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Respondents were presented with ten choice sets, each consisting of three out of ten plausible clinical outcomes. Hierarchical Bayesian modeling was used to determine the utilities associated with the outcomes.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Death was the outcome of greatest importance (mean utility\u2009=\u2009\u2212\u20098.91), followed by above knee amputation (\u2212\u20097.66), below knee amputation (\u2212\u20096.97), severe pain (\u2212\u20095.90), deep surgical site infection (SSI) (\u2212\u20095.69), bone healing complications (\u2212\u20095.20), and moderate pain (\u2212\u20094.59). Mild pain (\u2212\u20093.30) and superficial SSI (\u2212\u20093.29), on the other hand, were the outcomes of least importance to respondents.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>This study revealed that patients\u2019 relative importance towards clinical outcomes followed a logical gradient, with distinct and quantifiable preferences for each possible component outcome. These findings were incorporated into a novel composite endpoint weighting technique.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s12874-019-0885-7","type":"journal-article","created":{"date-parts":[[2019,12,26]],"date-time":"2019-12-26T17:02:34Z","timestamp":1577379754000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["A patient-centered composite endpoint weighting technique for orthopaedic trauma research"],"prefix":"10.1186","volume":"19","author":[{"given":"Ugochukwu N.","family":"Udogwu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Howe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Frey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marckenley","family":"Isaac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Connelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrius","family":"Marinos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell","family":"Baker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renan C.","family":"Castillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard P.","family":"Slobogean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert V.","family":"O\u2019Toole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0537-3474","authenticated-orcid":false,"given":"Nathan N.","family":"O\u2019Hara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,12,26]]},"reference":[{"issue":"2","key":"885_CR1","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1161\/01.CIR.86.2.683","volume":"86","author":"E Braunwald","year":"1992","unstructured":"Braunwald E, Cannon CP, McCabe CH. 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