{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:40:08Z","timestamp":1772988008550,"version":"3.50.1"},"reference-count":9,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,6,10]],"date-time":"2020-06-10T00:00:00Z","timestamp":1591747200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,6,10]],"date-time":"2020-06-10T00:00:00Z","timestamp":1591747200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Gastroenterol"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n<jats:title>Background<\/jats:title>\n<jats:p>Blue rubber bleb nevus syndrome (BRBNS) is a rare congenital disease characterized by multifocal venous malformations. It remains a considerable challenge in treating the gastrointestinal (GI) venous malformations due to multiple lesions throughout the GI tract, and the likelihood of recurrence. We report a case study of BRBNS in the GI tract, in which GI venous malformations and related GI bleeding were successfully treated with a combination of multiple endoscopic procedures.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Case presentation<\/jats:title>\n<jats:p>A 17-year-old man was admitted to our hospital for dizziness and hypodynamia. The symptoms persisted for nearly 1 year. The laboratory tests revealed iron-deficiency anemia with abnormally low hemoglobin (Hb), and a strong positive fecal occult blood test. A total of four hemangiomas were detected: one in the stomach, one in the descending colon, and two in the small intestines with a high risk of hemorrhage. Under gastroendoscopy, enteroscopy, and video capsule endoscopy (VCE) throughout the GI tract, the patient underwent surgical treatment. Endoscopic mucosal resection was initially performed in the stomach and colon, and the lesions in the small intestine were resected with laparoscopy auxiliaried by single-balloon enteroscopy (SBE), during which SBE assisted in identifying the lesions. The patient well-tolerated the procedures, and had a favorable prognosis.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>The combination of single-balloon enteroscopy-assisted laparoscopy and endoscopic mucosal resection was effective for the present case, which could be considered for patients with similar clinical conditions.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s12876-020-01328-6","type":"journal-article","created":{"date-parts":[[2020,6,10]],"date-time":"2020-06-10T08:02:44Z","timestamp":1591776164000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A combination of single-balloon enteroscopy-assisted laparoscopy and endoscopic mucosal resection for treating gastrointestinal venous malformations in blue rubber bleb nevus syndrome: a case report"],"prefix":"10.1186","volume":"20","author":[{"given":"Yuemei","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingjie","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenzhen","family":"Dai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feizhen","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,6,10]]},"reference":[{"key":"1328_CR1","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1007\/s00431-012-1706-8","volume":"171","author":"C Esposito","year":"2012","unstructured":"Esposito C, Giurin I, Farina A, Ascione G, Miele E, Staiano A, Di Benedetto V, Settimi A. Blue rubber bleb nevus: an uncommon cause of intestinal intussusception. Eur J Pediatr. 2012;171:1139\u201340.","journal-title":"Eur J Pediatr"},{"key":"1328_CR2","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1111\/j.1440-1754.2009.01619.x","volume":"46","author":"MY Hasosah","year":"2010","unstructured":"Hasosah MY, Abdul-Wahab AA, Bin-Yahab SA, Al-Rabeaah AA, Rimawi MM, Eyoni YA, Satti MB. Blue rubber bleb nevus syndrome: extensive small bowel vascular lesions responsible for gastrointestinal bleeding. J Paediatr Child Health. 2010;46:63\u20135.","journal-title":"J Paediatr Child Health"},{"key":"1328_CR3","first-page":"1566","volume":"6","author":"S Aroor","year":"2012","unstructured":"Aroor S, Varma C, Mundkur SC. Blue rubber-bleb nevus syndrome which was associated with an atrial Septal defect: a case report. J Clin Diagn Res. 2012;6:1566\u20137.","journal-title":"J Clin Diagn Res"},{"key":"1328_CR4","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1016\/j.jamcollsurg.2008.11.020","volume":"208","author":"LM da Fonseca","year":"2009","unstructured":"da Fonseca LM, Neiva AM, Ferrari Mde L, da Silva RG. Blue rubber bleb naevus syndrome: a rare cause of melena, anemia, and intestinal intussusception. J Am Coll Surg. 2009;208:1143.","journal-title":"J Am Coll Surg"},{"key":"1328_CR5","doi-asserted-by":"publisher","first-page":"316","DOI":"10.4174\/jkss.2012.83.5.316","volume":"83","author":"KK Choi","year":"2012","unstructured":"Choi KK, Kim JY, Kim MJ, Park H, Choi DW, Choi SH, Heo JS. Radical resection of intestinal blue rubber bleb nevus syndrome. J Korean Surg Soc. 2012;83:316\u201320.","journal-title":"J Korean Surg Soc"},{"key":"1328_CR6","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.gie.2006.06.025","volume":"65","author":"L Lopes","year":"2007","unstructured":"Lopes L, Ramada J, Certo M. Blue rubber bleb nevus syndrome: capsule endoscopy in a patient with GI bleeding. Gastrointest Endosc. 2007;65:151\u20132 discussion 2.","journal-title":"Gastrointest Endosc"},{"key":"1328_CR7","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/1757-1626-3-29","volume":"3","author":"F O'Kelly","year":"2010","unstructured":"O'Kelly F, Lim KT, Ravi N, Mahmud N, Reynolds JV. The value of double balloon enteroscopy in diagnosing blue rubber bleb naevus syndrome: a case report. Cases J. 2010;3:29.","journal-title":"Cases J"},{"key":"1328_CR8","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1055\/s-2002-30172","volume":"12","author":"M Domini","year":"2002","unstructured":"Domini M, Aquino A, Fakhro A, Tursini S, Marino N, Di Matteo S, Lelli CP. Blue rubber bleb nevus syndrome and gastrointestinal haemorrhage: which treatment? Eur J Pediatr Surg. 2002;12:129\u201333.","journal-title":"Eur J Pediatr Surg"},{"key":"1328_CR9","doi-asserted-by":"publisher","first-page":"2067","DOI":"10.1111\/j.1524-4725.2010.01785.x","volume":"36","author":"S Blaise","year":"2010","unstructured":"Blaise S, Riom H, Charavin-Cocuzza M, Templier I, Zambelli L, Diamand JM. Blue rubber bleb nevus syndrome treated with polidocanol foam sclerotherapy. Dermatol Surg. 2010;36:2067\u20138.","journal-title":"Dermatol Surg"}],"container-title":["BMC Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-020-01328-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12876-020-01328-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-020-01328-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T07:41:40Z","timestamp":1625125300000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcgastroenterol.biomedcentral.com\/articles\/10.1186\/s12876-020-01328-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,10]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["1328"],"URL":"https:\/\/doi.org\/10.1186\/s12876-020-01328-6","relation":{},"ISSN":["1471-230X"],"issn-type":[{"value":"1471-230X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,10]]},"assertion":[{"value":"31 December 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 June 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 June 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study was reviewed and approved by the Ethics Committee of Yinzhou Hospital Affiliated to Ningbo University. A written informed consent was obtained from the patient.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"A written informed consent was obtained from the patient\u2019s parent for the publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor of this journal.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"182"}}