{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T02:12:16Z","timestamp":1769825536482,"version":"3.49.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"vor","delay-in-days":70,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"The Finnish Foundation for General Practice","award":["research grant"],"award-info":[{"award-number":["research grant"]}]},{"name":"Southwest Finland Wellbeing Services County, Turku, Finland","award":["research grant"],"award-info":[{"award-number":["research grant"]}]},{"DOI":"10.13039\/501100009094","name":"Turku University Hospital Education and Research Foundation","doi-asserted-by":"crossref","award":["research grant"],"award-info":[{"award-number":["research grant"]}],"id":[{"id":"10.13039\/501100009094","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Prim. Care"],"DOI":"10.1186\/s12875-025-03104-5","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T09:36:15Z","timestamp":1763717775000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Contacts to general practitioners and renewal of antihypertensive medication - a four-year follow-up in primary health care, Turku, Finland"],"prefix":"10.1186","volume":"27","author":[{"given":"Jouni K.","family":"Johansson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e4ivi","family":"Korhonen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,11,21]]},"reference":[{"key":"3104_CR1","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1016\/S0140-6736(21)01330-1","volume":"398","author":"Worldwide trends in","year":"2021","unstructured":"Worldwide trends in. Hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants. Lancet. 2021;398:957\u201380.","journal-title":"Lancet"},{"key":"3104_CR2","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1038\/s41581-019-0244-2","volume":"16","author":"KT Mills","year":"2020","unstructured":"Mills KT, Stefanescu A, He J. The global epidemiology of hypertension. Nat Rev Nephrol. 2020;16:223\u201337.","journal-title":"Nat Rev Nephrol"},{"key":"3104_CR3","unstructured":"Koponen P, Borodulin K, Lundqvist A, S\u00e4\u00e4ksj\u00e4rvi K, Koskinen S et al. Health, functional capacity and welfare in Finland \u2013 FinHealth 2017 study. National Institute for Health and Welfare (THL), Report 4\/2018, 236 pages. Helsinki 2018. ISBN 978-952-343-104-1 (printed), https:\/\/urn.fi\/URN:ISBN:978-952-343-105-8 (online publication)."},{"key":"3104_CR4","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1016\/S0140-6736(20)30752-2","volume":"396","author":"Global burden","year":"2020","unstructured":"Global burden. Of 87 risk factors in 204 countries and territories, 1990\u20132019: a systematic analysis for the global burden of disease study 2019. Lancet. 2020;396:1223\u201349.","journal-title":"Lancet"},{"key":"3104_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ejim.2024.05.033","volume":"126","author":"R Kreutz","year":"2024","unstructured":"Kreutz R, Brunstr\u00f6m M, Burnier M, Grassi G, Januszewicz A, Muiesan ML, et al. 2024 European society of hypertension clinical practice guidelines for the management of arterial hypertension. Eur J Intern Med. 2024;126:1\u201315.","journal-title":"Eur J Intern Med"},{"key":"3104_CR6","doi-asserted-by":"publisher","first-page":"e17825","DOI":"10.1097\/MD.0000000000017825","volume":"98","author":"SJ Kim","year":"2019","unstructured":"Kim SJ, Kwon OD, Han EB, Lee CM, Oh S-W, Joh H-K, et al. Impact of number of medications and age on adherence to antihypertensive medications: A nationwide population-based study. Med (Baltim). 2019;98:e17825.","journal-title":"Med (Baltim)"},{"key":"3104_CR7","doi-asserted-by":"publisher","first-page":"e029862","DOI":"10.1136\/bmjopen-2019-029862","volume":"9","author":"SJ Kim","year":"2019","unstructured":"Kim SJ, Kwon OD, Cho B, Oh S-W, Lee CM, Choi H-C. Effects of combination drugs on antihypertensive medication adherence in a real-world setting: a Korean nationwide study. BMJ Open. 2019;9:e029862.","journal-title":"BMJ Open"},{"key":"3104_CR8","doi-asserted-by":"publisher","first-page":"e026582","DOI":"10.1161\/JAHA.122.026582","volume":"11","author":"EKP Lee","year":"2022","unstructured":"Lee EKP, Poon P, Yip BHK, Bo Y, Zhu M-T, Yu C-P, et al. Global Burden, regional Differences, Trends, and health consequences of medication nonadherence for hypertension during 2010 to 2020: A Meta-Analysis involving 27 million patients. J Am Heart Assoc. 2022;11:e026582.","journal-title":"J Am Heart Assoc"},{"key":"3104_CR9","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1161\/CIRCRESAHA.118.313220","volume":"124","author":"M Burnier","year":"2019","unstructured":"Burnier M, Egan BM. Adherence in hypertension. Circ Res. 2019;124:1124\u201340.","journal-title":"Circ Res"},{"key":"3104_CR10","first-page":"2945","volume":"70","author":"S Kokko","year":"2015","unstructured":"Kokko S, Virta L, Vehko T. The roles and relative contributions of municipal health centres and alternative service providers in the management of type 2 diabetes and hypertension in Finland. Finnish Med J 2015; 70:2945\u20139.","journal-title":"Finnish Med J"},{"key":"3104_CR11","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1111\/j.1545-5300.2001.4010100067.x","volume":"40","author":"D Ryan","year":"2001","unstructured":"Ryan D, Carr A. A study of the differential effects of tomm\u2019s questioning styles on therapeutic alliance. Fam Process. 2001;40:67\u201377.","journal-title":"Fam Process"},{"key":"3104_CR12","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1056\/NEJMra050100","volume":"353","author":"L Osterberg","year":"2005","unstructured":"Osterberg L, Blaschke T. Adherence to medication. N Engl J Med. 2005;353:487\u201397.","journal-title":"N Engl J Med"},{"key":"3104_CR13","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.pec.2008.09.018","volume":"75","author":"A Schoenthaler","year":"2009","unstructured":"Schoenthaler A, Chaplin WF, Allegrante JP, Fernandez S, Diaz-Gloster M, Tobin JN, et al. Provider communication effects medication adherence in hypertensive African Americans. Patient Educ Couns. 2009;75:185\u201391.","journal-title":"Patient Educ Couns"},{"key":"3104_CR14","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.jash.2011.01.001","volume":"5","author":"MN Hill","year":"2011","unstructured":"Hill MN, Miller NH, Degeest S, Materson BJ, Black HR, Izzo JLJ, et al. Adherence and persistence with taking medication to control high blood pressure. J Am Soc Hypertens. 2011;5:56\u201363.","journal-title":"J Am Soc Hypertens"},{"key":"3104_CR15","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.amjopharm.2011.02.004","volume":"9","author":"WF Gellad","year":"2011","unstructured":"Gellad WF, Grenard JL, Marcum ZA. A systematic review of barriers to medication adherence in the elderly: looking beyond cost and regimen complexity. Am J Geriatr Pharmacother. 2011;9:11\u201323.","journal-title":"Am J Geriatr Pharmacother"},{"key":"3104_CR16","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.phrs.2017.08.015","volume":"125","author":"M Burnier","year":"2017","unstructured":"Burnier M. Drug adherence in hypertension. Pharmacol Res. 2017;125:142\u20139.","journal-title":"Pharmacol Res"},{"key":"3104_CR17","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1007\/s10865-010-9304-6","volume":"34","author":"CL Roumie","year":"2011","unstructured":"Roumie CL, Greevy R, Wallston KA, Elasy TA, Kaltenbach L, Kotter K, et al. Patient centered primary care is associated with patient hypertension medication adherence. J Behav Med. 2011;34:244\u201353.","journal-title":"J Behav Med"},{"key":"3104_CR18","unstructured":"Fox J. Applied Regression Analysis and Generalized Linear Models. Third Edition. March 2015, 816 pages. Sage Publications, Inc.. ISBN: 978-145-220-566-3"},{"key":"3104_CR19","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1016\/j.amjmed.2011.12.013","volume":"125","author":"SH Naderi","year":"2012","unstructured":"Naderi SH, Bestwick JP, Wald DS. Adherence to drugs that prevent cardiovascular disease: meta-analysis on 376,162 patients. Am J Med. 2012;125:882\u2013e8871.","journal-title":"Am J Med"},{"key":"3104_CR20","doi-asserted-by":"publisher","first-page":"1598","DOI":"10.1161\/CIRCULATIONAHA.108.830299","volume":"120","author":"G Mazzaglia","year":"2009","unstructured":"Mazzaglia G, Ambrosioni E, Alacqua M, Filippi A, Sessa E, Immordino V, et al. Adherence to antihypertensive medications and cardiovascular morbidity among newly diagnosed hypertensive patients. Circulation. 2009;120:1598\u2013605.","journal-title":"Circulation"},{"key":"3104_CR21","doi-asserted-by":"publisher","first-page":"1955","DOI":"10.1007\/s00228-013-1555-z","volume":"69","author":"M Qvarnstr\u00f6m","year":"2013","unstructured":"Qvarnstr\u00f6m M, Kahan T, Kieler H, Brandt L, Hasselstr\u00f6m J, Bengtsson Bostr\u00f6m K, et al. Persistence to antihypertensive drug treatment in Swedish primary healthcare. Eur J Clin Pharmacol. 2013;69:1955\u201364.","journal-title":"Eur J Clin Pharmacol"},{"key":"3104_CR22","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1080\/08037051.2021.1963209","volume":"30","author":"M Burnier","year":"2021","unstructured":"Burnier M, Prejbisz A, Weber T, Azizi M, Cunha V, Versmissen J, et al. Hypertension healthcare professional beliefs and behaviour regarding patient medication adherence: a survey conducted among European society of hypertension centres of excellence. Blood Press. 2021;30:282\u201390.","journal-title":"Blood Press"},{"key":"3104_CR23","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1186\/s12913-024-12010-y","volume":"24","author":"H R\u00e4tt\u00f6","year":"2024","unstructured":"R\u00e4tt\u00f6 H, Nurminen M, Aaltonen K. Prescribing patterns before the initiation of novel antidiabetic medicines in public, occupational, and private healthcare: a register study reflecting the guidelines of care in type 2 diabetes. BMC Health Serv Res. 2024;24:1553.","journal-title":"BMC Health Serv Res"}],"container-title":["BMC Primary Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12875-025-03104-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12875-025-03104-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12875-025-03104-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T13:36:09Z","timestamp":1769780169000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12875-025-03104-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,21]]},"references-count":23,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["3104"],"URL":"https:\/\/doi.org\/10.1186\/s12875-025-03104-5","relation":{},"ISSN":["2731-4553"],"issn-type":[{"value":"2731-4553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,21]]},"assertion":[{"value":"24 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This register-based study was authorised by the institutional review board of the Hospital District of Southwest Finland and the Turku Municipal Health Care Centre review board. Since routinely recorded administrative health records were used, informed consent was not required, nor were the participants contacted. Legal grounds for data handling are public interest and scientific research (EU General Data Protection Regulation 2016\/679 (GDPR), Article 6(1)(e) and Article 9(2)(j); Data Protection Act, Sects.\u00a04 and 6.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"32"}}