{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T23:19:43Z","timestamp":1775603983527,"version":"3.50.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,11,24]],"date-time":"2015-11-24T00:00:00Z","timestamp":1448323200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Gastroenterol"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1186\/s12876-015-0396-x","type":"journal-article","created":{"date-parts":[[2015,11,24]],"date-time":"2015-11-24T08:42:03Z","timestamp":1448354523000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Prognostic impact of immunohistochemical expression of CK7 and CK20 in curatively resected ampulla of Vater cancer"],"prefix":"10.1186","volume":"15","author":[{"given":"Sung Pil","family":"Yun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyung Il","family":"Seo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,11,24]]},"reference":[{"key":"396_CR1","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1002\/bjs.1800821235","volume":"82","author":"J Roder","year":"1995","unstructured":"Roder J, Schneider P, Stein H, Siewert J. Number of lymph node metastases is significantly associated with survival in patients with radically resected carcinoma of the ampulla of Vater. Br J Surg. 1995;82:1693\u20136.","journal-title":"Br J Surg"},{"key":"396_CR2","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1097\/00000658-199807000-00013","volume":"228","author":"JR Howe","year":"1998","unstructured":"Howe JR, Klimstra DS, Moccia RD, Conlon KC, Brennan MF. Factors predictive of survival in ampullary carcinoma. Ann Surg. 1998;228:87\u201394.","journal-title":"Ann Surg"},{"key":"396_CR3","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1002\/jso.21374","volume":"100","author":"J Albores-Saavedra","year":"2009","unstructured":"Albores-Saavedra J, Schwartz AM, Batich K, Henson DE. Cancers of the ampulla of vater: demographics, morphology, and survival based on 5,625 cases from the SEER program. J Surg Oncol. 2009;100:598\u2013605.","journal-title":"J Surg Oncol"},{"key":"396_CR4","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1097\/00000658-199806000-00005","volume":"227","author":"CJ Yeo","year":"1998","unstructured":"Yeo CJ, Sohn TA, Cameron JL, Hruban RH, Lillemoe KD, Pitt HA. Periampullary adenocarcinoma: analysis of 5-year survivors. Ann Surg. 1998;227:821\u201331.","journal-title":"Ann Surg"},{"key":"396_CR5","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1177\/145749691110000205","volume":"100","author":"SB Choi","year":"2011","unstructured":"Choi SB, Kim WB, Song TJ, Suh SO, Kim YC, Choi SY. Surgical outcomes and prognostic factors for ampulla of Vater cancer. Scand J Surg. 2011;100:92\u20138.","journal-title":"Scand J Surg"},{"key":"396_CR6","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1016\/j.surg.2006.04.006","volume":"140","author":"TS Riall","year":"2006","unstructured":"Riall TS, Cameron JL, Lillemoe KD, Winter JM, Campbell KA, Hruban RH, et al. Resected periampullary adenocarcinoma: 5-year survivors and their 6- to 10-year follow-up. Surgery. 2006;140:764\u201372.","journal-title":"Surgery"},{"key":"396_CR7","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.surg.2013.08.004","volume":"155","author":"HJ Kang","year":"2014","unstructured":"Kang HJ, Eo SH, Kim SC, Park KM, Lee YJ, Lee SK, et al. Increased number of metastatic lymph nodes in adenocarcinoma of the ampulla of Vater as a prognostic factor: a proposal of new nodal classification. Surgery. 2014;155:74\u201384.","journal-title":"Surgery"},{"key":"396_CR8","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1097\/01.pas.0000149708.12335.6a","volume":"29","author":"PG Chu","year":"2005","unstructured":"Chu PG, Schwarz RE, Lau SK, Yen Y, Weiss LM. Immunohistochemical staining in the diagnosis of pancreatobiliary and ampulla of Vater adenocarcinoma: application of CDX2, CK17, MUC1, and MUC2. Am J Surg Pathol. 2005;29:359\u201367.","journal-title":"Am J Surg Pathol"},{"key":"396_CR9","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1002\/jso.22090","volume":"105","author":"WS Kim","year":"2012","unstructured":"Kim WS, Choi DW, Choi SH, Heo JS, You DD, Lee HG. Clinical significance of pathologic subtype in curatively resected ampulla of vater cancer. J Surg Oncol. 2012;105:266\u201372.","journal-title":"J Surg Oncol"},{"key":"396_CR10","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1097\/MPA.0b013e318258fda8","volume":"42","author":"S Morini","year":"2013","unstructured":"Morini S, Perrone G, Borzomati D, Vincenzi B, Rabitti C, Righi D, et al. Carcinoma of the ampulla of Vater: morphological and immunophenotypical classification predicts overall survival. Pancreas. 2013;42:60\u20136.","journal-title":"Pancreas"},{"key":"396_CR11","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.jamcollsurg.2008.01.028","volume":"207","author":"JT Carter","year":"2008","unstructured":"Carter JT, Grenert JP, Rubenstein L, Stewart L, Way LW. Tumors of the ampulla of vater: histopathologic classification and predictors of survival. J Am Coll Surg. 2008;207:210\u20138.","journal-title":"J Am Coll Surg"},{"key":"396_CR12","volume-title":"Atlas of tumor pathology. Tumors of the gallbladder, extrahepatic bile ducts, and ampulla of Vater","author":"J Albores-Saavedra","year":"2000","unstructured":"Albores-Saavedra J, Henson D, Klimstra D. Atlas of tumor pathology. Tumors of the gallbladder, extrahepatic bile ducts, and ampulla of Vater. Washington, DC: Armed Forces Institute of Pathology; 2000."},{"key":"396_CR13","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1245\/s10434-011-2117-1","volume":"19","author":"M Palta","year":"2012","unstructured":"Palta M, Patel P, Broadwater G, Willett C, Pepek J, Tyler D, et al. Carcinoma of the ampulla of Vater: patterns of failure following resection and benefit of chemoradiotherapy. Ann Surg Oncol. 2012;19:1535\u201340.","journal-title":"Ann Surg Oncol"},{"key":"396_CR14","doi-asserted-by":"publisher","first-page":"1820","DOI":"10.1245\/s10434-008-9886-1","volume":"15","author":"JB O'Connell","year":"2008","unstructured":"O'Connell JB, Maggard MA, Manunga Jr J, Tomlinson JS, Reber HA, Ko CY, et al. Survival after resection of ampullary carcinoma: a national population-based study. Ann Surg Oncol. 2008;15:1820\u20137.","journal-title":"Ann Surg Oncol"},{"key":"396_CR15","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/s00268-006-0213-3","volume":"31","author":"QL Qiao","year":"2007","unstructured":"Qiao QL, Zhao YG, Ye ML, Yang YM, Zhao JX, Huang YT, et al. Carcinoma of the ampulla of Vater: factors influencing long-term survival of 127 patients with resection. World J Surg. 2007;31:137\u201343.","journal-title":"World J Surg"},{"key":"396_CR16","doi-asserted-by":"publisher","first-page":"2281","DOI":"10.1007\/s10620-007-0117-6","volume":"53","author":"T Sudo","year":"2008","unstructured":"Sudo T, Murakami Y, Uemura K, Hayashidani Y, Hashimoto Y, Ohge H, et al. Prognostic impact of perineural invasion following pancreatoduodenectomy with lymphadenectomy for ampullary carcinoma. Dig Dis Sci. 2008;53:2281\u20136.","journal-title":"Dig Dis Sci"},{"key":"396_CR17","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1007\/s00534-006-1113-5","volume":"13","author":"T Moriya","year":"2006","unstructured":"Moriya T, Kimura W, Hirai I, Mizutani M, Ma J, Kamiga M, et al. Nodal involvement as an indicator of postoperative liver metastasis in carcinoma of the papilla of Vater. J Hepatobiliary Pancreat Surg. 2006;13:549\u201355.","journal-title":"J Hepatobiliary Pancreat Surg"},{"key":"396_CR18","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.ejso.2006.10.008","volume":"33","author":"J Sakata","year":"2007","unstructured":"Sakata J, Shirai Y, Wakai T, Yokoyama N, Sakata E, Akazawa K, et al. Number of positive lymph nodes independently affects long-term survival after resection in patients with ampullary carcinoma. Eur J Surg Oncol. 2007;33:346\u201351.","journal-title":"Eur J Surg Oncol"},{"key":"396_CR19","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1002\/jso.20665","volume":"95","author":"JS Park","year":"2007","unstructured":"Park JS, Yoon DS, Kim KS, Choi JS, Lee WJ, Chi HS, et al. Factors influencing recurrence after curative resection for ampulla of Vater carcinoma. J Surg Oncol. 2007;95:286\u201390.","journal-title":"J Surg Oncol"},{"key":"396_CR20","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1001\/archsurg.138.9.941","volume":"138","author":"JP Duffy","year":"2003","unstructured":"Duffy JP, Hines OJ, Liu JH, Ko CY, Cortina G, Isacoff WH, et al. Improved survival for adenocarcinoma of the ampulla of Vater: fifty-five consecutive resections. Arch Surg. 2003;138:941\u201350.","journal-title":"Arch Surg"},{"key":"396_CR21","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1001\/archsurg.140.6.529","volume":"140","author":"KM Brown","year":"2005","unstructured":"Brown KM, Tompkins AJ, Yong S, Aranha GV, Shoup M. Pancreaticoduodenectomy is curative in the majority of patients with node-negative ampullary cancer. Arch Surg. 2005;140:529\u201333.","journal-title":"Arch Surg"},{"key":"396_CR22","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1007\/s002689900108","volume":"20","author":"B Chareton","year":"1996","unstructured":"Chareton B, Coiffic J, Landen S, Bardaxoglou E, Campion J, Launois B. Diagnosis and therapy for ampullary tumors: 63 cases. World J Surg. 1996;20:707\u201312.","journal-title":"World J Surg"},{"key":"396_CR23","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1007\/s00268-004-7709-5","volume":"29","author":"N Yokoyama","year":"2005","unstructured":"Yokoyama N, Shirai Y, Wakai T, Nagakura S, Akazawa K, Hatakeyama K. Jaundice at presentation heralds advanced disease and poor prognosis in patients with ampullary carcinoma. World J Surg. 2005;29:519\u201323.","journal-title":"World J Surg"},{"key":"396_CR24","doi-asserted-by":"publisher","first-page":"3178","DOI":"10.1245\/s10434-008-0099-4","volume":"15","author":"M Falconi","year":"2008","unstructured":"Falconi M, Crippa S, Dominguez I, Barugola G, Capelli P, Marcucci S, et al. Prognostic relevance of lymph node ratio and number of resected nodes after curative resection of ampulla of Vater carcinoma. Ann Surg Oncol. 2008;15:3178\u201386.","journal-title":"Ann Surg Oncol"},{"key":"396_CR25","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1097\/00000658-199705000-00015","volume":"225","author":"MA Talamini","year":"1997","unstructured":"Talamini MA, Moesinger RC, Pitt HA, Sohn TA, Hruban RH, Lillemoe KD, et al. Adenocarcinoma of the ampulla of Vater. A 28-year experience. Ann Surg. 1997;225:590.","journal-title":"Ann Surg"},{"key":"396_CR26","doi-asserted-by":"publisher","first-page":"2056","DOI":"10.1007\/s11605-012-2015-2","volume":"16","author":"CL Roland","year":"2012","unstructured":"Roland CL, Katz MH, Gonzalez GM, Pisters PW, Vauthey JN, Wolff RA, et al. A high positive lymph node ratio is associated with distant recurrence after surgical resection of ampullary carcinoma. J Gastrointest Surg. 2012;16:2056\u201363.","journal-title":"J Gastrointest Surg"},{"key":"396_CR27","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1007\/s11605-009-1080-7","volume":"14","author":"JM Winter","year":"2010","unstructured":"Winter JM, Cameron JL, Olino K, Herman JM, de Jong MC, Hruban RH, et al. Clinicopathologic analysis of ampullary neoplasms in 450 patients: implications for surgical strategy and long-term prognosis. J Gastrointest Surg. 2010;14:379\u201387.","journal-title":"J Gastrointest Surg"},{"key":"396_CR28","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1186\/1471-2407-8-170","volume":"8","author":"A Westgaard","year":"2008","unstructured":"Westgaard A, Tafjord S, Farstad IN, Cvancarova M, Eide TJ, Mathisen O, et al. Pancreatobiliary versus intestinal histologic type of differentiation is an independent prognostic factor in resected periampullary adenocarcinoma. BMC Cancer. 2008;8:170.","journal-title":"BMC Cancer"},{"key":"396_CR29","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1097\/00000478-200407000-00005","volume":"28","author":"H Zhou","year":"2004","unstructured":"Zhou H, Schaefer N, Wolff M, Fischer H-P. Carcinoma of the ampulla of Vater: comparative histologic\/immunohistochemical classification and follow-up. Am J Surg Pathol. 2004;28:875\u201382.","journal-title":"Am J Surg Pathol"},{"key":"396_CR30","first-page":"1641","volume":"54","author":"Y-H Roh","year":"2007","unstructured":"Roh Y-H, Kim Y-H, Lee H-W, Kim S-J, Roh M-S, Jeong J-S, et al. The clinicopathologic and immunohistochemical characteristics of ampulla of Vater carcinoma: the intestinal type is associated with a better prognosis. Hepatogastroenterology. 2007;54:1641\u20134.","journal-title":"Hepatogastroenterology"}],"container-title":["BMC Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-015-0396-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12876-015-0396-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-015-0396-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T00:16:36Z","timestamp":1498263396000},"score":1,"resource":{"primary":{"URL":"http:\/\/bmcgastroenterol.biomedcentral.com\/articles\/10.1186\/s12876-015-0396-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,24]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["396"],"URL":"https:\/\/doi.org\/10.1186\/s12876-015-0396-x","relation":{},"ISSN":["1471-230X"],"issn-type":[{"value":"1471-230X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,24]]},"article-number":"165"}}