{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T23:27:05Z","timestamp":1781047625156,"version":"3.54.1"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Special Programme for Research and Training in Tropical Diseases (TDR), sponsored by UNICEF, UNDP, the World Bank, WHO","award":["P22-00736"],"award-info":[{"award-number":["P22-00736"]}]},{"name":"Nagasaki University WISE programs"},{"DOI":"10.13039\/501100013844","name":"Fundaci\u00f3n Mundo Sano","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013844","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Prim. Care"],"DOI":"10.1186\/s12875-024-02683-z","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T12:46:26Z","timestamp":1734612386000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Barriers and facilitators for preventing mother-to-child transmission of Trypanosoma cruzi and hepatitis B in the Gran Chaco region: a qualitative analysis using the consolidated framework for implementation research (CFIR)"],"prefix":"10.1186","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6904-4843","authenticated-orcid":false,"given":"Yoshiko","family":"Takahashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Avila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Correa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0249-6789","authenticated-orcid":false,"given":"Karina","family":"Cardone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1924-9725","authenticated-orcid":false,"given":"Favio","family":"Crudo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5220-1715","authenticated-orcid":false,"given":"Miho","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5910-3379","authenticated-orcid":false,"given":"Hirotsugu","family":"Aiga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9467-1777","authenticated-orcid":false,"given":"Kenji","family":"Hirayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2001-0057","authenticated-orcid":false,"given":"Freddy","family":"Perez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1470-5146","authenticated-orcid":false,"given":"Maria Victoria","family":"Periago","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,19]]},"reference":[{"key":"2683_CR1","unstructured":"World Health Organization. Chagas disease (also known as American trypanosomiasis). [cited 30 May 2024]. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/chagas-disease-(american-trypanosomiasis)."},{"issue":"6","key":"2683_CR2","first-page":"33","volume":"90","author":"World Health Organization","year":"2015","unstructured":"World Health Organization. Chagas disease in Latin America: an epidemiological update based on 2010 estimates. Relev\u00e9 \u00e9pid\u00e9miologique hebdomadaire \/ section d\u2019hygi\u00e8ne Du Secr\u00e9tariat De La Soci\u00e9t\u00e9 Des Nations\u2009=\u2009Weekly epidemiological record\/Health Sect Secretariat Leag Nations. 2015;90(6):33\u201343.","journal-title":"Health Sect Secretariat Leag Nations"},{"key":"2683_CR3","doi-asserted-by":"crossref","unstructured":"Carlier Y, Torrico F. Congenital infection with Trypanosoma cruzi: from mechanisms of transmission to strategies for diagnosis and control. Rev. Soc. Bras. Med. Trop. 2005;2003:767\u201371.","DOI":"10.1590\/S0037-86822003000600024"},{"key":"2683_CR4","unstructured":"Pan American Health Organization. EMTCT Plus: framework for elimination of mother-to-child transmission of HIV, Syphilis, Hepatitis B, and Chagas. Washington, D.C.: PA; 2017 Jul [cited Aug 15 2023]. https:\/\/iris.paho.org\/handle\/10665.2\/34306."},{"key":"2683_CR5","unstructured":"World Health Organization. Guideline for the prevention, care and treatment of persons with chronic hepatitis B infection. 2015;(April):124. [cited 15 Aug 2023]. https:\/\/iris.who.int\/bitstream\/handle\/10665\/154590\/9789241549059_eng.pdf?sequence=1."},{"issue":"1","key":"2683_CR6","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1111\/1471-0528.12396","volume":"121","author":"EJ Howard","year":"2014","unstructured":"Howard EJ, Xiong X, Carlier Y, Sosa-Estani S, Buekens P. Frequency of the congenital transmission of Trypanosoma Cruzi: a systematic review and meta-analysis. BJOG. 2014;121(1):22\u201333.","journal-title":"BJOG"},{"key":"2683_CR7","unstructured":"Pan American Health Organization. New generations free of HIV, Syphilis, Hepatitis B, Chagas Disease in the Americas. EMTCT Plus, and 2018; 2019 - PAHO\/WHO | Pan American Health Organization. 2019. 1\u201354 p. [cited 20 July 2024]. https:\/\/www.paho.org\/en\/documents\/new-generations-free-hiv-syphilis-hepatitis-b-and-chagas-disease-americas-emtct-plus-2018."},{"issue":"2","key":"2683_CR8","first-page":"81","volume":"79","author":"E Danesi","year":"2019","unstructured":"Danesi E, Olenka Codeb\u00f3 M, Sosa-Estani S. Congenital transmission of Trypanosoma Cruzi. Argentina 2002\u20132014. Med (B Aires). 2019;79(2):81\u20139.","journal-title":"Med (B Aires)"},{"key":"2683_CR9","unstructured":"SENEPA. Memoria institucional de actividades 2019. [cited 20 July 2024]. https:\/\/drive.google.com\/file\/d\/1wZ4t9ZlI6qkQ-fNLkcfqCYEGgCgd8k2z\/view."},{"key":"2683_CR10","unstructured":"UNICEF. State of the World\u2019s Children 2019: Children, food and nutrition. 2019. 4 p. [cited 20 July 2024]. https:\/\/www.unicef.org\/media\/63016\/file\/SOWC-2019.pdf."},{"key":"2683_CR11","unstructured":"Maldonado P, Hohne E; ilustrado por, Naumann M. Atlas del Gran Chaco Americano. 1st ed. Vol. 18, GTZ. Proyecto Manejo Sostenible de los Recursos Naturales. la ciudad de Buenos Aires, en Argentina: Argentina. Ministerio de Educaci\u00f3n, Ciencia y Tecnolog\u00eda; Bolivia. Ministerio de Educaci\u00f3n; Paraguay. Ministerio de Educaci\u00f3n; 2006. 1\u201398 p."},{"issue":"5","key":"2683_CR12","doi-asserted-by":"publisher","first-page":"e2496","DOI":"10.1371\/journal.pntd.0002496","volume":"8","author":"PJ Hotez","year":"2014","unstructured":"Hotez PJ. Ten global hotspots for the neglected Tropical diseases. PLoS Negl Trop Dis. 2014;8(5):e2496.","journal-title":"PLoS Negl Trop Dis"},{"issue":"5","key":"2683_CR13","doi-asserted-by":"publisher","first-page":"e0008078","DOI":"10.1371\/journal.pntd.0008078","volume":"14","author":"F Crudo","year":"2020","unstructured":"Crudo F, Piorno P, Krupitzki H, Guilera A, L\u00f3pez-Albizu C, Danesi E, et al. How to implement the Framework for the elimination of mother-to-child transmission of HIV, Syphilis, Hepatitis B and chagas (EMTCT plus) in a disperse rural population from the gran chaco region: a tailormade program focused on pregnant women. PLoS Negl Trop Dis. 2020;14(5):e0008078.","journal-title":"PLoS Negl Trop Dis"},{"key":"2683_CR14","doi-asserted-by":"crossref","unstructured":"Falleti TG, Cunial SL, Sotelo SB, Crudo F, Davis L. State and NGO coproduction of health care in the Gran Chaco. 2024.","DOI":"10.1016\/j.worlddev.2023.106502"},{"key":"2683_CR15","unstructured":"Creswell JW, Plano Clark VL, Cresswell. and Clark (2011). Key concepts that inform mixed methods designs. Designing and conducting mixed methods research. 2011."},{"issue":"6","key":"2683_CR16","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1093\/cid\/ciq243","volume":"52","author":"EM Gardner","year":"2011","unstructured":"Gardner EM, McLees MP, Steiner JF, del Rio C, Burman WJ, Public Health D, et al. The Spectrum of Engagement in HIV Care and its relevance to test-and-treat strategies for Prevention of HIV infection at the end of 2006, 1.1 million adults and adolescents were living with HIV infection in the United States. Clin Infect Dis. 2011;52(6):793\u2013800.","journal-title":"Clin Infect Dis"},{"key":"2683_CR17","doi-asserted-by":"crossref","unstructured":"Nirel R, Glickman H. Chapter 21 - Sample surveys and censuses. In: Rao CR, editor. Handbook of statistics. Elsevier; 2009. pp. 539\u2013565. https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0169716108000217.","DOI":"10.1016\/S0169-7161(08)00021-7"},{"issue":"1","key":"2683_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1748-5908-4-50","volume":"4","author":"LJ Damschroder","year":"2009","unstructured":"Damschroder LJ, Aron DC, Keith RE, Kirsh SR, Alexander JA, Lowery JC. Fostering implementation of health services research findings into practice: a consolidated framework for advancing implementation science. Implement Sci. 2009;4(1):1\u201315.","journal-title":"Implement Sci"},{"key":"2683_CR19","unstructured":"The Consolidated Framework for Implementation Research. \u2013 Technical assistance for users of the CFIR framework. [cited 10 Nov 2024]. https:\/\/cfirguide.org\/."},{"key":"2683_CR20","unstructured":"Pan American Health Organization. Guidelines for the diagnosis and treatment of Chagas disease. 2019. [cited 14 Jul 2024]. http:\/\/iris.paho.org\/xmlui\/handle\/10665.2\/49653."},{"key":"2683_CR21","unstructured":"Observatorio Federal de Recursos Humanos en Salud. Fuerza de trabajo en el sector salud en Argentina 2020. [cited 2024 Jul 14]. https:\/\/www.argentina.gob.ar\/sites\/default\/files\/informe_fdt_datos2019_vf-1.pdf."},{"issue":"3","key":"2683_CR22","first-page":"216","volume":"20","author":"M Sanmartino","year":"2009","unstructured":"Sanmartino M. Tener Chagas en contexto urbano: concepciones de varones residentes en la regi\u00f3n de la plata (Argentina). Revista Biom\u00e9dica. 2009;20(3):216\u201327.","journal-title":"Revista Biom\u00e9dica"},{"key":"2683_CR23","doi-asserted-by":"crossref","unstructured":"Cevallos AM, Hern\u00e1ndez R. Chagas\u2019 disease: pregnancy and congenital transmission. Vol. 2014, BioMed Research International. Hindawi Publishing Corporation; 2014.","DOI":"10.1155\/2014\/401864"},{"key":"2683_CR24","doi-asserted-by":"crossref","unstructured":"Blasco-Hern\u00e1ndez T, Garc\u00eda-San Miguel L, Navaza B, rbara, Navarro M, Benito A. Knowledge and experiences of Chagas disease in Bolivian women living in Spain: a qualitative study. Glob Health Action 2016;9(1).","DOI":"10.3402\/gha.v9.30201"},{"issue":"1","key":"2683_CR25","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1186\/s13071-019-3546-0","volume":"12","author":"A Salm","year":"2019","unstructured":"Salm A, Gertsch J. Cultural perception of triatomine bugs and Chagas disease in Bolivia: a cross-sectional field study. Parasit Vectors. 2019;12(1):291.","journal-title":"Parasit Vectors"},{"key":"2683_CR26","doi-asserted-by":"crossref","unstructured":"Ventura-Garcia L, Roura M, Pell C, Posada E, Gasc\u00f3n J, Aldasoro E et al. Socio-Cultural aspects of chagas disease: a systematic review of qualitative research. PLoS Negl Trop Dis. 2013;7(9):e2410. https:\/\/journals.plos.org\/plosntds\/article?id=10.1371\/journal.pntd.0002410.","DOI":"10.1371\/journal.pntd.0002410"},{"key":"2683_CR27","doi-asserted-by":"publisher","unstructured":"Parisi S, Navarro M, Du Plessis JD, Shock JP, Apodaca Michel B, Lucuy Espinoza M et al. We have already heard that the treatment doesn\u2019t do anything, so why should we take it? A mixed method perspective on Chagas disease knowledge, attitudes, prevention, and treatment behaviour in the Bolivian Chaco. PLoS Negl Trop Dis. 2020;14(10):e0008752. https:\/\/doi.org\/10.1371\/journal.pntd.0008752.","DOI":"10.1371\/journal.pntd.0008752"},{"key":"2683_CR28","doi-asserted-by":"crossref","unstructured":"Gonzaga BM, de Ferreira S, Coelho RR, Carvalho LL, Garzoni ACC, Araujo-Jorge LR. TC. Clinical trials for Chagas disease: etiological and pathophysiological treatment. Front Microbiol. 2023 [cited 30 May 2024]. Available from: \/pmc\/articles\/PMC10768561\/.","DOI":"10.3389\/fmicb.2023.1295017"},{"key":"2683_CR29","doi-asserted-by":"crossref","unstructured":"Silvestre De Sousa A, Vermeij D, Ramos AN, Luquetti AO. Chagas disease. The Lancet [Internet]. 2024;403:203\u201318. https:\/\/doi.org\/10.1016\/S0140-6736(23)01787-7.","DOI":"10.1016\/S0140-6736(23)01787-7"},{"key":"2683_CR30","unstructured":"Lorenzetti MI. Experiencias de sufrimiento, memorias y salud en las comunidades wich\u00ed de Tartagal. Cuadernos de antropolog\u00eda social. 2013 [cited 14 Jul 2024];(38):131\u2013151. http:\/\/www.scielo.org.ar\/scielo.php?script=sci_arttext%26pid=S1850-275X2013000200006%26lng=es%26nrm=iso%26tlng=es."},{"key":"2683_CR31","unstructured":"Julio Pietrafaccia. La Noche anterior habia llovido. Fundaci\u00f3n Bien Estar. editor. Govierno de la Provincia de Salta, Ministerio de Salud P\u00fablica; 2011."},{"key":"2683_CR32","unstructured":"Argentina recibi\u00f3 reconocimiento internacional. por certificar la eliminaci\u00f3n de la transmisi\u00f3n vectorial de Chagas en Corrientes | Argentina.gob.ar. [cited 1 Jul 2024]. https:\/\/www.argentina.gob.ar\/noticias\/argentina-recibio-reconocimiento-internacional-por-certificar-la-eliminacion-de-la."}],"container-title":["BMC Primary Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12875-024-02683-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12875-024-02683-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12875-024-02683-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T13:03:12Z","timestamp":1734613392000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcfampract.biomedcentral.com\/articles\/10.1186\/s12875-024-02683-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,19]]},"references-count":32,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["2683"],"URL":"https:\/\/doi.org\/10.1186\/s12875-024-02683-z","relation":{},"ISSN":["2731-4553"],"issn-type":[{"value":"2731-4553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,19]]},"assertion":[{"value":"3 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Pan American Health Organization Ethics Review Committee (PAHOERC) (Ref. No. 0430.01), the Research Ethics Committee of the Centro de Educaci\u00f3n M\u00e9dica e Investigaciones Cl\u00ednicas \u201cNorberto Quirno\u201d (CEMIC), Buenos Aires (Argentina) (Ref. No.: 1232), the institutional review board of Nagasaki University, Nagasaki (Japan) (Ref. No. NU_TMGH_2022_219_1), and the Ethical Committee of the Ministerio de Salud P\u00fabica y Bienestar Social of Paraguay (Ref. No. SIMESE N\u00b0 76.3521202). For quantitative strand, the opt-out was posted on the bulletin board of the health centers. Regarding the qualitative strand, all eligible participants who provided written informed consent were enrolled in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"430"}}