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Colonic TET has been successfully used for frequent colonic administration of drugs or multiple fecal microbiota transplantations (FMTs). This prospective observational study aimed to evaluate possible factors affecting methodology, feasibility and safety of colonic TET.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients who underwent colonic TET at our center from October 2014 to November 2018 were included. The feasibility, efficacy, and safety of TET were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 224 patients were analyzed. The success rate of TET was 100%. The median retention time of TET tube within the colonic lumen was 8.5 (IQR 7\u201311) days in 158 patients with tube falling out spontaneously, and the maximum retention time was up to 28\u2009days. These patients were divided into the short-retention group (\u2264 8.5\u2009days) and the long-retention group (&gt;\u20098.5\u2009days). Univariate and multivariate analysis demonstrated that the type of endoscopic clip (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) was an independent factor for the retention time. The larger clips as well as a greater number of clips significantly affected the retention time (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.013). No severe adverse event was observed during and after TET.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Colonic TET is a feasible, practical, and safe colon-targeted drug delivery technique with a high degree of patients\u2019 satisfaction. Two to four large endoscopic clips are recommended to maintain stability of the TET tube within the colon for over 7\u2009days.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12876-020-01285-0","type":"journal-article","created":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T07:03:19Z","timestamp":1602572599000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Colonic transendoscopic tube-delivered enteral therapy (with video): a prospective study"],"prefix":"10.1186","volume":"20","author":[{"given":"Ting","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuyan","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bota","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heena","family":"Buch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guozhong","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4157-1144","authenticated-orcid":false,"given":"Faming","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,5,6]]},"reference":[{"issue":"11","key":"1285_CR1","doi-asserted-by":"publisher","first-page":"1920","DOI":"10.1136\/gutjnl-2018-316818","volume":"67","author":"BH Mullish","year":"2018","unstructured":"Mullish BH, Quraishi MN, Segal JP, McCune VL, Baxter M, Marsden GL, Moore DJ, Colville A, Bhala N, Iqbal TH, et al. 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Written informed consent was obtained from all adult subjects or parents in pediatric cases.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent for publication of clinical images and video was obtained from the patients.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Faming Zhang conceived the concept of GenFMTer and transendoscopic enteral tubing and related devices. Other authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"135"}}