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Of these, 67 cases and 50 controls completed the questionnaires. HRQoL, psychological well-being, physical activity and capacity were assessed using validated forms. Group comparisons were made with independent t-tests or Mann-Whitney U. For correlation analyses, Spearman\u2019s rank correlation was used.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      No statistically significant differences in quality of life were observed between cases and controls. Anxiety and depression scores were likewise comparable across groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.228 and 0.307, respectively). Perceived stress (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.096), physical capacity (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.173), and physical activity (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.471) also did not differ significantly between cases and controls.\n                    <\/jats:p>\n                    <jats:p>\n                      With respect to sedentary behaviour, cases demonstrated a higher mean rank than controls (62 vs. 52), although the p-value marginally exceeded the conventional threshold for significance (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.062). Finally, no significant correlations were identified between aortic diameter and perceived stress, anxiety, or depression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this population-based cohort, no statistically significant differences in HRQoL, psychological well-being, and physical activity were observed between subjects with mild to moderate ascending aortic dilation and matched controls. However, given the small sample size, small differences between groups cannot be excluded. Balanced management strategies that promote safe physical activity, psychological well-being and HRQoL remain important in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12872-026-06616-9","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T07:44:53Z","timestamp":1789976693000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Health-related quality of life, psychological well-being and physical activity in patients with mild-to-moderate ascending aortic dilation - a cross-sectional case-control study"],"prefix":"10.1186","volume":"26","author":[{"given":"Fredrik","family":"Nilsson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Lindenberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabina","family":"Borg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Kylhammar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petter","family":"Dyverfeldt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filip","family":"Hammar\u00e9us","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Jonasson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Krzynska-Trzebiatowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lennart","family":"Nilsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Trenti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Engvall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Swahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,21]]},"reference":[{"issue":"1","key":"6616_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1053\/j.semtcvs.2021.02.029","volume":"34","author":"EMR Gouveia","year":"2022","unstructured":"Gouveia EMR, Silva Duarte G, Lopes A, Alves M, Caldeira D, Fernandes EFR, et al. 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