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Our study aims to explore the alteration of SCFAs in patients with diarrhea-predominant IBS (IBS-D) and their potential role in the occurrence and development of IBS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We recruited patients with IBS-D defined by Rome IV criteria and age-and-gender matched healthy controls (HCs). A headspace solid-phase microextraction gas chromatography\u2013mass spectrometric (HS-SPME-GC-MS) method was developed for the analysis of acetic, propionic and butyric acid in feces and serum.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared with HCs, the levels of the serum propionate (2.957\u2009\u00b1\u20090.157 vs 2.843\u2009\u00b1\u20090.098\u2009mmol\/L,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.012) and butyrate (2.798\u2009\u00b1\u20090.126 vs 2.697\u2009\u00b1\u20090.077\u2009mmol\/L,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.012) were significantly higher in IBS-D group. No significant differences were found among two groups with regard to the concentration of fecal acetate (4.953\u2009\u00b1\u20091.065 vs 4.774\u2009\u00b1\u20091.465\u2009mg\/g,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.679), propionate (6.342\u2009\u00b1\u20091.005 vs 6.282\u2009\u00b1\u20091.077\u2009mg\/g,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.868) and butyrate (2.984\u2009\u00b1\u20090.512 vs 3.071\u2009\u00b1\u20090.447\u2009mg\/g,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.607).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Metabolites of gut microbiota, the propionic and butyric acid, are increased in patients with IBS-D in serum but not in feces. It suggests that propionic and butyric acid might be associated with the occurrence and development of IBS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12876-020-01212-3","type":"journal-article","created":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T09:07:07Z","timestamp":1584349627000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["The propionic acid and butyric acid in serum but not in feces are increased in patients with diarrhea-predominant irritable bowel syndrome"],"prefix":"10.1186","volume":"20","author":[{"given":"Zhenyi","family":"Tian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojun","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lishou","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,3,16]]},"reference":[{"issue":"2","key":"1212_CR1","first-page":"310","volume":"31","author":"TC Robazzi","year":"2013","unstructured":"Robazzi TC, Adan LF, Pimentel K, Guimar\u00e3es I, Magalh\u00e3es Filho J, Toralles MB, et al. 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