{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T02:17:58Z","timestamp":1789006678309,"version":"build-2803163510"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570577"],"award-info":[{"award-number":["81570577"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Gastroenterol"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s12876-017-0629-2","type":"journal-article","created":{"date-parts":[[2017,6,9]],"date-time":"2017-06-09T10:40:21Z","timestamp":1497004821000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":77,"title":["Alteration of gut microbiota in association with cholesterol gallstone formation in mice"],"prefix":"10.1186","volume":"17","author":[{"given":"Qihan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanqi","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haidong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qu","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianquan","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,6,9]]},"reference":[{"key":"629_CR1","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/S0016-5085(99)70456-7","volume":"117","author":"JE Everhart","year":"1999","unstructured":"Everhart JE, Khare M, Hill M, Maurer KR. Prevalence and ethnic differences in gallbladder disease in the United States. Gastroenterology. 1999;117:632\u20139.","journal-title":"Gastroenterology"},{"key":"629_CR2","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1053\/gast.2002.32978","volume":"122","author":"RS Sandler","year":"2002","unstructured":"Sandler RS, Everhart JE, Donowitz M, Adams E, Cronin K, Goodman C, Gemmen E, Shah S, Avdic A, Rubin R. The burden of selected digestive diseases in the United States. Gastroenterology. 2002;122:1500\u201311.","journal-title":"Gastroenterology"},{"key":"629_CR3","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1007\/s11894-005-0051-8","volume":"7","author":"EA Shaffer","year":"2005","unstructured":"Shaffer EA. Epidemiology and risk factors for gallstone disease: has the paradigm changed in the 21st century? Curr Gastroenterol Rep. 2005;7:132\u201340.","journal-title":"Curr Gastroenterol Rep"},{"key":"629_CR4","doi-asserted-by":"crossref","first-page":"14942","DOI":"10.3748\/wjg.v20.i40.14942","volume":"20","author":"L Zhu","year":"2014","unstructured":"Zhu L, Aili A, Zhang C, Saiding A, Abudureyimu K. Prevalence of and risk factors for gallstones in Uighur and Han Chinese. World J Gastroenterol. 2014;20:14942\u20139.","journal-title":"World J Gastroenterol"},{"key":"629_CR5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0889-8553(21)00531-8","volume":"20","author":"AK Diehl","year":"1991","unstructured":"Diehl AK. Epidemiology and natural history of gallstone disease. Gastroenterol Clin N Am. 1991;20:1\u201319.","journal-title":"Gastroenterol Clin N Am"},{"key":"629_CR6","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/S0140-6736(06)69044-2","volume":"368","author":"P Portincasa","year":"2006","unstructured":"Portincasa P, Moschetta A, Palasciano G. Cholesterol gallstone disease. Lancet. 2006;368:230\u20139.","journal-title":"Lancet"},{"key":"629_CR7","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1194\/jlr.M700295-JLR200","volume":"49","author":"ZY Jiang","year":"2008","unstructured":"Jiang ZY, Parini P, Eggertsen G, Davis MA, Hu H, Suo GJ, Zhang SD, Rudel LL, Han TQ, Einarsson C. Increased expression of LXR alpha, ABCG5, ABCG8, and SR-BI in the liver from normolipidemic, nonobese Chinese gallstone patients. J Lipid Res. 2008;49:464\u201372.","journal-title":"J Lipid Res"},{"key":"629_CR8","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1053\/j.gastro.2008.03.011","volume":"134","author":"HH Wang","year":"2008","unstructured":"Wang HH, Portincasa P, Mendezsanchez N, Uribe M, Wang DQH. Effect of Ezetimibe on the Prevention and Dissolution of Cholesterol Gallstones. Gastroenterology. 2008;134:2101\u201310.","journal-title":"Gastroenterology"},{"key":"629_CR9","doi-asserted-by":"crossref","unstructured":"Wang DQ, Cohen DE, Carey MC. Biliary lipids and cholesterol gallstone disease. J Lipid Res. 2009;(50 Suppl):S406\u201311.","DOI":"10.1194\/jlr.R800075-JLR200"},{"key":"629_CR10","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1136\/gut.44.3.435","volume":"44","author":"KJV Erpecum","year":"1999","unstructured":"Erpecum KJV. Gallstones. an intestinal disease? Gut. 1999;44:435\u20138.","journal-title":"Gut"},{"key":"629_CR11","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.cmet.2013.01.003","volume":"17","author":"SI Sayin","year":"2013","unstructured":"Sayin SI, Wahlstr\u00f6m A, Felin J, J\u00e4ntti S, Marschall HU, Bamberg K, Angelin B, Hy\u00f6tyl\u00e4inen T, Ore\u0161i\u010d M, B\u00e4ckhed F. Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist. Cell Metab. 2013;17:225\u201335.","journal-title":"Cell Metab"},{"key":"629_CR12","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.idairyj.2004.08.007","volume":"15","author":"MT Liong","year":"2005","unstructured":"Liong MT, Shah NP. Bile salt deconjugation ability, bile salt hydrolase activity and cholesterol co-precipitation ability of lactobacilli strains. Int Dairy J. 2005;15:391\u20138.","journal-title":"Int Dairy J"},{"key":"629_CR13","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1093\/ajcn\/27.11.1341","volume":"27","author":"T Midtvedt","year":"1974","unstructured":"Midtvedt T. Microbial bile acid transformation. Am J Clin Nutr. 1974;27:1341\u20137.","journal-title":"Am J Clin Nutr"},{"key":"629_CR14","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1194\/jlr.R500013-JLR200","volume":"47","author":"JM Ridlon","year":"2006","unstructured":"Ridlon JM, Kang DJ, Hylemon PB. Bile salt biotransformations by human intestinal bacteria. J Lipid Res. 2006;47:241\u201359.","journal-title":"J Lipid Res"},{"key":"629_CR15","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0022-2275(20)40615-7","volume":"20","author":"EJ Stellwag","year":"1979","unstructured":"Stellwag EJ, Hylemon PB. 7alpha-Dehydroxylation of cholic acid and chenodeoxycholic acid by Clostridium leptum. J Lipid Res. 1979;20:325\u201333.","journal-title":"J Lipid Res"},{"key":"629_CR16","doi-asserted-by":"crossref","unstructured":"Shao D, Wang Y, Huang Q, Shi J, Yang H, Pan Z, Jin M, Zhao H, Xu X. Cholesterol-Lowering Effects and Mechanisms in View of Bile Acid Pathway of Resveratrol and Resveratrol Glucuronides. J Food Sci. 2016.","DOI":"10.1111\/1750-3841.13528"},{"key":"629_CR17","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S0022-2275(20)34961-0","volume":"22","author":"MO Reynier","year":"1981","unstructured":"Reynier MO, Montet JC, Gerolami A, Marteau C, Crotte C, Montet AM, Mathieu S. Comparative effects of cholic, chenodeoxycholic, and ursodeoxycholic acids on micellar solubilization and intestinal absorption of cholesterol. J Lipid Res. 1981;22:467\u201373.","journal-title":"J Lipid Res"},{"key":"629_CR18","unstructured":"Samuelsson B. Bile acids and steroids. 96. On the mechanism of the biological formation of deoxycholic acid. J Biol Chem. 1960;235:361\u201366."},{"key":"629_CR19","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1128\/JB.188.5.1979-1986.2006","volume":"188","author":"P Kurdi","year":"2006","unstructured":"Kurdi P, Kawanishi K, Mizutani K, Yokota A. Mechanism of growth inhibition by free bile acids in lactobacilli and bifidobacteria. J Bacteriol. 2006;188:1979\u201386.","journal-title":"J Bacteriol"},{"key":"629_CR20","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.gendis.2014.08.001","volume":"1","author":"J Sun","year":"2014","unstructured":"Sun J, Chang EB. Exploring gut microbes in human health and disease: Pushing the envelope. Genes Dis. 2014;1:132\u20139.","journal-title":"Genes Dis"},{"key":"629_CR21","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/nrgastro.2012.156","volume":"9","author":"HJ Flint","year":"2012","unstructured":"Flint HJ, Scott KP, Louis P, Duncan SH. The role of the gut microbiota in nutrition and health. Nat Rev Gastroenterol Hepatol. 2012;9:577\u201389.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"629_CR22","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s11154-015-9309-0","volume":"16","author":"N Tai","year":"2015","unstructured":"Tai N, Wong FS, Wen L. The role of gut microbiota in the development of type 1, type 2 diabetes mellitus and obesity. Rev Endocr Metab Disord. 2015;16:55\u201365.","journal-title":"Rev Endocr Metab Disord"},{"key":"629_CR23","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1038\/ismej.2011.11","volume":"5","author":"J Zhou","year":"2011","unstructured":"Zhou J, Wu L, Deng Y, Zhi X, Jiang YH, Tu Q, Xie J, Nostrand JDV, He Z, Yang Y. Reproducibility and quantitation of amplicon sequencing-based detection. Isme J. 2011;5:1303\u201313.","journal-title":"Isme J"},{"key":"629_CR24","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1053\/j.gastro.2005.01.008","volume":"128","author":"KJ Maurer","year":"2005","unstructured":"Maurer KJ, Ihrig MM, Rogers AB, Ng V, Bouchard G, Leonard MR, Carey MC, Fox JG. Identification of cholelithogenic enterohepatic Helicobacter species and their role in murine cholesterol gallstone formation. Gastroenterology. 2005;128:1023\u201333.","journal-title":"Gastroenterology"},{"key":"629_CR25","first-page":"e70657-e70657","volume":"8","author":"J Jacqueline","year":"2013","unstructured":"Jacqueline J, Fremont-Rahl ZG, Umana CT, Whary MT, Taylor NS, Sureshkumar M, Carey MC, Fox JG, Maurer KJ. An Analysis of the Role of the Indigenous Microbiota in Cholesterol Gallstone Pathogenesis. Plos One. 2013;8:e70657-e70657.","journal-title":"Plos One"},{"key":"629_CR26","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3109\/07853899009147233","volume":"22","author":"M F\u00e4rkkil\u00e4","year":"1990","unstructured":"F\u00e4rkkil\u00e4 M, Miettinen TA. Lipid metabolism in bile acid malabsorption. Ann Med. 1990;22:5\u201313.","journal-title":"Ann Med"},{"key":"629_CR27","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1053\/gast.2000.16495","volume":"119","author":"LA Thomas","year":"2000","unstructured":"Thomas LA, Veysey MJ, Bathgate T, King A, French G, Smeeton NC, Murphy GM, Dowling RH. Mechanism for the transit-induced increase in colonic deoxycholic acid formation in cholesterol cholelithiasis \u2606. Gastroenterology. 2000;119:806\u201315.","journal-title":"Gastroenterology"},{"key":"629_CR28","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.femsre.2004.09.003","volume":"29","author":"M Begley","year":"2005","unstructured":"Begley M, Gahan CG, Hill C. The interaction between bacteria and bile. FEMS Microbiol Rev. 2005;29:625\u201351.","journal-title":"FEMS Microbiol Rev"},{"key":"629_CR29","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/hep.1840160114","volume":"16","author":"F Berr","year":"1992","unstructured":"Berr F, Schreiber E, Frick U. Interrelationships of bile acid and phospholipid fatty acid species with cholesterol saturation of duodenal bile in health and gallstone disease. Hepatology. 1992;16:71\u201381.","journal-title":"Hepatology"},{"key":"629_CR30","first-page":"1735","volume":"22","author":"SH Hussaini","year":"1995","unstructured":"Hussaini SH, Pereira SP, Murphy GM, Dowling RH. Deoxycholic acid influences cholesterol solubilization and microcrystal nucleation time in gallbladder bile. Hepatology. 1995;22:1735\u201344.","journal-title":"Hepatology"},{"key":"629_CR31","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1016\/S0016-5085(96)70024-0","volume":"111","author":"F Berr","year":"1996","unstructured":"Berr F, Kullakublick GA, Paumgartner G, M\u00fcnzing W, Hylemon PB. 7 alpha-dehydroxylating bacteria enhance deoxycholic acid input and cholesterol saturation of bile in patients with gallstones. Gastroenterology. 1996;111:1611\u201320.","journal-title":"Gastroenterology"},{"key":"629_CR32","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.3168\/jds.S0022-0302(99)75506-2","volume":"82","author":"H Tanaka","year":"1999","unstructured":"Tanaka H, Doesburg K, Iwasaki T, Mierau I. Screening of lactic acid bacteria for bile salt hydrolase activity. J Dairy Sci. 1999;82:2530\u20135.","journal-title":"J Dairy Sci"},{"key":"629_CR33","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1128\/AEM.59.4.1120-1124.1993","volume":"59","author":"FA Klaver","year":"1993","unstructured":"Klaver FA, Meer RVD. The assumed assimilation of cholesterol by Lactobacilli and Bifidobacterium bifidum is due to their bile salt-deconjugating activity. Appl Environ Microbiol. 1993;59:1120\u20134.","journal-title":"Appl Environ Microbiol"},{"key":"629_CR34","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.5713\/ajas.2004.1741","volume":"17","author":"U Pato","year":"2004","unstructured":"Pato U, Surono IS. Koesnandar, Hosono A: Hypocholesterolemic effect of indigenous dadih lactic acid bacteria by deconjugation of bile salts. Asian Australas J Anim Sci. 2004;17:1741\u20135.","journal-title":"Asian Australas J Anim Sci"},{"key":"629_CR35","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.foodres.2009.02.016","volume":"42","author":"N Sridevi","year":"2009","unstructured":"Sridevi N, Vishwe P, Prabhune A. Hypocholesteremic effect of bile salt hydrolase from Lactobacillus buchneri ATCC 4005. Food Res Int. 2009;42:516\u201320.","journal-title":"Food Res Int"},{"key":"629_CR36","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1271\/bbb.70581","volume":"72","author":"YH Park","year":"2008","unstructured":"Park YH, Kim JG, Shin YW, Kim HS, Kim YJ, Chun T, Kim SH, Whang KY. Effects of Lactobacillus acidophilus 43121 and a mixture of Lactobacillus casei and Bifidobacterium longum on the serum cholesterol level and fecal sterol excretion in hypercholesterolemia-induced pigs. Biosci Biotechnol Biochem. 2008;72:595\u2013600.","journal-title":"Biosci Biotechnol Biochem"},{"key":"629_CR37","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.3168\/jds.2009-2574","volume":"93","author":"HS Lye","year":"2010","unstructured":"Lye HS, Rusul G, Liong MT. Removal of cholesterol by lactobacilli via incorporation and conversion to coprostanol. J Dairy Sci. 2010;93:1383\u201392.","journal-title":"J Dairy Sci"},{"key":"629_CR38","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.idairyj.2009.10.003","volume":"20","author":"L Hueyshi","year":"2010","unstructured":"Hueyshi L, Gulamrusul RA, Mintze L. Mechanisms of cholesterol removal by lactobacilli under conditions that mimic the human gastrointestinal tract. Int Dairy J. 2010;20:169\u201375.","journal-title":"Int Dairy J"},{"key":"629_CR39","doi-asserted-by":"crossref","first-page":"9111","DOI":"10.1007\/s00253-015-6753-4","volume":"99","author":"X Hu","year":"2015","unstructured":"Hu X, Wang T, Liang S, Li W, Wu X, Jin F. Antibiotic-induced imbalances in gut microbiota aggravates cholesterol accumulation and liver injuries in rats fed a high-cholesterol diet. Appl Microbiol Biotechnol. 2015;99:9111\u201322.","journal-title":"Appl Microbiol Biotechnol"},{"key":"629_CR40","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.chom.2008.02.015","volume":"3","author":"PJ Turnbaugh","year":"2008","unstructured":"Turnbaugh PJ, B\u00e4ckhed F, Fulton L, Gordon JI. Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome. Cell Host Microbe. 2008;3:213\u201323.","journal-title":"Cell Host Microbe"},{"key":"629_CR41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1053\/j.gastro.2009.08.042","volume":"137","author":"MA Hildebrandt","year":"2009","unstructured":"Hildebrandt MA, Hoffmann C, Sherrillmix SA, Keilbaugh SA, Hamady M, Chen YY, Knight R, Ahima RS, Bushman F, Wu GD. High-fat diet determines the composition of the murine gut microbiome independently of obesity. Gastroenterology. 2009;137:1\u20132.","journal-title":"Gastroenterology"},{"key":"629_CR42","doi-asserted-by":"crossref","first-page":"6799","DOI":"10.1126\/scitranslmed.3000322","volume":"1","author":"PJ Turnbaugh","year":"2009","unstructured":"Turnbaugh PJ, Ridaura VK, Faith JJ, Rey FE, Knight R, Gordon JI. The effect of diet on the human gut microbiome: a metagenomic analysis in humanized gnotobiotic mice. Sci Transl Med. 2009;1:6799\u2013806.","journal-title":"Sci Transl Med"},{"key":"629_CR43","first-page":"e103398-e103398","volume":"9","author":"BP J\u00f8rgensen","year":"2013","unstructured":"J\u00f8rgensen BP, Hansen JT, Krych L, Larsen C, Klein AB, Nielsen DS, Josefsen K, Hansen AK, S\u00f8rensen DB. A Possible Link between Food and Mood: Dietary Impact on Gut Microbiota and Behavior in BALB\/c Mice. Plos One. 2013;9:e103398-e103398.","journal-title":"Plos One"},{"key":"629_CR44","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1128\/JB.188.5.1979-1986.2006","volume":"188","author":"KK Peter Kurdi","year":"2006","unstructured":"Peter Kurdi KK. Kanako Mizutani, Atsushi Yokota: Mechanism of Growth Inhibition by Free Bile Acids in Lactobacilli and Bifidobacteria. J Bacteriol. 2006;188:1979\u201386.","journal-title":"J Bacteriol"},{"key":"629_CR45","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1053\/j.gastro.2011.07.046","volume":"141","author":"KB Islam","year":"2011","unstructured":"Islam KB, Fukiya S, Hagio M, Fujii N, Ishizuka S, Ooka T, Ogura Y, Hayashi T, Yokota A. Bile acid is a host factor that regulates the composition of the cecal microbiota in rats. Gastroenterology. 2011;141:1773\u201381.","journal-title":"Gastroenterology"},{"key":"629_CR46","doi-asserted-by":"crossref","first-page":"3655","DOI":"10.1128\/AEM.04050-14","volume":"81","author":"J Reunanen","year":"2015","unstructured":"Reunanen J, Kainulainen V, Huuskonen L, Ottman N, Belzer C, Huhtinen H, de Vos WM, Satokari R. Akkermansia muciniphila Adheres to Enterocytes and Strengthens the Integrity of the Epithelial Cell Layer. Appl Environ Microbiol. 2015;81:3655\u201362.","journal-title":"Appl Environ Microbiol"},{"key":"629_CR47","doi-asserted-by":"crossref","first-page":"9066","DOI":"10.1073\/pnas.1219451110","volume":"110","author":"A Everard","year":"2013","unstructured":"Everard A, Belzer C, Geurts L, Ouwerkerk JP, Druart C, Bindels LB, Guiot Y, Derrien M, Muccioli GG, Delzenne NM, et al. Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity. Proc Natl Acad Sci U S A. 2013;110:9066\u201371.","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["BMC Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-017-0629-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T08:08:27Z","timestamp":1659082107000},"score":1,"resource":{"primary":{"URL":"http:\/\/bmcgastroenterol.biomedcentral.com\/articles\/10.1186\/s12876-017-0629-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,9]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["629"],"URL":"https:\/\/doi.org\/10.1186\/s12876-017-0629-2","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.727715020.793550815","asserted-by":"object"}]},"ISSN":["1471-230X"],"issn-type":[{"value":"1471-230X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,9]]},"article-number":"74"}}