{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,6]],"date-time":"2025-07-06T14:34:24Z","timestamp":1751812464165,"version":"3.37.3"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T00:00:00Z","timestamp":1660089600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T00:00:00Z","timestamp":1660089600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000092","name":"U.S. National Library of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000092","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Med Res Methodol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>In response to the COVID-19 pandemic many clinical studies have been initiated leading to the need for efficient ways to track and analyze study results. We expanded our previous project that tracked registered COVID-19 clinical studies to also track result articles generated from these studies. Our objective was to develop a data science approach to identify and analyze all publications linked to COVID-19 clinical studies and generate a prioritized list of publications for efficient understanding of the state of COVID-19 clinical research.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We conducted searches of ClinicalTrials.gov and PubMed to identify articles linked to COVID-19 studies, and developed criteria based on the trial phase, intervention, location, and record recency to develop a prioritized list of result publications.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The performed searchers resulted in 1\u00a0022 articles linked to 565 interventional trials (17.8% of all 3\u00a0167 COVID-19 interventional trials as of 31 January 2022). 609 publications were identified via abstract-link in PubMed and 413 via registry-link in ClinicalTrials.gov, with 27 articles linked from both sources. Of the 565 trials publishing at least one article, 197 (34.9%) had multiple linked publications. An attention score was assigned to each publication to develop a prioritized list of all publications linked to COVID-19 trials and 83 publications were identified that are result articles from late phase (Phase 3) trials with at least one US site and multiple study record updates. For COVID-19 vaccine trials, 108 linked result articles for 64 trials (14.7% of 436 total COVID-19 vaccine trials) were found.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Our method allows for the efficient identification of important COVID-19 articles that report results of registered clinical trials and are connected via a structured article-trial link. Our data science methodology also allows for consistent and as needed data updates and is generalizable to other conditions of interest.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12874-022-01703-9","type":"journal-article","created":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T16:02:57Z","timestamp":1660147377000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["regCOVID: Tracking publications of registered COVID-19 studies"],"prefix":"10.1186","volume":"22","author":[{"given":"Craig S.","family":"Mayer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vojtech","family":"Huser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,8,10]]},"reference":[{"key":"1703_CR1","doi-asserted-by":"crossref","unstructured":"Ejaz K, Kauser T, Siddiqa A. Comprehensive overview of COVID-19 clinical trials. J Pak Med Assoc. 2020;(0):1.","DOI":"10.5455\/JPMA.37"},{"issue":"10","key":"1703_CR2","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1016\/j.jiph.2020.07.004","volume":"13","author":"D Wang","year":"2020","unstructured":"Wang D, Li Z, Liu Y. An overview of the safety, clinical application and antiviral research of the COVID-19 therapeutics. J Infect Public Health. 2020;13(10):1405\u201314.","journal-title":"J Infect Public Health"},{"key":"1703_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2020.104490","volume":"106","author":"K Mohamed","year":"2021","unstructured":"Mohamed K, Yazdanpanah N, Saghazadeh A, Rezaei N. Computational drug discovery and repurposing for the treatment of COVID-19: A systematic review. Bioorganic Chem. 2021;106: 104490.","journal-title":"Bioorganic Chem"},{"key":"1703_CR4","doi-asserted-by":"publisher","first-page":"e10261","DOI":"10.7717\/peerj.10261","volume":"8","author":"CS Mayer","year":"2020","unstructured":"Mayer CS, Huser V. Computerized monitoring of COVID-19 trials, studies and registries in clinicaltrials. gov registry. PeerJ. 2020;8:e10261.","journal-title":"PeerJ"},{"key":"1703_CR5","unstructured":"Mayer C, Huser V. regCOVID project repository.  https:\/\/github.com\/lhncbc\/r-snippets-bmi\/tree\/master\/regCOVID. Accessed 26 May 2020."},{"issue":"7","key":"1703_CR6","doi-asserted-by":"publisher","first-page":"e68409","DOI":"10.1371\/journal.pone.0068409","volume":"8","author":"V Huser","year":"2013","unstructured":"Huser V, Cimino JJ. Linking clinicaltrials.gov and PubMed to track results of interventional human clinical trials. PLoS ONE. 2013;8(7):e68409 Sampson M, editor.","journal-title":"PLoS ONE"},{"issue":"8","key":"1703_CR7","doi-asserted-by":"publisher","first-page":"652","DOI":"10.7326\/M20-2959","volume":"173","author":"SE Kimmel","year":"2020","unstructured":"Kimmel SE, Califf RM, Dean NE, Goodman SN, Ogburn EL. COVID-19 Clinical Trials: A Teachable moment for improving our research infrastructure and relevance. Ann Intern Med. 2020;173(8):652\u20133.","journal-title":"Ann Intern Med"},{"issue":"8","key":"1703_CR8","doi-asserted-by":"publisher","first-page":"6761","DOI":"10.1007\/s11192-021-04059-x","volume":"126","author":"S Aviv-Reuven","year":"2021","unstructured":"Aviv-Reuven S, Rosenfeld A. Publication patterns\u2019 changes due to the COVID-19 pandemic: a longitudinal and short-term scientometric analysis. Scientometrics. 2021;126(8):6761\u201384.","journal-title":"Scientometrics"},{"issue":"1","key":"1703_CR9","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1186\/s12874-021-01404-9","volume":"21","author":"M Raynaud","year":"2021","unstructured":"Raynaud M, Goutaudier V, Louis K, Al-Awadhi S, Dubourg Q, Truchot A, et al. Impact of the COVID-19 pandemic on publication dynamics and non-COVID-19 research production. BMC Med Res Methodol. 2021;21(1):255.","journal-title":"BMC Med Res Methodol"},{"issue":"12","key":"1703_CR10","doi-asserted-by":"publisher","first-page":"350","DOI":"10.3390\/life10120350","volume":"10","author":"AG Mathioudakis","year":"2020","unstructured":"Mathioudakis AG, Fally M, Hashad R, Kouta A, Hadi AS, Knight SB, et al. Outcomes evaluated in controlled clinical trials on the management of COVID-19: A methodological systematic review. Life. 2020;10(12):350.","journal-title":"Life"},{"key":"1703_CR11","unstructured":"The New York Times: Covid-19 vaccine tracker.   https:\/\/www.nytimes.com\/interactive\/2020\/science\/coronavirus-vaccine-tracker.html. Accessed 9 Feb 2021."},{"key":"1703_CR12","unstructured":"Mayer C, Huser V. Study repository for regCOVID (publications).  https:\/\/github.com\/lhncbc\/r-snippets-bmi\/tree\/master\/regCOVID\/regCOVIDpublications. Accessed 24 Feb 2021."},{"key":"1703_CR13","unstructured":"AACT Team. Aggregate Analysis of ClinicalTrials.gov (AACT) database 2020. https:\/\/aact.ctti-clinicaltrials.org\/learn_more. Accessed 20 Mar 2020."},{"issue":"1","key":"1703_CR14","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1186\/s13643-017-0518-3","volume":"6","author":"R Bashir","year":"2017","unstructured":"Bashir R, Bourgeois FT, Dunn AG. A systematic review of the processes used to link clinical trial registrations to their published results. 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AMIA Annu Symp Proc AMIA Symp. 2012;2012:400\u20138."}],"container-title":["BMC Medical Research Methodology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12874-022-01703-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12874-022-01703-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12874-022-01703-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T16:03:40Z","timestamp":1660147420000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcmedresmethodol.biomedcentral.com\/articles\/10.1186\/s12874-022-01703-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,10]]},"references-count":22,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["1703"],"URL":"https:\/\/doi.org\/10.1186\/s12874-022-01703-9","relation":{},"ISSN":["1471-2288"],"issn-type":[{"type":"electronic","value":"1471-2288"}],"subject":[],"published":{"date-parts":[[2022,8,10]]},"assertion":[{"value":"10 February 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 August 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 August 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not Applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not Applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"221"}}