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Care"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The Check-up 35 has been a key element of primary prevention in German general practice since 1989. However, evidence on its effectiveness in detecting target diseases remains limited. Therefore, we analyzed the detection rates of the target diseases of the Check-up 35 in a large cohort of persons treated in German primary care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In a retrospective cohort study using data from 1,216 German primary care practices (IQVIA\u2122 Disease Analyzer, 2019\u20132023), we compared Check-up 35 participants with non-participants via 1:5 propensity score matching. We analyzed diagnoses of arterial hypertension, diabetes mellitus, dyslipidemia, and chronic kidney disease (CKD) within three months post-check-up versus a random visit in controls. Medication prescriptions following diagnosis served as a secondary outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We compared 51,829 participants with 259,145 matched non-participants. Participation was associated with higher diagnosis rates: hypertension (HR 1.56), diabetes (HR 1.69), dyslipidemia (HR 3.24), and CKD (HR 2.07). The effect was especially pronounced for dyslipidemia in individuals under 40 (HR 5.10). Prescription rates after diagnosis were similar or lower in the Check-up group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Check-up 35 is effective in early detection of key chronic diseases. Broader participation should be encouraged to improve prevention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12875-026-03307-4","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T09:49:19Z","timestamp":1775814559000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effectiveness of check-up 35 for detecting targeted diseases in Germany"],"prefix":"10.1186","volume":"27","author":[{"given":"Andreas","family":"Kommer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Weinmann-Menke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karel","family":"Kostev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Labenz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,10]]},"reference":[{"key":"3307_CR1","unstructured":"OECD\/European Observatory on Health Systems and Policies. 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As patient data was analyzed in aggregated form without any individual data being available, ethical approval and informed consent was waived by the ethics committee of the Landes\u00e4rztekammer Rheinland-Pfalz and also and in the past also by the ethics committee of the medical faculty of the Christian-Albrechts-University of Kiel within another project dealing with the exactly same database (AZ 413\/21). All methods were carried out in accordance with relevant guidelines and regulations.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"all authors agreed on the publication of the manuscript.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Karel Kostev is an employee of IQVIA. IQVIA has no influence on the preparation or subject matter of this manuscript. The other authors have no conflicts of interest regarding this manuscript.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"138"}}