{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:29:25Z","timestamp":1790818165571,"version":"4.1.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,8,23]],"date-time":"2019-08-23T00:00:00Z","timestamp":1566518400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,8,23]],"date-time":"2019-08-23T00:00:00Z","timestamp":1566518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Gastroenterol"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s12876-019-1074-1","type":"journal-article","created":{"date-parts":[[2019,8,23]],"date-time":"2019-08-23T14:02:41Z","timestamp":1566568961000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["A giant Brunner\u2019s gland hamartoma being treated as a pedunculated polyp: a case report"],"prefix":"10.1186","volume":"19","author":[{"given":"Lizhi","family":"Yi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengyu","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huarong","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,8,23]]},"reference":[{"key":"1074_CR1","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1055\/s-0043-102569","volume":"49","author":"M Ferlitsch","year":"2017","unstructured":"Ferlitsch M, Moss A, Hassan C, et al. Colorectal polypectomy and endoscopic mucosal resection (EMR): European Society of Gastrointestinal Endoscopy (ESGE) clinical guideline. Endoscopy. 2017;49:270\u201397.","journal-title":"Endoscopy."},{"key":"1074_CR2","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1007\/s005950200179","volume":"32","author":"YM Tan","year":"2002","unstructured":"Tan YM, Wong WK. Giant brunneroma as an unusual cause of upper gastrointestinal hemorrhage: report of a case. Surg Today. 2002;32:910\u20132.","journal-title":"Surg Today"},{"key":"1074_CR3","first-page":"6940649","volume":"2017","author":"NC Frenkel","year":"2017","unstructured":"Frenkel NC, Lacl\u00e9 MM, Borel Rinkes IH, Molenaar IQ, Hagendoorn J. A Giant Brunneroma causing gastrointestinal bleeding and severe Anemia requiring transfusion and surgery. Case Rep Surg. 2017;2017:6940649.","journal-title":"Case Rep Surg"},{"issue":"2","key":"1074_CR4","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1159\/000354138","volume":"7","author":"Y Jung","year":"2013","unstructured":"Jung Y, Chung IK, Lee TH, et al. Successful endoscopic resection of large pedunculated Brunner's gland hamartoma causing gastrointestinal bleeding arising from the pylorus. Case Rep Gastroenterol. 2013;7(2):304\u20137.","journal-title":"Case Rep Gastroenterol"},{"key":"1074_CR5","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.ajg.2018.08.004","volume":"19","author":"Y Kitagawa","year":"2018","unstructured":"Kitagawa Y, Osumi H, Kawachi H, et al. Giant duodenal Brunner\u2019s gland hamartoma successfully treated via endoscopic mucosal resection. Arab J Gastroenterol. 2018;19:125\u20139.","journal-title":"Arab J Gastroenterol"},{"key":"1074_CR6","doi-asserted-by":"publisher","first-page":"570","DOI":"10.5946\/ce.2016.022","volume":"49","author":"JH Lee","year":"2016","unstructured":"Lee JH, Jo KM, Kim TO, et al. Giant Brunner's gland hamartoma of the duodenal bulb presenting with upper gastrointestinal bleeding and obstruction. Clin Endosc. 2016;49:570\u20134.","journal-title":"Clin Endosc"},{"key":"1074_CR7","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1155\/2006\/806926","volume":"20","author":"E Stermer","year":"2006","unstructured":"Stermer E, Elias N, Keren D, Rainis T, et al. Acute pancreatitis and upper gastrointestinal bleeding as presenting symptoms of duodenal Brunner's gland hamartoma. Can J Gastroenterol. 2006;20:541\u20132.","journal-title":"Can J Gastroenterol"},{"key":"1074_CR8","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1067\/mge.2001.112041","volume":"53","author":"M Tai","year":"2001","unstructured":"Tai M, Yoshikawa I, Kume K, et al. A large Brunner\u2019s gland hamartoma resected by endoscopicpolypectomy. Gastrointest Endosc. 2001;53:207\u20138.","journal-title":"Gastrointest Endosc"},{"key":"1074_CR9","doi-asserted-by":"publisher","first-page":"2616","DOI":"10.3748\/wjg.v10.i17.2616","volume":"10","author":"YP Gao","year":"2004","unstructured":"Gao YP, Zhu JS, Zheng WJ. Brunner's gland adenoma of duodenum: a case report and literature review. World J Gastroenterol. 2004;10:2616\u20137.","journal-title":"World J Gastroenterol"},{"key":"1074_CR10","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1007\/s10620-012-2320-3","volume":"58","author":"K Kim","year":"2013","unstructured":"Kim K, Jan SJ, Song HJ, Yu E. Clinicopathologic characteristics and mucin expression in Brunner\u2019s gland proliferating lesions. Dig Dis Sci. 2013;58:194\u2013201.","journal-title":"Dig Dis Sci"},{"key":"1074_CR11","doi-asserted-by":"publisher","first-page":"370","DOI":"10.5858\/arpa.2018-0034-RA","volume":"143","author":"K Collins","year":"2019","unstructured":"Collins K, Ligato S. Duodenal epithelial polyps: a Clinicopathologic review. Arch Pathol Lab Med. 2019;143:370\u201385.","journal-title":"Arch Pathol Lab Med"},{"key":"1074_CR12","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1631\/jzus.B0710546","volume":"9","author":"GQ Xu","year":"2008","unstructured":"Xu GQ, Wu YQ, Wang LJ, Chen HT. Values of endoscopic ultrasonography for diagnosis and treatment of duodenal protruding lesions. J Zhejiang Univ Sci B. 2008;9:329\u201334.","journal-title":"J Zhejiang Univ Sci B"},{"key":"1074_CR13","first-page":"196","volume":"10","author":"V Gupta","year":"2009","unstructured":"Gupta V, Singh V, Kalra N, Vaiphei K. Pancreas sparing resection for giant hamartoma of Brunner\u2019s glands. JOP. 2009;10:196\u20139.","journal-title":"JOP."},{"issue":"4","key":"1074_CR14","first-page":"311","volume":"65","author":"L Limi","year":"2010","unstructured":"Limi L, Liew NC, Badrul RH, Faisal MJ, Daniel YP. Duodenal intussusception of Brunner\u2019s glandadenoma mimicking a pancreatic tumour. Med J Malaysia. 2010;65(4):311\u20132.","journal-title":"Med J Malaysia"},{"key":"1074_CR15","doi-asserted-by":"crossref","unstructured":"Pandey A, Chandra A, Wahal A. Brunneroma with duodenojejunal intussusception: a rare cause of gastric outlet obstruction. BMJ Case Reports. 2013;2013.","DOI":"10.1136\/bcr-2012-008119"},{"key":"1074_CR16","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1055\/s-2000-9623","volume":"32","author":"W Mayoral","year":"2000","unstructured":"Mayoral W, Salcedo JA, Montgomery E, Al-Kawas FH. Biliary obstruction and pancreatitis caused by Brunner\u2019s gland hyperplasia of the ampulla of water: a case report and review of the literature. Endoscopy. 2000;32:998\u20131001.","journal-title":"Endoscopy."},{"key":"1074_CR17","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1111\/j.1365-2303.2011.00932.x","volume":"24","author":"T Stoos-Veic","year":"2013","unstructured":"Stoos-Veic T, Tadic M, Aralica G. EUS-FNA of Brunner\u2019s gland hamartoma: a case report. Cytopathology. 2013;24:194\u20136.","journal-title":"Cytopathology."},{"key":"1074_CR18","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1016\/S0016-5107(02)70380-5","volume":"56","author":"R Mumtaz","year":"2002","unstructured":"Mumtaz R, Shah IA, Ramirez FC. Brunner\u2019s gland hamartoma simulating a pancreatic mass with duodenal obstruction. Gastrointest Endosc. 2002;56:932\u20134.","journal-title":"Gastrointest Endosc"},{"key":"1074_CR19","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1097\/00004836-200105000-00020","volume":"32","author":"D Yadav","year":"2001","unstructured":"Yadav D, Hertan H, Pitchumoni CS. A giant Brunner\u2019s gland adenoma presenting as gastrointestinal hemorrhage. J Clin Gastroenterol. 2001;32:448\u201350.","journal-title":"J Clin Gastroenterol"},{"key":"1074_CR20","first-page":"348","volume":"6","author":"D Iusco","year":"2005","unstructured":"Iusco D, Roncoroni L, Violi V, Donadei E, Sarli L. Brunner's gland hamartoma: \u2018over-treatment\u2019 of a voluminous mass simulating a malignancy of the pancreatic-duodenal area. JOP. 2005;6:348\u201353.","journal-title":"JOP."},{"key":"1074_CR21","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1186\/1477-7819-7-68","volume":"7","author":"ZA Stewart","year":"2009","unstructured":"Stewart ZA, Hruban RH, Fishman EF, Wolfgang CL. Surgical management of giant Brunner\u2019s gland hamartoma: case report and literature review. World J Surg Oncol. 2009;7:68.","journal-title":"World J Surg Oncol"},{"key":"1074_CR22","doi-asserted-by":"publisher","first-page":"e4","DOI":"10.1016\/j.cgh.2010.08.013","volume":"9","author":"E Qayed","year":"2011","unstructured":"Qayed E, Wehbi M, Rutherford R. Gastrointestinal bleeding from Brunner gland hamartoma. Clin Gastroenterol Hepatol. 2011;9:e4\u20135.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"1074_CR23","doi-asserted-by":"publisher","first-page":"e5","DOI":"10.1053\/j.gastro.2014.10.049","volume":"148","author":"T Namikawa","year":"2015","unstructured":"Namikawa T, Kobayashi M, Hanazaki K. An unusual giant duodenal mass lesion. Gastroenterology. 2015;148:e5\u20136.","journal-title":"Gastroenterology."},{"issue":"5","key":"1074_CR24","doi-asserted-by":"publisher","first-page":"460.e1-460.e2","DOI":"10.12809\/hkmj133776","volume":"19","author":"TT Cheung","year":"2013","unstructured":"Cheung TT, Ip EW, Poon RT, Trendell-Smith N. Brunner\u2019s gland adenoma: unusual cause of duodenal Haemorrhage and obstruction. Hong Kong Med J. 2013;19:460.e1\u20132.","journal-title":"Hong Kong Medical Journal"},{"key":"1074_CR25","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/0002-9610(77)90090-3","volume":"133","author":"S de Silva","year":"1977","unstructured":"de Silva S, Chandrasoma P. Chandrasoma. Giant duodenal hamartoma consisting mainly of Brunner's glands. Am J Surg. 1977;133:240\u20133.","journal-title":"Am J Surg"},{"key":"1074_CR26","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1093\/ajcp\/36.5.438","volume":"36","author":"L Silverman","year":"1961","unstructured":"Silverman L, Waugh JM, Huizenga KA, Harrison EG. Large adenomatous polyp of Brunner\u2019s glands. Am J Clin Pathol. 1961;36:438\u201343.","journal-title":"Am J Clin Pathol"},{"key":"1074_CR27","doi-asserted-by":"publisher","first-page":"446","DOI":"10.5152\/tjg.2014.5996","volume":"25","author":"J Liu","year":"2014","unstructured":"Liu J, Li YQ, Xu H, Tang TY. Significant upper gastrointestinal hemorrhage and intussusception due to a giant Brunners gland adenoma. Turk J Gastroenterol. 2014;25:446\u20137.","journal-title":"Turk J Gastroenterol"},{"key":"1074_CR28","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1007\/s11604-015-0425-2","volume":"33","author":"M Takeuchi","year":"2015","unstructured":"Takeuchi M, Cho H, Sugimoto M, Ohira T, Usuki N, Morimoto Y. CT and MRI findings for Brunner's gland hamartoma: report of three cases. Jpn J Radiol. 2015;33:375\u20139.","journal-title":"Jpn J Radiol"},{"issue":"4","key":"1074_CR29","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1097\/00019509-199708000-00008","volume":"7","author":"R Adell-Carceller","year":"1997","unstructured":"Adell-Carceller R, Salvador-Sanch\u00eds JL, Navarro-Navarro J, et al. Laparoscopically treated duodenal hamartoma of Brunner's glands. Surg Laparosc Endosc. 1997 Aug;7(4):298\u2013300.","journal-title":"Surg Laparosc Endosc"},{"key":"1074_CR30","first-page":"7565","volume":"8","author":"L Lu","year":"2015","unstructured":"Lu L, Li R, Zhang G, Zhao Z, Fu W, Li W. Brunner\u2019s gland adenoma of duodenum: report of two cases. Int J Clin Exp Pathol. 2015;8:7565\u20139.","journal-title":"Int J Clin Exp Pathol"},{"key":"1074_CR31","first-page":"52","volume":"20","author":"K Bayan","year":"2009","unstructured":"Bayan K, T\u00fcz\u00fcn Y, Yilmaz S, Yilmaz G, Bilici A. Pyloric giant brunner\u2019s gland hamartoma as a cause of both duodenojejunal intussusception and obscure gastrointestinal bleeding. Turk J Gastroenterol. 2009;20:52\u20136.","journal-title":"Turk J Gastroenterol"},{"key":"1074_CR32","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/j.gie.2013.11.002","volume":"79","author":"T Nakabori","year":"2014","unstructured":"Nakabori T, Shinzaki S, Yamada T, et al. Atypical duodenal ulcer and invagination caused by a large pedunculated duodenal Brunner's gland hamartoma. Gastrointest Endosc. 2014;79:679\u201380.","journal-title":"Gastrointest Endosc"},{"key":"1074_CR33","doi-asserted-by":"crossref","unstructured":"Verma I, Jha R, Parikh M, Agrawal A. Giant Brunner\u2019s gland hamartoma! BMJ Case Rep. 2015;2015. pii: bcr2015210670.","DOI":"10.1136\/bcr-2015-210670"},{"key":"1074_CR34","doi-asserted-by":"crossref","unstructured":"Akaki M1, Taniguchi S, Hatakeyama K, Kushima R, Kataoka H. Duodenal mucosal damage is associated with proliferative activity of Brunner\u2019s gland hamartoma: a case report. BMC Gastroenterol. 2014;14:14.","DOI":"10.1186\/1471-230X-14-14"},{"key":"1074_CR35","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/S1499-3872(11)60133-1","volume":"11","author":"S Vyas","year":"2012","unstructured":"Vyas S, Skipworth JR. Lytras Det al. Rare presentation of brunner\u2019s gland adenoma: another differentiation in patients with recurrent \u201cidiopathic\u201d pancreatitis. Hepatobiliary Pancreat Dis Int. 2012;11:107\u201310.","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"1074_CR36","first-page":"413","volume":"12","author":"V Gupta","year":"2011","unstructured":"Gupta V, Gupta P, Jain A. Giant Brunner\u2019s glandadenoma of the duodenal bulb presenting with ampullary and duodenal obstruction mimicking pancreatic malignancy. JOP. 2011;12:413\u20139.","journal-title":"JOP."},{"key":"1074_CR37","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1007\/s10620-006-9607-1","volume":"52","author":"R Ohba","year":"2007","unstructured":"Ohba R, Otaka M, Jin M, et al. Large Brunner\u2019s gland hyperplasia treated with modified endoscopic submucosal dissection. Dig Dis Sci. 2007;52:170\u20132.","journal-title":"Dig Dis Sci"},{"key":"1074_CR38","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1016\/j.gie.2005.11.025","volume":"63","author":"S Itaba","year":"2006","unstructured":"Itaba S, Iwasa T, Sadamoto Y, Nasu T, Misawa T, Nakamura K. An unusual duodenal polyp: pedunculated Brunner\u2019s glands hyperplasia. Gastrointest Endosc. 2006;63:1070\u20131.","journal-title":"Gastrointest Endosc"},{"issue":"9","key":"1074_CR39","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1007\/s10620-005-9039-3","volume":"51","author":"YY Chen","year":"2006","unstructured":"Chen YY, Su WW, Soon MS, Yen HH. Hemoclip-assisted polypectomy of large duodenal Brunner's gland hamartoma. Dig Dis Sci. 2006 Sep;51(9):1670\u20132.","journal-title":"Dig Dis Sci"},{"key":"1074_CR40","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1590\/0102-6720201700010020","volume":"30","author":"G Desai","year":"2017","unstructured":"Desai G, Yadav K, Pande P, Sali P, Tampi C, Wagle P. Brunner gland adenoma masquerading as duodenal gastrointestinal stromal tumor with intussusception: CASE report. Arq Bras Cir Dig. 2017;30:71\u20132.","journal-title":"Arq Bras Cir Dig"},{"key":"1074_CR41","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1016\/j.gie.2005.11.063","volume":"63","author":"S Dobrowolski","year":"2006","unstructured":"Dobrowolski S, Dobosz M, Babicki A, et al. Blood supply of colorectal polyps correlates with risk of bleeding after colonoscopic polypectomy. Gastrointest Endosc. 2006;63:1004\u20139.","journal-title":"Gastrointest Endosc"}],"container-title":["BMC Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-019-1074-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12876-019-1074-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-019-1074-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T23:10:19Z","timestamp":1598051419000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcgastroenterol.biomedcentral.com\/articles\/10.1186\/s12876-019-1074-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,23]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["1074"],"URL":"https:\/\/doi.org\/10.1186\/s12876-019-1074-1","relation":{},"ISSN":["1471-230X"],"issn-type":[{"value":"1471-230X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,23]]},"assertion":[{"value":"31 May 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 August 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 August 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A case report is intended to develop information to be shared for medical and educational purposes and do not meet the definition of \u201cresearch\u201d. Ethical approval was not necessary. Written informed consent was obtained from the patient.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate\u221a"}},{"value":"Written consent for publication was obtained from the patient.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors have disclosed that they have no significant relationships with, or financial interest in, any commercial companies pertaining to this article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"151"}}