{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T02:48:30Z","timestamp":1769741310322,"version":"3.49.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T00:00:00Z","timestamp":1745539200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T00:00:00Z","timestamp":1745539200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Prim. Care"],"DOI":"10.1186\/s12875-025-02826-w","type":"journal-article","created":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T13:57:12Z","timestamp":1745589432000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Classification rule for ten year MACE Risk in primary care tarragona older adults with type2 diabetes: a CHAID decision-tree analysis"],"prefix":"10.1186","volume":"26","author":[{"given":"D.","family":"Ribas Segu\u00ed","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MJos\u00e9","family":"Forcadell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angel","family":"Vila-C\u00f3rcoles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cinta","family":"de Diego-Cabanes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga","family":"Ochoa-Gondar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco Martin","family":"Lujan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva Satu\u00e9","family":"Gracia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,4,25]]},"reference":[{"key":"2826_CR1","unstructured":"Magliano DJ, Boyko EJ. IDF Diabetes Atlas 10th edition scientific committee . IDF DIABETES ATLAS. 10th ed. Brussels: International Diabetes Federation; 2021."},{"issue":"Supplement 1","key":"2826_CR2","first-page":"S13","volume":"41","author":"American Diabetes Association","year":"2017","unstructured":"American Diabetes Association. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes\u20142018. Diabetes Care. 2017;41(Supplement 1):S13-27.","journal-title":"Diabetes Care"},{"issue":"25","key":"2826_CR3","doi-asserted-by":"publisher","first-page":"2982","DOI":"10.1016\/j.jacc.2020.11.010","volume":"76","author":"GA Roth","year":"2020","unstructured":"Roth GA, Mensah GA, Johnson CO, et al. Global Burden of Cardiovascular Diseases and Risk Factors, 1990\u20132019: Update From the GBD 2019 Study. J Am Coll Cardiol. 2020;76(25):2982\u20133021.","journal-title":"J Am Coll Cardiol"},{"key":"2826_CR4","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1016\/S0140-6736(17)32152-9","volume":"390","author":"M Naghavi","year":"2016","unstructured":"Naghavi M, Abajobir AA, Abbafati C, et al. Global, regional, and national age-sex specific mortality for 264 causes of death, 1980\u20132016: a systematic analysis for the Global Burden of Disease Study. Lancet. 2016;390:1151\u2013210.","journal-title":"Lancet"},{"key":"2826_CR5","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.atherosclerosis.2016.05.037","volume":"252","author":"MF Piepoli","year":"2016","unstructured":"Piepoli MF, Hoes AW, Agewall S, et al. 2016 European Guidelines on cardiovascular disease prevention in clinical practice: The Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and by invited experts) Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR). Atherosclerosis. 2016;252:207\u201374.","journal-title":"Atherosclerosis"},{"key":"2826_CR6","doi-asserted-by":"crossref","unstructured":"Davies MJ, Aroda VR, Collins BS, et al. Management of hyperglycemia in type 2 diabetes, 2022. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of diabetes (EASD). Diabetes Care 2022;45(11):2753\u201386.","DOI":"10.2337\/dci22-0034"},{"issue":"1","key":"2826_CR7","doi-asserted-by":"publisher","first-page":"15238","DOI":"10.1038\/s41598-017-15579-z","volume":"7","author":"EYF Wan","year":"2017","unstructured":"Wan EYF, Fong DYT, Fung CSC, et al. Classification Rule for 5-year Cardiovascular Diseases Risk using decision tree in Primary Care Chinese patients with Type 2 Diabetes Mellitus. Sci Rep. 2017;7(1):15238. https:\/\/doi.org\/10.1038\/s41598-017-15579-z.","journal-title":"Sci Rep"},{"issue":"1","key":"2826_CR8","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1007\/s11357-021-00486-z","volume":"44","author":"JT Neumann","year":"2022","unstructured":"Neumann JT, Thao LTP, Callander E, et al. Cardiovascular risk prediction in healthy older people. GeroScience. 2022;44(1):403\u201313. https:\/\/doi.org\/10.1007\/s11357-021-00486-z.","journal-title":"GeroScience"},{"issue":"25","key":"2826_CR9","doi-asserted-by":"publisher","first-page":"2439","DOI":"10.1093\/eurheartj\/ehab309","volume":"42","author":"SCORE2 working group and ESC Cardiovascular risk collaboration","year":"2021","unstructured":"SCORE2 working group and ESC Cardiovascular risk collaboration. SCORE2 risk prediction algorithms: new models to estimate 10-year risk of cardiovascular disease in Europe. Eur Heart J. 2021;42(25):2439\u201354.","journal-title":"Eur Heart J"},{"key":"2826_CR10","doi-asserted-by":"crossref","unstructured":"Nanna MG, Peterson ED, et al. The accuracy of cardiovascular pooled cohort risk estimates in U.s. older adults. J Gen Intern Med 2020;35(6):1701\u20138.","DOI":"10.1007\/s11606-019-05361-4"},{"key":"2826_CR11","doi-asserted-by":"crossref","unstructured":"SCORE2-OP risk prediction algorithms:estimating incident cardiovascular event risk in older persons in four geographical risk regions. SCORE2-OP working group and ESC Cardiovascular risk collaboration. Eur Heart J. 2021;42:2455\u201367.","DOI":"10.1093\/eurheartj\/ehab312"},{"key":"2826_CR12","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1111\/jch.13617","volume":"21","author":"EF Bussel","year":"2019","unstructured":"Bussel EF, Richard E, Busschers WB, et al. A cardiovascular risk prediction model for older people: Development and validation in a primary care population. J Clin Hypertens. 2019;21:1145\u201352.","journal-title":"J Clin Hypertens"},{"issue":"8","key":"2826_CR13","doi-asserted-by":"publisher","first-page":"1724","DOI":"10.2337\/dc19-1870","volume":"43","author":"KN Griffith","year":"2020","unstructured":"Griffith KN, Prentice JC, Mohr DC, et al. Predicting 5- and 10-year mortality risk in older adults with diabetes. Diabetes Care. 2020;43(8):1724\u201331.","journal-title":"Diabetes Care"},{"issue":"1","key":"2826_CR14","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1186\/s12877-022-02893-z","volume":"22","author":"MA Salinero-Fort","year":"2022","unstructured":"Salinero-Fort MA, Mostaza J, Lahoz C, et al. All-cause mortality and cardiovascular events in a Spanish nonagenarian cohort according to type 2 diabetes mellitus status and established cardiovascular disease. BMC Geriatr. 2022;22(1):224.","journal-title":"BMC Geriatr"},{"issue":"1","key":"2826_CR15","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/1471-2458-10-25","volume":"10","author":"A Vila-Corcoles","year":"2010","unstructured":"Vila-Corcoles A, Hospital-Guardiola I, Ochoa-Gondar O, de Diego C, Salsench E, Raga X, et al. Rationale and design of the CAPAMIS study: Effectiveness of pneumococcal vaccination against community-acquired pneumonia, acute myocardial infarction and stroke. BMC Public Health. 2010;10(1):25.","journal-title":"BMC Public Health"},{"key":"2826_CR16","doi-asserted-by":"publisher","first-page":"2103","DOI":"10.1161\/CIR.0000000000000380","volume":"133","author":"MW Rich","year":"2016","unstructured":"Rich MW, Chyun DA, Skolnick AH, et al. Knowledge Gaps in Cardiovascular Care of the Older Adult Population A Scientific Statement From the American Heart Association, American College of Cardiology, and American Geriatrics Society. Circulation Volume. 2016;133:2103\u201322.","journal-title":"Circulation Volume."},{"issue":"3","key":"2826_CR17","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1161\/HYPERTENSIONAHA.118.11609","volume":"72","author":"JA Lamprea-Montealegre","year":"2018","unstructured":"Lamprea-Montealegre JA, Zelnick LR, Hall YN, et al. Prevalence of hypertension and cardiovascular risk according to Blood Pressure thresholds used for diagnosis. Hypertension. 2018;72(3):602\u20139.","journal-title":"Hypertension"},{"issue":"2","key":"2826_CR18","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1038\/sj.jhh.1000949","volume":"14","author":"WB Kannel","year":"2000","unstructured":"Kannel WB. Fifty years of Framingham Study contributions to understanding hypertension. J Hum Hypertension. 2000;14(2):83\u201390.","journal-title":"J Hum Hypertension"},{"issue":"23","key":"2826_CR19","doi-asserted-by":"publisher","first-page":"2921","DOI":"10.1016\/j.jacc.2020.04.038","volume":"75","author":"C Wang","year":"2020","unstructured":"Wang C, Yuan Y, Zheng M, et al. Association of age of onset of hypertension with cardiovascular diseases and mortality. J Am Coll Cardiol. 2020;75(23):2921\u201330.","journal-title":"J Am Coll Cardiol"},{"issue":"6","key":"2826_CR20","first-page":"737","volume":"8","author":"PW Wilson","year":"1988","unstructured":"Wilson PW, Abbott RD, Castelli WP. High density lipoprotein cholesterol and mortality. The Framingham Heart Study Arteriosclerosis. 1988;8(6):737\u201341.","journal-title":"The Framingham Heart Study Arteriosclerosis"},{"key":"2826_CR21","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1161\/CIRCRESAHA.119.312617","volume":"124","author":"M Ouimet","year":"2019","unstructured":"Ouimet M, Barrett TJ, Fisher EA, et al. HDL and Reverse Cholesterol Transport. Circ Res. 2019;124:1505\u201318.","journal-title":"Circ Res"},{"issue":"6","key":"2826_CR22","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1016\/S0300-8932(04)77146-8","volume":"57","author":"M Tom\u00e1s","year":"2004","unstructured":"Tom\u00e1s M, Latorre G, Sent\u00ed M, et al. The antioxidant function of high density lipoproteins: a new paradigm in atherosclerosis. Rev Esp Cardiol. 2004;57(6):557\u201369.","journal-title":"Rev Esp Cardiol"},{"issue":"3","key":"2826_CR23","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1093\/cvr\/cvu137","volume":"103","author":"M Van der Stoep","year":"2014","unstructured":"Van der Stoep M, Korporaal SJA, Van Eck M. High-density lipoprotein as a modulator of platelet and coagulation responses. Cardiovasc Res. 2014;103(3):362\u201371.","journal-title":"Cardiovasc Res"},{"key":"2826_CR24","doi-asserted-by":"publisher","first-page":"1993","DOI":"10.1001\/jama.2009.1619","volume":"302","author":"D Angelantonio","year":"2009","unstructured":"Angelantonio D, Sarwar E, Perry N, et al. Major lipids, apolipoproteins, and risk of vascular disease. JAMA. 2009;302:1993\u20132000.","journal-title":"JAMA"},{"issue":"2","key":"2826_CR25","doi-asserted-by":"publisher","first-page":"e000519","DOI":"10.1161\/JAHA.113.000519","volume":"3","author":"JT Wilkins","year":"2014","unstructured":"Wilkins JT, Ning H, Stone NJ, et al. Coronary heart disease risks associated with high levels of HDL cholesterol. J Am Heart Assoc. 2014;3(2):e000519.","journal-title":"J Am Heart Assoc"},{"issue":"32","key":"2826_CR26","doi-asserted-by":"publisher","first-page":"2478","DOI":"10.1093\/eurheartj\/ehx163","volume":"38","author":"CM Madsen","year":"2017","unstructured":"Madsen CM, Varbo A, Nordestgaard BG. Extreme high high-density lipoprotein cholesterol is paradoxically associated with high mortality in men and women: two prospective cohort studies. Eur Heart J. 2017;38(32):2478\u201386.","journal-title":"Eur Heart J"},{"issue":"10","key":"2826_CR27","doi-asserted-by":"publisher","first-page":"1784","DOI":"10.2215\/CJN.00730116","volume":"11","author":"B Bowe","year":"2016","unstructured":"Bowe B, Xie Y, Xian H, et al. High density lipoprotein cholesterol and the risk of all-cause mortality among Us veterans. Clin J Am Soc Nephrol. 2016;11(10):1784\u201393.","journal-title":"Clin J Am Soc Nephrol"},{"key":"2826_CR28","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1002\/hed.23058","volume":"35","author":"FX Aviles-Jurado","year":"2013","unstructured":"Aviles-Jurado FX, Leon X. Prognostic factors in head and neck squamous cell carcinoma: comparison of CHAID decision trees Technology and Cox analysis. Head Neck. 2013;35:877\u201383.","journal-title":"Head Neck"},{"issue":"7","key":"2826_CR29","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1016\/S2213-8587(15)00040-6","volume":"3","author":"K Matsushita","year":"2015","unstructured":"Matsushita K, Coresh J, Sang Y, et al. Estimated glomerular filtration rate and albuminuria for prediction of cardiovascular outcomes: a collaborative meta-analysis of individual participant data. Lancet Diabetes Endocrinol. 2015;3(7):514\u201325.","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"2","key":"2826_CR30","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.jdiacomp.2015.10.007","volume":"30","author":"M\u00c1 Salinero-Fort","year":"2016","unstructured":"Salinero-Fort M\u00c1, San Andr\u00e9s-Rebollo FJ, de Burgos-Lunar C, et al. Cardiovascular and all-cause mortality in patients with type 2 diabetes mellitus in the MADIABETES Cohort Study: Association with chronic kidney disease. J Diabetes Complications. 2016;30(2):227\u201336.","journal-title":"J Diabetes Complications"}],"container-title":["BMC Primary Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12875-025-02826-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12875-025-02826-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12875-025-02826-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T13:57:17Z","timestamp":1745589437000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcfampract.biomedcentral.com\/articles\/10.1186\/s12875-025-02826-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,25]]},"references-count":30,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["2826"],"URL":"https:\/\/doi.org\/10.1186\/s12875-025-02826-w","relation":{},"ISSN":["2731-4553"],"issn-type":[{"value":"2731-4553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,25]]},"assertion":[{"value":"24 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All the authors: D Ribas Segu\u00ed, M Jos\u00e9 Forcadell, Angel Vila-C\u00f3rcoles, Cinta de Diego, Olga Ochoa-Gondar, Francisco Martin Lujan and Eva Satu\u00e9 consent to participate in the manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"This study was conducted in accordance with the principles of the Declaration of Helsinki and the guidelines of good clinical practice. Due to the retrospective nature of the study, the Ethics Committee for Clinical Research (CEIC) of the Instituto de Investigaci\u00f3n en Atenci\u00f3n Primaria (IDIAP) Jordi Gol waived the need to obtain informed consent. This study was conducted within the framework of the CAPAMIS project, (Evaluation of the effectiveness of the pneumococcal 23-valent vaccine to prevent pneumonia and acute vascular events in the population over 60 years) project,which was reviewed and approved by the IDIAP Jordi Gol ethics committee in 2009 (file 4R09\/019). The protocol of the project was published in BMC Public Health Journal (https:\/\/doi.org\/10.1186\/1471 -\u20092458 -\u200910 -\u200925). Also received a grant from the\"Instituto de Salud Carlos III\"(file PI09\/0043) whose budget has already been exhausted.\u00a0The project included a follow-up of the cohort with the update of monitoring variables and study events. This information was provided to the research team in pseudonym by a member of the institutional Information and Communication Technology Unit.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"129"}}