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Results will be disseminated via publications in peer-reviewed journals. Per the data sharing agreement signed with each of the external sites, this anonymized dataset may be transferred to one of the lead investigators at each site for future research purposes if the study team agrees to a research proposal submitted by the lead investigator and all relevant ethics approvals have been obtained. There are no plans to grant the public access to the dataset or statistical code.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Dissemination policy"}},{"value":"We originally obtained approval for this study from the Ottawa Health Science Network Research Ethics Board (OHSN) on December 23, 2016. After two amendments, we obtained approval for this version of the protocol, version 2.5, We obtained approval for this version of the study protocol from OHSN on May 11, 2017. Ethics approval for this version and all previous versions was also obtained from each of the four external centres (Hamilton Integrated Research Ethics Board, le Comit\u00e9 de la recherche du CHU de Qu\u00e9bec-Universit\u00e9 Laval, University of British Columbia Clinical Research Ethics Board, and the University of Manitoba Health Research Board). Details about the amendments were communicated to each site via email. We are using a waived consent model.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"SE has received peer-reviewed funding from Canadian Blood Services and the Canadian Institutes of Health Research for unrelated work in subarachnoid hemorrhage. RZ receives salary support and operating grants from the Canadian Institutes of Health Research.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"94"}}