{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T00:57:27Z","timestamp":1784941047544,"version":"3.55.0"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T00:00:00Z","timestamp":1611014400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T00:00:00Z","timestamp":1611014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Gastroenterol"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Mucosal Schwann cell hamartomas are rare neurogenic tumors which present most commonly in the distal colon. They are usually discovered as small, single polyps in asymptomatic patients.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>An asymptomatic 64-year-old man was referred to us after a 12\u00a0mm subepithelial lesion was discovered incidentally on screening colonoscopy. Follow-up colonoscopy conducted 2\u00a0months later revealed that the tumor had disappeared, leaving multiple edematous, submucosal tumor-like elevations presenting as skip lesions throughout the sigmoid colon. Lesions had elongated pits on magnifying endoscopy and were limited to the first layer on endoscopic ultrasound. Biopsies revealed unclearly delineated foci of spindle-shaped cells limited to the lamina propria. On immunohistochemistry, all lesions were positive for S-100 protein and negative for CD34, CD56, and neurofilament protein. The patient was diagnosed with multiple mucosal Schwann cell hamartomas of the sigmoid colon. He remains asymptomatic after 18\u00a0months of follow-up, but the lesions have also remained unchanged.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>We report a case of multiple non-polypoid mucosal Schwann cell hamartomas. Endoscopic findings may assist in the differential diagnosis, particularly when presenting as non-polypoid, submucosal tumor-like lesions.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12876-021-01607-w","type":"journal-article","created":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T21:02:52Z","timestamp":1611090172000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Multiple non-polypoid mucosal Schwann cell hamartomas presenting as edematous and submucosal tumor-like lesions: a case report"],"prefix":"10.1186","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9719-0282","authenticated-orcid":false,"given":"Takeshi","family":"Okamoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaaki","family":"Yoshimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuyuki","family":"Fukuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,19]]},"reference":[{"key":"1607_CR1","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1097\/PAS.0b013e31818dd6ca","volume":"33","author":"JA Gibson","year":"2009","unstructured":"Gibson JA, Hornick JL. Mucosal Schwann cell \u201chamartoma\u201d: clinicopathologic study of 26 neural colorectal polyps distinct from neurofibromas and mucosal neuromas. Am J Surg Pathol. 2009;33:781\u20137.","journal-title":"Am J Surg Pathol"},{"key":"1607_CR2","doi-asserted-by":"publisher","first-page":"151531","DOI":"10.1016\/j.anndiagpath.2020.151531","volume":"47","author":"Y Li","year":"2020","unstructured":"Li Y, Beizai P, Russell JW, Westbrook L, Nowain A, Wang HL. Mucosal Schwann cell hamartoma of the gastroesophageal junction: a series of 6 cases and comparison with colorectal counterpart. Ann Diagn Pathol. 2020;47:151531.","journal-title":"Ann Diagn Pathol"},{"key":"1607_CR3","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1111\/pin.12376","volume":"66","author":"P Hytiroglou","year":"2016","unstructured":"Hytiroglou P, Petrakis G, Tsimoyiannis EC. Mucosal Schwann cell hamartoma can occur in the stomach and must be distinguished from other spindle cell lesions. Pathol Int. 2016;66:242\u20133.","journal-title":"Pathol Int"},{"key":"1607_CR4","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1016\/j.pathol.2017.11.095","volume":"50","author":"G Khanna","year":"2018","unstructured":"Khanna G, Ghosh S, Barwad A, Yadav R, Das P. Mucosal Schwann cell hamartoma of gall bladder: a novel observation. Pathology. 2018;50:480\u20132.","journal-title":"Pathology"},{"key":"1607_CR5","doi-asserted-by":"publisher","first-page":"130","DOI":"10.3393\/ac.2013.29.3.130","volume":"29","author":"MN Bae","year":"2013","unstructured":"Bae MN, Lee JE, Bae SM, Kim EY, Kim EO, Jung SH, et al. Mucosal schwann-cell hamartoma diagnosed by using an endoscopic snare polypectomy. Ann Coloproctol. 2013;29:130\u20134.","journal-title":"Ann Coloproctol"},{"key":"1607_CR6","doi-asserted-by":"publisher","first-page":"187","DOI":"10.4132\/jptm.2016.07.02","volume":"51","author":"J Han","year":"2017","unstructured":"Han J, Chong Y, Kim TJ, Lee EJ, Kang CS. Mucosal schwann cell hamartoma in colorectal mucosa: a rare benign lesion that resembles gastrointestinal neuroma. J Pathol Transl Med. 2017;51:187\u20139.","journal-title":"J Pathol Transl Med"},{"key":"1607_CR7","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1186\/s12876-015-0349-4","volume":"15","author":"JM Bae","year":"2015","unstructured":"Bae JM, Lee JY, Cho J, Lim SA, Kang GH. Synchronous mucosal Schwann-cell hamartomas in a young adult suggestive of mucosal Schwann-cell harmatomatosis: a case report. BMC Gastroenterol. 2015;15:128.","journal-title":"BMC Gastroenterol"},{"key":"1607_CR8","unstructured":"Sagami S, Fukumoto A, Amano M, Yamao K. A case of mucosal Schwann cell hamartoma. Nihon Shokakibyo Gakkai Zasshi. 2012;109:1776\u201383. (abstract only in English)."},{"key":"1607_CR9","doi-asserted-by":"publisher","first-page":"417","DOI":"10.4251\/wjgo.v2.i11.417","volume":"2","author":"S Kawasaki","year":"2010","unstructured":"Kawasaki S, Osawa S, Sugimoto K, Uotani T, Nishino M, Yamada T, et al. Cecal vanishing tumor associated with cytomegalovirus infection in an immunocompetent elderly adult. World J Gastrointest Oncol. 2010;2:417\u201320.","journal-title":"World J Gastrointest Oncol"},{"key":"1607_CR10","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1179\/acb.2010.024","volume":"65","author":"DG Ebo","year":"2010","unstructured":"Ebo DG, De Knop KJ, Maes JW, De Clerck LS, Stevens WJ. Vanishing tumour of the colon ascendens due to acquired type II C1-inhibitor deficiency. Acta Clin Belg. 2010;65:122\u20136.","journal-title":"Acta Clin Belg"},{"key":"1607_CR11","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1007\/s005950070133","volume":"30","author":"Y Fujino","year":"2000","unstructured":"Fujino Y, Fujio Y, Shimada E, Okazaki A. Intussusception due to vanishing colon cancer with metastasis of the regional lymph nodes: report of a case. Surg Today. 2000;30:188\u201390.","journal-title":"Surg Today"},{"key":"1607_CR12","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1002\/jgf2.248","volume":"20","author":"Z Dai","year":"2019","unstructured":"Dai Z, Kobayashi D. Gastric anisakiasis presenting as a vanishing tumor. J Gen Fam Med. 2019;20:159\u201360.","journal-title":"J Gen Fam Med"},{"key":"1607_CR13","doi-asserted-by":"publisher","first-page":"L13","DOI":"10.1530\/ERC-16-0475","volume":"24","author":"V Amoroso","year":"2017","unstructured":"Amoroso V, Agazzi GM, Roca E, Fazio N, Mosca A, Ravanelli M, Spada F, Maroldi R, Berruti A. Regression of advanced neuroendocrine tumors among patients receiving placebo. Endocr Relat Cancer. 2017;24:L13\u20136.","journal-title":"Endocr Relat Cancer"}],"container-title":["BMC Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-021-01607-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12876-021-01607-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-021-01607-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T21:06:21Z","timestamp":1611090381000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcgastroenterol.biomedcentral.com\/articles\/10.1186\/s12876-021-01607-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,19]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["1607"],"URL":"https:\/\/doi.org\/10.1186\/s12876-021-01607-w","relation":{},"ISSN":["1471-230X"],"issn-type":[{"value":"1471-230X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,19]]},"assertion":[{"value":"22 October 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 January 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 January 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The patient provided written informed consent for the publication of this manuscript and images.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors have no competing interests to declare.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"29"}}