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Our goal is to explore the relationship between NAFLD and colorectal cancer (CRC) and to analyze potential indicators for screening CRC in NAFLD based on clinical big data.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Demographic information and routine clinical indicators were extracted from Xiangya Medical Big Data Platform. 35,610 NAFLD cases without CRC (as group NAFLD-CRC), 306 NAFLD cases with CRC (as group NAFLD-NonCRC) and 10,477 CRC cases without NAFLD were selected and evaluated. The CRC incidence was compared between NAFLD population and general population by Chi-square test. Independent sample t-test was used to find differences of age, gender and routine clinical indicators in pairwise comparisons of NAFLD-CRC, NAFLD-NonCRC and nonNAFLD-CRC.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>NAFLD population had a higher CRC incidence than general population (7.779\u2030 vs 3.763\u2030, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Average age of NAFLD-CRC (58.79\u2009\u00b1\u200912.353) or nonNAFLD-CRC (59.26\u2009\u00b1\u200913.156) was significantly higher than NAFLD-nonCRC (54.15\u2009\u00b1\u200914.167, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). But age had no significant difference between NAFLD-CRC and nonNAFLD-CRC (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). There was no different gender distribution for three groups (P\u2009&gt;\u20090.05). NAFLD-CRC had lower anaemia-related routine clinical indicators such as decrease of red blood cell count, mean hemoglobin content and hemoglobin than NAFLD-nonCRC (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05 for all). Anemia of NAFLD-CRC was typical but it might be slighter than nonNAFLD-CRC. More interestingly, NAFLD-CRC had distinct characteristics of leukocyte system such as lower white blood cell count (WBC) and neutrophil count (NEU_C) and higher basophil percentage (BAS_Per) than nonNAFLD-CRC and NAFLD-nonCRC (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05 for all). Compared with NAFLD-nonCRC, the change of WBC, BAS_Per and NEU_C in NAFLD-CRC was different from that in nonNAFLD-CRC. In addition, NAFLD-CRC had a higher level of low density lipoprotein (LDL) and high density lipoprotein (HDL), lower level of triglyceride (TG) and Albumin-to-globulin ratio (A\/G) than NFLD-nonCRC (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05 for all).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>NAFLD is associated with a high incidence of CRC. Age is an important factor for CRC and the CRC incidence increases with age. Anemia-related blood routine clinical indicators, leukocyte system and blood lipid indicators may be more important variables for identifying CRC in NAFLD. So blood routine test and liver function\/blood lipid test are valuable for screening CRC in NAFLD.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12876-020-01327-7","type":"journal-article","created":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T13:20:04Z","timestamp":1591708804000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Value of routine test for identifying colorectal cancer from patients with nonalcoholic fatty liver disease"],"prefix":"10.1186","volume":"20","author":[{"given":"Rong","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4338-015X","authenticated-orcid":false,"given":"Xianlai","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,6,9]]},"reference":[{"issue":"5","key":"1327_CR1","doi-asserted-by":"publisher","first-page":"E359","DOI":"10.1002\/ijc.29210","volume":"136","author":"J Ferlay","year":"2015","unstructured":"Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F. 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