{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T20:43:52Z","timestamp":1778964232502,"version":"3.51.4"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T00:00:00Z","timestamp":1587427200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T00:00:00Z","timestamp":1587427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Gastroenterol"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n<jats:title>Background<\/jats:title>\n<jats:p>The association between <jats:italic>Helicobacter pylori<\/jats:italic> and reflux esophagitis (RE) remains controversial. This study aimed to prospectively evaluate the effect of <jats:italic>H. pylori<\/jats:italic> eradication on RE and gastroesophageal reflux (GERD) symptoms in <jats:italic>H. pylori<\/jats:italic>-positive patients who underwent endoscopic resection of gastric neoplasm.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>Of the 244 patients enrolled in this study, 173 <jats:italic>H. pylori<\/jats:italic>-positive patients underwent follow-up at least once. We evaluated the prevalence of RE and GERD symptoms in these patients following <jats:italic>H. pylori<\/jats:italic> eradication.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>There were 75.7% (131\/173), 78.6% (125\/159), and 78.9% (105\/133) subjects who were successfully eradicated after 6, 12, and 18\u201324\u2009months, respectively. During the 2-year follow-up period, the eradication of <jats:italic>H. pylori<\/jats:italic> did not increase the incidence of RE (OR 0.93; 95% CI, 0.49\u20131.77, <jats:italic>p<\/jats:italic>\u2009=\u20090.828). <jats:italic>H. pylori<\/jats:italic> status was also not associated with the development of GERD symptoms (OR 1.12; 95% CI, 0.47\u20132.95, <jats:italic>p<\/jats:italic>\u2009=\u20090.721). In the univariate analysis for RE, present smoking history (OR 4.79; 95% CI 1.98\u201311.60, <jats:italic>p<\/jats:italic>\u2009=\u20090.001), present alcohol consumption history (OR 2.18; 95% CI 1.03\u20134.63, <jats:italic>p<\/jats:italic>\u2009=\u20090.041), and diabetes mellitus (OR 2.44; 95% CI 1.02\u20135.86, <jats:italic>p<\/jats:italic>\u2009=\u20090.045) were found to be associated with RE. Multivariate analysis showed that present smoking history (OR 4.54; 95% CI 1.84\u201311.02, <jats:italic>p<\/jats:italic>\u2009=\u20090.001) was a significant risk factor for RE.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p><jats:italic>H. pylori<\/jats:italic> eradication did not increase the incidence of RE or GERD symptoms in patients who underwent endoscopic resection of gastric neoplasm.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s12876-020-01276-1","type":"journal-article","created":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T17:07:05Z","timestamp":1587488825000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Effect of Helicobacter pylori eradication on reflux esophagitis and GERD symptoms after endoscopic resection of gastric neoplasm: a single-center prospective study"],"prefix":"10.1186","volume":"20","author":[{"given":"Hee Kyong","family":"Na","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong Hoon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Se Jeong","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hee Jung","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sun Ok","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Yong","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Do Hoon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kee Wook","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kee Don","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ho June","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gin Hyug","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hwoon-Yong","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,4,21]]},"reference":[{"key":"1276_CR1","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1136\/gut.36.6.831","volume":"36","author":"K Schutze","year":"1995","unstructured":"Schutze K, Hentschel E, Dragosics B, Hirschl AM. 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The study was conducted according to the guidelines of the Declaration of Helsinki and was approved by the Institutional Review of Board of Asan Medical Center (IRB number: 2014-2-10).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"123"}}