{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T13:46:41Z","timestamp":1783777601233,"version":"3.55.0"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"name":"Nordmark Arzneimittel GmbH & Co. KG","award":["NM-Efo-401"],"award-info":[{"award-number":["NM-Efo-401"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Gastroenterol"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s12876-017-0675-9","type":"journal-article","created":{"date-parts":[[2017,11,24]],"date-time":"2017-11-24T22:41:20Z","timestamp":1511563280000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A non-interventional, observational study of a fixed combination of pepsin and amino acid hydrochloride in patients with functional dyspepsia"],"prefix":"10.1186","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8882-9862","authenticated-orcid":false,"given":"Kristin","family":"Forssmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa","family":"Meier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Uehleke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia","family":"Breuer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Stange","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,11,25]]},"reference":[{"key":"675_CR1","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1097\/MCG.0b013e318241b335","volume":"46","author":"P Oustamanolakis","year":"2012","unstructured":"Oustamanolakis P, Tack J. Dyspepsia: organic versus functional. J Clin Gastroenterol. 2012;46:175\u201390.","journal-title":"J Clin Gastroenterol"},{"key":"675_CR2","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1097\/MOG.0b013e32834b7ca8","volume":"27","author":"J Tack","year":"2011","unstructured":"Tack J, Masaoka T, Janssen P. Functional dyspepsia. Curr Opin Gastroenterol. 2011;27:549\u201357.","journal-title":"Curr Opin Gastroenterol"},{"key":"675_CR3","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1111\/j.1572-0241.2005.00225.x","volume":"100","author":"NJ Talley","year":"2005","unstructured":"Talley NJ, Vakil N. Practice parameters Committee of the American College of gastroenterology. Guidelines for management of dyspepsia. Am J Gastroenterol. 2005;100:2324\u201337.","journal-title":"Am J Gastroenterol"},{"key":"675_CR4","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1053\/j.gastro.2016.02.011","volume":"150","author":"V Stanghellini","year":"2016","unstructured":"Stanghellini V, Talley NJ, Chan F, Hasler WL, Malagelada J, et al. Rome IV - Gastroduodenal Disorders. Gastroenterology. 2016;150:1380\u201392.","journal-title":"Gastroenterology"},{"key":"675_CR5","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.3748\/wjg.v12.i17.2661","volume":"12","author":"S Mahadeva","year":"2006","unstructured":"Mahadeva S, Goh K-L. Epidemiology of functional dyspepsia: a global perspective. World J Gastroenterol. 2006;12:2661\u20136.","journal-title":"World J Gastroenterol"},{"key":"675_CR6","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s10620-011-1822-8","volume":"57","author":"RA Brook","year":"2012","unstructured":"Brook RA, Kleinman NL, Choung RS, Smeeding JE, Talley NJ. Excess comorbidity prevalence and cost associated with functional dyspepsia in an employed population. Dig Dis Sci. 2012;57:109\u201318.","journal-title":"Dig Dis Sci"},{"key":"675_CR7","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.cgh.2010.03.003","volume":"8","author":"RA Brook","year":"2010","unstructured":"Brook RA, Kleinman NL, Choung RS, Melkonian AK, Smeeding JE, Talley NJ. Functional dyspepsia impacts absenteeism and direct and indirect costs. Clin Gastroenterol Hepatol. 2010;8:498\u2013503.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"675_CR8","unstructured":"Enzynorm\u00aef: Usage information: Information for users. [German] 2014. http:\/\/www.enzynorm.de\/fileadmin\/user_upload\/enzynorm\/Beipackzettel.pdf . Accessed 25 Oct 2016."},{"key":"675_CR9","unstructured":"Enzynorm\u00aef: What makes it so effective? [German] http:\/\/www.enzynorm.de\/ . Accessed 25 Oct 2016."},{"key":"675_CR10","unstructured":"Nordmark Arzneimittel GmbH & Co. KG. Nordmark - Your partner in biologic drug development and production. 2015. http:\/\/www.nordmark-pharma.de\/ . Accessed 25 Oct 2016."},{"key":"675_CR11","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1080\/00365521.1990.12067107","volume":"25","author":"PM Kleveland","year":"1990","unstructured":"Kleveland PM, Johannessen T, Kristensen P, L\u00f8ge I, Sandbakken P, Dybdahl J, Petersen H. Effect of pancreatic enzymes in non-ulcer dyspepsia. A pilot study. Scand J Gastroenterol. 1990;25:298\u2013301.","journal-title":"Scand J Gastroenterol"},{"issue":"Suppl 2","key":"675_CR12","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1159\/000201098","volume":"54","author":"P Malfertheiner","year":"1993","unstructured":"Malfertheiner P, Dom\u00ednguez-Mu\u00f1oz JE. Effect of exogenous pancreatic enzymes on gastrointestinal and pancreatic hormone release and gastrointestinal motility. Digestion. 1993;54(Suppl 2):15\u201320.","journal-title":"Digestion"},{"key":"675_CR13","first-page":"307","volume":"15","author":"Rome Foundation","year":"2006","unstructured":"Rome Foundation. Guidelines\u2014Rome III diagnostic criteria for functional gastrointestinal disorders. J Gastrointestin Liver Dis. 2006;15:307\u201312.","journal-title":"J Gastrointestin Liver Dis"},{"key":"675_CR14","first-page":"56","volume":"1","author":"DQ Shih","year":"2007","unstructured":"Shih DQ, Kwan LY. All roads lead to Rome: update on Rome III criteria and new treatment options. Gastroenterol Rep. 2007;1:56\u201365.","journal-title":"Gastroenterol Rep"},{"key":"675_CR15","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/j.1365-2036.2005.02572.x","volume":"22","author":"B Adam","year":"2005","unstructured":"Adam B, Liebregts T, Saadat-Gilani K, Vinson B, Holtmann G. Validation of the gastrointestinal symptom score for the assessment of symptoms in patients with functional dyspepsia. Aliment Pharmacol Ther. 2005;22:357\u201363.","journal-title":"Aliment Pharmacol Ther"},{"key":"675_CR16","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1007\/s10354-004-0119-3","volume":"154","author":"G Holtmann","year":"2004","unstructured":"Holtmann G, Adam B, Vinson B. Evidence-based medicine and phytotherapy for functional dyspepsia and irritable bowel syndrome: a systematic analysis of evidence for the herbal preparation Iberogast. Wien Med Wochenschr. 2004;154:528\u201334. [German]","journal-title":"Wien Med Wochenschr"},{"key":"675_CR17","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1046\/j.1365-2036.1999.00445.x","volume":"13","author":"NJ Talley","year":"1999","unstructured":"Talley NJ, Haque M, Wyeth JW, Stace NH, Tytgat GN, et al. Development of a new dyspepsia impact scale: the Nepean dyspepsia index. Aliment Pharmacol Ther. 1999;13:225\u201335.","journal-title":"Aliment Pharmacol Ther"},{"key":"675_CR18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/MEG.0b013e32834bb951","volume":"24","author":"P Enck","year":"2012","unstructured":"Enck P, Horing B, Weimer K, Klosterhalfen S. Placebo responses and placebo effects in functional bowel disorders. Eur J Gastroenterol Hepatol. 2012;24:1\u20138.","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"675_CR19","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1111\/j.1365-2982.2008.01241.x","volume":"21","author":"P Enck","year":"2009","unstructured":"Enck P, Vinson B, Malfertheiner P, Zipfel S, Klosterhalfen S. The placebo response in functional dyspepsia--reanalysis of trial data. Neurogastroenterol Motil. 2009;21:370\u20137.","journal-title":"Neurogastroenterol Motil"}],"container-title":["BMC Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-017-0675-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,6]],"date-time":"2019-10-06T16:36:57Z","timestamp":1570379817000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcgastroenterol.biomedcentral.com\/articles\/10.1186\/s12876-017-0675-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,25]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["675"],"URL":"https:\/\/doi.org\/10.1186\/s12876-017-0675-9","relation":{},"ISSN":["1471-230X"],"issn-type":[{"value":"1471-230X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,25]]},"article-number":"123"}}