{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T22:48:15Z","timestamp":1793832495895,"version":"4.6.1"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T00:00:00Z","timestamp":1642550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T00:00:00Z","timestamp":1642550400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Emerg Med"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Green pit vipers (GPVs), namely\n                      <jats:italic>Trimeresurus albolabris<\/jats:italic>\n                      and\n                      <jats:italic>Trimeresurus stejnegeri<\/jats:italic>\n                      accounts for most snakebites in Southern China. Green pit viper venom contains thrombin-like enzymes, resulting in defibrination syndrome. Using of clotting factor replacement after antivenom administration is controversial. The objective of this study was to investigate the effects of clotting factor replacement in coagulopathic patients with\n                      <jats:italic>T. albolabris<\/jats:italic>\n                      and\n                      <jats:italic>T. stejnegeri<\/jats:italic>\n                      bites after antivenom administration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We retrospectively reviewed 123 patients who were bitten by\n                      <jats:italic>T. albolabris<\/jats:italic>\n                      and\n                      <jats:italic>T. stejnegeri<\/jats:italic>\n                      and were admitted to the Emergency Department of a hospital in Guangzhou, Southern China, from 2013 to 2019. Recovery of prothrombin time (PT) and fibrinogen level were compared among (1) fresh-frozen plasma (FFP) group; (2) cryoprecipitate (cryo) group; (3) FFP and cryo group; and (4) control group after antivenom administration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The incidence of coagulopathy was 31%. Persistent and late coagulopathy were the most common patterns among four groups. The median reduction in PT was 20.1\u2009\u00b1\u200931.2\u2009s for FFP and cryo group. The median increase in fibrinogen level was very small: 0.05\u2009\u00b1\u20090.20\u2009g\/L for FFP group, 0.09\u2009\u00b1\u20090.37\u2009g\/L for cryo group and 0.07\u2009\u00b1\u20090.31\u2009g\/L for FFP and cryo group, respectively. The percentage of unimproved PT was markedly higher in the FFP and cryo group than the control group (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.01 by log-rank test,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.02 by Gehan-Breslow-Wilcoxon test). The percentage of unimproved fibrinogen level tended to be worse in the FFP and cryo group than the control group, but the different was marginal (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.05 by Gehan-Breslow-Wilcoxon test,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.07 by log-rank test). A total of 7.8% (7\/90) of the patients in the clotting factor replacement groups developed anaphylaxis and heart failure.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      There is no improvement in coagulopathy profile in patients with\n                      <jats:italic>T. albolabris<\/jats:italic>\n                      and\n                      <jats:italic>T. stejnegeri<\/jats:italic>\n                      bites who received clotting factor replacement after antivenom administration. But the results from GPVs may not be generalized to other species of venomous snakes.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12873-022-00569-w","type":"journal-article","created":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T08:02:54Z","timestamp":1642579374000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Effectiveness of clotting factor replacement therapy after antivenom treatment on coagulopathic envenomation following green pit viper bites: a retrospective observational study"],"prefix":"10.1186","volume":"22","author":[{"given":"Liangbo","family":"Zeng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijing","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieyun","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaozhu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xida","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,1,19]]},"reference":[{"issue":"6","key":"569_CR1","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1016\/0035-9203(90)90111-Q","volume":"84","author":"RA Hutton","year":"1990","unstructured":"Hutton RA, Looareesuwan S, Ho M, Silamut K, Chanthavanich P, Karbwang J, et al. 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Written informed consent to replacement therapy was obtained from participants of legal age and the parents or legal guardians of children (under16 years old).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"9"}}