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In this study, we investigated if the fecal microbiota composition, determined by a high throughput test quantifying a pre-selected set of bacteria, is associated with the postoperative disease course of CD patients.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Fecal samples were obtained from healthy subjects as well as from CD patients, 3\u201310\u2009weeks and 1 year after ileocaecal resection. The fecal microbial composition was analyzed by Genetic Analysis GA-map Dysbiosis test, targeting \u2265300 bacteria on different taxonomic levels. Postoperative disease status was assessed endoscopically according to Rutgeerts scoring system 1 year after surgery. Differences in fecal microbiota composition between groups were analyzed by multivariate factor analyses and cluster analysis. Microbial stability over time was determined using Bray-Curtis dissimilarity.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>One year after surgery, the fecal microbiota composition differed between CD patients (<jats:italic>n<\/jats:italic>\u2009=\u200921) and healthy subjects (<jats:italic>n<\/jats:italic>\u2009=\u20097). At this time point, the microbiota composition of CD patients was associated with disease course, clearly separating patients with disease relapse (<jats:italic>n<\/jats:italic>\u2009=\u20098) and patients in remission (<jats:italic>n<\/jats:italic>\u2009=\u200913). Further, the microbial within-patient stability was high during the first year after surgery, irrespective of disease course.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The fecal microbiota composition of CD patients, analyzed by GA-map Dysbiosis test, is subject to little variation over time, and may potentially be used as a non-invasive diagnostic tool for the postoperative disease course.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12876-020-01281-4","type":"journal-article","created":{"date-parts":[[2020,5,4]],"date-time":"2020-05-04T11:02:57Z","timestamp":1588590177000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Fecal microbiota composition is linked to the postoperative disease course in patients with Crohn\u2019s disease"],"prefix":"10.1186","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9864-3973","authenticated-orcid":false,"given":"Anna","family":"Str\u00f6mbeck","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Lasson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Strid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna","family":"Sundin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per-Ove","family":"Stotzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magnus","family":"Simr\u00e9n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria K.","family":"Magnusson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lena","family":"\u00d6hman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,5,4]]},"reference":[{"issue":"10","key":"1281_CR1","doi-asserted-by":"publisher","first-page":"2042","DOI":"10.1016\/j.cgh.2018.12.022","volume":"17","author":"NE Burr","year":"2019","unstructured":"Burr NE, Lord R, Hull MA, Subramanian V. 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This article has been updated to correct this.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All patients gave written informed consent according to the 1975 declaration of Helsinki. The study was approved by the Regional Ethical Review Board at the University of Gothenburg (Ref 268\u201308, approved 25-06-2008; Ref T227\u201318, approved 12-03-2018).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Lena \u00d6hman is a member of the advisory board of Genetic Analysis. The remaining authors declare that they have no competing interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"130"}}