{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T09:46:20Z","timestamp":1784799980599,"version":"3.55.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,6,13]],"date-time":"2019-06-13T00:00:00Z","timestamp":1560384000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,6,13]],"date-time":"2019-06-13T00:00:00Z","timestamp":1560384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the National Basic Research Program of China","award":["2015CB554300"],"award-info":[{"award-number":["2015CB554300"]}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81301472"],"award-info":[{"award-number":["81301472"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Gastroenterol"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s12876-019-1003-3","type":"journal-article","created":{"date-parts":[[2019,6,13]],"date-time":"2019-06-13T14:47:14Z","timestamp":1560437234000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The association of hepatitis c virus infection status with serum glucose levels"],"prefix":"10.1186","volume":"19","author":[{"given":"Yinping","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibo","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiumei","family":"Chi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruihong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuzhu","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junqi","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,6,13]]},"reference":[{"issue":"1","key":"1003_CR1","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1056\/NEJM200107053450107","volume":"345","author":"GM Lauer","year":"2001","unstructured":"Lauer GM, Walker BD. Hepatitis C virus infection. N Engl J Med. 2001;345(1):41\u201352.","journal-title":"N Engl J Med"},{"issue":"4","key":"1003_CR2","doi-asserted-by":"publisher","first-page":"293","DOI":"10.5144\/0256-4947.2015.293","volume":"35","author":"S Qing","year":"2015","unstructured":"Qing S, Ji D, Li B, Li F, Wang Y, Niu X, Ling B, Meng Y, Lau G, Chen G. Improvement of glucose and lipid metabolism with pegylated interferon-a plus ribavirin therapy in Chinese patients chronically infected with genotype 1b hepatitis C virus. Ann Saudi Med. 2015;35(4):293\u20137.","journal-title":"Ann Saudi Med"},{"issue":"1","key":"1003_CR3","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1097\/00005792-200001000-00005","volume":"79","author":"P Cacoub","year":"2000","unstructured":"Cacoub P, Renou C, Rosenthal E, Cohen P, Loury I, Loustaud-Ratti V, Yamamoto AM, Camproux AC, Hausfater P, Musset L, et al. Extrahepatic manifestations associated with hepatitis C virus infection. A prospective multicenter study of 321 patients. The GERMIVIC. Groupe d'Etude et de Recherche en Medecine interne et maladies Infectieuses Sur le virus de l'Hepatite C. Medicine (Baltimore). 2000;79(1):47\u201356.","journal-title":"Medicine (Baltimore)"},{"issue":"Suppl 5","key":"1003_CR4","doi-asserted-by":"publisher","first-page":"S165","DOI":"10.1016\/j.dld.2014.10.005","volume":"46","author":"P Cacoub","year":"2014","unstructured":"Cacoub P, Gragnani L, Comarmond C, Zignego AL. Extrahepatic manifestations of chronic hepatitis C virus infection. Dig Liver Dis. 2014;46(Suppl 5):S165\u201373.","journal-title":"Dig Liver Dis"},{"issue":"1","key":"1003_CR5","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.jhep.2004.03.020","volume":"41","author":"R Narita","year":"2004","unstructured":"Narita R, Abe S, Kihara Y, Akiyama T, Tabaru A, Otsuki M. Insulin resistance and insulin secretion in chronic hepatitis C virus infection. J Hepatol. 2004;41(1):132\u20138.","journal-title":"J Hepatol"},{"issue":"2","key":"1003_CR6","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1053\/j.gastro.2007.11.010","volume":"134","author":"R Moucari","year":"2008","unstructured":"Moucari R, Asselah T, Cazals-Hatem D, Voitot H, Boyer N, Ripault MP, Sobesky R, Martinot-Peignoux M, Maylin S, Nicolas-Chanoine MH, et al. Insulin resistance in chronic hepatitis C: association with genotypes 1 and 4, serum HCV RNA level, and liver fibrosis. Gastroenterology. 2008;134(2):416\u201323.","journal-title":"Gastroenterology"},{"issue":"6","key":"1003_CR7","doi-asserted-by":"publisher","first-page":"1384","DOI":"10.1053\/jhep.2003.09012","volume":"38","author":"S Aytug","year":"2003","unstructured":"Aytug S, Reich D, Sapiro LE, Bernstein D, Begum N. Impaired IRS-1\/PI3-kinase signaling in patients with HCV: a mechanism for increased prevalence of type 2 diabetes. Hepatology. 2003;38(6):1384\u201392.","journal-title":"Hepatology"},{"issue":"107\u2013108","key":"1003_CR8","first-page":"875","volume":"58","author":"M Taskoparan","year":"2011","unstructured":"Taskoparan M, Serin E, Gokturk HS, Icer MO, Abaci K, Ozer B, Zumrutdal A, Yilmaz U. Early effect of peginterferon alpha-2b plus ribavirin treatment on blood pressure and insulin resistance in patients with chronic hepatitis C. Hepatogastroenterology. 2011;58(107\u2013108):875\u20139.","journal-title":"Hepatogastroenterology"},{"issue":"2","key":"1003_CR9","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1111\/j.1872-034X.2008.00439.x","volume":"39","author":"S Tada","year":"2009","unstructured":"Tada S, Saito H, Ebinuma H, Ojiro K, Yamagishi Y, Kumagai N, Inagaki Y, Masuda T, Nishida J, Takahashi M, et al. Treatment of hepatitis C virus with peg-interferon and ribavirin combination therapy significantly affects lipid metabolism. Hepatol Res. 2009;39(2):195\u20139.","journal-title":"Hepatol Res"},{"issue":"3","key":"1003_CR10","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1016\/S0168-8278(00)00036-2","volume":"34","author":"L Serfaty","year":"2001","unstructured":"Serfaty L, Andreani T, Giral P, Carbonell N, Chazouilleres O, Poupon R. Hepatitis C virus induced hypobetalipoproteinemia: a possible mechanism for steatosis in chronic hepatitis C. J Hepatol. 2001;34(3):428\u201334.","journal-title":"J Hepatol"},{"issue":"7","key":"1003_CR11","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1111\/jgh.14067","volume":"33","author":"LE Adinolfi","year":"2018","unstructured":"Adinolfi LE, Nevola R, Guerrera B, D'Alterio G, Marrone A, Giordano M, Rinaldi L. Hepatitis C virus clearance by direct-acting antiviral treatments and impact on insulin resistance in chronic hepatitis C patients. J Gastroenterol Hepatol. 2018;33(7):1379\u201382.","journal-title":"J Gastroenterol Hepatol"},{"issue":"2","key":"1003_CR12","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/S1665-2681(19)30780-X","volume":"14","author":"YL Cheng","year":"2015","unstructured":"Cheng YL, Wang YC, Lan KH, Huo TI, Huang YH, Su CW, Lin HC, Lee FY, Wu JC, Lee SD. Anti-hepatitis C virus seropositivity is not associated with metabolic syndrome irrespective of age, gender and fibrosis. Ann Hepatol. 2015;14(2):181\u20139.","journal-title":"Ann Hepatol"},{"key":"1003_CR13","unstructured":"Yinping Li XW, Hongqin X, Ruihong W, Chi X, Gao X, Pan Y, Niu J. The influence of hepatitis C virus infection and its clearance on the serum lipid profile and glucose leve. American Association for the Study of Liver Diseases (AASLD). 2015."},{"issue":"30","key":"1003_CR14","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.4254\/wjh.v8.i30.1269","volume":"8","author":"S Yair-Sabag","year":"2016","unstructured":"Yair-Sabag S, Nussinson E, Ben-Assuli O, Shibli F, Shahbari A, Zelber-Sagi S. Retrospective study of the associations between hepatitis C virus infection and metabolic factors. World J Hepatol. 2016;8(30):1269\u201378.","journal-title":"World J Hepatol"},{"issue":"2","key":"1003_CR15","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1093\/aje\/kwm061","volume":"166","author":"CS Wang","year":"2007","unstructured":"Wang CS, Wang ST, Yao WJ, Chang TT, Chou P. Hepatitis C virus infection and the development of type 2 diabetes in a community-based longitudinal study. Am J Epidemiol. 2007;166(2):196\u2013203.","journal-title":"Am J Epidemiol"},{"issue":"3","key":"1003_CR16","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1111\/j.1365-2036.2011.04716.x","volume":"34","author":"M Eslam","year":"2011","unstructured":"Eslam M, Aparcero R, Kawaguchi T, Del Campo JA, Sata M, Khattab MA, Romero-Gomez M. Meta-analysis: insulin resistance and sustained virological response in hepatitis C. Aliment Pharmacol Ther. 2011;34(3):297\u2013305.","journal-title":"Aliment Pharmacol Ther"},{"issue":"3","key":"1003_CR17","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1053\/j.gastro.2004.12.049","volume":"128","author":"M Romero-Gomez","year":"2005","unstructured":"Romero-Gomez M, Del Mar Viloria M, Andrade RJ, Salmeron J, Diago M, Fernandez-Rodriguez CM, Corpas R, Cruz M, Grande L, Vazquez L, et al. Insulin resistance impairs sustained response rate to peginterferon plus ribavirin in chronic hepatitis C patients. Gastroenterology. 2005;128(3):636\u201341.","journal-title":"Gastroenterology"},{"issue":"1","key":"1003_CR18","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.jhep.2007.07.026","volume":"48","author":"H Poustchi","year":"2008","unstructured":"Poustchi H, Negro F, Hui J, Cua IH, Brandt LR, Kench JG, George J. Insulin resistance and response to therapy in patients infected with chronic hepatitis C virus genotypes 2 and 3. J Hepatol. 2008;48(1):28\u201334.","journal-title":"J Hepatol"},{"issue":"1","key":"1003_CR19","doi-asserted-by":"publisher","first-page":"66","DOI":"10.14218\/JCTH.2015.00051","volume":"4","author":"D Kralj","year":"2016","unstructured":"Kralj D, Virovic Jukic L, Stojsavljevic S, Duvnjak M, Smolic M, Curcic IB. Hepatitis C virus, insulin resistance, and steatosis. J Clin Transl Hepatol. 2016;4(1):66\u201375.","journal-title":"J Clin Transl Hepatol"},{"issue":"3","key":"1003_CR20","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1111\/j.1572-0241.2006.01038.x","volume":"102","author":"T Kawaguchi","year":"2007","unstructured":"Kawaguchi T, Ide T, Taniguchi E, Hirano E, Itou M, Sumie S, Nagao Y, Yanagimoto C, Hanada S, Koga H, et al. Clearance of HCV improves insulin resistance, beta-cell function, and hepatic expression of insulin receptor substrate 1 and 2. Am J Gastroenterol. 2007;102(3):570\u20136.","journal-title":"Am J Gastroenterol"},{"issue":"12","key":"1003_CR21","doi-asserted-by":"crossref","first-page":"2751","DOI":"10.1111\/j.1572-0241.2003.08728.x","volume":"98","author":"H Knobler","year":"2003","unstructured":"Knobler H, Zhornicky T, Sandler A, Haran N, Ashur Y, Schattner A. Tumor necrosis factor-alpha-induced insulin resistance may mediate the hepatitis C virus-diabetes association. Am J Gastroenterol. 2003;98(12):2751\u20136.","journal-title":"Am J Gastroenterol"},{"issue":"2","key":"1003_CR22","doi-asserted-by":"publisher","first-page":"263","DOI":"10.2222\/jsv.65.263","volume":"65","author":"I Shoji","year":"2015","unstructured":"Shoji I, Deng L, Matsui C, Hotta H. Hepatitis C virus-induced glucose metabolic disorder. Uirusu. 2015;65(2):263\u20138.","journal-title":"Uirusu"},{"key":"1003_CR23","doi-asserted-by":"crossref","unstructured":"Carvalho JR, Velosa J, Serejo F. Lipids, glucose and iron metabolic alterations in chronic hepatitis C after viral eradication - comparison of the new direct-acting antiviral agents with the old regimens. Scand J Gastroenterol. 2018:1\u20137.","DOI":"10.1080\/00365521.2018.1473486"},{"issue":"6","key":"1003_CR24","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1111\/j.1478-3231.2009.01993.x","volume":"29","author":"Y Kawaguchi","year":"2009","unstructured":"Kawaguchi Y, Mizuta T, Oza N, Takahashi H, Ario K, Yoshimura T, Eguchi Y, Ozaki I, Hisatomi A, Fujimoto K. Eradication of hepatitis C virus by interferon improves whole-body insulin resistance and hyperinsulinaemia in patients with chronic hepatitis C. Liver Int. 2009;29(6):871\u20137.","journal-title":"Liver Int"},{"issue":"4","key":"1003_CR25","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1034\/j.1600-0676.2003.00841.x","volume":"23","author":"M Furutani","year":"2003","unstructured":"Furutani M, Nakashima T, Sumida Y, Hirohama A, Yoh T, Kakisaka Y, Mitsuyoshi H, Senmaru H, Okanoue T. Insulin resistance\/beta-cell function and serum ferritin level in non-diabetic patients with hepatitis C virus infection. Liver Int. 2003;23(4):294\u20139.","journal-title":"Liver Int"},{"issue":"8","key":"1003_CR26","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1111\/j.1478-3231.2011.02545.x","volume":"31","author":"JF Huang","year":"2011","unstructured":"Huang JF, Dai CY, Yu ML, Huang CF, Huang CI, Yeh ML, Yang JF, Hou NJ, Hsiao PJ, Lin ZY, et al. Pegylated interferon plus ribavirin therapy improves pancreatic beta-cell function in chronic hepatitis C patients. Liver Int. 2011;31(8):1155\u201362.","journal-title":"Liver Int"},{"issue":"6","key":"1003_CR27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0038522","volume":"7","author":"Q Wang","year":"2012","unstructured":"Wang Q, Chen J, Wang Y, Han X, Chen X. Hepatitis C virus induced a novel apoptosis-like death of pancreatic beta cells through a caspase 3-dependent pathway. PLoS One. 2012;7(6):e38522.","journal-title":"PLoS One"},{"issue":"4","key":"1003_CR28","doi-asserted-by":"publisher","first-page":"940","DOI":"10.2337\/diacare.28.4.940","volume":"28","author":"M Masini","year":"2005","unstructured":"Masini M, Campani D, Boggi U, Menicagli M, Funel N, Pollera M, Lupi R, Del Guerra S, Bugliani M, Torri S, et al. Hepatitis C virus infection and human pancreatic beta-cell dysfunction. Diabetes Care. 2005;28(4):940\u20131.","journal-title":"Diabetes Care"},{"issue":"5","key":"1003_CR29","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.2337\/dc05-2509","volume":"29","author":"A Lecube","year":"2006","unstructured":"Lecube A, Hernandez C, Genesca J, Simo R. Proinflammatory cytokines, insulin resistance, and insulin secretion in chronic hepatitis C patients: a case-control study. Diabetes Care. 2006;29(5):1096\u2013101.","journal-title":"Diabetes Care"}],"container-title":["BMC Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-019-1003-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12876-019-1003-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-019-1003-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T18:28:29Z","timestamp":1663698509000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcgastroenterol.biomedcentral.com\/articles\/10.1186\/s12876-019-1003-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,13]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["1003"],"URL":"https:\/\/doi.org\/10.1186\/s12876-019-1003-3","relation":{},"ISSN":["1471-230X"],"issn-type":[{"value":"1471-230X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,13]]},"assertion":[{"value":"21 June 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 May 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 June 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study protocol was approved by the ethics committee of the First Hospital of Jilin University. Written informed consent for all testing was obtained prior to enrollment.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable. No details, images, or videos relating to individual participants are included in the manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"All authors declare no conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"86"}}