{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T03:02:40Z","timestamp":1768964560733,"version":"3.49.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,6,13]],"date-time":"2019-06-13T00:00:00Z","timestamp":1560384000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,6,13]],"date-time":"2019-06-13T00:00:00Z","timestamp":1560384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education","award":["2017R1D1A1B03029050"],"award-info":[{"award-number":["2017R1D1A1B03029050"]}]},{"name":"the Korea Health Technology R&D Project through the Korea Health Industry Development Institute, funded by the Ministry of Health and Welfare, Republic of Korea","award":["HI14C1324"],"award-info":[{"award-number":["HI14C1324"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Gastroenterol"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s12876-019-1007-z","type":"journal-article","created":{"date-parts":[[2019,6,13]],"date-time":"2019-06-13T14:47:14Z","timestamp":1560437234000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Fibrosis-4 index at diagnosis is associated with all-cause mortality in patients with microscopic polyangiitis and granulomatosis with polyangiitis"],"prefix":"10.1186","volume":"19","author":[{"given":"Hee Jin","family":"Park","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun Yong","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Min","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason Jungsik","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-Beom","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8038-3341","authenticated-orcid":false,"given":"Sang-Won","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,6,13]]},"reference":[{"key":"1007_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/art.37715","volume":"65","author":"JC Jennette","year":"2013","unstructured":"Jennette JC, Falk RJ, Bacon PA, Basu N, Cid MC, Ferrario F, et al. 2012 revised international Chapel Hill consensus conference nomenclature of vasculitides. Arthritis Rheum. 2013;65:1\u201311.","journal-title":"Arthritis Rheum"},{"key":"1007_CR2","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1136\/ard.2006.054593","volume":"66","author":"R Watts","year":"2007","unstructured":"Watts R, Lane S, Hanslik T, Hauser T, Hellmich B, Koldingsnes W, et al. Development and validation of a consensus methodology for the classification of the ANCA-associated vasculitides and polyarteritis nodosa for epidemiological studies. Ann Rheum Dis. 2007;66:222\u20137.","journal-title":"Ann Rheum Dis"},{"key":"1007_CR3","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1136\/annrheumdis-2013-203255","volume":"72","author":"A Millet","year":"2013","unstructured":"Millet A, Pederzoli-Ribeil M, Guillevin L, Witko-Sarsat V, Mouthon L. Antineutrophil cytoplasmic antibody-associated vasculitides: is it time to split up the group? Ann Rheum Dis. 2013;72:1273\u20139.","journal-title":"Ann Rheum Dis"},{"key":"1007_CR4","doi-asserted-by":"publisher","first-page":"1566","DOI":"10.1136\/annrheumdis-2016-210942","volume":"76","author":"JA Tan","year":"2017","unstructured":"Tan JA, Dehghan N, Chen W, Xie H, Esdaile JM, Avina-Zubieta JA. Mortality in ANCA-associated vasculitis: ameta-analysis of observational studies. Ann Rheum Dis. 2017;76:1566\u201374.","journal-title":"Ann Rheum Dis"},{"key":"1007_CR5","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1007\/s10157-012-0598-2","volume":"16","author":"K Yamagata","year":"2012","unstructured":"Yamagata K, Usui J, Saito C, Yamaguchi N, Hirayama K, Mase K, et al. ANCA-associated systemic vasculitis in Japan: clinical features and prognostic changes. Clin Exp Nephrol. 2012;16:580\u20138.","journal-title":"Clin Exp Nephrol"},{"issue":"Suppl 111","key":"1007_CR6","first-page":"65","volume":"36","author":"CH Mun","year":"2018","unstructured":"Mun CH, Yoo J, Jung SM, Song JJ, Park YB, Lee SW. The initial predictors of death in 153 patients with ANCA-associated vasculitis in a single Korean Centre. Clin Exp Rheumatol. 2018;36(Suppl 111):65\u201372.","journal-title":"Clin Exp Rheumatol"},{"key":"1007_CR7","doi-asserted-by":"publisher","first-page":"1805","DOI":"10.1007\/s10067-016-3195-z","volume":"35","author":"BM C\u00f3rdova-S\u00e1nchez","year":"2016","unstructured":"C\u00f3rdova-S\u00e1nchez BM, Mej\u00eda-Vilet JM, Morales-Buenrostro LE, Loyola-Rodr\u00edguez G, Uribe-Uribe NO, Correa-Rotter R. Clinical presentation and outcome prediction of clinical, serological, and histopathological classification schemes in ANCA-associated vasculitis with renal involvement. Clin Rheumatol. 2016;35:1805\u201316.","journal-title":"Clin Rheumatol"},{"key":"1007_CR8","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1001\/jama.2013.13805","volume":"310","author":"CJ Murray","year":"2013","unstructured":"Murray CJ, Atkinson C, Bhalla K, Birbeck G, Burstein R, Chou D, et al. The state of US health, 1990-2010: burden of diseases, injuries, and risk factors. JAMA. 2013;310:591\u2013608.","journal-title":"JAMA"},{"key":"1007_CR9","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1002\/hep.21669","volume":"46","author":"A Vallet-Pichard","year":"2007","unstructured":"Vallet-Pichard A, Mallet V, Nalpas B, Verkarre V, Nalpas A, Dhalluin-Venier V, et al. FIB-4: an inexpensive and accurate marker of fibrosis in HCV infection. Comparison with liver biopsy and fibrotest. Hepatology. 2007;46:32\u20136.","journal-title":"Hepatology"},{"key":"1007_CR10","doi-asserted-by":"publisher","first-page":"807","DOI":"10.7326\/0003-4819-158-11-201306040-00005","volume":"158","author":"R Chou","year":"2013","unstructured":"Chou R, Wasson N. Blood tests to diagnose fibrosis or cirrhosis in patients with chronic hepatitis C virus infection: a systematic review. Ann Intern Med. 2013;158:807\u201320.","journal-title":"Ann Intern Med"},{"key":"1007_CR11","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1002\/hep.27654","volume":"61","author":"B Suh","year":"2015","unstructured":"Suh B, Park S, Shin DW, Yun JM, Yang HK, Yu SJ, et al. High liver fibrosis index FIB-4 is highly predictive of hepatocellular carcinoma in chronic hepatitis B carriers. Hepatology. 2015;61:1261\u20138.","journal-title":"Hepatology"},{"key":"1007_CR12","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1007\/s00535-013-0914-y","volume":"49","author":"N Tamaki","year":"2014","unstructured":"Tamaki N, Kurosaki M, Matsuda S, Muraoka M, Yasui Y, Suzuki S, et al. Non-invasive prediction of hepatocellular carcinoma development using serum fibrosis marker in chronic hepatitis C patients. J Gastroenterol. 2014;49:1495\u2013503.","journal-title":"J Gastroenterol"},{"key":"1007_CR13","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1007\/s12072-015-9690-5","volume":"10","author":"HW Xu","year":"2016","unstructured":"Xu HW, Hsu YC, Chang CH, Wei KL, Lin CL. High FIB-4 index as an independent risk factor of prevalent chronic kidney disease in patients with nonalcoholic fatty liver disease. Hepatol Int. 2016;10:340\u20136.","journal-title":"Hepatol Int"},{"key":"1007_CR14","doi-asserted-by":"publisher","DOI":"10.1136\/openhrt-2017-000598","volume":"4","author":"Y Sato","year":"2017","unstructured":"Sato Y, Yoshihisa A, Kanno Y, Watanabe S, Yokokawa T, Abe S, et al. Liver stiffness assessed by Fibrosis-4 index predicts mortality in patients with heart failure. Open Heart. 2017;4:e000598.","journal-title":"Open Heart"},{"key":"1007_CR15","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.1136\/ard.2008.101279","volume":"68","author":"C Mukhtyar","year":"2009","unstructured":"Mukhtyar C, Lee R, Brown D, Carruthers D, Dasgupta B, Dubey S, et al. Modification and validation of the Birmingham Vasculitis activity score (version 3). Ann Rheum Dis. 2009;68:1827\u201332.","journal-title":"Ann Rheum Dis"},{"key":"1007_CR16","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1097\/MD.0b013e318205a4c6","volume":"90","author":"L Guillevin","year":"2011","unstructured":"Guillevin L, Pagnoux C, Seror R, Mahr A, Mouthon L, Le Toumelin P, French Vasculitis Study Group (FVSG). The five-factor score revisited: assessment of prognoses of systemic necrotizing vasculitides based on the French Vasculitis study group (FVSG) cohort. Medicine (Baltimore). 2011;90:19\u201327.","journal-title":"Medicine (Baltimore)"},{"key":"1007_CR17","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1111\/hepr.12405","volume":"45","author":"Y Takahashi","year":"2015","unstructured":"Takahashi Y, Kurosaki M, Tamaki N, Yasui Y, Hosokawa T, Tsuchiya K, et al. Non-alcoholic fatty liver disease fibrosis score and FIB-4 scoring system could identify patients at risk of systemic complications. Hepatol Res. 2015;45:667\u201375.","journal-title":"Hepatol Res"},{"key":"1007_CR18","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.diabres.2017.10.023","volume":"135","author":"CB Giorda","year":"2018","unstructured":"Giorda CB, Forlani G, Manti R, Mazzotti A, De Cosmo S, Rossi MC, et al. Trend over time in hepatic fibrosis score in a cohort of type 2 diabetes patients. Diabetes Res Clin Pract. 2018;135:65\u201372.","journal-title":"Diabetes Res Clin Pract"},{"key":"1007_CR19","first-page":"633","volume":"9","author":"J Guy","year":"2013","unstructured":"Guy J, Peters MG. Liver disease in women: the influence of gender on epidemiology, natural history, and patient outcomes. Gastroenterol Hepatol (N Y). 2013;9:633\u20139.","journal-title":"Gastroenterol Hepatol (N Y)"},{"key":"1007_CR20","doi-asserted-by":"publisher","first-page":"1926","DOI":"10.1111\/jgh.12643","volume":"29","author":"JH Ryoo","year":"2014","unstructured":"Ryoo JH, Suh YJ, Shin HC, Cho YK, Choi JM, Park SK. Clinical association between non-alcoholic fatty liver disease and the development of hypertension. J Gastroenterol Hepatol. 2014;29:1926\u201331.","journal-title":"J Gastroenterol Hepatol"},{"key":"1007_CR21","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1038\/nrrheum.2012.149","volume":"9","author":"EJ Wehrens","year":"2013","unstructured":"Wehrens EJ, Prakken BJ, van Wijk F. T cells out of control--impaired immune regulation in the inflamed joint. Nat Rev Rheumatol. 2013;9:34\u201342.","journal-title":"Nat Rev Rheumatol"},{"key":"1007_CR22","doi-asserted-by":"publisher","first-page":"131737","DOI":"10.1155\/2014\/131737","volume":"2014","author":"N Sampson","year":"2014","unstructured":"Sampson N, Berger P, Zenzmaier C. Redox signaling as a therapeutic target to inhibit myofibroblast activation in degenerative fibrotic disease. Biomed Res Int. 2014;2014:131737.","journal-title":"Biomed Res Int"}],"container-title":["BMC Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-019-1007-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12876-019-1007-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-019-1007-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,11]],"date-time":"2020-06-11T23:19:16Z","timestamp":1591917556000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcgastroenterol.biomedcentral.com\/articles\/10.1186\/s12876-019-1007-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,13]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["1007"],"URL":"https:\/\/doi.org\/10.1186\/s12876-019-1007-z","relation":{},"ISSN":["1471-230X"],"issn-type":[{"value":"1471-230X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,13]]},"assertion":[{"value":"6 August 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 May 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 June 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was approved by the Institutional Review Board of Severance Hospital (4\u20132017-0673), who waived the need for patient written informed consent, as this was a retrospective study.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"90"}}