{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T16:10:22Z","timestamp":1785168622264,"version":"3.55.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,10,16]],"date-time":"2015-10-16T00:00:00Z","timestamp":1444953600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Gastroenterol"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1186\/s12876-015-0372-5","type":"journal-article","created":{"date-parts":[[2015,10,18]],"date-time":"2015-10-18T19:03:32Z","timestamp":1445195012000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Urine neutrophil gelatinase-associated lipocalin: a diagnostic and prognostic marker for acute kidney injury (AKI) in hospitalized cirrhotic patients with AKI-prone conditions"],"prefix":"10.1186","volume":"15","author":[{"given":"Sombat","family":"Treeprasertsuk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amornpun","family":"Wongkarnjana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veeravich","family":"Jaruvongvanich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sasipim","family":"Sallapant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khajohn","family":"Tiranathanagul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piyawat","family":"Komolmit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pisit","family":"Tangkijvanich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,10,16]]},"reference":[{"issue":"6","key":"372_CR1","doi-asserted-by":"publisher","first-page":"2064","DOI":"10.1002\/hep.22605","volume":"48","author":"G Garcia-Tsao","year":"2008","unstructured":"Garcia-Tsao G, Parikh CR, Viola A. Acute kidney injury in cirrhosis. Hepatology. 2008;48(6):2064\u201377. PubMed Epub 2008\/11\/13. eng.","journal-title":"Hepatology"},{"issue":"12","key":"372_CR2","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1007\/s00134-005-2842-7","volume":"31","author":"D Cheyron du","year":"2005","unstructured":"du Cheyron D, Bouchet B, Parienti JJ, Ramakers M, Charbonneau P. The attributable mortality of acute renal failure in critically ill patients with liver cirrhosis. Intensive Care Med. 2005;31(12):1693\u20139. PubMed Epub 2005\/10\/26.","journal-title":"Intensive Care Med"},{"issue":"2","key":"372_CR3","doi-asserted-by":"publisher","first-page":"R31","DOI":"10.1186\/cc5713","volume":"11","author":"RL Mehta","year":"2007","unstructured":"Mehta RL, Kellum JA, Shah SV, Molitoris BA, Ronco C, Warnock DG, et al. Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury. Crit Care. 2007;11(2):R31. PubMed Pubmed Central PMCID: 2206446. Epub 2007\/03\/03.","journal-title":"Crit Care"},{"key":"372_CR4","doi-asserted-by":"crossref","unstructured":"Proulx NL, Akbari A, Garg AX, Rostom A, Jaffey J, Clark HD, et al. Measured creatinine clearance from timed urine collections substantially overestimates glomerular filtration rate in patients with liver cirrhosis: a systematic review and individual patient meta-analysis. Nephrol Dial Transplant. 2005;20(8):1617\u201322. PubMed Epub 2005\/04\/28. eng.","DOI":"10.1093\/ndt\/gfh839"},{"issue":"4","key":"372_CR5","doi-asserted-by":"publisher","first-page":"R204","DOI":"10.1186\/cc2872","volume":"8","author":"R Bellomo","year":"2004","unstructured":"Bellomo R, Ronco C, Kellum JA, Mehta RL, Palevsky P. Acute dialysis quality initiative w. Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the second international consensus conference of the Acute Dialysis Quality Initiative (ADQI) group. Crit Care. 2004;8(4):R204\u201312. PubMed Pubmed Central PMCID: 522841. Epub 2004\/08\/18.","journal-title":"Crit Care"},{"issue":"1","key":"372_CR6","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.jhep.2005.10.013","volume":"44","author":"G D\u2019Amico","year":"2006","unstructured":"D\u2019Amico G, Garcia-Tsao G, Pagliaro L. Natural history and prognostic indicators of survival in cirrhosis: a systematic review of 118 studies. J Hepatol. 2006;44(1):217\u201331. PubMed Epub 2005\/11\/22. eng.","journal-title":"J Hepatol"},{"key":"372_CR7","doi-asserted-by":"crossref","unstructured":"Haase M, Bellomo R, Devarajan P, Schlattmann P, Haase-Fielitz A, Group NM-aI, et al. Accuracy of neutrophil gelatinase-associated lipocalin (NGAL) in diagnosis and prognosis in acute kidney injury: a systematic review and meta-analysis. Am J Kidney Dis. 2009;54(6):1012\u201324. PubMed Epub 2009\/10\/24.","DOI":"10.1053\/j.ajkd.2009.07.020"},{"issue":"10","key":"372_CR8","doi-asserted-by":"publisher","first-page":"2534","DOI":"10.1097\/01.ASN.0000088027.54400.C6","volume":"14","author":"J Mishra","year":"2003","unstructured":"Mishra J, Ma Q, Prada A, Mitsnefes M, Zahedi K, Yang J, et al. Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury. J Am Soc Nephrol. 2003;14(10):2534\u201343. PubMed Epub 2003\/09\/30. eng.","journal-title":"J Am Soc Nephrol"},{"issue":"7","key":"372_CR9","doi-asserted-by":"publisher","first-page":"1639","DOI":"10.1111\/j.1600-6143.2006.01352.x","volume":"6","author":"CR Parikh","year":"2006","unstructured":"Parikh CR, Jani A, Mishra J, Ma Q, Kelly C, Barasch J, et al. Urine NGAL and IL-18 are predictive biomarkers for delayed graft function following kidney transplantation. Am J Transplant. 2006;6(7):1639\u201345. PubMed Epub 2006\/07\/11. eng.","journal-title":"Am J Transplant"},{"issue":"3","key":"372_CR10","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1097\/00000542-200609000-00011","volume":"105","author":"G Wagener","year":"2006","unstructured":"Wagener G, Jan M, Kim M, Mori K, Barasch JM, Sladen RN, et al. Association between increases in urinary neutrophil gelatinase-associated lipocalin and acute renal dysfunction after adult cardiac surgery. Anesthesiology. 2006;105(3):485\u201391. PubMed Epub 2006\/08\/26. eng.","journal-title":"Anesthesiology"},{"issue":"3","key":"372_CR11","doi-asserted-by":"publisher","first-page":"665","DOI":"10.2215\/CJN.04010907","volume":"3","author":"M Bennett","year":"2008","unstructured":"Bennett M, Dent CL, Ma Q, Dastrala S, Grenier F, Workman R, et al. Urine NGAL predicts severity of acute kidney injury after cardiac surgery: a prospective study. Clin J Am Soc Nephrol. 2008;3(3):665\u201373. PubMed Pubmed Central PMCID: PMC2386703. Epub 2008\/03\/14. eng.","journal-title":"Clin J Am Soc Nephrol"},{"issue":"11","key":"372_CR12","doi-asserted-by":"publisher","first-page":"810","DOI":"10.7326\/0003-4819-148-11-200806030-00003","volume":"148","author":"TL Nickolas","year":"2008","unstructured":"Nickolas TL, O\u2019Rourke MJ, Yang J, Sise ME, Canetta PA, Barasch N, et al. Sensitivity and specificity of a single emergency department measurement of urinary neutrophil gelatinase-associated lipocalin for diagnosing acute kidney injury. Ann Intern Med. 2008;148(11):810\u20139. PubMed Pubmed Central PMCID: PMC2909852. Epub 2008\/06\/04. eng.","journal-title":"Ann Intern Med"},{"issue":"8","key":"372_CR13","doi-asserted-by":"publisher","first-page":"1823","DOI":"10.1681\/ASN.2008070673","volume":"20","author":"ED Siew","year":"2009","unstructured":"Siew ED, Ware LB, Gebretsadik T, Shintani A, Moons KG, Wickersham N, et al. Urine neutrophil gelatinase-associated lipocalin moderately predicts acute kidney injury in critically ill adults. J Am Soc Nephrol. 2009;20(8):1823\u201332. PubMed Pubmed Central PMCID: PMC2723988. Epub 2009\/07\/25. eng.","journal-title":"J Am Soc Nephrol"},{"issue":"2","key":"372_CR14","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.jhep.2012.03.015","volume":"57","author":"C Fagundes","year":"2012","unstructured":"Fagundes C, Pepin MN, Guevara M, Barreto R, Casals G, Sola E, et al. Urinary neutrophil gelatinase-associated lipocalin as biomarker in the differential diagnosis of impairment of kidney function in cirrhosis. J Hepatol. 2012;57(2):267\u201373. PubMed Epub 2012\/04\/24. eng.","journal-title":"J Hepatol"},{"issue":"9","key":"372_CR15","doi-asserted-by":"publisher","first-page":"2362","DOI":"10.1007\/s10620-012-2180-x","volume":"57","author":"EC Verna","year":"2012","unstructured":"Verna EC, Brown RS, Farrand E, Pichardo EM, Forster CS, Sola-Del Valle DA, et al. Urinary neutrophil gelatinase-associated lipocalin predicts mortality and identifies acute kidney injury in cirrhosis. Dig Dis Sci. 2012;57(9):2362\u201370. PubMed Pubmed Central PMCID: 3979299. Epub 2012\/05\/09.","journal-title":"Dig Dis Sci"},{"key":"372_CR16","doi-asserted-by":"crossref","unstructured":"Ahmed QA, El Sayed FS, Emad H, Mohamed E, Ahmed B, Heba P, et al. Urinary biomarkers of acute kidney injury in patients with liver cirrhosis. Med Arch. 2014;68(2):132\u20136. PubMed Epub 2014\/06\/19.","DOI":"10.5455\/medarh.2014.68.132-136"},{"issue":"10","key":"372_CR17","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1111\/apt.12299","volume":"37","author":"AJ Slack","year":"2013","unstructured":"Slack AJ, McPhail MJ, Ostermann M, Bruce M, Sherwood R, Musto R, et al. Predicting the development of acute kidney injury in liver cirrhosis--an analysis of glomerular filtration rate, proteinuria and kidney injury biomarkers. Aliment Pharmacol Ther. 2013;37(10):989\u201397. PubMed Pubmed Central PMCID: 3761189. Epub 2013\/04\/13.","journal-title":"Aliment Pharmacol Ther"},{"issue":"2","key":"372_CR18","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1002\/hep.26980","volume":"60","author":"JM Belcher","year":"2014","unstructured":"Belcher JM, Sanyal AJ, Peixoto AJ, Perazella MA, Lim J, Thiessen-Philbrook H, et al. Kidney biomarkers and differential diagnosis of patients with cirrhosis and acute kidney injury. Hepatology. 2014;60(2):622\u201332. PubMed Pubmed Central PMCID: 4065642. Epub 2014\/01\/01.","journal-title":"Hepatology"},{"issue":"1","key":"372_CR19","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1111\/liv.12232","volume":"34","author":"G Gungor","year":"2014","unstructured":"Gungor G, Ataseven H, Demir A, Solak Y, Gaipov A, Biyik M, et al. Neutrophil gelatinase-associated lipocalin in prediction of mortality in patients with hepatorenal syndrome: a prospective observational study. Liver Int. 2014;34(1):49\u201357. PubMed Epub 2013\/06\/27.","journal-title":"Liver Int"},{"issue":"7","key":"372_CR20","doi-asserted-by":"publisher","first-page":"2206","DOI":"10.1111\/j.1572-0241.2001.03958.x","volume":"96","author":"H Hampel","year":"2001","unstructured":"Hampel H, Bynum GD, Zamora E, El-Serag HB. Risk factors for the development of renal dysfunction in hospitalized patients with cirrhosis. Am J Gastroenterol. 2001;96(7):2206\u201310. PubMed Epub 2001\/07\/27. eng.","journal-title":"Am J Gastroenterol"},{"issue":"13","key":"372_CR21","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1056\/NEJMra0809139","volume":"361","author":"P Gines","year":"2009","unstructured":"Gines P, Schrier RW. Renal failure in cirrhosis. N Engl J Med. 2009;361(13):1279\u201390. PubMed Epub 2009\/09\/25. eng.","journal-title":"N Engl J Med"},{"issue":"2","key":"372_CR22","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1053\/j.gastro.2010.07.043","volume":"140","author":"M Martin-Llahi","year":"2011","unstructured":"Martin-Llahi M, Guevara M, Torre A, Fagundes C, Restuccia T, Gilabert R, et al. Prognostic importance of the cause of renal failure in patients with cirrhosis. Gastroenterology. 2011;140(2):488\u201396 e4. PubMed Epub 2010\/08\/05. eng.","journal-title":"Gastroenterology"},{"issue":"998","key":"372_CR23","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1136\/gut.2006.107789","volume":"84","author":"F Salerno","year":"2008","unstructured":"Salerno F, Gerbes A, Gines P, Wong F, Arroyo V. Diagnosis, prevention and treatment of hepatorenal syndrome in cirrhosis. Postgrad Med J. 2008;84(998):662\u201370. PubMed Epub 2009\/02\/10.","journal-title":"Postgrad Med J"},{"issue":"4","key":"372_CR24","doi-asserted-by":"publisher","first-page":"2847","DOI":"10.1378\/chest.128.4.2847","volume":"128","author":"N Gill","year":"2005","unstructured":"Gill N, Nally Jr JV, Fatica RA. Renal failure secondary to acute tubular necrosis: epidemiology, diagnosis, and management. Chest. 2005;128(4):2847\u201363. PubMed Epub 2005\/10\/21.","journal-title":"Chest"},{"issue":"12","key":"372_CR25","doi-asserted-by":"publisher","first-page":"2387","DOI":"10.1007\/s00467-009-1279-6","volume":"24","author":"A Yilmaz","year":"2009","unstructured":"Yilmaz A, Sevketoglu E, Gedikbasi A, Karyagar S, Kiyak A, Mulazimoglu M, et al. Early prediction of urinary tract infection with urinary neutrophil gelatinase associated lipocalin. Pediatr Nephrol. 2009;24(12):2387\u201392. PubMed Epub 2009\/08\/04.","journal-title":"Pediatr Nephrol"},{"issue":"6","key":"372_CR26","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1515\/CCLM.2011.156","volume":"49","author":"AS Decavele","year":"2011","unstructured":"Decavele AS, Dhondt L, De Buyzere ML, Delanghe JR. Increased urinary neutrophil gelatinase associated lipocalin in urinary tract infections and leukocyturia. Clin Chem Lab Med. 2011;49(6):999\u20131003. PubMed Epub 2011\/03\/12.","journal-title":"Clin Chem Lab Med"},{"issue":"6","key":"372_CR27","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1186\/cc6162","volume":"11","author":"C Ronco","year":"2007","unstructured":"Ronco C. N-GAL: diagnosing AKI as soon as possible. Crit Care. 2007;11(6):173. PubMed Pubmed Central PMCID: 2246201. Epub 2007\/11\/16.","journal-title":"Crit Care"},{"key":"372_CR28","doi-asserted-by":"crossref","unstructured":"Torregrosa I, Montoliu C, Urios A, Andres-Costa MJ, Gimenez-Garzo C, Juan I, et al. Urinary KIM-1, NGAL and L-FABP for the diagnosis of AKI in patients with acute coronary syndrome or heart failure undergoing coronary angiography. Heart and Vessels. 2014. PubMed Epub 2014\/07\/06.","DOI":"10.1007\/s00380-014-0538-z"},{"key":"372_CR29","doi-asserted-by":"crossref","unstructured":"Taghizadeh-Ghehi M, Sarayani A, Ashouri A, Ataei S, Moslehi A, Hadjibabaie M. Urine neutrophil gelatinase associated lipocalin as an early marker of acute kidney injury in hematopoietic stem cell transplantation patients. Renal Fail. 2015. May 6:1\u20135. PubMed Epub 2015\/05\/07.","DOI":"10.3109\/0886022X.2015.1040699"},{"issue":"1","key":"372_CR30","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1186\/s13054-015-0910-0","volume":"19","author":"AJ Zwiers","year":"2015","unstructured":"Zwiers AJ, de Wildt SN, van Rosmalen J, de Rijke YB, Buijs EA, Tibboel D, et al. Urinary neutrophil gelatinase-associated lipocalin identifies critically ill young children with acute kidney injury following intensive care admission: a prospective cohort study. Crit Care. 2015;19(1):181. PubMed Pubmed Central PMCID: 4422047. Epub 2015\/04\/22.","journal-title":"Crit Care"},{"issue":"9","key":"372_CR31","first-page":"1310","volume":"56","author":"F Salerno","year":"2007","unstructured":"Salerno F, Gerbes A, Gines P, Wong F, Arroyo V. Diagnosis, prevention and treatment of hepatorenal syndrome in cirrhosis. Gut. 2007;56(9):1310\u20138. PubMed Pubmed Central PMCID: PMC1954971. Epub 2007\/03\/29. eng.","journal-title":"Gut"},{"issue":"Suppl 1","key":"372_CR32","doi-asserted-by":"publisher","first-page":"S93","DOI":"10.1016\/j.jhep.2008.01.010","volume":"48","author":"P Angeli","year":"2008","unstructured":"Angeli P, Merkel C. Pathogenesis and management of hepatorenal syndrome in patients with cirrhosis. J Hepatol. 2008;48 Suppl 1:S93\u2013103. PubMed Epub 2008\/02\/29.","journal-title":"J Hepatol"},{"issue":"3","key":"372_CR33","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1093\/ndt\/gfr006","volume":"26","author":"KM Schmidt-Ott","year":"2011","unstructured":"Schmidt-Ott KM. Neutrophil gelatinase-associated lipocalin as a biomarker of acute kidney injury--where do we stand today? Nephrol Dial Transplant. 2011;26(3):762\u20134. PubMed Epub 2011\/02\/12.","journal-title":"Nephrol Dial Transplant"},{"issue":"1","key":"372_CR34","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.jhep.2014.02.023","volume":"61","author":"R Barreto","year":"2014","unstructured":"Barreto R, Elia C, Sola E, Moreira R, Ariza X, Rodriguez E, et al. Urinary neutrophil gelatinase-associated lipocalin predicts kidney outcome and death in patients with cirrhosis and bacterial infections. J Hepatol. 2014;61(1):35\u201342. PubMed Epub 2014\/03\/13.","journal-title":"J Hepatol"},{"issue":"7","key":"372_CR35","doi-asserted-by":"publisher","first-page":"1426","DOI":"10.1053\/j.gastro.2013.02.042","volume":"144","author":"R Moreau","year":"2013","unstructured":"Moreau R, Jalan R, Gines P, Pavesi M, Angeli P, Cordoba J, et al. Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis. Gastroenterology. 2013;144(7):1426\u201337. 37 e1-9. PubMed Epub 2013\/03\/12. eng.","journal-title":"Gastroenterology"},{"issue":"1","key":"372_CR36","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1002\/hep.27795","volume":"62","author":"Y Shi","year":"2015","unstructured":"Shi Y, Yang Y, Hu Y, Wu W, Yang Q, Zheng M, et al. Acute-on-chronic liver failure precipitated by hepatic injury is distinct from that precipitated by extrahepatic insults. Hepatology. 2015;62(1):232\u201342. PubMed Epub 2015\/03\/25. eng.","journal-title":"Hepatology"}],"container-title":["BMC Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-015-0372-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12876-015-0372-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-015-0372-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,31]],"date-time":"2019-08-31T13:31:08Z","timestamp":1567258268000},"score":1,"resource":{"primary":{"URL":"http:\/\/bmcgastroenterol.biomedcentral.com\/articles\/10.1186\/s12876-015-0372-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,16]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["372"],"URL":"https:\/\/doi.org\/10.1186\/s12876-015-0372-5","relation":{},"ISSN":["1471-230X"],"issn-type":[{"value":"1471-230X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,16]]},"article-number":"140"}}