{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T17:20:34Z","timestamp":1767979234059,"version":"3.49.0"},"reference-count":8,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,12,21]],"date-time":"2019-12-21T00:00:00Z","timestamp":1576886400000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81402374"],"award-info":[{"award-number":["81402374"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Excellent Young Foundation of Jilin Scientific and Technological Development Program","award":["20170520002JH"],"award-info":[{"award-number":["20170520002JH"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Gastroenterol"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n<jats:title>Background<\/jats:title>\n<jats:p>Various types of medical glues\/adhesives\/topical coagulants\u2019 (referred to as MG hereinafter) have widespread application as surgical adhesives, and have been shown to be safe and effective for a broad range of usage, such as in hemostasis, reinforcement of intestinal anastomoses or sites of potential fluid leakage, adhesion of two surfaces, wound closure, and vascular embolization. However, inappropriate application of MG may sometimes lead to serious complications. Herein, we describe three cases of serious postoperative complications induced by a possible inappropriate use of N-butyl-2-cyanoacrylate MG (NBCA MG).<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Case presentation<\/jats:title>\n<jats:p>Three patients presented with abdominal pain (chronic pain in cases 1 and 2, and acute pain in Case 3), hematochezia (Case 2), and intestinal obstruction (Case 3). All patients had a history of abdominal surgery and intraoperative use of NBCA MG. Abdominal computed tomography and gastroenterological endoscopy revealed foreign bodies (solidified MG in cases 1 and 2) and intestinal obstruction related to a mass of residual non-absorbed MG causing an internal hernia from a dense adhesion (Case 3). All patients underwent exploratory laparotomy, which revealed duodenal perforation, colonic erosion, and an internal hernia, all of which was related to MG use. We undertook removal of the foreign bodies (cases 1 and 2), surgical closure of the site of duodenal erosion (Case 1), partial colectomy (Case 2), and partial enterectomy (Case 3).<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Inappropriate application of MG may induce serious complications. We emphasize the importance of careful evaluation of the indications, dosage, and spraying thickness of MG in clinical practice. Serious complications caused by inappropriate application of MG should be reported to raise awareness in the surgical fraternity.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s12876-019-1142-6","type":"journal-article","created":{"date-parts":[[2019,12,21]],"date-time":"2019-12-21T15:02:40Z","timestamp":1576940560000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Serious postoperative complications induced by medical glue: three case reports"],"prefix":"10.1186","volume":"19","author":[{"given":"Wei","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingming","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujia","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaxing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donghui","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Suo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4935-4056","authenticated-orcid":false,"given":"Daguang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,12,21]]},"reference":[{"issue":"2","key":"1142_CR1","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1510\/icvts.2011.273094A","volume":"13","author":"G Dimitrakakis","year":"2011","unstructured":"Dimitrakakis G, Podila SR, O\u2019Keefe PA, Kulatilake NE. Biological glue: a word of careful assessment! Interact Cardiovasc Thorac Surg. 2011;13(2):244.","journal-title":"Interact Cardiovasc Thorac Surg"},{"issue":"4","key":"1142_CR2","doi-asserted-by":"publisher","first-page":"e5","DOI":"10.1016\/j.amjsurg.2010.06.026","volume":"203","author":"CH Zhang","year":"2012","unstructured":"Zhang CH. Use of absorbable hemostatic gauze with medical adhesive is effective for achieving hemostasis in presacral hemorrhage. Am J Surg. 2012;203(4):e5.","journal-title":"Am J Surg"},{"issue":"4","key":"1142_CR3","first-page":"680","volume":"21","author":"YM Shen","year":"2017","unstructured":"Shen YM, Liu YT, Chen J, Sun L. Efficacy and safety of NBCA (n-butyl-2-cyanoacrylate) medical adhesive for patch fixation in totally extraperitoneal prosthesis (TEP): a prospective, randomized, controlled trial. 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Sci Rep. 2015;5:9106.","journal-title":"Sci Rep"},{"issue":"4","key":"1142_CR6","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1111\/j.1540-8191.2012.01466.x","volume":"27","author":"R Ramineni","year":"2012","unstructured":"Ramineni R, Mandalapu T, Chernobelsky A. Aggregation of BioGlue\u00ae; presenting as a right atrial mass: a case report. J Card Surg. 2012;27(4):463\u20135.","journal-title":"J Card Surg"},{"issue":"4","key":"1142_CR7","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1016\/j.ejvs.2010.11.030","volume":"41","author":"FM El","year":"2011","unstructured":"El FM, Chahine E, Abi GM, Abou ZO, Alayli M, Abu KB. Acute limb ischaemia due to embolisation of biological glue 45 days after surgery. Eur J Vasc Endovasc Surg. 2011;41(4):518.","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"1142_CR8","unstructured":"Byern JV, Grunwald I. Biological adhesives: from Nature to Technical and Medical Application. Vienna: Springer; 2010. p. 213\u2013224."}],"container-title":["BMC Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-019-1142-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12876-019-1142-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-019-1142-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,20]],"date-time":"2020-12-20T00:17:48Z","timestamp":1608423468000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcgastroenterol.biomedcentral.com\/articles\/10.1186\/s12876-019-1142-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["1142"],"URL":"https:\/\/doi.org\/10.1186\/s12876-019-1142-6","relation":{},"ISSN":["1471-230X"],"issn-type":[{"value":"1471-230X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"3 October 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 December 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 December 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All patients provided written informed consent for the publication of these case reports and the accompanying images.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"224"}}