{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T11:42:03Z","timestamp":1774525323690,"version":"3.50.1"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T00:00:00Z","timestamp":1616457600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T00:00:00Z","timestamp":1616457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Gastroenterol"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Acute pancreatitis as a trigger of Takotsubo cardiomyopathy has been infrequently described in the literature. Misdiagnosis of this phenomenon can often occur due to overlap in symptomology, particularly in those outside of the usual patient demographic.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 27-year-old man with a history of alcohol abuse presented with epigastric and chest pain. Electrocardiography showed ischemic changes, and laboratory workup revealed elevated lipase and troponin. He was diagnosed with acute pancreatitis and managed presumptively as acute coronary syndrome. Subsequent coronary angiography was negative for obstructive coronary artery disease, and left ventriculography demonstrated basal hyperkinesis and apical akinesis, characteristic of Takotsubo cardiomyopathy.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Takotsubo cardiomyopathy is a rare complication of acute pancreatitis. Increased awareness of this phenomenon is required to prevent delays in diagnosis and avoid unnecessary interventions and complications.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12876-021-01725-5","type":"journal-article","created":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T20:03:05Z","timestamp":1616529785000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Takotsubo cardiomyopathy complicating acute pancreatitis: a case report"],"prefix":"10.1186","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7071-3984","authenticated-orcid":false,"given":"John","family":"Yeh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Carroll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,3,23]]},"reference":[{"key":"1725_CR1","first-page":"56","volume-title":"Clinical aspect of myocardial injury: from ischemia to heart failure","author":"H Sato","year":"1990","unstructured":"Sato H. Tako-tsubo-like left ventricular dysfunction due to multivessel coronary spasm. In: Kodama K, Haze K, Hori M, editors. Clinical aspect of myocardial injury: from ischemia to heart failure. Tokyo: Kagakuhyoronsha Publishing Co; 1990. p. 56\u201364."},{"key":"1725_CR2","doi-asserted-by":"publisher","first-page":"2032","DOI":"10.1093\/eurheartj\/ehy076","volume":"39","author":"JR Ghadri","year":"2018","unstructured":"Ghadri JR, Wittstein IS, Prasad A, Sharkey S, Dote K, Akashi YJ, et al. International expert consensus document on takotsubo syndrome (Part I): clinical characteristics, diagnostic criteria, and pathophysiology. Eur Heart J. 2018;39:2032\u201346.","journal-title":"Eur Heart J"},{"key":"1725_CR3","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.hrtlng.2006.05.007","volume":"36","author":"AG Sankri-Tarbichi","year":"2007","unstructured":"Sankri-Tarbichi AG, Mathew PK, Matos M, His D. Stress-related cardiomyopathy. Heart Lung. 2007;36:43\u20136.","journal-title":"Heart Lung"},{"key":"1725_CR4","doi-asserted-by":"crossref","first-page":"232470961989319","DOI":"10.1177\/2324709619893197","volume":"7","author":"T Abe","year":"2019","unstructured":"Abe T, Simien M, Dolphurs H. Acute pancreatitis complicated by stress cardiomyopathy with persistent apical akinesis: a case report and literature review. J Investig Med High Impact Case Rep. 2019;7:2324709619893197.","journal-title":"J Investig Med High Impact Case Rep"},{"key":"1725_CR5","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1097\/MEJ.0b013e32832cf70d","volume":"17","author":"R Rajani","year":"2010","unstructured":"Rajani R, Przedlacka A, Saha M, Belder A. Pancreatitis and the broken heart. Eur J Emerg Med. 2010;17:27\u20139.","journal-title":"Eur J Emerg Med"},{"key":"1725_CR6","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1038\/ajg.2009.520","volume":"105","author":"MK Cheezum","year":"2010","unstructured":"Cheezum MK, Willis SL, Duffy SP, Moawad FJ, Horwhat JD, Huffer LL, et al. Broken pancreas, broken heart. Am J Gastroenterol. 2010;105:327\u20138.","journal-title":"Am J Gastroenterol"},{"key":"1725_CR7","unstructured":"Pednekar M, Chandra P. Sudden cardiac death from takotsubo cardiomyopathy triggered by acute pancreatitis. J Hosp Med 2010;5."},{"key":"1725_CR8","doi-asserted-by":"publisher","first-page":"1814","DOI":"10.1111\/jgs.12999","volume":"62","author":"JK Leubner","year":"2014","unstructured":"Leubner JK, Ortiz Z, Wolfrey J, Drake L. Can Gallstones Break the Heart? Pancreatitis-induced Takotsubo cardiomyopathy mimicking acute myocardial infarction. J Am Geriatr Soc. 2014;62:1814\u20135.","journal-title":"J Am Geriatr Soc"},{"key":"1725_CR9","doi-asserted-by":"publisher","first-page":"53","DOI":"10.14309\/crj.2015.99","volume":"3","author":"JD Bruenjes","year":"2015","unstructured":"Bruenjes JD, Vallabhajosyula S, Vacek CJ, Fixley JE. Acute pancreatitis-induced takotsubo cardiomyopathy in an African American Male. ACG Case Rep J. 2015;3:53\u20136.","journal-title":"ACG Case Rep J"},{"key":"1725_CR10","first-page":"A349","volume":"10","author":"P Boulos","year":"2015","unstructured":"Boulos P. An inflamed pancreas and a broken heart: pancreatitis-induced Takotsubo cardiomyopathy. J Hosp Med. 2015;10:A349.","journal-title":"J Hosp Med"},{"key":"1725_CR11","doi-asserted-by":"publisher","first-page":"473","DOI":"10.5603\/FC.a2016.0084","volume":"11","author":"M Garbowska","year":"2016","unstructured":"Garbowska M, Kurek K, Sobkowicz B. Takotsubo cardiomyopathy resulting from exacerbation of chronic pancreatitis. Folia Cardiol. 2016;11:473\u20136.","journal-title":"Folia Cardiol"},{"key":"1725_CR12","doi-asserted-by":"crossref","unstructured":"Koop AH, Bailey RE, Lowman PE. Acute pancreatitis-induced Takotsubo Cardiomyopathy and Cardiogenic Shock Treated With a Percutaneous Left Ventricular Assist Device. BMJ Case Rep 2018;bcr2018225877.","DOI":"10.1136\/bcr-2018-225877"},{"key":"1725_CR13","first-page":"A3568","volume":"199","author":"S Ashraf","year":"2019","unstructured":"Ashraf S, Lam K, Hu G. When your pancreas breaks your heart: a case of pancreatitis induced Takotsubo Cardiomyopathy. Am J Respir Crit Care Med. 2019;199:A3568.","journal-title":"Am J Respir Crit Care Med"},{"key":"1725_CR14","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1016\/j.ahj.2007.11.008","volume":"155","author":"A Prasad","year":"2008","unstructured":"Prasad A, Lerman A, Rihal CS. Apical ballooning syndrome (Tako-Tsubo or stress cardiomyopathy): a mimic of acute myocardial infarction. Am Heart J. 2008;155:408\u201317.","journal-title":"Am Heart J"},{"key":"1725_CR15","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1016\/j.hlc.2016.06.789","volume":"25","author":"DP Chew","year":"2016","unstructured":"Chew DP, Scott IA, Cullen L, French JK, Briffa TG, Tideman PA, et al. National Heart Foundation of Australia & Cardiac Society of Australia and New Zealand: Australian Clinical Guidelines for the Management of Acute Coronary Syndromes 2016. Heart Lung Circ. 2016;25:895\u2013951.","journal-title":"Heart Lung Circ"},{"key":"1725_CR16","doi-asserted-by":"publisher","first-page":"2047","DOI":"10.1093\/eurheartj\/ehy077","volume":"39","author":"JR Ghadri","year":"2018","unstructured":"Ghadri JR, Wittstein IS, Prasad A, Sharkey S, Dote K, Akashi YJ, et al. International expert consensus document on Takotsubo syndrome (part II): diagnostic workup, outcome, and management. Eur Heart J. 2018;39:2047\u201362.","journal-title":"Eur Heart J"}],"container-title":["BMC Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-021-01725-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12876-021-01725-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-021-01725-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T20:05:26Z","timestamp":1616529926000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcgastroenterol.biomedcentral.com\/articles\/10.1186\/s12876-021-01725-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,23]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["1725"],"URL":"https:\/\/doi.org\/10.1186\/s12876-021-01725-5","relation":{},"ISSN":["1471-230X"],"issn-type":[{"value":"1471-230X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,23]]},"assertion":[{"value":"19 October 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 March 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 March 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Informed consent was obtained from the patient.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"134"}}