{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T19:42:51Z","timestamp":1782502971614,"version":"3.54.5"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T00:00:00Z","timestamp":1597881600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T00:00:00Z","timestamp":1597881600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Gastroenterol"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      While\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      (\n                      <jats:italic>H. pylori<\/jats:italic>\n                      ) ulcers has declined recently,\n                      <jats:italic>H. pylori<\/jats:italic>\n                      -negative and\/or gastrotoxic drug-negative peptic ulcers (HNGN-PU) has increased. This study aimed to analyze the etiology of peptic ulcers in children and the differences in clinical, laboratory, endoscopic, and histopathologic findings of peptic ulcers according to etiology, including eosinophilic gastroenteritis (EoGE).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In total, 255 children (157 boys and 98 girls) with peptic ulcers were recruited. The subjects were categorized into 5 groups according to the etiology of the ulcer: 1)\n                      <jats:italic>H. pylori<\/jats:italic>\n                      infection (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200951); 2) gastrotoxic drugs (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200918); 3) idiopathic (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009144); 4) systemic disease (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200923); 5) EoGE (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200919). Clinical data were reviewed and analyzed retrospectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Age at diagnosis, ulcer recurrence, atopic dermatitis history, white blood cell count, blood eosinophil count, platelet count, serum albumin level, iron level, erythrocyte sedimentation rate, and C-reactive protein level differed significantly among the 5 groups (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Regarding endoscopic findings, multiple ulcers and gastric mucosal nodularity differed among the 5 groups (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). When comparing the EoGE ulcer group with the others, EoGE group revealed older ages (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.022), higher rates of ulcer recurrence (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.018), atopic dermatitis history (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001), and both blood and tissue eosinophilia (both\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>EoGE ulcers constituted 10.2% of HNGN-PU in pediatric patients. In children with HNGN-PU, peripheral eosinophilia, ulcer recurrence, and atopic dermatitis history might imply EoGE, necessitating thorough investigation of tissue eosinophils during endoscopic biopsy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>A total of 255 children was retrospectively registered between between July 2003 and April 2017.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12876-020-01416-7","type":"journal-article","created":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T07:02:57Z","timestamp":1597906977000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Eosinophilic gastroenteritis as a cause of non-Helicobacter pylori, non-gastrotoxic drug ulcers in children"],"prefix":"10.1186","volume":"20","author":[{"given":"Jung Yeon","family":"Joo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Min","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In Hyuk","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1607-0890","authenticated-orcid":false,"given":"Hye Ran","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,8,20]]},"reference":[{"key":"1416_CR1","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.1016\/S0140-6736(09)60938-7","volume":"374","author":"P Malfertheiner","year":"2009","unstructured":"Malfertheiner P, Chan FKL, McColl KEL. 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