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Genistein (4\u2032,5,7-trihydroxyisoflavone), a tyrosine-specific-protein kinase inhibitor, has been shown to exert an anti-inflammatory property\n                      <jats:bold>.<\/jats:bold>\n                      The aim of this study was to examine the treatment effects of genistein and its mechanisms in rats with\n                      <jats:italic>H. pylori<\/jats:italic>\n                      infection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Eighteen male Sprague-Dawley rats were divided into three groups (6 rats per group): (1) control group (Con); (2)\n                      <jats:italic>H. pylori<\/jats:italic>\n                      infected group (HP): the rats were inoculated with\n                      <jats:italic>H. pylori<\/jats:italic>\n                      (10\n                      <jats:sup>8\u2212<\/jats:sup>\n                      \u200910\n                      <jats:sup>10<\/jats:sup>\n                      \u2009CFU\/mL; 1\u2009mL\/rat\n                      <jats:italic>.<\/jats:italic>\n                      ) for 3 consecutive days; and (3) HP\u2009+\u2009genistein group (HP\u2009+\u2009Gen): the rats were inoculated with\n                      <jats:italic>H. pylori<\/jats:italic>\n                      as above. Then, they were gavaged with genistein (16\u2009mg\/kg BW) for 14\u2009days. Gastric tissue was used for the determination of nuclear factor (NF)-\u03baB expression by immunohistochemistry (IHC), degree of apoptosis by the terminal deoxynucleotidyl transferasemediated dUTP nick-end labeling (TUNEL) reaction, and histopathology. Serum samples were used to measure the levels of tumor necrosis factor-alpha (TNF-\u03b1) and cytokine-induced neutrophil chemoattractant-1 (CINC-1).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Rats in the HP group had significantly higher levels of pro-inflammatory mediators, NF-\u03baB expression and apoptotic cells when compared with the Con group, and these markers significantly decreased in HP\u2009+\u2009Gen group when compared with the HP group. The histopathology of HP group showed moderate gastric inflammation and many HP colonization. Gastric pathology in HP\u2009+\u2009Gen group demonstrated the attenuation of inflammatory cell infiltration and\n                      <jats:italic>H. pylori<\/jats:italic>\n                      colonization.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Genistein exerted its gastroprotective effects through the reduction of pro-inflammatory mediators, nuclear receptor NF-\u03baB expression and gastric mucosal apoptosis in rats with\n                      <jats:italic>H. pylori<\/jats:italic>\n                      -induced gastropathy.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12876-020-01555-x","type":"journal-article","created":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T07:30:05Z","timestamp":1607499005000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Genistein attenuated gastric inflammation and apoptosis in Helicobacter pylori-induced gastropathy in rats"],"prefix":"10.1186","volume":"20","author":[{"given":"Prasong","family":"Siriviriyakul","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8847-9690","authenticated-orcid":false,"given":"Duangporn","family":"Werawatganon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nisarat","family":"Phetnoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanjana","family":"Somanawat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanittha","family":"Chatsuwan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naruemon","family":"Klaikeaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maneerat","family":"Chayanupatkul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,12,9]]},"reference":[{"issue":"Suppl 1(0 1)","key":"1555_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1523-5378.2011.00874.x","volume":"16","author":"K-L Goh","year":"2011","unstructured":"Goh K-L, Chan W-K, Shiota S, et al. 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