{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:28:19Z","timestamp":1787020099747,"version":"build-2736575974"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T00:00:00Z","timestamp":1600992000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T00:00:00Z","timestamp":1600992000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Research Program on Hepatitis from the Japan Agency for Medical Research and Development, AMED","award":["18fk0210020h0002"],"award-info":[{"award-number":["18fk0210020h0002"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Gastroenterol"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Evaluation of fibrosis stage is important to monitor progression of liver disease and risk of hepatocellular carcinoma (HCC). While liver biopsy is the gold standard, the method is invasive and faces several limitations. The aim of this study was to determine correlations among METAVIR scores and FibroScan, Virtual-Touch tissue quantification (VTQ), fibrosis index based on four factors (FIB-4 index), and Mac-2 binding protein glycosylation isomer (M2BPGi) level, and for examine differences in the reliability of non-invasive methods to evaluate fibrosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used liver resection specimens from patients with hepatitis C virus (HCV), correlations were assessed between METAVIR scores and non-invasive method. Receiver operating characteristic (ROC) curves were generated to determine the sensitivity, specificity, and cut off values of the methods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      All Patients group: In F0\u20132 vs F3\u20134, the areas under the ROC curve (AUC) (0.85) of FibroScan was significantly higher than that (0.67) of FIB-4 index (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002) and that (0.67) of M2BPGi (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). The AUC (0.83) of VTQ was significantly higher than that (0.67) of FIB-4 index (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01) and that (0.67) of M2BPGi (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002). In F0\u20133 vs F4, the AUC (0.86) of VTQ was significantly higher than that (0.65) of FIB-4 index (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04). The AUC (0.89) of FibroScan was significantly higher than that (0.65) of FIB-4 index (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002) and that (0.76) of M2BPGi (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02).\n                    <\/jats:p>\n                    <jats:p>\n                      Non-SVR group: In F0\u20132 vs F3\u20134, the AUC (0.85) of FibroScan was significantly higher than that (0.84) of FIB-4 index (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02) and that (0.73) of M2BPGi (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003). The AUC (0.84) of VTQ was significantly higher than that (0.74) of FIB-4 index (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04). In F0\u20133 vs F4, the AUC (0.91) of FibroScan was significantly higher than that (0.67) of FIB-4 index (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003) and that (0.78) of M2BPGi (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02). The AUC (0.88) of VTQ was significantly higher than that of FIB-4 index (0.67) and that of M2BPGi (0.78) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>FibroScan and VTQ best reflected the results of hepatic fibrosis diagnosis using liver resection specimens among the four examination methods evaluated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12876-020-01459-w","type":"journal-article","created":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T08:03:03Z","timestamp":1601020983000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Liver fibrosis assessments using FibroScan, virtual-touch tissue quantification, the FIB-4 index, and mac-2 binding protein glycosylation isomer levels compared with pathological findings of liver resection specimens in patients with hepatitis C infection"],"prefix":"10.1186","volume":"20","author":[{"given":"Naoyuki","family":"Ueda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5113-4031","authenticated-orcid":false,"given":"Tomokazu","family":"Kawaoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michio","family":"Imamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Aikata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Nakahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eisuke","family":"Murakami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masataka","family":"Tsuge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Hiramatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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E-946). Informed consent was obtained from each patient in writing.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Kazuaki Chayama has received honoraria from Bristol-Myers Squibb and MSD K.K. and research funding from Dainippon Sumitomo Pharma and AbbVie. Michio Imamura has received research funding from Bristol-Myers Squibb.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"314"}}