxide From Dietary Choline Is Prothrombotic in Subjects. Circulation. 2017;135:1671\u20133. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.116.025338.","journal-title":"Circulation"},{"key":"6214_CR13","doi-asserted-by":"publisher","first-page":"6580","DOI":"10.1038\/s41598-021-85950-8","volume":"11","author":"R Ma","year":"2021","unstructured":"Ma R, Fu W, Zhang J, Hu X, Yang J, Jiang H. TMAO: a potential mediator of clopidogrel resistance. Sci Rep. 2021;11:6580. https:\/\/doi.org\/10.1038\/s41598-021-85950-8.","journal-title":"Sci Rep"},{"key":"6214_CR14","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.cell.2016.02.011","volume":"165","author":"W Zhu","year":"2016","unstructured":"Zhu W, Gregory JC, Org E, Buffa JA, Gupta N, Wang Z, Li L, Fu X, Wu Y, Mehrabian M, Sartor RB, McIntyre TM, Silverstein RL, Tang WHW, DiDonato JA, Brown JM, Lusis AJ, Hazen SL. Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk. Cell. 2016;165:111\u201324. https:\/\/doi.org\/10.1016\/j.cell.2016.02.011.","journal-title":"Cell"},{"key":"6214_CR15","doi-asserted-by":"publisher","first-page":"123304","DOI":"10.1016\/j.lfs.2024.123304","volume":"361","author":"F Latif","year":"2025","unstructured":"Latif F, Mubbashir A, Khan MS, Shaikh Z, Memon A, Alvares J, Azhar A, Jain H, Ahmed R, Kanagala SG. Trimethylamine N-oxide in cardiovascular disease: Pathophysiology and the potential role of statins. Life Sci. 2025;361:123304. https:\/\/doi.org\/10.1016\/j.lfs.2024.123304.","journal-title":"Life Sci"},{"key":"6214_CR16","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1161\/CIRCRESAHA.120.316242","volume":"127","author":"M Witkowski","year":"2020","unstructured":"Witkowski M, Weeks TL, Hazen SL. Gut microbiota and cardiovascular disease. Circ Res. 2020;127:553\u201370. https:\/\/doi.org\/10.1161\/CIRCRESAHA.120.316242.","journal-title":"Circ Res"},{"key":"6214_CR17","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.1056\/NEJMoa1109400","volume":"368","author":"WHW Tang","year":"2013","unstructured":"Tang WHW, Wang Z, Levison BS, Koeth RA, Britt EB, Fu X, Wu Y, Hazen SL. Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk. N Engl J Med. 2013;368:1575\u201384. https:\/\/doi.org\/10.1056\/NEJMoa1109400.","journal-title":"N Engl J Med"},{"key":"6214_CR18","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1373\/clinchem.2016.264853","volume":"63","author":"T Suzuki","year":"2017","unstructured":"Suzuki T, Heaney LM, Jones DJL, Ng LL. Trimethylamine N-oxide and Risk Stratification after Acute Myocardial Infarction. Clin Chem. 2017;63:420\u20138. https:\/\/doi.org\/10.1373\/clinchem.2016.264853.","journal-title":"Clin Chem"},{"key":"6214_CR19","doi-asserted-by":"publisher","first-page":"1360861","DOI":"10.3389\/fendo.2024.1360861","volume":"15","author":"X Yu","year":"2024","unstructured":"Yu X, Wang Y, Yang R, Wang Z, Wang X, Wang S, Zhang W, Dong J, Chen W, Ji F, Gao W. Trimethylamine N-oxide predicts cardiovascular events in coronary artery disease patients with diabetes mellitus: a prospective cohort study. Front Endocrinol. 2024;15:1360861. https:\/\/doi.org\/10.3389\/fendo.2024.1360861.","journal-title":"Front Endocrinol"},{"key":"6214_CR20","doi-asserted-by":"publisher","unstructured":"Zhang M, Shi Y, Zhou B, Huang Z, Zhao Z, Li C, Zhang X, Han G, Peng K, Li X, Wang Y, Ezzati M, Wang L, Li Y. Prevalence, awareness, treatment, and control of hypertension in China, 2004-18: findings from six rounds of a national survey. BMJ. 2023;e071952. https:\/\/doi.org\/10.1136\/bmj-2022-071952.","DOI":"10.1136\/bmj-2022-071952"},{"key":"6214_CR21","doi-asserted-by":"publisher","unstructured":"American Diabetes Association Professional Practice Committee. 6. Glycemic Targets: Standards of Medical Care in Diabetes\u20142022. Diabetes Care 2022;45:S83\u201396. https:\/\/doi.org\/10.2337\/dc22-S006","DOI":"10.2337\/dc22-S006"},{"key":"6214_CR22","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1161\/CIRCRESAHA.116.305360","volume":"116","author":"WH Wilson Tang","year":"2015","unstructured":"Wilson Tang WH, Wang Z, Kennedy DJ, Wu Y, Buffa JA, Agatisa-Boyle B, Li XS, Levison BS, Hazen SL. Gut Microbiota-Dependent Trimethylamine N-oxide (TMAO) Pathway Contributes to Both Development of Renal Insufficiency and Mortality Risk in Chronic Kidney Disease. Circ Res. 2015;116:448\u201355. https:\/\/doi.org\/10.1161\/CIRCRESAHA.116.305360.","journal-title":"Circ Res"},{"key":"6214_CR23","doi-asserted-by":"publisher","first-page":"e0294236","DOI":"10.1371\/journal.pone.0294236","volume":"18","author":"D Tang","year":"2023","unstructured":"Tang D, Chen M, Huang X, Zhang G, Zeng L, Zhang G, Wu S, Wang Y. SRplot: A free online platform for data visualization and graphing. PLoS ONE. 2023;18:e0294236. https:\/\/doi.org\/10.1371\/journal.pone.0294236.","journal-title":"PLoS ONE"},{"key":"6214_CR24","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1016\/j.cmet.2019.08.021","volume":"30","author":"S Chen","year":"2019","unstructured":"Chen S, Henderson A, Petriello MC, Romano KA, Gearing M, Miao J, Schell M, Sandoval-Espinola WJ, Tao J, Sha B, Graham M, Crooke R, Kleinridders A, Balskus EP, Rey FE, Morris AJ, Biddinger SB. Trimethylamine N-Oxide Binds and Activates PERK to Promote Metabolic Dysfunction. Cell Metab. 2019;30:1141\u2013e11515. https:\/\/doi.org\/10.1016\/j.cmet.2019.08.021.","journal-title":"Cell Metab"},{"key":"6214_CR25","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1016\/j.jbiosc.2014.03.001","volume":"118","author":"X Gao","year":"2014","unstructured":"Gao X, Liu X, Xu J, Xue C, Xue Y, Wang Y. Dietary trimethylamine N-oxide exacerbates impaired glucose tolerance in mice fed a high fat diet. J Biosci Bioeng. 2014;118:476\u201381. https:\/\/doi.org\/10.1016\/j.jbiosc.2014.03.001.","journal-title":"J Biosci Bioeng"},{"key":"6214_CR26","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1194\/jlr.M051680","volume":"56","author":"DM Shih","year":"2015","unstructured":"Shih DM, Wang Z, Lee R, Meng Y, Che N, Charugundla S, Qi H, Wu J, Pan C, Brown JM, Vallim T, Bennett BJ, Graham M, Hazen SL, Lusis AJ. Flavin containing monooxygenase 3 exerts broad effects on glucose and lipid metabolism and atherosclerosis. J Lipid Res. 2015;56:22\u201337. https:\/\/doi.org\/10.1194\/jlr.M051680.","journal-title":"J Lipid Res"},{"key":"6214_CR27","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1186\/s12967-022-03581-7","volume":"20","author":"S Li","year":"2022","unstructured":"Li S, Chen S, Lu X, Fang A, Chen Y, Huang R, Lin X, Huang Z, Ma J, Huang B, Zhu H. Serum trimethylamine-N-oxide is associated with incident type 2 diabetes in middle-aged and older adults: a prospective cohort study. J Transl Med. 2022;20:374. https:\/\/doi.org\/10.1186\/s12967-022-03581-7.","journal-title":"J Transl Med"},{"key":"6214_CR28","doi-asserted-by":"publisher","unstructured":"Kalagi NA, Thota RN, Stojanovski E, Alburikan KA, Garg ML. Association between Plasma Trimethylamine N-Oxide Levels and Type 2 Diabetes: A Case Control Study. Nutrients 2022;14:2093. https:\/\/doi.org\/10.3390\/nu14102093","DOI":"10.3390\/nu14102093"},{"key":"6214_CR29","doi-asserted-by":"publisher","first-page":"888","DOI":"10.3945\/ajcn.117.157107","volume":"106","author":"Z Shan","year":"2017","unstructured":"Shan Z, Sun T, Huang H, Chen S, Chen L, Luo C, Yang W, Yang X, Yao P, Cheng J, Hu FB, Liu L. Association between microbiota-dependent metabolite trimethylamine-N-oxide and type 2 diabetes. Am J Clin Nutr. 2017;106:888\u201394. https:\/\/doi.org\/10.3945\/ajcn.117.157107.","journal-title":"Am J Clin Nutr"},{"key":"6214_CR30","doi-asserted-by":"publisher","first-page":"e2122844","DOI":"10.1001\/jamanetworkopen.2021.22844","volume":"4","author":"RN Lemaitre","year":"2021","unstructured":"Lemaitre RN, Jensen PN, Wang Z, Fretts AM, McKnight B, Nemet I, Biggs ML, Sotoodehnia N, De Oliveira Otto MC, Psaty BM, Siscovick DS, Hazen SL, Mozaffarian D. Association of Trimethylamine N -Oxide and Related Metabolites in Plasma and Incident Type 2 Diabetes: The Cardiovascular Health Study. JAMA Netw Open. 2021;4:e2122844. https:\/\/doi.org\/10.1001\/jamanetworkopen.2021.22844.","journal-title":"JAMA Netw Open"},{"key":"6214_CR31","doi-asserted-by":"publisher","first-page":"e002816","DOI":"10.1161\/JAHA.115.002816","volume":"5","author":"V Senthong","year":"2016","unstructured":"Senthong V, Wang Z, Li XS, Fan Y, Wu Y, Wilson Tang WH, Hazen SL. Intestinal Microbiota-Generated Metabolite Trimethylamine\u2010 N\u2010 Oxide and 5\u2010Year Mortality Risk in Stable Coronary Artery Disease: The Contributory Role of Intestinal Microbiota in a COURAGE\u2010Like Patient Cohort. J Am Heart Assoc. 2016;5:e002816. https:\/\/doi.org\/10.1161\/JAHA.115.002816.","journal-title":"J Am Heart Assoc"},{"key":"6214_CR32","doi-asserted-by":"publisher","first-page":"e0141738","DOI":"10.1371\/journal.pone.0141738","volume":"11","author":"C Missailidis","year":"2016","unstructured":"Missailidis C, H\u00e4llqvist J, Qureshi AR, Barany P, Heimb\u00fcrger O, Lindholm B, Stenvinkel P, Bergman P. Serum Trimethylamine-N-Oxide Is Strongly Related to Renal Function and Predicts Outcome in Chronic Kidney Disease. PLoS ONE. 2016;11:e0141738. https:\/\/doi.org\/10.1371\/journal.pone.0141738.","journal-title":"PLoS ONE"},{"key":"6214_CR33","doi-asserted-by":"publisher","first-page":"e2213242","DOI":"10.1001\/jamanetworkopen.2022.13242","volume":"5","author":"AM Fretts","year":"2022","unstructured":"Fretts AM, Hazen SL, Jensen P, Budoff M, Sitlani CM, Wang M, de Oliveira Otto MC, DiDonato JA, Lee Y, Psaty BM, Siscovick DS, Sotoodehnia N, Tang WHW, Lai H, Lemaitre RN, Mozaffarian D. Association of Trimethylamine N-Oxide and Metabolites With Mortality in Older Adults. JAMA Netw Open. 2022;5:e2213242. https:\/\/doi.org\/10.1001\/jamanetworkopen.2022.13242.","journal-title":"JAMA Netw Open"},{"key":"6214_CR34","doi-asserted-by":"publisher","first-page":"131815","DOI":"10.1016\/j.ijcard.2024.131815","volume":"400","author":"M Yildirim","year":"2024","unstructured":"Yildirim M, Salbach C, Reich C, Milles BR, Biener M, Frey N, Giannitsis E, Mueller-Hennessen M. Comparison of the clinical chemistry score to other biomarker algorithms for rapid rule-out of acute myocardial infarction and risk stratification in patients with suspected acute coronary syndrome. Int J Cardiol. 2024;400:131815. https:\/\/doi.org\/10.1016\/j.ijcard.2024.131815.","journal-title":"Int J Cardiol"},{"key":"6214_CR35","doi-asserted-by":"publisher","first-page":"2957","DOI":"10.3390\/jcm14092957","volume":"14","author":"M Yildirim","year":"2025","unstructured":"Yildirim M, Salbach C, Mueller-Hennessen M, Frey N, Giannitsis E. Diagnostic and Prognostic Evaluation of Novel Biomarkers Compared to ESC 0\/1\u00a0h and 0\/3\u00a0h Algorithms in Patients with Suspected Non-ST-Elevation Myocardial Infarction. J Clin Med. 2025;14:2957. https:\/\/doi.org\/10.3390\/jcm14092957.","journal-title":"J Clin Med"},{"key":"6214_CR36","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1007\/s00392-025-02642-3","volume":"114","author":"M Yildirim","year":"2025","unstructured":"Yildirim M, Reich C, Salbach C, Biener M, Mueller-Hennessen M, S\u00f6rensen NA, Haller PM, Blankenberg S, Neumann JT, Twerenbold R, Frey N, Giannitsis E. Identification of patients with suspected NSTE-ACS in the observe zone: evaluating GRACE 1.0 score and a biomarker panel for risk stratification and management optimization. Clin Res Cardiol. 2025;114:783\u201395. https:\/\/doi.org\/10.1007\/s00392-025-02642-3.","journal-title":"Clin Res Cardiol"},{"key":"6214_CR37","doi-asserted-by":"publisher","unstructured":"Yildirim M, Salbach C, Mueller M, Frey N, Giannitsis E. Comparative Analysis of Single- and Dual\u2010Marker Strategies for Rapid Non\u2013ST\u2010Segment\u2013Elevation Myocardial Infarction Rule\u2010Out Using Cardiac Myosin\u2010Binding Protein C, Copeptin, and High\u2010Sensitivity Cardiac Troponin T in the Emergency Department. J Am Heart Assoc. 2025;14(10):e039379. https:\/\/doi.org\/10.1161\/JAHA.124.039379","DOI":"10.1161\/JAHA.124.039379"},{"key":"6214_CR38","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.jtha.2022.10.010","volume":"21","author":"P-X Ge","year":"2023","unstructured":"Ge P-X, Tai T, Jiang L-P, Ji J-Z, Mi Q-Y, Zhu T, Li Y-F, Xie H-G. Choline and trimethylamine N-oxide impair metabolic activation of and platelet response to clopidogrel through activation of the NOX\/ROS\/Nrf2\/CES1 pathway. J Thromb Haemost. 2023;21:117\u201332. https:\/\/doi.org\/10.1016\/j.jtha.2022.10.010.","journal-title":"J Thromb Haemost"}],"container-title":["BMC Cardiovascular Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12872-026-06214-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-026-06214-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-026-06214-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T22:33:41Z","timestamp":1790289221000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12872-026-06214-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,4]]},"references-count":38,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["6214"],"URL":"https:\/\/doi.org\/10.1186\/s12872-026-06214-9","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-9065037\/v1","asserted-by":"object"}]},"ISSN":["1471-2261"],"issn-type":[{"value":"1471-2261","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,4]]},"assertion":[{"value":"8 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study was conducted in accordance with the Declaration of Helsinki (as revised in 2024) and received approval from the Ethics Committee of Xiangya Hospital, Central South University (Approval number: 2024040396).","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declerations"}},{"value":"Not applicable","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declerations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declerations"}}],"article-number":"836"}}