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Written informed consent was obtained from all participants.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All participants provided written consent to their anonymised data being presented in journal publications, case reports and presentations.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"AstraZeneca UK were study sponsor and had input into the study design. The study was conceived and executed independently by UoH and BCU. JD has received a fee for delivering a conference presentation for AstraZenica and honoraria for offering advice independent study design support to Astellas Pharma Inc. GW None to declare. HC received Honoraria from AstraZeneca, Chiesi, Sanofi\/Regeneron and GSK; conference fees from AstraZeneca and Chiesi, Asthma service joint working agreement with AstraZeneca 2024. 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