{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T16:08:39Z","timestamp":1762272519522,"version":"3.37.3"},"reference-count":8,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T00:00:00Z","timestamp":1576627200000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Emerg Med"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n<jats:title>Background<\/jats:title>\n<jats:p>Warfarin, a vitamin K antagonist, is a widely used medication for the treatment and prophylaxis of thromboembolic events. Patients with various clinical conditions due to warfarin overdose present to emergency departments. Although there may be serious bleeding due to a warfarin overdose, no bleeding may also be seen in some clinical conditions. Some of these bleedings may be life-threatening and result in death. Warfarin overdose and related cases of spontaneous bladder rupture are not frequently observed in the literature. We present a case of spontaneous bladder rupture due to warfarin overdose that was unexpectedly seen in a patient using warfarin for coronary artery disease and arrhythmia.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Case presentation<\/jats:title>\n<jats:p>A 77-year-old Caucasian male patient was admitted to the emergency department with abdominal pain, haematuria, and a reduced volume of urine lasting for three days. The patient\u2019s amount of urine was reduced, and he came to the hospital for the first time with this complaint. The patient had local bruises on his arms and legs. From the ultrasound, retrograde cystography and computed tomography images, it was thought that there was blood accumulation due to bladder rupture to the intraperitoneal region. Spontaneous bladder rupture secondary to warfarin overdose was considered for this patient who also had an international normalized ratio (INR) level of 13.4. After the INR level was normalized with vitamin K and a prothrombin complex concentrate, the patient underwent surgery. During the operation, a catheter was placed in the bladder, and the bladder mucosa and muscle were closed separately with a primary repair performed by a urologist. The patient was discharged on the 8th postoperative day without any complications.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>In addition to the known findings of warfarin overdose in these patients presenting to the emergency department, we think that the emergency department staff should suspect bladder rupture, which is a fatal complication in the presence of signs such as oliguria, haematuria, anuria, abdominal pain, and syncope.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s12873-019-0294-6","type":"journal-article","created":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T12:02:58Z","timestamp":1576670578000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Spontaneous bladder rupture secondary to warfarin overdose: a case report"],"prefix":"10.1186","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7783-5343","authenticated-orcid":false,"given":"Taner","family":"Sahin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ufuk","family":"Oner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omer","family":"Baser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ismail","family":"Kurtuncu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,12,18]]},"reference":[{"issue":"10","key":"294_CR1","doi-asserted-by":"publisher","first-page":"1590","DOI":"10.1016\/j.amjcard.2017.02.015","volume":"119","author":"BA Steinberg","year":"2017","unstructured":"Steinberg BA, Simon DJN, Thomas L, Ansell J, Fonarow GC, Gersh BJ, et al. Management of Major Bleeding in patients with atrial fibrillation treated with non\u2013vitamin K antagonist Oral anticoagulants compared with warfarin in clinical practice from phase II of the outcomes registry for better informed treatment of atrial Fibrill. Am J Cardiol. 2017;119(10):1590\u20135 Available from: https:\/\/doi.org\/10.1016\/j.amjcard.2017.02.015.","journal-title":"Am J Cardiol"},{"issue":"3","key":"294_CR2","doi-asserted-by":"publisher","first-page":"188","DOI":"10.5505\/vtd.2017.84803","volume":"24","author":"HF \u00d6ncel","year":"2017","unstructured":"\u00d6ncel HF, Salar R, Karl\u0131da\u011f \u0130, Durmu\u015f E, Yal\u00e7\u0131n M, \u00d6zbay E, et al. Spontaneous bladder perforation due to Giant bladder stone: a case report. 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In Treasure Island (FL); 2019."},{"issue":"1","key":"294_CR6","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1006\/gyno.2000.6030","volume":"80","author":"K Fujikawa","year":"2001","unstructured":"Fujikawa K, Miyamoto T, Ihara Y, Matsui Y, Takeuchi H. High incidence of severe urologic complications following radiotherapy for cervical cancer in Japanese women. Gynecol Oncol. 2001;80(1):21\u20133.","journal-title":"Gynecol Oncol"},{"issue":"2","key":"294_CR7","first-page":"121","volume":"82","author":"M Oomura","year":"2018","unstructured":"Oomura M, Naritomi H, Yasaka M, Ikeno K, Minematsu K. Effect of prothrombin complex concentrate on INR and blood coagulation system in emergency patients treated with warfarin overdose. Ann Hematol. 2018;82(2):121\u20133.","journal-title":"Ann Hematol"},{"issue":"2","key":"294_CR8","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/S0002-9343(98)00408-2","volume":"106","author":"C Gregg","year":"1999","unstructured":"Gregg C. Drug interactions and anti-infective therapies. Am J Med. 1999;106(2):227\u201337.","journal-title":"Am J Med"}],"container-title":["BMC Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12873-019-0294-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12873-019-0294-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12873-019-0294-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T00:28:45Z","timestamp":1608164925000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcemergmed.biomedcentral.com\/articles\/10.1186\/s12873-019-0294-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["294"],"URL":"https:\/\/doi.org\/10.1186\/s12873-019-0294-6","relation":{},"ISSN":["1471-227X"],"issn-type":[{"type":"electronic","value":"1471-227X"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"26 August 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 December 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 December 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Ethical approval was received from The Ethics Committee of Erciyes University Faculty of Medicine with the number of 96,681,246\/116681246 dated 11 July 2019.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"A copy of the written consent is available for review by the editor of this journal. Written informed consent for publication of the clinical details and clinical images was obtained from the patient.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.All authors whose names are included in the article declare that they comply with the transparency and reproducibility standards of the journal, the order of their names, the accuracy of all figures, the suggestions they have received from the journal editor and the corrections stated in the article and they accept the final version of the article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"80"}}