{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T21:39:30Z","timestamp":1788903570464,"version":"build-2803163510"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T00:00:00Z","timestamp":1769817600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"vor","delay-in-days":27,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Prim. Care"],"DOI":"10.1186\/s12875-026-03189-6","type":"journal-article","created":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T10:04:02Z","timestamp":1769853842000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The predictive value of complete blood count and the systemic immune-inflammation index (SII) for diagnosing malignancy in patients undergoing colonoscopy"],"prefix":"10.1186","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-0281-8792","authenticated-orcid":false,"given":"\u0130rem","family":"G\u00dcZELY\u00dcZ BODUR","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7995-0866","authenticated-orcid":false,"given":"Ufuk","family":"\u00dcNL\u00dc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7614-122X","authenticated-orcid":false,"given":"B\u00fclent","family":"KOCA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1681-364X","authenticated-orcid":false,"given":"Abdullah \u00d6zg\u00fcr","family":"YEN\u0130OVA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7389-6811","authenticated-orcid":false,"given":"Re\u015fit Do\u011fan","family":"K\u00d6SEO\u011eLU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,31]]},"reference":[{"key":"3189_CR1","unstructured":"What Is. Colorectal Cancer? | CDC. https:\/\/www.cdc.gov\/cancer\/colorectal\/basic_info\/what-is-colorectal-cancer.html Accessed 12 Dec 2025."},{"key":"3189_CR2","unstructured":"GLOBOCAN. 2022. Global Cancer Observatory. Lyon, France: International Agency for Research on Cancer; 2022 http:\/\/gco.iarc.fr\/ Accessed 12 Dec 2025."},{"key":"3189_CR3","unstructured":"2018 T\u00fcrkiye Cancer Statistics. https:\/\/hsgm.saglik.gov.tr\/tr\/kanser-istatistikleri Accessed 12 Dec 2025."},{"key":"3189_CR4","unstructured":"Cancer. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/cancer Accessed 12 Dec 2025."},{"key":"3189_CR5","doi-asserted-by":"publisher","unstructured":"Feng Z, Lin H, Yang X, et al. Diagnostic value of Inflammation-Related indicators in distinguishing early colon cancer and adenomatous polyps. Cancer Control. 2023;30:10732748231180745. https:\/\/doi.org\/10.1177\/10732748231180745.","DOI":"10.1177\/10732748231180745"},{"key":"3189_CR6","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1093\/carcin\/bgz027","volume":"40","author":"WY Huang","year":"2019","unstructured":"Huang WY, Berndt SI, Shiels MS, et al. Circulating inflammation markers and colorectal adenoma risk. Carcinogenesis. 2019;40:765\u201370.","journal-title":"Carcinogenesis"},{"key":"3189_CR7","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/S0140-6736(00)04046-0","volume":"357","author":"F Balkwill","year":"2001","unstructured":"Balkwill F, Mantovani A. Inflammation and cancer: back to virchow? Lancet. 2001;357:539\u201345.","journal-title":"Lancet"},{"issue":"1","key":"3189_CR8","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3390\/cancers13010003","volume":"13","author":"J Fu","year":"2021","unstructured":"Fu J, Zhu J, Du F et al. (2021). Prognostic Inflammatory Index Based on Preoperative Peripheral Blood for Predicting the Prognosis of Colorectal Cancer Patients. Cancers. 2021;13(1):3.","journal-title":"Cancers"},{"issue":"6","key":"3189_CR9","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1016\/j.cell.2010.01.025","volume":"140","author":"SI Grivennikov","year":"2010","unstructured":"Grivennikov SI, Greten FR, Karin M. Immunity, inflammation, and cancer. Cell. 2010;140(6):883\u201399.","journal-title":"Cell"},{"issue":"2","key":"3189_CR10","doi-asserted-by":"publisher","first-page":"e22228","DOI":"10.1002\/jcla.22228","volume":"32","author":"X Meng","year":"2018","unstructured":"Meng X, Chang Q, Liu Y, et al. Determinant roles of gender and age on SII, PLR, NLR, LMR and MLR and their reference intervals defining in Henan, china: A posteriori and big-data-based. J Clin Lab Anal. 2018;32(2):e22228.","journal-title":"J Clin Lab Anal"},{"key":"3189_CR11","doi-asserted-by":"publisher","first-page":"6036979","DOI":"10.1155\/2019\/6036979","volume":"2019","author":"M Stojkovic Lalosevic","year":"2019","unstructured":"Stojkovic Lalosevic M, Pavlovic Markovic A, Stankovic S, et al. Combined diagnostic efficacy of Neutrophil-to-Lymphocyte ratio (NLR), platelet-to-Lymphocyte ratio (PLR), and mean platelet volume (MPV) as biomarkers of systemic inflammation in the diagnosis of colorectal cancer. Dis Markers. 2019;2019:6036979.","journal-title":"Dis Markers"},{"issue":"10","key":"3189_CR12","first-page":"694","volume":"109","author":"JM Navarro Rodr\u00edguez","year":"2017","unstructured":"Navarro Rodr\u00edguez JM, Gallego Plazas J, Borr\u00e1s Rocher F, et al. Is it possible to predict the presence of colorectal cancer in a blood test? A probabilistic approach method. Rev Esp Enferm Dig. 2017;109(10):694\u2013703.","journal-title":"Rev Esp Enferm Dig"},{"key":"3189_CR13","doi-asserted-by":"publisher","first-page":"107327482312221","DOI":"10.1177\/10732748231222109","volume":"30","author":"H Wang","year":"2023","unstructured":"Wang H, Zhou Z, Li H, et al. Blood biomarkers panels for screening of colorectal cancer and adenoma on a machine Learning-Assisted detection platform. Cancer Control. 2023;30:10732748231222109.","journal-title":"Cancer Control"},{"issue":"19","key":"3189_CR14","first-page":"3613","volume":"19","author":"S Emir","year":"2015","unstructured":"Emir S, Aydin M, Can G, et al. Comparison of colorectal neoplastic polyps and adenocarcinoma with regard to NLR and PLR. Eur Rev Med Pharmacol Sci. 2015;19(19):3613\u20138.","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"3189_CR15","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1016\/j.ccell.2018.03.002","volume":"33","author":"M Haemmerle","year":"2018","unstructured":"Haemmerle M, Stone RL, Menter DG, et al. The platelet lifeline to cancer: challenges and opportunities. Cancer Cell. 2018;33:965\u201383.","journal-title":"Cancer Cell"},{"key":"3189_CR16","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.cca.2019.11.036","volume":"501","author":"Z Hu","year":"2020","unstructured":"Hu Z, Tan S, Chen S, et al. Diagnostic value of hematological parameters platelet to lymphocyte ratio and hemoglobin to platelet ratio in patients with colon cancer. Clin Chim Acta. 2020;501:48\u201352.","journal-title":"Clin Chim Acta"},{"key":"3189_CR17","doi-asserted-by":"publisher","first-page":"107327482210913","DOI":"10.1177\/10732748221091333","volume":"29","author":"L Huang","year":"2022","unstructured":"Huang L, Hu Z, Luo R, et al. Predictive values of the selected inflammatory indexes in colon cancer. Cancer Control. 2022;29:10732748221091333.","journal-title":"Cancer Control"},{"issue":"4","key":"3189_CR18","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1097\/CEJ.0000000000000092","volume":"24","author":"S Kilincalp","year":"2015","unstructured":"Kilincalp S, \u00c7oban \u015e, Akinci H, et al. Neutrophil\/lymphocyte ratio, platelet\/lymphocyte ratio, and mean platelet volume as potential biomarkers for early detection and monitoring of colorectal adenocarcinoma. Eur J Cancer Prev. 2015;24(4):328\u201333.","journal-title":"Eur J Cancer Prev"},{"issue":"2","key":"3189_CR19","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1002\/JLB.4RI0818-311R","volume":"106","author":"CE Olingy","year":"2019","unstructured":"Olingy CE, Dinh HQ, Hedrick CC. Monocyte heterogeneity and functions in cancer. J Leukoc Biol. 2019;106(2):309\u201322.","journal-title":"J Leukoc Biol"},{"key":"3189_CR20","doi-asserted-by":"publisher","first-page":"4889616","DOI":"10.1155\/2022\/4889616","volume":"2022","author":"XC Liu","year":"2022","unstructured":"Liu XC, Dai YL, Huang F, et al. Diagnostic value of carcinoembryonic antigen combined with Multi-Inflammatory cell ratios in colorectal cancer. Dis Markers. 2022;2022:4889616.","journal-title":"Dis Markers"},{"key":"3189_CR21","doi-asserted-by":"publisher","first-page":"e936745","DOI":"10.12659\/MSM.936745","volume":"28","author":"J Huang","year":"2022","unstructured":"Huang J, Xu P, Chen Y. A retrospective study from a single center to identify hematological factors that distinguish between patients with colorectal carcinoma and colorectal adenoma. Med Sci Monit. 2022;28:e936745.","journal-title":"Med Sci Monit"},{"issue":"9","key":"3189_CR22","first-page":"2003","volume":"67","author":"Y Kang","year":"2021","unstructured":"Kang Y, Zhu X, Lin Z, et al. Compare the diagnostic and prognostic value of MLR, NLR and PLR in CRC patients. Clin Lab. 2021;67(9):2003\u20139.","journal-title":"Clin Lab"},{"key":"3189_CR23","doi-asserted-by":"publisher","first-page":"6212","DOI":"10.1158\/1078-0432.CCR-14-0442","volume":"20","author":"B Hu","year":"2014","unstructured":"Hu B, Yang X-R, Xu Y, et al. Systemic immune-inflammation index predicts prognosis of patients after curative resection for hepatocellular carcinoma. Clin Cancer Res. 2014;20:6212\u20136.","journal-title":"Clin Cancer Res"},{"issue":"3","key":"3189_CR24","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1002\/ijc.32303","volume":"146","author":"J Fest","year":"2020","unstructured":"Fest J, Ruiter R, Mulder M, et al. The systemic immune-inflammation index is associated with an increased risk of incident cancer-A population-based cohort study. Int J Cancer. 2020;146(3):692\u20138. https:\/\/doi.org\/10.1002\/ijc.32303.","journal-title":"Int J Cancer"},{"key":"3189_CR25","doi-asserted-by":"publisher","first-page":"843074","DOI":"10.3389\/fmed.2022.843074","volume":"9","author":"M Hernandez-Ainsa","year":"2022","unstructured":"Hernandez-Ainsa M, Velamazan R, Lanas A, et al. Blood-Cell-Based inflammatory markers as a useful tool for early diagnosis in colorectal cancer. Front Med (Lausanne). 2022;9:843074.","journal-title":"Front Med (Lausanne)"},{"issue":"5","key":"3189_CR26","doi-asserted-by":"publisher","first-page":"e22075","DOI":"10.1002\/jcla.22075","volume":"31","author":"HX Peng","year":"2017","unstructured":"Peng HX, Yang L, He BS, et al. Combination of preoperative NLR, PLR and CEA could increase the diagnostic efficacy for I-III stage CRC. J Clin Lab Anal. 2017;31(5):e22075.","journal-title":"J Clin Lab Anal"}],"container-title":["BMC Primary Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12875-026-03189-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12875-026-03189-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12875-026-03189-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T10:17:26Z","timestamp":1772187446000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12875-026-03189-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,31]]},"references-count":26,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["3189"],"URL":"https:\/\/doi.org\/10.1186\/s12875-026-03189-6","relation":{},"ISSN":["2731-4553"],"issn-type":[{"value":"2731-4553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,31]]},"assertion":[{"value":"14 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Clinical Research Ethics Committee of Tokat Gaziosmanpa\u015fa University Health Research and Practice Center (Approval No: 23-KAEK-239, dated 12 October 2023). The study was conducted in accordance with the ethical principles of the Declaration of Helsinki. Written informed consent was obtained from all participants prior to their participation in the study. Institutional permission was obtained prior to data collection.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"80"}}