{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T19:46:39Z","timestamp":1788291999874,"version":"build-2803163510"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T00:00:00Z","timestamp":1669161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T00:00:00Z","timestamp":1669161600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Prim. Care"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Benzydamine hydrochloride is a locally-acting Non-Steroidal Anti-Inflammatory Drug (NSAID) with combined local anesthetic and analgesic properties, indicated for the symptomatic relief of pain in acute sore throat. The aim of this study was to obtain an European Consensus among pharmacists, general practitioners and pediatricians on the appropriate use of benzydamine hydrochloride in the treatment of sore throat.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The authors developed a Delphi questionnaire organized into 15 statements focused on 4 topics: the mechanism of action of benzydamine, the benzydamine treatment in an adult patient and in a pediatric patient, and the advantages of benzydamine over other topical treatments. The survey was administered to a panel of to 320 participants including general practitioners, pediatricians, and pharmacists from 6 European countries (Italy, Germany, Portugal, Romania, Russia, and Spain), who rated their level of agreement or disagreement with each statement on a 6-point Likert scale. Consensus was predefined as more than 66% of the panel agreeing\/disagreeing with each statement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Panelists\u2019 agreement on statements was very high. Consensus was reached for all 15 statements in the Delphi survey, with more than 98% positive agreement on topic 4, suggesting a shared view among European healthcare professionals (HCPs) about the advantages of benzydamine over other topical treatments. A strong consensus (&gt;\u200999%) was reached for all the statements of topic 1 regarding the mechanism of action of benzydamine, except for its anesthetic properties (79%). Strong agreement was reached for all statements in topics 2 and 3 regarding the treatment of acute sore throat symptoms in the adult and pediatric patient, except for one on the efficacy of benzydamine in preventing post-operative sore throat, for which it was 67%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Because all relevant publications on benzydamine are dated and there are no recommendations on its use for the symptomatic treatment of sore throat in European guidelines, this Delphi-based international consensus may be important in reinforcing the appropriate use and effect of benzydamine in the treatment of sore throat among health care professionals.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s12875-022-01901-w","type":"journal-article","created":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T17:08:04Z","timestamp":1669309684000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["International Delphi-based consensus on the appropriate use and effect of Benzydamine hydrochloride in the treatment of sore throat"],"prefix":"10.1186","volume":"23","author":[{"given":"Desiderio","family":"Passali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Barat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Cadevall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo Miguel","family":"Freire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignazio","family":"Grattagliano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioan","family":"Gutu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"M\u00f6sges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrey","family":"Pavlysh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,11,23]]},"reference":[{"issue":"7","key":"1901_CR1","first-page":"791","volume":"57","author":"G Worrall","year":"2011","unstructured":"Worrall G. Acute sore throat. Can Fam Physician. 2011;57(7):791\u20134.","journal-title":"Can Fam Physician"},{"key":"1901_CR2","first-page":"1509","volume":"2014","author":"T Kenealy","year":"2014","unstructured":"Kenealy T. Sore throat. BMJ Clin Evid. 2014;2014:1509.","journal-title":"BMJ Clin Evid"},{"issue":"1220","key":"1901_CR3","first-page":"U1609","volume":"118","author":"M Kljakovic","year":"2005","unstructured":"Kljakovic M, Crampton P. Sore throat management in New Zealand general practice. N Z Med J. 2005;118(1220):U1609.","journal-title":"N Z Med J"},{"issue":"3","key":"1901_CR4","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1093\/fampra\/cmv015","volume":"32","author":"S Mistik","year":"2015","unstructured":"Mistik S, Gokahmetoglu S, Balci E, Onuk FA. Sore throat in primary care project: a clinical score to diagnose viral sore throat. Fam Pract. 2015;32(3):263\u20138.","journal-title":"Fam Pract"},{"key":"1901_CR5","first-page":"CD000023","volume":"11","author":"A Spinks","year":"2013","unstructured":"Spinks A, Glasziou PP, Del Mar CB. Antibiotics for sore throat. Cochrane Database Syst Rev. 2013;11:CD000023.","journal-title":"Cochrane Database Syst Rev"},{"issue":"604","key":"1901_CR6","doi-asserted-by":"publisher","first-page":"e787","DOI":"10.3399\/bjgp12X658322","volume":"62","author":"P Little","year":"2012","unstructured":"Little P, Hobbs FR, Mant D, McNulty CA, Mullee M. Incidence and clinical variables associated with streptococcal throat infections: a prospective diagnostic cohort study. Br J Gen Pract. 2012;62(604):e787\u201394.","journal-title":"Br J Gen Pract"},{"issue":"4","key":"1901_CR7","doi-asserted-by":"publisher","first-page":"e956","DOI":"10.1542\/peds.2014-0605","volume":"134","author":"MP Kronman","year":"2014","unstructured":"Kronman MP, Zhou C, Mangione-Smith R. Bacterial prevalence and antimicrobial prescribing trends for acute respiratory tract infections. Pediatrics. 2014;134(4):e956\u201365.","journal-title":"Pediatrics"},{"issue":"1","key":"1901_CR8","first-page":"25","volume":"12","author":"M Roxas","year":"2007","unstructured":"Roxas M, Jurenka J. Colds and influenza: a review of diagnosis and conventional botanical and nutritional considerations. Altern Med Rev. 2007;12(1):25\u201348.","journal-title":"Altern Med Rev"},{"key":"1901_CR9","first-page":"127","volume":"280","author":"S Marshall","year":"2008","unstructured":"Marshall S. Giving advice on sore throats. Pharm J. 2008;280:127\u201330.","journal-title":"Pharm J"},{"issue":"Suppl 1","key":"1901_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1469-0691.2012.03766.x","volume":"18","author":"C Pelucchi","year":"2012","unstructured":"Pelucchi C, Grigoryan L, Galeone C, Esposito S, Huovinen P, Little P, et al. Guideline for the management of acute sore throat. Clin Microbiol Infect. 2012;18(Suppl 1):1\u201328.","journal-title":"Clin Microbiol Infect"},{"key":"1901_CR11","volume-title":"Sore throat (acute): antimicrobial prescribing","author":"National Institute for Health and Care Excellence (NICE) guideline","year":"2018","unstructured":"National Institute for Health and Care Excellence (NICE) guideline. Sore throat (acute): antimicrobial prescribing. 2018. Available from: https:\/\/www.nice.org.uk\/guidance\/ng84\/resources\/sore-throat-acute-antimicrobial-prescribing-pdf-1837694694085"},{"issue":"12","key":"1901_CR12","doi-asserted-by":"publisher","first-page":"915","DOI":"10.3109\/00365548.2012.700768","volume":"44","author":"MS Gunnarsson","year":"2012","unstructured":"Gunnarsson MS, Sundvall P-D, Gunnarsson R. In primary health care, never prescribe antibiotics to patients suspected of having an uncomplicated sore throat caused by group a beta-haemolytic streptococci without first confirming the presence of this bacterium. Scand J Infect Dis. 2012;44(12):915\u201321.","journal-title":"Scand J Infect Dis"},{"issue":"2","key":"1901_CR13","first-page":"127","volume":"61","author":"RS Turnbull","year":"1995","unstructured":"Turnbull RS. Benzydamine hydrochloride (Tantum) in the management of oral inflammatory conditions. J Can Den Assoc. 1995;61(2):127\u201334.","journal-title":"J Can Den Assoc"},{"key":"1901_CR14","first-page":"734","volume":"23","author":"S Simard-Savoie","year":"1978","unstructured":"Simard-Savoie S, Forest D. Topical anaesthetic activity of benzydamine. Curr Ther Res. 1978;23:734\u201345.","journal-title":"Curr Ther Res"},{"issue":"6","key":"1901_CR15","first-page":"243","volume":"19","author":"DE Griswold","year":"1993","unstructured":"Griswold DE, Hillegass LM, Breton JJ, Esser KM, Adams JL. Differentiation in vivo of classical non-steroidal anti-inflammatory drugs from cytokine suppressive anti-inflammatory drugs and other pharmacological classes using mouse tumour necrosis factor alpha production. Drugs Exp Clin Res. 1993;19(6):243\u20138.","journal-title":"Drugs Exp Clin Res"},{"issue":"6","key":"1901_CR16","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1080\/1120009X.1992.11739190","volume":"4","author":"NH Fanaki","year":"1992","unstructured":"Fanaki NH, el-Nakeeb MA. Antimicrobial activity of benzydamine, a non-steroid anti-inflammatory agent. J Chemother. 1992;4(6):347\u201352.","journal-title":"J Chemother"},{"issue":"3","key":"1901_CR17","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1185\/03007998209112381","volume":"8","author":"MW Whiteside","year":"1982","unstructured":"Whiteside MW. A controlled study of benzydamine oral rinse ('Difflam') in general practice. Curr Med Res Opin. 1982;8(3):188\u201390.","journal-title":"Curr Med Res Opin"},{"key":"1901_CR18","first-page":"1388","volume":"38","author":"VA Chudoba","year":"1983","unstructured":"Chudoba VA. Benzydamine hydrochloride: oral rinse for chronic pharyngitis in tonsillectomized patients. Mod Med Canada. 1983;38:1388\u201392.","journal-title":"Mod Med Canada"},{"key":"1901_CR19","first-page":"856","volume":"26","author":"J Froom","year":"1979","unstructured":"Froom J, Boisseau V. Benzydamine oral rinse for sore throat. Curr Ther Res. 1979;26:856\u201361.","journal-title":"Curr Ther Res"},{"key":"1901_CR20","first-page":"641","volume":"7","author":"JF Wethington","year":"1985","unstructured":"Wethington JF. Double-blind study of benzydamine hydrochloride, a new treatment for sore throat. Clin Ther. 1985;7:641\u20136.","journal-title":"Clin Ther"},{"key":"1901_CR21","unstructured":"Angelini Pharma. BENZYDAMINE Oropharyngeal formulations. Available from: https:\/\/docplayer.net\/55680442-Benzydamine-oropharyngeal-formulations-contents.html. Accessed 1 Mar 2022."},{"issue":"1","key":"1901_CR22","doi-asserted-by":"publisher","first-page":"8","DOI":"10.4103\/0976-237X.79292","volume":"2","author":"G Roopashri","year":"2011","unstructured":"Roopashri G, Jayanthi K, Guruprasad R. Efficacy of benzydamine hydrochloride, chlorhexidine, and povidone iodine in the treatment of oral mucositis among patients undergoing radiotherapy in head and neck malignancies: a drug trail. Contemp Clin Dent. 2011;2(1):8\u201312.","journal-title":"Contemp Clin Dent"},{"issue":"6","key":"1901_CR23","doi-asserted-by":"publisher","first-page":"623","DOI":"10.3109\/10837450902882351","volume":"14","author":"SY Karavana","year":"2009","unstructured":"Karavana SY, G\u00fcneri P, Ertan G. Benzydamine hydrochloride buccal bioadhesive gels designed for oral ulcers: preparation, rheological, textural, mucoadhesive and release properties. Pharm Dev Technol. 2009;14(6):623\u201331.","journal-title":"Pharm Dev Technol"},{"issue":"4","key":"1901_CR24","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1213\/01.ane.0000231637.28427.00","volume":"103","author":"A Agarwal","year":"2006","unstructured":"Agarwal A, Nath SS, Goswami D, Gupta D, Dhiraaj S, Singh PK. An evaluation of the efficacy of aspirin and benzydamine hydrochloride gargle for attenuating postoperative sore throat: a prospective, randomized, singleblind study. Anesth Analg. 2006;103(4):1001\u20133.","journal-title":"Anesth Analg"},{"issue":"4","key":"1901_CR25","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1002\/1097-0142(20010815)92:4<875::AID-CNCR1396>3.0.CO;2-1","volume":"92","author":"JB Epstein","year":"2001","unstructured":"Epstein JB, Silverman S Jr, Paggiarino DA, et al. Benzydamine HCl for prophylaxis of radiation-induced oral mucositis: results from a multicenter, randomized, double-blind, placebo-controlled clinical trial. Cancer. 2001;92(4):875\u201385.","journal-title":"Cancer"},{"issue":"4","key":"1901_CR26","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1046\/j.1365-2648.2000.t01-1-01567.x","volume":"32","author":"F Hasson","year":"2000","unstructured":"Hasson F, Keeney S, McKenna H. Research guidelines for the Delphi survey technique. J Adv Nurs. 2000;32(4):1008\u201315.","journal-title":"J Adv Nurs"},{"issue":"2","key":"1901_CR27","doi-asserted-by":"crossref","first-page":"65","DOI":"10.69864\/ijbsam.9-2.106","volume":"9","author":"L Giannarou","year":"2014","unstructured":"Giannarou L, Zervas E. Using Delphi technique to build consensus in practice. Int J Bus Sci Appl Manag. 2014;9(2):65\u201382.","journal-title":"Int J Bus Sci Appl Manag"},{"key":"1901_CR28","doi-asserted-by":"publisher","first-page":"677","DOI":"10.12968\/bjtr.1996.3.12.14731","volume":"3","author":"A Walker","year":"1996","unstructured":"Walker A, Selfe J. The Delphi method: a useful tool for the allied health researcher. Br J Ther Rehabil. 1996;3:677\u201381.","journal-title":"Br J Ther Rehabil"},{"issue":"2","key":"1901_CR29","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1007\/s10787-998-0026-0","volume":"6","author":"PA Quane","year":"1998","unstructured":"Quane PA, Graham GG, Ziegler JB. Pharmacology of benzydamine. Inflammopharmacology. 1998;6(2):95\u2013107.","journal-title":"Inflammopharmacology."},{"issue":"9","key":"1901_CR30","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1006\/cyto.1996.0094","volume":"8","author":"M Sironi","year":"1996","unstructured":"Sironi M, Pozzi P, Polentarutti N, Benigni F, Coletta I, Guglielmotti A, et al. Inhibition of inflammatory cytokine production and protection against endotoxin toxicity by benzydamine. Cytokine. 1996;8(9):710\u20136.","journal-title":"Cytokine"},{"issue":"1","key":"1901_CR31","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/s005990070028","volume":"30","author":"M Sironi","year":"2000","unstructured":"Sironi M, Massimiliano L, Transidico P, Pinza M, Sozzani S, Mantovani A, et al. Differential effect of benzydamine on pro- versus anti-inflammatory cytokine production: lack of inhibition of interleukin-10 and interleukin-1 receptor antagonist. Int J Clin Lab Res. 2000;30(1):17\u20139.","journal-title":"Int J Clin Lab Res"},{"issue":"6","key":"1901_CR32","first-page":"851","volume":"67","author":"S Mathivanan","year":"2016","unstructured":"Mathivanan S, de la Torre-Martinez R, Wolf C, Mangano G, Polenzani L, Milanese C, et al. Effect of econazole and benzydamine on sensory neurons in culture. J Physiol Pharmacol. 2016;67(6):851\u20138.","journal-title":"J Physiol Pharmacol"},{"key":"1901_CR33","unstructured":"Mangano G, Apicella C, Vitiello M, Milanese C, Polenzani L. Benzydamine local Anestetic activity and [3h]-Batrachotoxin binding sites. In: Poster presented to 31st National Congress of the Italian Society of Pharmacology. Trieste; 2003."},{"key":"1901_CR34","first-page":"188","volume":"118","author":"K Kr\u00fcger","year":"2021","unstructured":"Kr\u00fcger K, T\u00f6pfner N, Berner R, Windfuhr J, Oltrogge JH. Clinical practice guideline: sore throat. Dtsch Arztebl Int. 2021;118:188\u201394.","journal-title":"Dtsch Arztebl Int"},{"key":"1901_CR35","volume-title":"Management of sore throat and indications for tonsillectomy. A national clinical guideline","author":"Scottish Intercollegiate Guidelines Network (SIGN)","year":"2010","unstructured":"Scottish Intercollegiate Guidelines Network (SIGN). Management of sore throat and indications for tonsillectomy. A national clinical guideline 2010. Available from: https:\/\/www.sign.ac.uk\/media\/1055\/sign117.pdf"},{"issue":"7082","key":"1901_CR36","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1136\/bmj.314.7082.722","volume":"314","author":"P Little","year":"1997","unstructured":"Little P, Williamson I, Warner G, Gould C, Gantley M, Kinmonth AL. Open randomised trial of prescribing strategies in managing sore throat. BMJ. 1997;314(7082):722\u20137.","journal-title":"BMJ"},{"issue":"9","key":"1901_CR37","doi-asserted-by":"publisher","first-page":"644","DOI":"10.5694\/j.1326-5377.1992.tb121463.x","volume":"156","author":"C Del Mar","year":"1992","unstructured":"Del Mar C. Managing sore throat: a literature review. II. Do antibiotics confer benefit? Med J Aust. 1992;156(9):644\u20139.","journal-title":"Med J Aust"},{"issue":"1","key":"1901_CR38","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1186\/s12875-019-0970-3","volume":"20","author":"KB Reinholdt","year":"2019","unstructured":"Reinholdt KB, Rusan M, Hansen PR, Klug TE. Management of sore throat in Danish general practices. BMC Fam Pract. 2019;20(1):75.","journal-title":"BMC Fam Pract"},{"key":"1901_CR39","volume-title":"Benzydamine for acute sore throat: A review of clinical effectiveness and guidelines","author":"B Farah","year":"2018","unstructured":"Farah B, Visintini S. Benzydamine for acute sore throat: A review of clinical effectiveness and guidelines. Ottawa: Canadian Agency for Drugs and Technologies in Health; 2018. CADTH Rapid Response Reports. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK537954\/"},{"issue":"8","key":"1901_CR40","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1007\/s12630-019-01371-2","volume":"66","author":"D Kim","year":"2019","unstructured":"Kim D, Jeong H, Kwon J, Kang S, Han B, Lee EK, et al. The effect of benzydamine hydrochloride on preventing postoperative sore throat after total thyroidectomy: a randomized-controlled trial. Can J Anaesth. 2019;66(8):934\u201342.","journal-title":"Can J Anaesth"},{"issue":"7","key":"1901_CR41","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1111\/anae.14224","volume":"73","author":"A Kuriyama","year":"2018","unstructured":"Kuriyama A, Aga M, Maeda H. Topical benzydamine hydrochloride for prevention of postoperative sore throat in adults undergoing tracheal intubation for elective surgery: a systematic review and meta-analysis. Anaesthesia. 2018;73(7):889\u2013900.","journal-title":"Anaesthesia."},{"key":"1901_CR42","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.ijporl.2019.03.020","volume":"121","author":"T Hanani","year":"2019","unstructured":"Hanani T, Gadban H, Jahshan F, Ronen O. Tantum verde mouthwash for tonsillectomy: a prospective, double-blind, randomized control trial. Int J Pediatr Otorhinolaryngol. 2019;121:173\u20138.","journal-title":"Int J Pediatr Otorhinolaryngol"},{"issue":"459","key":"1901_CR43","first-page":"817","volume":"50","author":"M Thomas","year":"2000","unstructured":"Thomas M, Del MC, Glasziou P. How effective are treatments other than antibiotics for acute sore throat? Br J Gen Pract. 2000;50(459):817\u201320.","journal-title":"Br J Gen Pract"},{"issue":"6","key":"1901_CR44","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1001\/archpedi.158.6.521","volume":"158","author":"DA Perrott","year":"2004","unstructured":"Perrott DA, Piira T, Goodenough B, Champion GD. Efficacy and safety of acetaminophen vs ibuprofen for treating children\u2019s pain or fever: a meta-analysis. Arch Pediatr Adolesc Med. 2004;158(6):521\u20136.","journal-title":"Arch Pediatr Adolesc Med"},{"issue":"3","key":"1901_CR45","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1345\/aph.1M332","volume":"44","author":"CA Pierce","year":"2010","unstructured":"Pierce CA, Voss B. Efficacy and safety of ibuprofen and acetaminophen in children and adults. A meta-analysis and qualitative review. Ann Pharmacother. 2010;44(3):489\u2013506.","journal-title":"Ann Pharmacother"},{"issue":"6","key":"1901_CR46","doi-asserted-by":"publisher","first-page":"1442","DOI":"10.1016\/j.clinthera.2012.04.028","volume":"34","author":"E Chiappini","year":"2012","unstructured":"Chiappini E, Principi N, Mansi N, Serra A, De Masi S, Camaioni A, et al. Management of acute pharyngitis in children: summary of the Italian National Institute of health guidelines. Clin Ther. 2012;34(6):1442\u201358.","journal-title":"Clin Ther"},{"key":"1901_CR47","unstructured":"Ministry of Health, NSW. Infants and Children: Acute Management of Sore throat, 3rd ed. Clinical practice guidelines 2014. Available from: https:\/\/www.medfromtheshed.com.au\/uploads\/6\/7\/6\/2\/67622653\/gl2014_021.pdf"},{"key":"1901_CR48","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1038\/sj.clpt.1996.83","volume":"59","author":"BP Schachtel","year":"1996","unstructured":"Schachtel BP, Paggiarino DA. A randomized, double-blind, placebo-controlled model demonstrating the topical effect of Benzydamine in children with sore throat. Clin Pharmacol Ther. 1996;59:146.","journal-title":"Clin Pharmacol Ther"},{"key":"1901_CR49","unstructured":"Benzydamine in Sore Throat Pain Relief (BePaiR Study) Available from: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04941976. Accessed 1 Mar 2022."},{"key":"1901_CR50","unstructured":"Benzydamine Oromucosal Solution in Oral Mucositis (BOOM) Available from: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT05055726. Accessed 1 Mar 2022."}],"container-title":["BMC Primary Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12875-022-01901-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12875-022-01901-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12875-022-01901-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T13:47:55Z","timestamp":1728481675000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcfampract.biomedcentral.com\/articles\/10.1186\/s12875-022-01901-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,23]]},"references-count":50,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["1901"],"URL":"https:\/\/doi.org\/10.1186\/s12875-022-01901-w","relation":{},"ISSN":["2731-4553"],"issn-type":[{"value":"2731-4553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,23]]},"assertion":[{"value":"28 February 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 November 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 November 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was carried out in accordance with the European Data Protection Rules with informed consent from all participants. According to the article 1, paragraph\u00a01, of the legislative decree n. 211 of 2003 (legislation implementing the European Directive 2001\/20 \/ EC on the application of good clinical practice in the execution of clinical trials of medicinal products for clinical use) no formal ethics approval was needed since no research on human tissue or other biological material was performed.The participants were informed about the use and publication of their anonymized data for this study. Participation in the study was voluntary. Returning the completed questionnaire was interpreted as informed consent to participate in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participants"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Prof. Dr. M\u00f6sges reports personal fees from Angelini Pharma, during the conduct of the study; personal fees from ALK, grants from ASIT biotech, personal fees from allergopharma, personal fees from Allergy Therapeutics, grants and personal fees from Bencard, grants from Leti, grants, personal fees and non-financial support from Lofarma, non-financial support from Roxall, grants and personal fees from Stallergenes, grants from Optima, personal fees from Friulchem, personal fees from Hexal, personal fees from Servier, personal fees from Klosterfrau, non-financial support from Atmos, personal fees from Bayer, non-financial support from Bionorica, personal fees from FAES, personal fees from GSK, personal fees from MSD, personal fees from Johnson&Johnson, personal fees from Meda, personal fees and non-financial support from Novartis, non-financial support from Otonomy, personal fees from Stada, personal fees from UCB, non-financial support from Ferrero, grants from BitopAG, grants from Hulka, personal fees from Nuvo, grants and personal fees from Ursapharm, personal fees from Menarini, personal fees from Mundipharma, personal fees from Pohl-Boskamp, grants from Inmunotek, grants from Cassella-med GmbH & Co. KG, personal fees from Laboratoire de la Mer, personal fees from Sidroga, grants and personal fees from HAL BV, personal fees from Lek, personal fees from PRO-AdWise, outside the submitted work.The other authors have no conflicts of interest to declare.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"296"}}