{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T21:15:55Z","timestamp":1793308555210,"version":"4.5.0"},"reference-count":6,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005270","name":"Fujian Provincial Department of Science and Technology","doi-asserted-by":"publisher","award":["2019I0026"],"award-info":[{"award-number":["2019I0026"]}],"id":[{"id":"10.13039\/501100005270","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005270","name":"Fujian Provincial Department of Science and Technology","doi-asserted-by":"publisher","award":["2018Y9116"],"award-info":[{"award-number":["2018Y9116"]}],"id":[{"id":"10.13039\/501100005270","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Gastroenterol"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Oesophageal submucosal tumours are usually benign. We report a rare case of esophageal squamous cell carcinoma presenting as a submucosal tumour.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 58-year-old man undergoing screening oesophago-gastroduodenoscopy was found to have a smooth-surfaced 0.6-cm sized submucosal tumour in the oesophagus 30\u00a0cm from the incisor. Endoscopic ultrasonography showed the tumour to be located in the muscularis mucosa; the lesion was heterogeneously hypoechoic and had a clear boundary. With a provisional diagnosis of leiomyoma, the tumour was removed by endoscopic submucosal dissection. Pathological examination showed it to be a moderately differentiated infiltrating squamous cell carcinoma, with normal overlying squamous epithelium. Immunohistochemistry indicated that it was caused by malignant transformation in mucosal glandular duct epithelium. Positron emission tomography\u2013computer tomography showed no tumour spread to any other site. The patient was treated by oesophageal resection.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The clinician should be aware that oesophageal submucosal tumours with smooth overlying mucosa may not always be benign; malignancy must be ruled out.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12876-021-01731-7","type":"journal-article","created":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T22:02:45Z","timestamp":1617314565000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Oesophageal squamous cell carcinoma mimicking submucosal tumour"],"prefix":"10.1186","volume":"21","author":[{"given":"Wen","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dazhou","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9137-124X","authenticated-orcid":false,"given":"Linfu","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongli","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,4,1]]},"reference":[{"issue":"2","key":"1731_CR1","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1111\/j.1442-2050.2010.01158.x","volume":"25","author":"ZJ Liu","year":"2012","unstructured":"Liu ZJ, Sun SY, Guo JT, et al. A primary esophageal mucoepidermoid carcinoma mimicking a benign submucosal tumor. Dis Esophagus. 2012;25(2):178\u20139.","journal-title":"Dis Esophagus"},{"issue":"2","key":"1731_CR2","first-page":"36","volume":"40","author":"O Chino","year":"2015","unstructured":"Chino O, Makuuchi H, Ozawa S, et al. Small cell type of esophageal neuroendocrine carcinoma resembling a submucosal tumor. Tokai J Exp Clin Med. 2015;40(2):36\u20139.","journal-title":"Tokai J Exp Clin Med"},{"key":"1731_CR3","doi-asserted-by":"publisher","first-page":"63","DOI":"10.4137\/CGast.S40605","volume":"9","author":"N Sonthalia","year":"2016","unstructured":"Sonthalia N, Jain SS, Surude RG, Pawar VB, Udgirkar S, Rathi PM. Primary esophageal intramural squamous cell carcinoma masquerading as a submucosal tumor: a rare presentation of a common disease. Clin Med Insights Gastroenterol. 2016;9:63\u20136.","journal-title":"Clin Med Insights Gastroenterol"},{"issue":"1","key":"1731_CR4","doi-asserted-by":"publisher","first-page":"e6","DOI":"10.1053\/j.gastro.2016.08.017","volume":"152","author":"M Shibata","year":"2017","unstructured":"Shibata M, Kusafuka K, Ono H. A Rare Submucosal Tumor of the Esophagus. Gastroenterology. 2017;152(1):e6\u20137.","journal-title":"Gastroenterology"},{"key":"1731_CR5","doi-asserted-by":"publisher","first-page":"16038","DOI":"10.1038\/srep16038","volume":"5","author":"T Chen","year":"2015","unstructured":"Chen T, Cheng H, Chen X, et al. Family history of esophageal cancer increases the risk of esophageal squamous cell carcinoma. Sci Rep. 2015;5:16038.","journal-title":"Sci Rep"},{"key":"1731_CR6","doi-asserted-by":"publisher","first-page":"8795","DOI":"10.2147\/OTT.S262512","volume":"13","author":"W He","year":"2020","unstructured":"He W, Leng X, Yang Y, et al. Genetic heterogeneity of esophageal squamous cell carcinoma with inherited family history. Onco Targets Ther. 2020;13:8795\u2013802.","journal-title":"Onco Targets Ther"}],"container-title":["BMC Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-021-01731-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12876-021-01731-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-021-01731-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T22:03:10Z","timestamp":1617314590000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcgastroenterol.biomedcentral.com\/articles\/10.1186\/s12876-021-01731-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,1]]},"references-count":6,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["1731"],"URL":"https:\/\/doi.org\/10.1186\/s12876-021-01731-7","relation":{},"ISSN":["1471-230X"],"issn-type":[{"value":"1471-230X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,1]]},"assertion":[{"value":"12 November 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 March 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"150"}}