{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T07:08:33Z","timestamp":1772694513053,"version":"3.50.1"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T00:00:00Z","timestamp":1557792000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T00:00:00Z","timestamp":1557792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"crossref","award":["C51094\/A18267"],"award-info":[{"award-number":["C51094\/A18267"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Fam Pract"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s12875-019-0944-5","type":"journal-article","created":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T18:04:58Z","timestamp":1557857098000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Low knowledge and awareness of monoclonal gammopathy of undetermined significance (MGUS) among general practitioners"],"prefix":"10.1186","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8609-0788","authenticated-orcid":false,"given":"Charlene M.","family":"McShane","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blain","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olinda","family":"Santin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lesley A.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,5,14]]},"reference":[{"key":"944_CR1","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1038\/s41408-018-0065-8","volume":"8","author":"P Ravi","year":"2018","unstructured":"Ravi P, Kumar SK, Cerhan JR, Maurer MJ, Dingli D, Ansell SM, et al. Defining cure in multiple myeloma: a comparative study of outcomes of young individuals with myeloma and curable hematologic malignancies. Blood Cancer J. 2018;8:26.","journal-title":"Blood Cancer J"},{"key":"944_CR2","doi-asserted-by":"crossref","unstructured":"Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394\u2013424.","DOI":"10.3322\/caac.21492"},{"key":"944_CR3","doi-asserted-by":"publisher","first-page":"1691","DOI":"10.1038\/leu.2009.134","volume":"23","author":"O Landgren","year":"2009","unstructured":"Landgren O, Weiss BM. Patterns of monoclonal gammopathy of undetermined significance and multiple myeloma in various ethnic\/racial groups: support for genetic factors in pathogenesis. Leukemia. 2009;23:1691\u20137.","journal-title":"Leukemia."},{"key":"944_CR4","doi-asserted-by":"publisher","first-page":"5418","DOI":"10.1182\/blood-2008-12-195008","volume":"113","author":"BM Weiss","year":"2009","unstructured":"Weiss BM, Abadie J, Verma P, Howard RS, Kuehl WM. A monoclonal gammopathy precedes multiple myeloma in most patients. Blood. 2009;113:5418\u201322.","journal-title":"Blood"},{"key":"944_CR5","doi-asserted-by":"publisher","first-page":"933","DOI":"10.4065\/mcp.2010.0337","volume":"85","author":"RK Wadhera","year":"2010","unstructured":"Wadhera RK, Rajkumar SV. Prevalence of monoclonal gammopathy of undetermined significance: a systematic review. Mayo Clin Proc. 2010;85:933\u201342.","journal-title":"Mayo Clin Proc"},{"key":"944_CR6","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1038\/leu.2010.60","volume":"24","author":"RA Kyle","year":"2010","unstructured":"Kyle RA, Durie BGM, Rajkumar SV, Landgren O, Blade J, Merlini G, et al. Monoclonal gammopathy of undetermined significance (MGUS) and smoldering (asymptomatic) multiple myeloma: IMWG consensus perspectives risk factors for progression and guidelines for monitoring and management. Leukemia. 2010;24:1121\u20137.","journal-title":"Leukemia."},{"key":"944_CR7","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1016\/j.mayocp.2012.06.014","volume":"87","author":"TM Therneau","year":"2012","unstructured":"Therneau TM, Kyle RA, Melton LJ, Larson DR, Benson JT, Colby CL, et al. Incidence of monoclonal gammopathy of undetermined significance and estimation of duration before first clinical recognition. Mayo Clin Proc. 2012;87:1071\u20139.","journal-title":"Mayo Clin Proc"},{"key":"944_CR8","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1046\/j.1365-2141.2003.04355.x","volume":"121","author":"The International Myeloma Working Group","year":"2003","unstructured":"The International Myeloma Working Group. Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the international myeloma working group. Br J Haematol. 2003;121:749\u201357.","journal-title":"Br J Haematol"},{"key":"944_CR9","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1056\/NEJMoa01133202","volume":"346","author":"RA Kyle","year":"2002","unstructured":"Kyle RA, Therneau TM, Rajkumar SV, Offord JR, Larson DR, Plevak MF, et al. A long-term study of prognosis in monoclonal gammopathy of undetermined significance. N Engl J Med. 2002;346:564\u20139.","journal-title":"N Engl J Med"},{"key":"944_CR10","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1182\/blood-2013-05-505487","volume":"123","author":"I Turesson","year":"2014","unstructured":"Turesson I, Kovalchik SA, Pfeiffer RM, Kristinsson SY, Goldin LR, Drayson MT, et al. Monoclonal gammopathy of undetermined significance and risk of lymphoid and myeloid malignancies: 728 cases followed up to 30 years in Sweden. Blood. 2014;123:338\u201345.","journal-title":"Blood."},{"key":"944_CR11","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1111\/j.1365-2141.2009.07807.x","volume":"147","author":"J Bird","year":"2009","unstructured":"Bird J, Behrens J, Westin J, Turesson I, Drayson M, Beetham R, et al. UK myeloma forum (UKMF) and Nordic myeloma study group (NMSG): guidelines for the investigation of newly detected M-proteins and the management of monoclonal gammopathy of undetermined significance (MGUS). Br J Haematol. 2009;147:22\u201342.","journal-title":"Br J Haematol"},{"key":"944_CR12","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.1365-2141.2010.08207.x","volume":"150","author":"JR Berenson","year":"2010","unstructured":"Berenson JR, Anderson KC, Audell RA, Boccia RV, Coleman M, Dimopoulos MA, et al. Monoclonal gammopathy of undetermined significance: a consensus statement. Br J Haematol. 2010;150:28\u201338.","journal-title":"Br J Haematol"},{"key":"944_CR13","doi-asserted-by":"publisher","first-page":"984","DOI":"10.3324\/haematol.2013.100552","volume":"99","author":"NWCJ van de Donk","year":"2014","unstructured":"van de Donk NWCJ, Palumbo A, Johnsen HE, Engelhardt M, Gay F, Gregersen H, et al. The clinical relevance and management of monoclonal gammopathy of undetermined significance and related disorders: recommendations from the European myeloma network. Haematologica. 2014;99:984\u201396.","journal-title":"Haematologica."},{"key":"944_CR14","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1111\/ejh.12962","volume":"100","author":"CM McShane","year":"2018","unstructured":"McShane CM, Murphy B, Lim KH, Anderson LA. Monoclonal gammopathy of undetermined significance as viewed by haematology healthcare professionals. Eur J Haematol. 2018;100:20\u20136.","journal-title":"Eur J Haematol"},{"key":"944_CR15","doi-asserted-by":"crossref","unstructured":"O\u2019Cathain A, Thomas KJ. &quot;Any other comments?&quot; Open questions on questionnaires - a bane or a bonus to research? BMC Med Res Methodol 2004;4:25.","DOI":"10.1186\/1471-2288-4-25"},{"key":"944_CR16","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1016\/S1470-2045(15)00205-3","volume":"16","author":"FRCGPG Rubin","year":"2015","unstructured":"Rubin FRCGPG, Hunter D, Earle C, Grunfeld E, Lyratzopoulos HG, Wardle J, et al. The lancet oncology commission the expanding role of primary care in cancer control. Lancet Oncol. 2015;16:1231\u201372.","journal-title":"Lancet Oncol"},{"key":"944_CR17","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/S1470-2045(12)70041-4","volume":"13","author":"G Lyratzopoulos","year":"2012","unstructured":"Lyratzopoulos G, Neal RD, Barbiere JM, Rubin GP. Abel G a. variation in number of general practitioner consultations before hospital referral for cancer: findings from the 2010 National Cancer Patient Experience Survey in England. Lancet Oncol. 2012;13:353\u201365.","journal-title":"Lancet Oncol"},{"key":"944_CR18","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1038\/bjc.2012.408","volume":"107","author":"L Elliss-Brookes","year":"2012","unstructured":"Elliss-Brookes L, McPhail S, Ives A, Greenslade M, Shelton J, Hiom S, et al. Routes to diagnosis for cancer \u2013 determining the patient journey using multiple routine data sets. Br J Cancer. 2012;107:1220\u20136.","journal-title":"Br J Cancer"},{"key":"944_CR19","first-page":"g7400","volume":"349","author":"G Lyratzopoulos","year":"2014","unstructured":"Lyratzopoulos G, Wardle J, Rubin G. Rethinking diagnostic delay in cancer: how difficult is the diagnosis? BMJ (Clin Res Ed). 2014;349:g7400.","journal-title":"BMJ (Clin Res Ed)"},{"key":"944_CR20","doi-asserted-by":"publisher","first-page":"e106","DOI":"10.3399\/bjgp15X683545","volume":"65","author":"E Shephard","year":"2015","unstructured":"Shephard E, Neal R, Rose P, Walter F, Litt E, Hamilton W. Quantifying the risk of multiple myeloma from symptoms reported in primary care patients: a large case\u2013control study using electronic records. Br J Gen Pract. 2015;65:e106\u201313.","journal-title":"Br J Gen Pract"},{"key":"944_CR21","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1038\/bjc.2015.311","volume":"113","author":"DA Howell","year":"2015","unstructured":"Howell DA, Warburton F, Ramirez A-J, Roman E, Smith AG, Forbes LJL. Risk factors and time to symptomatic presentation in leukaemia, lymphoma and myeloma. Br J Cancer. 2015;113:1114\u201320.","journal-title":"Br J Cancer"},{"key":"944_CR22","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1056\/NEJMoa1300439","volume":"369","author":"M-V Mateos","year":"2013","unstructured":"Mateos M-V, Hern\u00e1ndez M-T, Giraldo P, de la Rubia J, de Arriba F, Corral LL, et al. Lenalidomide plus dexamethasone for high-risk smoldering multiple myeloma. N Engl J Med. 2013;369:438\u201347.","journal-title":"N Engl J Med"},{"key":"944_CR23","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1001\/jamaoncol.2015.23","volume":"1","author":"EE Sigurdardottir","year":"2015","unstructured":"Sigurdardottir EE, Turesson I, Lund SH, Lindqvist EK, Mailankody S, Korde N, et al. The role of diagnosis and clinical follow-up of monoclonal Gammopathy of undetermined significance on survival in multiple myeloma. JAMA oncology. 2015;1:168\u201374.","journal-title":"JAMA oncology"},{"key":"944_CR24","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1111\/j.1365-2141.2007.06864.x","volume":"139","author":"AC Rawstron","year":"2007","unstructured":"Rawstron AC, Jones RA, Ferguson C, Hughes G, Selby P, Reid C, et al. Outreach monitoring service for patients with indolent B-cell and plasma cell disorders: a UK experience. Br J Haematol. 2007;139:845\u20138.","journal-title":"Br J Haematol"}],"container-title":["BMC Family Practice"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12875-019-0944-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12875-019-0944-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12875-019-0944-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T01:11:41Z","timestamp":1721265101000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcfampract.biomedcentral.com\/articles\/10.1186\/s12875-019-0944-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,14]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["944"],"URL":"https:\/\/doi.org\/10.1186\/s12875-019-0944-5","relation":{},"ISSN":["1471-2296"],"issn-type":[{"value":"1471-2296","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,14]]},"assertion":[{"value":"9 February 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 April 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 May 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study received ethical approval from the School of Medicine, Dentistry and Biomedical Sciences Research Ethics Committee, Queen\u2019s University Belfast (Ref 17.22). Participants were informed that participation was voluntary, that all responses were anonymous and that the study would be published in a peer-reviewed journal. Participation in the survey implied consent.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"61"}}